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The map label for this gene is lysA [H]

Identifier: 71905849

GI number: 71905849

Start: 222484

End: 223746

Strand: Reverse

Name: lysA [H]

Synonym: Daro_0207

Alternate gene names: 71905849

Gene position: 223746-222484 (Counterclockwise)

Preceding gene: 71905851

Following gene: 71905848

Centisome position: 4.97

GC content: 60.65

Gene sequence:

>1263_bases
ATGACCCACTTTGCCCTGAATAACGGCGTCCTGCACGCCGAATCCGTTGCCCTGCCCGCTATCGCCGACCAGTTCGGCAC
TCCGGCCTACGTTTACTCCCGCGCTGCGCTGGAAGCTTCGTTGCGCGAATTCCACGATGTCCTCGGCGGCCACGTCGCCG
GCCAGGGAGCCTTGGTTTGCTATGCAGTTAAAGCCAATTCCAATTTAGCCATCCTGAACGTTTTCGCCCGCCTTGGCGCT
GGTTTCGATATTGTCTCCGGCGGCGAACTGCAGCGCGTGCTGGCTGCTGGTGCCGATCCGAAGAAGGTCGTTTTCTCCGG
CGTCGGCAAGACGGCTGATGAAATGAAGCTGGCACTGGACGTCGGCATTTTTTGCTTCAATGTCGAATCTGCCGCCGAAC
TGGAACGGCTGAATGAGGTCGCCAGCCAGTGCGGCAAGAAGGCGCCGATCAGTCTGCGCGTCAATCCAAACGTCGATCCG
AAAACCCACCCCTACATTTCGACGGGTCTCAAGGGTGCCAAGTTCGGCGTGGCCTACGACAATGCGCTAGACTTGTACCG
CCGCGCTGCTGCGCTACCGAGCATAGAAGTCACTGGCATCGACTGCCATATCGGCTCGCAATTGCTCGACCCGTCGCCTT
TCGTCGAAGCGCTCGATCGCATTCTGGCCCTGGTCGATCAGATGGCTGCCGAAGGCATCCACATTCATCACCTCGACCTC
GGCGGCGGCCTTGGCATCAAGTACAACGCCGAACAGGCGCAACCAACTGTCGCCTCCTACCTGACGCCGCTGCTCGACAA
GCTCGCCGGTCGCGGCCTGCAGGTCGTTCTCGAACCGGGTCGCCGGCTGGTTGGTAATGCTGGCCTGCTGCTCACCCGCA
TCGAATACCTCAAGCAGGGCGAGGCCAAGAATTTTGCCATCATCGACGCCGCCATGAACGACCTGATGCGCCCTGCGCTC
TATGAAGCGTGGCACGACATCAATCCGGTAGTGCCACGCTCAGGTGTGGCCACGGAGTACGACGTCGTTGGTCCGGTCTG
CGAAACCGGCGATTTTCTCGGCCAGGCCCGCCCGCTGGTGGTTGAAGCAGGGGATTTGCTGGCTGTGATGTCAGCCGGCG
CTTATGGCATGGCCATGGCCTCGAACTACAACACCCGGCCACGGGCGGTTGAAGTGATGGTCGATGGCGACAAGATTCAC
GTCATCCGCCAGCGTGAAACCGTCGAACAGCTGTACGCCGGTGAGTCCATCCTGCCGCAGTGA

Upstream 100 bases:

>100_bases
GCCAACTAGAACGGCCTTCCGGCCCGGCGCCGGAACCGCTGCTCGGCAGCGGAAAAACAACGCCCAAGGATGTTAGCACG
ACCACCAGCCCCAAAGCCCA

Downstream 100 bases:

>100_bases
ACGGTTTGCGCGTCGATAAATGGCTGTGGGCAGCGCGATTCTTCAAGACGCGCTCCCTGGCCAGCGATGCCGTCAGTGGC
GGCAAGGTGAAGGTCAATGG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTHFALNNGVLHAESVALPAIADQFGTPAYVYSRAALEASLREFHDVLGGHVAGQGALVCYAVKANSNLAILNVFARLGA
GFDIVSGGELQRVLAAGADPKKVVFSGVGKTADEMKLALDVGIFCFNVESAAELERLNEVASQCGKKAPISLRVNPNVDP
KTHPYISTGLKGAKFGVAYDNALDLYRRAAALPSIEVTGIDCHIGSQLLDPSPFVEALDRILALVDQMAAEGIHIHHLDL
GGGLGIKYNAEQAQPTVASYLTPLLDKLAGRGLQVVLEPGRRLVGNAGLLLTRIEYLKQGEAKNFAIIDAAMNDLMRPAL
YEAWHDINPVVPRSGVATEYDVVGPVCETGDFLGQARPLVVEAGDLLAVMSAGAYGMAMASNYNTRPRAVEVMVDGDKIH
VIRQRETVEQLYAGESILPQ

Sequences:

>Translated_420_residues
MTHFALNNGVLHAESVALPAIADQFGTPAYVYSRAALEASLREFHDVLGGHVAGQGALVCYAVKANSNLAILNVFARLGA
GFDIVSGGELQRVLAAGADPKKVVFSGVGKTADEMKLALDVGIFCFNVESAAELERLNEVASQCGKKAPISLRVNPNVDP
KTHPYISTGLKGAKFGVAYDNALDLYRRAAALPSIEVTGIDCHIGSQLLDPSPFVEALDRILALVDQMAAEGIHIHHLDL
GGGLGIKYNAEQAQPTVASYLTPLLDKLAGRGLQVVLEPGRRLVGNAGLLLTRIEYLKQGEAKNFAIIDAAMNDLMRPAL
YEAWHDINPVVPRSGVATEYDVVGPVCETGDFLGQARPLVVEAGDLLAVMSAGAYGMAMASNYNTRPRAVEVMVDGDKIH
VIRQRETVEQLYAGESILPQ
>Mature_419_residues
THFALNNGVLHAESVALPAIADQFGTPAYVYSRAALEASLREFHDVLGGHVAGQGALVCYAVKANSNLAILNVFARLGAG
FDIVSGGELQRVLAAGADPKKVVFSGVGKTADEMKLALDVGIFCFNVESAAELERLNEVASQCGKKAPISLRVNPNVDPK
THPYISTGLKGAKFGVAYDNALDLYRRAAALPSIEVTGIDCHIGSQLLDPSPFVEALDRILALVDQMAAEGIHIHHLDLG
GGLGIKYNAEQAQPTVASYLTPLLDKLAGRGLQVVLEPGRRLVGNAGLLLTRIEYLKQGEAKNFAIIDAAMNDLMRPALY
EAWHDINPVVPRSGVATEYDVVGPVCETGDFLGQARPLVVEAGDLLAVMSAGAYGMAMASNYNTRPRAVEVMVDGDKIHV
IRQRETVEQLYAGESILPQ

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=375, Percent_Identity=26.6666666666667, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI22538418, Length=241, Percent_Identity=26.9709543568465, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI21361583, Length=241, Percent_Identity=26.9709543568465, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI16506287, Length=230, Percent_Identity=29.5652173913043, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=444, Percent_Identity=31.0810810810811, Blast_Score=168, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17562780, Length=354, Percent_Identity=22.8813559322034, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=365, Percent_Identity=22.7397260273973, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586474, Length=365, Percent_Identity=25.7534246575342, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24586472, Length=339, Percent_Identity=24.7787610619469, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44733; Mature: 44602

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHFALNNGVLHAESVALPAIADQFGTPAYVYSRAALEASLREFHDVLGGHVAGQGALVC
CCEEEECCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
YAVKANSNLAILNVFARLGAGFDIVSGGELQRVLAAGADPKKVVFSGVGKTADEMKLALD
EEEECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHEE
VGIFCFNVESAAELERLNEVASQCGKKAPISLRVNPNVDPKTHPYISTGLKGAKFGVAYD
EEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCCEECEEEH
NALDLYRRAAALPSIEVTGIDCHIGSQLLDPSPFVEALDRILALVDQMAAEGIHIHHLDL
HHHHHHHHHHCCCCEEEEEEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEC
GGGLGIKYNAEQAQPTVASYLTPLLDKLAGRGLQVVLEPGRRLVGNAGLLLTRIEYLKQG
CCCCCEEECCHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCHHHHHHHHHHCC
EAKNFAIIDAAMNDLMRPALYEAWHDINPVVPRSGVATEYDVVGPVCETGDFLGQARPLV
CCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCHHHCCCCCEE
VEAGDLLAVMSAGAYGMAMASNYNTRPRAVEVMVDGDKIHVIRQRETVEQLYAGESILPQ
EECCCCHHHHHCCCHHEEEECCCCCCCCEEEEEECCCEEEEEECHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
THFALNNGVLHAESVALPAIADQFGTPAYVYSRAALEASLREFHDVLGGHVAGQGALVC
CEEEECCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
YAVKANSNLAILNVFARLGAGFDIVSGGELQRVLAAGADPKKVVFSGVGKTADEMKLALD
EEEECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHEE
VGIFCFNVESAAELERLNEVASQCGKKAPISLRVNPNVDPKTHPYISTGLKGAKFGVAYD
EEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCCEECEEEH
NALDLYRRAAALPSIEVTGIDCHIGSQLLDPSPFVEALDRILALVDQMAAEGIHIHHLDL
HHHHHHHHHHCCCCEEEEEEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEC
GGGLGIKYNAEQAQPTVASYLTPLLDKLAGRGLQVVLEPGRRLVGNAGLLLTRIEYLKQG
CCCCCEEECCHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCHHHHHHHHHHCC
EAKNFAIIDAAMNDLMRPALYEAWHDINPVVPRSGVATEYDVVGPVCETGDFLGQARPLV
CCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCHHHCCCCCEE
VEAGDLLAVMSAGAYGMAMASNYNTRPRAVEVMVDGDKIHVIRQRETVEQLYAGESILPQ
EECCCCHHHHHCCCHHEEEECCCCCCCCEEEEEECCCEEEEEECHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]