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The map label for this gene is fabI1 [H]

Identifier: 71906617

GI number: 71906617

Start: 1069672

End: 1070457

Strand: Reverse

Name: fabI1 [H]

Synonym: Daro_0978

Alternate gene names: 71906617

Gene position: 1070457-1069672 (Counterclockwise)

Preceding gene: 71906623

Following gene: 71906616

Centisome position: 23.78

GC content: 60.56

Gene sequence:

>786_bases
ATGAACGACACCGTCCAAAACCATCTCCCGCTGGCTGGAAAAAAAGGCCTGGTGACCGGTATTGCCAACGACAAGTCAAT
CGCCTTTGCCGTCGCCAAGGCCATCGTCGCGCTCGGAGGCGAAGTCGCCCTGACCTACCAGAATGACAAGACCGCCAAAT
ACACACAGCCGCTGGCCGAGTCCATTGGTGCCAAACTTTTCGAAAAGCTCGACGTTTCCGAACCGGGCAGCCTGGAAGCC
GTCATCGCCAAGTGCGGCGAAGTGTTTGGCGAACTCGATTTCGCCATTCATTCGATGGCTTTTTGCAATGCCGATGACCT
GCACGGTCGCGTTATCGATACGACCGAAGAAGGCTTCGACTCGGCGATGAACGTTTCCTGCCACAGTTTCCTGCGCATGG
CCAAACTGCTGGAGCCGCTGATGGCCCACGGTGGCTCGTTGATCACCATGTCCTACCTCGGTGCCGAGCGCGTCGTCCGT
AACTATGGCGTGATGGGCATCATCAAGGCCGCGCTCGAGTCCGCCGTCCGCTACATGGCCTACGATCTCGGCCCCAAGGG
CATCCGCGTCTTCGCCGTGTCACCCGGCCCGATCATGACCCGCGCGGCTTCCGGCATCGCCAACTTCAATACCCTGCTGG
AAAAGGATGCCGAGAAGGCCCCACTCGGCCGCACCGTGACCATCGAGGAAGTCGGCGCCCTGACCGCCTTCCTGTGCACT
TCCGGCTCGTCCGGCATGACCGGCCAGACGATCTACGTCGACGCCGGTTCGCACATCGTCGCCTAA

Upstream 100 bases:

>100_bases
AATGCTGCACCACAGCATTATTTAATAATTGCTCTAAAAACGGTAACAATGCCGCAGCACTATCCCGACTTGAAGACCGC
ATAACTAAAGGAAGAACAGC

Downstream 100 bases:

>100_bases
GACCAATCCGGCCGCTTCGTTGCGGCCAACCGGCAAAACGGGCTAAATCCATGTTGGCGGGAACTCTTCCCGCCAACATG
TAGCCATTTCGGAGACCATC

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MNDTVQNHLPLAGKKGLVTGIANDKSIAFAVAKAIVALGGEVALTYQNDKTAKYTQPLAESIGAKLFEKLDVSEPGSLEA
VIAKCGEVFGELDFAIHSMAFCNADDLHGRVIDTTEEGFDSAMNVSCHSFLRMAKLLEPLMAHGGSLITMSYLGAERVVR
NYGVMGIIKAALESAVRYMAYDLGPKGIRVFAVSPGPIMTRAASGIANFNTLLEKDAEKAPLGRTVTIEEVGALTAFLCT
SGSSGMTGQTIYVDAGSHIVA

Sequences:

>Translated_261_residues
MNDTVQNHLPLAGKKGLVTGIANDKSIAFAVAKAIVALGGEVALTYQNDKTAKYTQPLAESIGAKLFEKLDVSEPGSLEA
VIAKCGEVFGELDFAIHSMAFCNADDLHGRVIDTTEEGFDSAMNVSCHSFLRMAKLLEPLMAHGGSLITMSYLGAERVVR
NYGVMGIIKAALESAVRYMAYDLGPKGIRVFAVSPGPIMTRAASGIANFNTLLEKDAEKAPLGRTVTIEEVGALTAFLCT
SGSSGMTGQTIYVDAGSHIVA
>Mature_261_residues
MNDTVQNHLPLAGKKGLVTGIANDKSIAFAVAKAIVALGGEVALTYQNDKTAKYTQPLAESIGAKLFEKLDVSEPGSLEA
VIAKCGEVFGELDFAIHSMAFCNADDLHGRVIDTTEEGFDSAMNVSCHSFLRMAKLLEPLMAHGGSLITMSYLGAERVVR
NYGVMGIIKAALESAVRYMAYDLGPKGIRVFAVSPGPIMTRAASGIANFNTLLEKDAEKAPLGRTVTIEEVGALTAFLCT
SGSSGMTGQTIYVDAGSHIVA

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=27.3076923076923, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=28.3400809716599, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI126723750, Length=262, Percent_Identity=27.0992366412214, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI7705925, Length=252, Percent_Identity=28.1746031746032, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787545, Length=252, Percent_Identity=44.4444444444444, Blast_Score=216, Evalue=1e-57,
Organism=Escherichia coli, GI1787905, Length=257, Percent_Identity=26.4591439688716, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787335, Length=264, Percent_Identity=28.7878787878788, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87082100, Length=198, Percent_Identity=26.7676767676768, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=25.296442687747, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=262, Percent_Identity=28.6259541984733, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=201, Percent_Identity=29.8507462686567, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=177, Percent_Identity=27.683615819209, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=27.8810408921933, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=27.0676691729323, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=264, Percent_Identity=28.4090909090909, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=28.0898876404494, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=25.4901960784314, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357041, Length=228, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=27.8884462151394, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=26.5060240963855, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644339, Length=260, Percent_Identity=26.5384615384615, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643142, Length=146, Percent_Identity=28.7671232876712, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 27494; Mature: 27494

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTVQNHLPLAGKKGLVTGIANDKSIAFAVAKAIVALGGEVALTYQNDKTAKYTQPLAE
CCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
SIGAKLFEKLDVSEPGSLEAVIAKCGEVFGELDFAIHSMAFCNADDLHGRVIDTTEEGFD
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHH
SAMNVSCHSFLRMAKLLEPLMAHGGSLITMSYLGAERVVRNYGVMGIIKAALESAVRYMA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YDLGPKGIRVFAVSPGPIMTRAASGIANFNTLLEKDAEKAPLGRTVTIEEVGALTAFLCT
HCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEHHHHHHHHHHHHC
SGSSGMTGQTIYVDAGSHIVA
CCCCCCCCCEEEEECCCEECC
>Mature Secondary Structure
MNDTVQNHLPLAGKKGLVTGIANDKSIAFAVAKAIVALGGEVALTYQNDKTAKYTQPLAE
CCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
SIGAKLFEKLDVSEPGSLEAVIAKCGEVFGELDFAIHSMAFCNADDLHGRVIDTTEEGFD
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHH
SAMNVSCHSFLRMAKLLEPLMAHGGSLITMSYLGAERVVRNYGVMGIIKAALESAVRYMA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YDLGPKGIRVFAVSPGPIMTRAASGIANFNTLLEKDAEKAPLGRTVTIEEVGALTAFLCT
HCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEHHHHHHHHHHHHC
SGSSGMTGQTIYVDAGSHIVA
CCCCCCCCCEEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]