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The map label for this gene is thrB

Identifier: 71891899

GI number: 71891899

Start: 138774

End: 139712

Strand: Direct

Name: thrB

Synonym: BPEN_116

Alternate gene names: 71891899

Gene position: 138774-139712 (Clockwise)

Preceding gene: 71891898

Following gene: 71891900

Centisome position: 17.53

GC content: 33.44

Gene sequence:

>939_bases
ATGGTCAGAGTTTATGCGCCAGCGTCTATCGCTAATATTGGAGTGGGGTTTGATACGTTAGGTATGGCAATTGCTCCAAT
AAATGGTAGCTTACTTGGAGATTGCATTAGCATCGAGCATGCTAATGCATTTAGTTTAAGAAGTACAGGATTTTTTCATA
GTCAATTACCAATACAATTAGAAGAAAATATCGTATTCCAATGTTGGAGAAAGTTTTGTGAAATTTTAGGACAAACATAT
TTTTTAAGTATTAAATTGGAAAAAAATATTCCTGTTGCTTCTGGTTTGGGTTCTAGCGCTTGTTCCATAGTAGCTGTATT
GGTAGCAATGAATTATCATTGTGGATGTCCACTTAATACAGATCAATTGCTCATGTTAATGGGGGAAATGGAAGGTAAAA
TTTCTGGTTCAATTCATTTTGATAATGTGTCTCCTTGCTTTTTAGGAGGTATGCGTTTAATATTGCAGAATTGTAATATT
GTTAACCAGGTAATACCTAGCTTTGATGATTGGTTGTGGATTGTAGCGTATCCAGGTATTAAAATATCTACAGCAGTATC
TCGATCAGTATTACCAAATAAATATGATCGTGAAGATTGTATTAATCATAGTCAATATCTATCCGGATTTGTACATGCTT
GCCATACTAAACAAGAATATTTAGCAATTAGATGTATGAAGGACATCATTGCAGAACCTTATCGATCACGATTGTTTCCG
ATTGAATTATCTTGTATACGGCATAATATTATGAAGAGAGGTGCTATATCTTGCGGTATTTCAGGATCTGGTCCAACAGT
TTTTGTATTATGTAACAATCACGATGTAATAGGAGATATTTCTGATTGGTTATCACGTTTTTATTTACAAAATAATTCAG
GTTTTATTCGAATCTGTTCTTTAGATAATCTTGGAGCGCGTATTATGGTGAATAATTAA

Upstream 100 bases:

>100_bases
TATTACGTGGCTATGGAGCAGGTAATGATGTTACAGCAGCCGGAGTATTTGCAGATTTATTACGCACTTTATCATAATAA
AAGTAAGGATGTGTGTGGAT

Downstream 100 bases:

>100_bases
TGAAACTATATAATATTAAGCAACCTAGTGAACAAGTCACGTTTACTCAAGCTCTCTTACAAGGATTAGGAAAAAATCAG
GGGTTATTTTTCCCAAAAGA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MVRVYAPASIANIGVGFDTLGMAIAPINGSLLGDCISIEHANAFSLRSTGFFHSQLPIQLEENIVFQCWRKFCEILGQTY
FLSIKLEKNIPVASGLGSSACSIVAVLVAMNYHCGCPLNTDQLLMLMGEMEGKISGSIHFDNVSPCFLGGMRLILQNCNI
VNQVIPSFDDWLWIVAYPGIKISTAVSRSVLPNKYDREDCINHSQYLSGFVHACHTKQEYLAIRCMKDIIAEPYRSRLFP
IELSCIRHNIMKRGAISCGISGSGPTVFVLCNNHDVIGDISDWLSRFYLQNNSGFIRICSLDNLGARIMVNN

Sequences:

>Translated_312_residues
MVRVYAPASIANIGVGFDTLGMAIAPINGSLLGDCISIEHANAFSLRSTGFFHSQLPIQLEENIVFQCWRKFCEILGQTY
FLSIKLEKNIPVASGLGSSACSIVAVLVAMNYHCGCPLNTDQLLMLMGEMEGKISGSIHFDNVSPCFLGGMRLILQNCNI
VNQVIPSFDDWLWIVAYPGIKISTAVSRSVLPNKYDREDCINHSQYLSGFVHACHTKQEYLAIRCMKDIIAEPYRSRLFP
IELSCIRHNIMKRGAISCGISGSGPTVFVLCNNHDVIGDISDWLSRFYLQNNSGFIRICSLDNLGARIMVNN
>Mature_312_residues
MVRVYAPASIANIGVGFDTLGMAIAPINGSLLGDCISIEHANAFSLRSTGFFHSQLPIQLEENIVFQCWRKFCEILGQTY
FLSIKLEKNIPVASGLGSSACSIVAVLVAMNYHCGCPLNTDQLLMLMGEMEGKISGSIHFDNVSPCFLGGMRLILQNCNI
VNQVIPSFDDWLWIVAYPGIKISTAVSRSVLPNKYDREDCINHSQYLSGFVHACHTKQEYLAIRCMKDIIAEPYRSRLFP
IELSCIRHNIMKRGAISCGISGSGPTVFVLCNNHDVIGDISDWLSRFYLQNNSGFIRICSLDNLGARIMVNN

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=311, Percent_Identity=55.3054662379421, Blast_Score=396, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_BLOPB (Q493S9)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277629.1
- ProteinModelPortal:   Q493S9
- SMR:   Q493S9
- STRING:   Q493S9
- GeneID:   3563174
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_116
- eggNOG:   COG0083
- HOGENOM:   HBG646290
- OMA:   GSAHADN
- ProtClustDB:   PRK01212
- BioCyc:   CBLO291272:BPEN_116-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 34527; Mature: 34527

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVYAPASIANIGVGFDTLGMAIAPINGSLLGDCISIEHANAFSLRSTGFFHSQLPIQL
CEEEECCCCHHHCCCCHHHHCEEEECCCCCHHHHEEEECCCCEEEECCCCCEECCCCEEE
EENIVFQCWRKFCEILGQTYFLSIKLEKNIPVASGLGSSACSIVAVLVAMNYHCGCPLNT
CCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCH
DQLLMLMGEMEGKISGSIHFDNVSPCFLGGMRLILQNCNIVNQVIPSFDDWLWIVAYPGI
HHHHHHHHHCCCCEECEEEECCCCHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEECCE
KISTAVSRSVLPNKYDREDCINHSQYLSGFVHACHTKQEYLAIRCMKDIIAEPYRSRLFP
EEEHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHCCCE
IELSCIRHNIMKRGAISCGISGSGPTVFVLCNNHDVIGDISDWLSRFYLQNNSGFIRICS
EEHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHEEECCCCEEEEEE
LDNLGARIMVNN
ECCCCCEEEECC
>Mature Secondary Structure
MVRVYAPASIANIGVGFDTLGMAIAPINGSLLGDCISIEHANAFSLRSTGFFHSQLPIQL
CEEEECCCCHHHCCCCHHHHCEEEECCCCCHHHHEEEECCCCEEEECCCCCEECCCCEEE
EENIVFQCWRKFCEILGQTYFLSIKLEKNIPVASGLGSSACSIVAVLVAMNYHCGCPLNT
CCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCH
DQLLMLMGEMEGKISGSIHFDNVSPCFLGGMRLILQNCNIVNQVIPSFDDWLWIVAYPGI
HHHHHHHHHCCCCEECEEEECCCCHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEECCE
KISTAVSRSVLPNKYDREDCINHSQYLSGFVHACHTKQEYLAIRCMKDIIAEPYRSRLFP
EEEHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHCCCE
IELSCIRHNIMKRGAISCGISGSGPTVFVLCNNHDVIGDISDWLSRFYLQNNSGFIRICS
EEHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHEEECCCCEEEEEE
LDNLGARIMVNN
ECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA