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The map label for this gene is uvrY [H]

Identifier: 71907204

GI number: 71907204

Start: 1685785

End: 1686441

Strand: Reverse

Name: uvrY [H]

Synonym: Daro_1572

Alternate gene names: 71907204

Gene position: 1686441-1685785 (Counterclockwise)

Preceding gene: 71907205

Following gene: 71907203

Centisome position: 37.47

GC content: 55.71

Gene sequence:

>657_bases
ATGATCAGAACATTGATCGCCGACGACCACGACATACTTCGTATCGGCCTCAAGCACATACTCTCGGACACCGGAGATAT
CGTCGTCACCGCCGAAGCGAGCAACGGCATCGAGGCCCTCGTCGAACTACGCAAGGGAACGTTCGACGCCCTTGTGCTGG
ACCTGACCATGCCGGGCCGCAATGGCATCGAACTGATCAAGCAGATCAAGGGAGAGTTTCCCAAACTCCCCATCCTGATC
CTCAGCATGCACAAGGAGGATATTTACGCCGTTCGCAGCCTGAAGGCCGGTGCATCAGGCTACCTGTGCAAGGACAGTGC
GGAAACCCTGCTCGCCGATGCCATTCGCAAAGTCGCGGATGGAGGGCTGTTCATCAACCAAGCTGTGGCCGAAAAACTGA
CGCTCCAGATACTGCATGGACGAGACACTGATGCACCACATACTGGCCTGACTGATCGAGAGCACCAAATCTTCCTGATG
ATATTGCAGGGTCTGGGCGTCACCGAGATCGGACGCCAACTCAATCTTAGCGTCAAGACAGTCAGCACGCACAAGGCCAG
CATTCTCGCCAAAATGAATCTTCGAAACAGCGCCGAACTAGTGCGCTACGCGATCCAGCACCGACTGATTGACGAGAACG
ACGCTCTTCTCGGGTAG

Upstream 100 bases:

>100_bases
TGCGCGAACGTGTCACAATGCTTGGCGGCACGATCGACATTGACGGTAGCCGGGGGACTCGAATCCTCGCCCGCTTTCCG
TTATTCAAGGGAGAAAAGTC

Downstream 100 bases:

>100_bases
GACGATTCCTACCCCACCCCCTCCAGTTACCGAGTCCATATTTCAGCCACCGTCACCTGAGAATTTGGTGAACGGAAGCG
CACAATGCGACAAATTCCCG

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MIRTLIADDHDILRIGLKHILSDTGDIVVTAEASNGIEALVELRKGTFDALVLDLTMPGRNGIELIKQIKGEFPKLPILI
LSMHKEDIYAVRSLKAGASGYLCKDSAETLLADAIRKVADGGLFINQAVAEKLTLQILHGRDTDAPHTGLTDREHQIFLM
ILQGLGVTEIGRQLNLSVKTVSTHKASILAKMNLRNSAELVRYAIQHRLIDENDALLG

Sequences:

>Translated_218_residues
MIRTLIADDHDILRIGLKHILSDTGDIVVTAEASNGIEALVELRKGTFDALVLDLTMPGRNGIELIKQIKGEFPKLPILI
LSMHKEDIYAVRSLKAGASGYLCKDSAETLLADAIRKVADGGLFINQAVAEKLTLQILHGRDTDAPHTGLTDREHQIFLM
ILQGLGVTEIGRQLNLSVKTVSTHKASILAKMNLRNSAELVRYAIQHRLIDENDALLG
>Mature_218_residues
MIRTLIADDHDILRIGLKHILSDTGDIVVTAEASNGIEALVELRKGTFDALVLDLTMPGRNGIELIKQIKGEFPKLPILI
LSMHKEDIYAVRSLKAGASGYLCKDSAETLLADAIRKVADGGLFINQAVAEKLTLQILHGRDTDAPHTGLTDREHQIFLM
ILQGLGVTEIGRQLNLSVKTVSTHKASILAKMNLRNSAELVRYAIQHRLIDENDALLG

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=36.4928909952607, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1790102, Length=203, Percent_Identity=34.9753694581281, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788521, Length=210, Percent_Identity=32.8571428571429, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1786747, Length=207, Percent_Identity=29.4685990338164, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788546, Length=205, Percent_Identity=31.219512195122, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787473, Length=209, Percent_Identity=34.4497607655502, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=37.3913043478261, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788712, Length=210, Percent_Identity=23.3333333333333, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=32.2314049586777, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23859; Mature: 23859

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRTLIADDHDILRIGLKHILSDTGDIVVTAEASNGIEALVELRKGTFDALVLDLTMPGR
CCCEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCEEEEEEEEECCCC
NGIELIKQIKGEFPKLPILILSMHKEDIYAVRSLKAGASGYLCKDSAETLLADAIRKVAD
CHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHC
GGLFINQAVAEKLTLQILHGRDTDAPHTGLTDREHQIFLMILQGLGVTEIGRQLNLSVKT
CCEEEHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHEEHHHCCCHHHHCHHHEEEEEE
VSTHKASILAKMNLRNSAELVRYAIQHRLIDENDALLG
ECHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIRTLIADDHDILRIGLKHILSDTGDIVVTAEASNGIEALVELRKGTFDALVLDLTMPGR
CCCEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCEEEEEEEEECCCC
NGIELIKQIKGEFPKLPILILSMHKEDIYAVRSLKAGASGYLCKDSAETLLADAIRKVAD
CHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHC
GGLFINQAVAEKLTLQILHGRDTDAPHTGLTDREHQIFLMILQGLGVTEIGRQLNLSVKT
CCEEEHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHEEHHHCCCHHHHCHHHEEEEEE
VSTHKASILAKMNLRNSAELVRYAIQHRLIDENDALLG
ECHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]