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The map label for this gene is mhpR [H]

Identifier: 71906536

GI number: 71906536

Start: 970899

End: 971735

Strand: Reverse

Name: mhpR [H]

Synonym: Daro_0897

Alternate gene names: 71906536

Gene position: 971735-970899 (Counterclockwise)

Preceding gene: 71906537

Following gene: 71906495

Centisome position: 21.59

GC content: 59.98

Gene sequence:

>837_bases
ATGCGACCAGAGAGCGGAGCCAGTTATCGCAACGTGCAGGGCCTGAGCCGTGGCTTGTCCATCCTGCGGGCCATCAGCCA
GTCAGCCAACGGCTGGGCGAGCATTGCCGAACTCAGTGCGGCCACCGCGCTGCATCGGACAACGGTACGCCGCATGCTGG
AAACCTTGCAGGCCGAAGGCTATGTCAGGCGCAGCGCATCCGACGACAGTTACCGCCTCAACCAGAAGGTACGCCAGCTG
AGCGATGGTTTCACCGACGACGAATGGATTTCCGAAGTAGCCAACCCGGTACTCGGCGAACTGCTGCAAAAAATCGTCTG
GCCCTCGGATCTATCGACCCTCGATGGCGACTGCATGCTGGTTCGCGAGACAACCCACCGCTTCAGCGTGCTCTCCTTCC
ATCGGGCAATGATCCGCCAGCGCATGCCCTTGCTGTTCACCTCGGCCGGCCGGGCCTATCTGGCCTATTGCAGCGATGAA
GAGCGCAAGCAGATACTTCAACTGTTGGTCGCCGGCAACGACGAGCAGGCCAATTTTGCCCGCAATCGTGTGCTGGTCAA
TCAAATGCTGGAAAGGGTACGGCGTCAGGGCTACGCCTCGAATGAGGGCGAATGGAGTCAGCAACAGAAAATCGCTGCGA
TTGCCCTGCCCATTCGCCACAAGAACCACGTGCTGGCCTGCCTCAACATCGTCTTCTTGAAGAAGGCGATGAGCGTTGCC
GAGGCAGCCAGCCGTTACCTGCCCGACCTGAAAGCCGCCGTCGAAAAAATAGAGGCCCAACTGGATGGAAGCGAGATCGA
GGTCCCGCTGCCCACCGCCATCACACCACCCCGTTAA

Upstream 100 bases:

>100_bases
CAGGCAAAAATGCATATCGATAGCGTCGCCAGGACACTGCTTGAGCATCTCAAATTAACGACGGGCTGATTGCCTTATCG
TATTGATCACCAAGACAAAC

Downstream 100 bases:

>100_bases
ATGGAGCGGCCCCGCCCCGACCTACAGGCCAGGGCAATTCCTTACATGCGCAGGGCGTCCGGATCGGCCCGCATCAGCCG
CTTGTTCATCTTGCCGACAC

Product: DNA-binding transcriptional activator MhpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MRPESGASYRNVQGLSRGLSILRAISQSANGWASIAELSAATALHRTTVRRMLETLQAEGYVRRSASDDSYRLNQKVRQL
SDGFTDDEWISEVANPVLGELLQKIVWPSDLSTLDGDCMLVRETTHRFSVLSFHRAMIRQRMPLLFTSAGRAYLAYCSDE
ERKQILQLLVAGNDEQANFARNRVLVNQMLERVRRQGYASNEGEWSQQQKIAAIALPIRHKNHVLACLNIVFLKKAMSVA
EAASRYLPDLKAAVEKIEAQLDGSEIEVPLPTAITPPR

Sequences:

>Translated_278_residues
MRPESGASYRNVQGLSRGLSILRAISQSANGWASIAELSAATALHRTTVRRMLETLQAEGYVRRSASDDSYRLNQKVRQL
SDGFTDDEWISEVANPVLGELLQKIVWPSDLSTLDGDCMLVRETTHRFSVLSFHRAMIRQRMPLLFTSAGRAYLAYCSDE
ERKQILQLLVAGNDEQANFARNRVLVNQMLERVRRQGYASNEGEWSQQQKIAAIALPIRHKNHVLACLNIVFLKKAMSVA
EAASRYLPDLKAAVEKIEAQLDGSEIEVPLPTAITPPR
>Mature_278_residues
MRPESGASYRNVQGLSRGLSILRAISQSANGWASIAELSAATALHRTTVRRMLETLQAEGYVRRSASDDSYRLNQKVRQL
SDGFTDDEWISEVANPVLGELLQKIVWPSDLSTLDGDCMLVRETTHRFSVLSFHRAMIRQRMPLLFTSAGRAYLAYCSDE
ERKQILQLLVAGNDEQANFARNRVLVNQMLERVRRQGYASNEGEWSQQQKIAAIALPIRHKNHVLACLNIVFLKKAMSVA
EAASRYLPDLKAAVEKIEAQLDGSEIEVPLPTAITPPR

Specific function: Activator of the mhpRABCDEF operon coding for components of the 3-hydroxyphenylpropionate degradation pathway [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI145693096, Length=260, Percent_Identity=48.8461538461538, Blast_Score=268, Evalue=3e-73,
Organism=Escherichia coli, GI1786468, Length=235, Percent_Identity=25.1063829787234, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788131, Length=262, Percent_Identity=27.0992366412214, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87082359, Length=199, Percent_Identity=24.1206030150754, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 31164; Mature: 31164

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPESGASYRNVQGLSRGLSILRAISQSANGWASIAELSAATALHRTTVRRMLETLQAEG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YVRRSASDDSYRLNQKVRQLSDGFTDDEWISEVANPVLGELLQKIVWPSDLSTLDGDCML
HHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
VRETTHRFSVLSFHRAMIRQRMPLLFTSAGRAYLAYCSDEERKQILQLLVAGNDEQANFA
EEHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHH
RNRVLVNQMLERVRRQGYASNEGEWSQQQKIAAIALPIRHKNHVLACLNIVFLKKAMSVA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
EAASRYLPDLKAAVEKIEAQLDGSEIEVPLPTAITPPR
HHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MRPESGASYRNVQGLSRGLSILRAISQSANGWASIAELSAATALHRTTVRRMLETLQAEG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YVRRSASDDSYRLNQKVRQLSDGFTDDEWISEVANPVLGELLQKIVWPSDLSTLDGDCML
HHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
VRETTHRFSVLSFHRAMIRQRMPLLFTSAGRAYLAYCSDEERKQILQLLVAGNDEQANFA
EEHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHH
RNRVLVNQMLERVRRQGYASNEGEWSQQQKIAAIALPIRHKNHVLACLNIVFLKKAMSVA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
EAASRYLPDLKAAVEKIEAQLDGSEIEVPLPTAITPPR
HHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]