Click here to switch to the map view.

The map label for this gene is clpP

Identifier: 71907348

GI number: 71907348

Start: 1846434

End: 1847063

Strand: Reverse

Name: clpP

Synonym: Daro_1718

Alternate gene names: 71907348

Gene position: 1847063-1846434 (Counterclockwise)

Preceding gene: 71907349

Following gene: 71907347

Centisome position: 41.04

GC content: 58.41

Gene sequence:

>630_bases
ATGAATATCGACAACGCAAGCAACTGGGATCCGCAGGCTCTGGGCCTGGTCCCGATGGTGGTTGAACAGAGCGGACGCGG
CGAACGCGCGTACGACATCTATTCACGCCTGCTGAAAGAGCGGGTGATCTTTCTTGTCGGCCCTGTGAACGACGTAACCG
CCAACCTGGTCGTCGCCCAGTTGCTGTTCCTTGAAGCGGAAAACCCGGACAAGGACATTTATTTCTACATCAACTCACCG
GGCGGTTCGGTCACGGCTGGCATGTCGATCTACGACACCATGCAGTTTATCAAGCCCGACGTGTCGACGCTTTGCATCGG
CCAGGCCGCCTCGATGGGCGCCTTCCTGCTCAACGCCGGCGCCAAAGGCAAGCGTTTCGCCCTGCCCAATTCCCGCGTGA
TGATTCACCAGCCGCTCGGCGGCTTCCAGGGCCAGGCTTCGGATATCGCCATCCACGCCAAAGAAATCCTGTCGATTCGT
GATCGCCTGAACCGGATCATGGCCGAACACAGCGGCCAGCCGCTGGAACGGATCGAAAAAGACACTGATCGCGACAACTT
TCTTTCTGCAGCGGAAGCCGCAGAATATGGTTTGATCGACAAGGTATTGACCCGCCGCGACGCGGCTTGA

Upstream 100 bases:

>100_bases
GTTTTTGATGAATTGATGGGTCAGAAGCAGTAATCTGGACCTTGTCGCGAAAGCGACAATCGTCTTGAATGTAACCAACA
AGCAACACACAAGGGCTGAC

Downstream 100 bases:

>100_bases
ACGGAGAGCTAACGATGTCTAAAGGCGGCCAGGAAAAACTGCTCTACTGCTCCTTCTGCGGCAAGAGCCAGCACGAAGTC
AAAAAGCTCATCGCCGGACC

Product: ATP-dependent Clp protease proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MNIDNASNWDPQALGLVPMVVEQSGRGERAYDIYSRLLKERVIFLVGPVNDVTANLVVAQLLFLEAENPDKDIYFYINSP
GGSVTAGMSIYDTMQFIKPDVSTLCIGQAASMGAFLLNAGAKGKRFALPNSRVMIHQPLGGFQGQASDIAIHAKEILSIR
DRLNRIMAEHSGQPLERIEKDTDRDNFLSAAEAAEYGLIDKVLTRRDAA

Sequences:

>Translated_209_residues
MNIDNASNWDPQALGLVPMVVEQSGRGERAYDIYSRLLKERVIFLVGPVNDVTANLVVAQLLFLEAENPDKDIYFYINSP
GGSVTAGMSIYDTMQFIKPDVSTLCIGQAASMGAFLLNAGAKGKRFALPNSRVMIHQPLGGFQGQASDIAIHAKEILSIR
DRLNRIMAEHSGQPLERIEKDTDRDNFLSAAEAAEYGLIDKVLTRRDAA
>Mature_209_residues
MNIDNASNWDPQALGLVPMVVEQSGRGERAYDIYSRLLKERVIFLVGPVNDVTANLVVAQLLFLEAENPDKDIYFYINSP
GGSVTAGMSIYDTMQFIKPDVSTLCIGQAASMGAFLLNAGAKGKRFALPNSRVMIHQPLGGFQGQASDIAIHAKEILSIR
DRLNRIMAEHSGQPLERIEKDTDRDNFLSAAEAAEYGLIDKVLTRRDAA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=58.8541666666667, Blast_Score=247, Evalue=7e-66,
Organism=Escherichia coli, GI1786641, Length=200, Percent_Identity=74.5, Blast_Score=324, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17538017, Length=189, Percent_Identity=56.0846560846561, Blast_Score=229, Evalue=9e-61,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=57.8947368421053, Blast_Score=242, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_DECAR (Q47FB6)

Other databases:

- EMBL:   CP000089
- RefSeq:   YP_284935.1
- ProteinModelPortal:   Q47FB6
- SMR:   Q47FB6
- STRING:   Q47FB6
- MEROPS:   S14.001
- GeneID:   3568536
- GenomeReviews:   CP000089_GR
- KEGG:   dar:Daro_1718
- NMPDR:   fig|159087.4.peg.1731
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   TGQPFER
- ProtClustDB:   CLSK2525839
- BioCyc:   DARO159087:DARO_1718-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22927; Mature: 22927

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 111-111 ACT_SITE 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDNASNWDPQALGLVPMVVEQSGRGERAYDIYSRLLKERVIFLVGPVNDVTANLVVAQ
CCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHH
LLFLEAENPDKDIYFYINSPGGSVTAGMSIYDTMQFIKPDVSTLCIGQAASMGAFLLNAG
HHHHHCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCHHHHHHCCHHHHHHHEECCC
AKGKRFALPNSRVMIHQPLGGFQGQASDIAIHAKEILSIRDRLNRIMAEHSGQPLERIEK
CCCCEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DTDRDNFLSAAEAAEYGLIDKVLTRRDAA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIDNASNWDPQALGLVPMVVEQSGRGERAYDIYSRLLKERVIFLVGPVNDVTANLVVAQ
CCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHH
LLFLEAENPDKDIYFYINSPGGSVTAGMSIYDTMQFIKPDVSTLCIGQAASMGAFLLNAG
HHHHHCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCHHHHHHCCHHHHHHHEECCC
AKGKRFALPNSRVMIHQPLGGFQGQASDIAIHAKEILSIRDRLNRIMAEHSGQPLERIEK
CCCCEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DTDRDNFLSAAEAAEYGLIDKVLTRRDAA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA