| Definition | Dechloromonas aromatica RCB, complete genome. |
|---|---|
| Accession | NC_007298 |
| Length | 4,501,104 |
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The map label for this gene is mrcA [H]
Identifier: 71905851
GI number: 71905851
Start: 224264
End: 226579
Strand: Reverse
Name: mrcA [H]
Synonym: Daro_0209
Alternate gene names: 71905851
Gene position: 226579-224264 (Counterclockwise)
Preceding gene: 71905865
Following gene: 71905849
Centisome position: 5.03
GC content: 57.08
Gene sequence:
>2316_bases GTGCCTTCAACCCACTCAGCGCTGCGTCTGATCCTTTACCCTGTCATTTTTCTGCTCGGACTTCTGGCCATCGGAATAGC GATAGCATTGATTGTCCTCGTTCTGGCCTACCCGAACCTCCCCTCGCTTGAGGTGCTGACCGACTATCGCCCAAAGATAC CTTTACGCGTGTATACCGCTGACGGCTTCCTGATTGGCGAATACGGCGAAGAGCGTCGCGCCGTGGTTGCGATCAAGGAC GTTCCGCCGATCATGAAGCAGGCCATTCTCGCCGCTGAAGACGATCGCTTCTATCAACACGGCGGTATCGACTACACCGG GATACTGCGTGCGGCGGGAGCCAACCTGATTGGCGGCGGAAAACGCCAAGGCGCATCGACTATCACTCAACAAGTTGCCA GGAACTTCTTTCTGACCGGAGAGAAAACCTACACGCGCAAACTTTATGAGGCTCTTCTCTCTTTCAAGATAGAAAGCAAT CTGACGAAAGACCAGATTTTCGAGTTATACATCAATCAGATATTCCTCGGCCAGCGCGCCTATGGATTTGCTGCGGCCGC CCAGATTTATTTCGGCAAGCCGCTAAAAGACATCTCGATTGCCGAAGCCGCCATGCTGGCCGGCCTGCCAAAAGCACCAT CGGCCTACAACCCGGTCGTGAACCCGACTCGCGCCAAGCAACGCCAACAGTACGTACTGCGCCGTATGCATGAATTGGGG CATATCTCGGATACCCAATATGCCGCAGCCCTGAAGGAACCTCTGATCGTCAAGCGCGAACTGGCTGGCTATGCCGTTCA TGCCGAGTATGTGGCCGAAATGGCGCGCCAGATCACCGCCGAACGCTTTCCGGAAGAAGTTTATTCACGCGGCATGAAGG TTTATACGACACTGATCAAGGCCGAACAGGAAGCCGCCTATATCAGCCTGCGCAAAGGCGTCATGGACTATGACCGACGG CATGGTTATCGAGGCGCCGAATCCTATCTGGACATGAAGGACATCAAGTCCGATCAGGACGAAGCTATCGACGAAGCCCT TCAGGACATTCCCGATACCGGCGATCTTATTCCGGCTTTGGTCCTGTCGGCAGATCCAAAACAGATCAAGGTCTACCGCA AGGGTGGCGAAGTGGTGACGCTGACCGGTGATGCCATGAAATTTGCGGCCAAGATGCTCGACGACAAGGCACCGCCAAAC AAACGCCTGAAGCGCAGCGCCATCGTTCGCCTGCAGAAGGACGACAAGGGCAACTGGCAGATCAGCCAACTGCCAGAGGT TGAATCCGCATTTGTCGCGGTAGACCCGAAGGACGGCGCCATTCGCGCCTTGGTTGGCGGTTTCGATTTCAATCGCAACA AGTTCAACCATGTCACGCAGGCCTGGCGGCAACCGGGTTCCAGCTTTAAACCATTCATCTACTCCGCATCGCTGGAAAAA GGTTTCAGCCCGAACAGCGTGATCGCCGACGAACCAATCGTCATTCCGGCCAGCCAGACCGGCACCCAGGCTTGGGAGCC GCACAACTACGATGGCAAGTATGAAGGCCCGATGAAGATGCGTACCGCGCTGGCCAAGTCCAAGAACATGGTATCGATCC GCATTCTGCAGGCTATCGGGACGCAATATGCTCAGGACTACGCCGGGCGCTTCGGTTTTGATCCCGCCAAGCACCCGCCT TACCTGACCATGGCCCTCGGCGCCGGTTCGGTCACCCCGTGGCAAATGGTTACCGCGTACTCCGTGTTCGCCAACGGTGG TTTCAAGGTCAGCCCATTCGTCGTCCGCGAAATTCGTGACGAACGCGAGCAGATATTGGCCCACTCTGCGGAGATCGAAG CCGGCAGTGACAATATCCGGGTCATCGACCCGCGCAACGCCTTCATGATGGACACCATGTTGCGCGACGTCGCCATCTAC GGCACGGCGGCCAAGGCATCGGCAATCCTGAAACGTCAGGATCTGGCCGGGAAGACGGGTACGACAAACGAGTATGTCGA CGCCTGGTTCTGCGGCTACCAAATGACGGTTGCCGGCTGTGCCTGGATTGGCTTCGACCAACCGAGAAAACTGGGCGACA AGGAAACCGGTGGCGCGGCCGCACTGCCGATCTGGATTGGCTACATGGCCCGTGCCCTGAAGGATGTACCGATGCAGGTG CCGCAAGCACCGGAAGGCCTCATCGCCTATGGCGAAGGTCGTGACCGGAGCTATATCTATGCCGAGAATGCCGCCAAGGA ACGTACGCCTGAAGAAGAAAGCCAGGATGCGACGCCTCTGCCCAAACCGGACCTGAGTACGCCACCCAGCGACTAA
Upstream 100 bases:
>100_bases AGATGCTAACAACAACCTATAGGCATGTAAAGCAATTTCACGAGCGAAAAATTGCCCGGCGTATAATCTGCGCAACTTCA ATTTCACCTCCCCGCTCCCC
Downstream 100 bases:
>100_bases TCAGCGCAGAACGATAGCCTCGCCAGCCTGCTGACTGGCGAGCGTCGATAATTTTTCCATCAATTCGGCGTTATCGCGAG TATCGCGCCAACTGGCACCA
Product: penicillin-binding protein 1A
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 771; Mature: 770
Protein sequence:
>771_residues MPSTHSALRLILYPVIFLLGLLAIGIAIALIVLVLAYPNLPSLEVLTDYRPKIPLRVYTADGFLIGEYGEERRAVVAIKD VPPIMKQAILAAEDDRFYQHGGIDYTGILRAAGANLIGGGKRQGASTITQQVARNFFLTGEKTYTRKLYEALLSFKIESN LTKDQIFELYINQIFLGQRAYGFAAAAQIYFGKPLKDISIAEAAMLAGLPKAPSAYNPVVNPTRAKQRQQYVLRRMHELG HISDTQYAAALKEPLIVKRELAGYAVHAEYVAEMARQITAERFPEEVYSRGMKVYTTLIKAEQEAAYISLRKGVMDYDRR HGYRGAESYLDMKDIKSDQDEAIDEALQDIPDTGDLIPALVLSADPKQIKVYRKGGEVVTLTGDAMKFAAKMLDDKAPPN KRLKRSAIVRLQKDDKGNWQISQLPEVESAFVAVDPKDGAIRALVGGFDFNRNKFNHVTQAWRQPGSSFKPFIYSASLEK GFSPNSVIADEPIVIPASQTGTQAWEPHNYDGKYEGPMKMRTALAKSKNMVSIRILQAIGTQYAQDYAGRFGFDPAKHPP YLTMALGAGSVTPWQMVTAYSVFANGGFKVSPFVVREIRDEREQILAHSAEIEAGSDNIRVIDPRNAFMMDTMLRDVAIY GTAAKASAILKRQDLAGKTGTTNEYVDAWFCGYQMTVAGCAWIGFDQPRKLGDKETGGAAALPIWIGYMARALKDVPMQV PQAPEGLIAYGEGRDRSYIYAENAAKERTPEEESQDATPLPKPDLSTPPSD
Sequences:
>Translated_771_residues MPSTHSALRLILYPVIFLLGLLAIGIAIALIVLVLAYPNLPSLEVLTDYRPKIPLRVYTADGFLIGEYGEERRAVVAIKD VPPIMKQAILAAEDDRFYQHGGIDYTGILRAAGANLIGGGKRQGASTITQQVARNFFLTGEKTYTRKLYEALLSFKIESN LTKDQIFELYINQIFLGQRAYGFAAAAQIYFGKPLKDISIAEAAMLAGLPKAPSAYNPVVNPTRAKQRQQYVLRRMHELG HISDTQYAAALKEPLIVKRELAGYAVHAEYVAEMARQITAERFPEEVYSRGMKVYTTLIKAEQEAAYISLRKGVMDYDRR HGYRGAESYLDMKDIKSDQDEAIDEALQDIPDTGDLIPALVLSADPKQIKVYRKGGEVVTLTGDAMKFAAKMLDDKAPPN KRLKRSAIVRLQKDDKGNWQISQLPEVESAFVAVDPKDGAIRALVGGFDFNRNKFNHVTQAWRQPGSSFKPFIYSASLEK GFSPNSVIADEPIVIPASQTGTQAWEPHNYDGKYEGPMKMRTALAKSKNMVSIRILQAIGTQYAQDYAGRFGFDPAKHPP YLTMALGAGSVTPWQMVTAYSVFANGGFKVSPFVVREIRDEREQILAHSAEIEAGSDNIRVIDPRNAFMMDTMLRDVAIY GTAAKASAILKRQDLAGKTGTTNEYVDAWFCGYQMTVAGCAWIGFDQPRKLGDKETGGAAALPIWIGYMARALKDVPMQV PQAPEGLIAYGEGRDRSYIYAENAAKERTPEEESQDATPLPKPDLSTPPSD >Mature_770_residues PSTHSALRLILYPVIFLLGLLAIGIAIALIVLVLAYPNLPSLEVLTDYRPKIPLRVYTADGFLIGEYGEERRAVVAIKDV PPIMKQAILAAEDDRFYQHGGIDYTGILRAAGANLIGGGKRQGASTITQQVARNFFLTGEKTYTRKLYEALLSFKIESNL TKDQIFELYINQIFLGQRAYGFAAAAQIYFGKPLKDISIAEAAMLAGLPKAPSAYNPVVNPTRAKQRQQYVLRRMHELGH ISDTQYAAALKEPLIVKRELAGYAVHAEYVAEMARQITAERFPEEVYSRGMKVYTTLIKAEQEAAYISLRKGVMDYDRRH GYRGAESYLDMKDIKSDQDEAIDEALQDIPDTGDLIPALVLSADPKQIKVYRKGGEVVTLTGDAMKFAAKMLDDKAPPNK RLKRSAIVRLQKDDKGNWQISQLPEVESAFVAVDPKDGAIRALVGGFDFNRNKFNHVTQAWRQPGSSFKPFIYSASLEKG FSPNSVIADEPIVIPASQTGTQAWEPHNYDGKYEGPMKMRTALAKSKNMVSIRILQAIGTQYAQDYAGRFGFDPAKHPPY LTMALGAGSVTPWQMVTAYSVFANGGFKVSPFVVREIRDEREQILAHSAEIEAGSDNIRVIDPRNAFMMDTMLRDVAIYG TAAKASAILKRQDLAGKTGTTNEYVDAWFCGYQMTVAGCAWIGFDQPRKLGDKETGGAAALPIWIGYMARALKDVPMQVP QAPEGLIAYGEGRDRSYIYAENAAKERTPEEESQDATPLPKPDLSTPPSD
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG5009
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=825, Percent_Identity=35.5151515151515, Blast_Score=489, Evalue=1e-139, Organism=Escherichia coli, GI1786343, Length=327, Percent_Identity=31.8042813455657, Blast_Score=138, Evalue=1e-33, Organism=Escherichia coli, GI1789601, Length=165, Percent_Identity=36.3636363636364, Blast_Score=111, Evalue=2e-25, Organism=Escherichia coli, GI1788867, Length=208, Percent_Identity=35.0961538461538, Blast_Score=107, Evalue=2e-24,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.-
Molecular weight: Translated: 85261; Mature: 85129
Theoretical pI: Translated: 8.38; Mature: 8.38
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPSTHSALRLILYPVIFLLGLLAIGIAIALIVLVLAYPNLPSLEVLTDYRPKIPLRVYTA CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEEC DGFLIGEYGEERRAVVAIKDVPPIMKQAILAAEDDRFYQHGGIDYTGILRAAGANLIGGG CCEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHCCCCCCCCC KRQGASTITQQVARNFFLTGEKTYTRKLYEALLSFKIESNLTKDQIFELYINQIFLGQRA CCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHH YGFAAAAQIYFGKPLKDISIAEAAMLAGLPKAPSAYNPVVNPTRAKQRQQYVLRRMHELG HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC HISDTQYAAALKEPLIVKRELAGYAVHAEYVAEMARQITAERFPEEVYSRGMKVYTTLIK CCCCHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHH AEQEAAYISLRKGVMDYDRRHGYRGAESYLDMKDIKSDQDEAIDEALQDIPDTGDLIPAL HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHH VLSADPKQIKVYRKGGEVVTLTGDAMKFAAKMLDDKAPPNKRLKRSAIVRLQKDDKGNWQ HHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHEEEEECCCCCEE ISQLPEVESAFVAVDPKDGAIRALVGGFDFNRNKFNHVTQAWRQPGSSFKPFIYSASLEK ECCCCCCCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCHHC GFSPNSVIADEPIVIPASQTGTQAWEPHNYDGKYEGPMKMRTALAKSKNMVSIRILQAIG CCCCCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHH TQYAQDYAGRFGFDPAKHPPYLTMALGAGSVTPWQMVTAYSVFANGGFKVSPFVVREIRD HHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHH EREQILAHSAEIEAGSDNIRVIDPRNAFMMDTMLRDVAIYGTAAKASAILKRQDLAGKTG HHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC TTNEYVDAWFCGYQMTVAGCAWIGFDQPRKLGDKETGGAAALPIWIGYMARALKDVPMQV CCCHHHHHHHHCHHHHHHHEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC PQAPEGLIAYGEGRDRSYIYAENAAKERTPEEESQDATPLPKPDLSTPPSD CCCCCCEEEECCCCCCCEEEECCCHHHCCCCCCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure PSTHSALRLILYPVIFLLGLLAIGIAIALIVLVLAYPNLPSLEVLTDYRPKIPLRVYTA CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEEC DGFLIGEYGEERRAVVAIKDVPPIMKQAILAAEDDRFYQHGGIDYTGILRAAGANLIGGG CCEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHCCCCCCCCC KRQGASTITQQVARNFFLTGEKTYTRKLYEALLSFKIESNLTKDQIFELYINQIFLGQRA CCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHH YGFAAAAQIYFGKPLKDISIAEAAMLAGLPKAPSAYNPVVNPTRAKQRQQYVLRRMHELG HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC HISDTQYAAALKEPLIVKRELAGYAVHAEYVAEMARQITAERFPEEVYSRGMKVYTTLIK CCCCHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHH AEQEAAYISLRKGVMDYDRRHGYRGAESYLDMKDIKSDQDEAIDEALQDIPDTGDLIPAL HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHH VLSADPKQIKVYRKGGEVVTLTGDAMKFAAKMLDDKAPPNKRLKRSAIVRLQKDDKGNWQ HHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHEEEEECCCCCEE ISQLPEVESAFVAVDPKDGAIRALVGGFDFNRNKFNHVTQAWRQPGSSFKPFIYSASLEK ECCCCCCCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCHHC GFSPNSVIADEPIVIPASQTGTQAWEPHNYDGKYEGPMKMRTALAKSKNMVSIRILQAIG CCCCCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHH TQYAQDYAGRFGFDPAKHPPYLTMALGAGSVTPWQMVTAYSVFANGGFKVSPFVVREIRD HHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHH EREQILAHSAEIEAGSDNIRVIDPRNAFMMDTMLRDVAIYGTAAKASAILKRQDLAGKTG HHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC TTNEYVDAWFCGYQMTVAGCAWIGFDQPRKLGDKETGGAAALPIWIGYMARALKDVPMQV CCCHHHHHHHHCHHHHHHHEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC PQAPEGLIAYGEGRDRSYIYAENAAKERTPEEESQDATPLPKPDLSTPPSD CCCCCCEEEECCCCCCCEEEECCCHHHCCCCCCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA