| Definition | Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome. |
|---|---|
| Accession | NC_007292 |
| Length | 791,654 |
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The map label for this gene is thrA [H]
Identifier: 71891898
GI number: 71891898
Start: 136300
End: 138750
Strand: Direct
Name: thrA [H]
Synonym: BPEN_115
Alternate gene names: 71891898
Gene position: 136300-138750 (Clockwise)
Preceding gene: 71891897
Following gene: 71891899
Centisome position: 17.22
GC content: 32.44
Gene sequence:
>2451_bases ATGCGAGTATTGAAATTTGGCGGCACTGCACTTTCTAATGCAAATCAGTTTATCCATGTCGCCAATATTCTTGAAAAAAA CGCGCAAGAAGAACAAATAGCAGCGGTGTTATCGGCGCCTGCAATGATTACTAATTATCTAGTATCAGTTATTGATTGCA CATTAAGTGGTAGTTCTGTATGTGAACATATTCACAATATAGAAACTATTTTTAATACTTTGTTGGAAGATATAGCACAA ATTCAACCAGGATTTAATCATATAACTTTGCGTCTTATATTAGAACAAGAGTTTATTCATTTAAAAAATTTACTGCATGG AATTTCATTGTTAAAATTTTGTCCAGATAATATAAATGCTAATATTATTTGTTTGGGGGAAAAGTTGTCCATTATTTTAA TGGAAAGGCTTTTAAATGCGAGGAATCTCCAAATAACTGTTATTAATCCAGTAGATAATATTATAGCACAAGGAAGAGAA GAATATCTGACCTCCATGGTAAATATTGAAGAATCTGCTCGGCGTATTAAAAATATACCTATTTCTCATTTAGATATTAT ATTAATGGCCGGATTTACTGCGGGAAATGAGCAGGGTGAATTAGTTGCTTTAGGTCGAAATGGTTCTGATTATTCAGCTG CGATTTTAGCGGCTTGTTTAGGTGCTAGTCGTTGTGAAATTTGGACAGATGTAGACGGGATTTATACGTGTGATCCGCGT CAAGTACCTAATGCAAAATTATTAAATTCATTATCTTATCAAGAGGCTATGGAGCTGTCTTATTTTGGAGCTAAAATTTT ACATCCACGTACTATTGTGCCGATTGCTCAATTTCATATACCTTGTTTAATAAAAAATGTTTTCAAACCTGATGCTCCTG GAACATTAATTGGATCAATTAATAATGATGCTACTAATATAGTTAAAGGAATTACATATTTAAATGATATGGTAATGTTA AATATTTCTGGACCGGGAATGAAAGGCATGATTGGAATGGCCGCTCGTGTGTTTTCTGCAATGTCTCAAGCCATATGTTC AGTAGTGTTAATCACTCAATCATCTTCTGAGTATAGCATAAGTTTTTGCGTGCCTTATCAAGAGTTATCAAAAGCTTGCA CTGCATTAAATGAAGAATTTAATTTAGAATTAAAAAATGGACTTTTGGAACCAATAGATGTCATACGAGATCTCGCAATT ATTTCAGTTGTGGGCGATGGCATGCGTACGCAACTTGGTTTGTCTAGCAAATTGTTTGAGTCATTAGCTCGTGCTAATAT TAATATTATTGCAATTGCTCAAGGATCTTCAGAGCGTTCTATTTCGGTGGTGGTAAAAAACAATGTTACTGCTATTGGAA TTAGAGTAGCTCATCAAATGTTATTTAGTACTGATCAATTAATAGAAGTATTTATTATTGGATCTGGCGGCGTTGGTACT GCTTTAATAGAACAAATTCGACGTCAAAGACATTGGTTAAAAAATAAACATGTTGACTTACGAGTATGTGGTATTATTAA TTCCCGAATGATGTGTATCGACATAAATGGGATTGATTTAAATAACTGGGAATCTTCTCTAAAGAAAACTCATGAACCTT GTAATTTAAAAAAATTAATGGAAATTATACAAGAAAATCATTTATTAAATCCAGTTATCGCTGATTGCACTAGTAGTATT GACGTAGTTAATTATTATGTAGATTTTTTGTCAAATGGTTGTCATGTGATTACACCAAATAAAAAAGCTAATACCGGATC TATGGAGCAGTATAGAAGACTTAGGGATATCGTGATAAAATCACGAAGGAAATTTTTATATGATACTAATGTCGGAGCTG GATTACCAGTTATAGAAAATTTGCAAAATTTATTAAATGCTGGAGATGAATTAATTAGTTTTTCAGGTATTTTATCTGGA TCTTTATCATTTATTTTTGGAAAATTAGATGAAGGATTATCATTATCTGCTGCAACTTTATTAGCTCAGCAGAAAGGCTA TACTGAACCGGATCCCCGAGATGATCTTTCTGGTATAGACGTAGCTAGAAAATTATTAATTTTAGCACGAGAAGTTGGGT ATGAATTAGAATTGAATGATATTCAAGTCGATCCAGTAATACCACATAATTTTATAAATAAAAATGATACGGATAGTTTT TTTAAAAAATTGTCTTTATTAGATGATATTATTTATGATAAAGCTCAAAGGGCGTATAAATTAGGACATGTATTGCGTTA TGTTGGGAATATACAGGAAGGACAGTGTCGCGTGAAAATCGAATCTATAAATAATAATCATCCATTATTTAAAGTAAAAG ATGGAGAAAATGCTCTTGCATTTTTTACTCGGTATTATCAACCATTACCATTGGTATTACGTGGCTATGGAGCAGGTAAT GATGTTACAGCAGCCGGAGTATTTGCAGATTTATTACGCACTTTATCATAA
Upstream 100 bases:
>100_bases TAAAACATAGTAGTAAGATGGATAAATATTACGTGATCTTTGCTGTTTATTTTTATTAATGAAAATTCAGGATATTAGAG TCATATTTAGGAGATAAAAT
Downstream 100 bases:
>100_bases TAAAAGTAAGGATGTGTGTGGATATGGTCAGAGTTTATGCGCCAGCGTCTATCGCTAATATTGGAGTGGGGTTTGATACG TTAGGTATGGCAATTGCTCC
Product: bifunctional aspartokinase I/homeserine dehydrogenase I
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 816; Mature: 816
Protein sequence:
>816_residues MRVLKFGGTALSNANQFIHVANILEKNAQEEQIAAVLSAPAMITNYLVSVIDCTLSGSSVCEHIHNIETIFNTLLEDIAQ IQPGFNHITLRLILEQEFIHLKNLLHGISLLKFCPDNINANIICLGEKLSIILMERLLNARNLQITVINPVDNIIAQGRE EYLTSMVNIEESARRIKNIPISHLDIILMAGFTAGNEQGELVALGRNGSDYSAAILAACLGASRCEIWTDVDGIYTCDPR QVPNAKLLNSLSYQEAMELSYFGAKILHPRTIVPIAQFHIPCLIKNVFKPDAPGTLIGSINNDATNIVKGITYLNDMVML NISGPGMKGMIGMAARVFSAMSQAICSVVLITQSSSEYSISFCVPYQELSKACTALNEEFNLELKNGLLEPIDVIRDLAI ISVVGDGMRTQLGLSSKLFESLARANINIIAIAQGSSERSISVVVKNNVTAIGIRVAHQMLFSTDQLIEVFIIGSGGVGT ALIEQIRRQRHWLKNKHVDLRVCGIINSRMMCIDINGIDLNNWESSLKKTHEPCNLKKLMEIIQENHLLNPVIADCTSSI DVVNYYVDFLSNGCHVITPNKKANTGSMEQYRRLRDIVIKSRRKFLYDTNVGAGLPVIENLQNLLNAGDELISFSGILSG SLSFIFGKLDEGLSLSAATLLAQQKGYTEPDPRDDLSGIDVARKLLILAREVGYELELNDIQVDPVIPHNFINKNDTDSF FKKLSLLDDIIYDKAQRAYKLGHVLRYVGNIQEGQCRVKIESINNNHPLFKVKDGENALAFFTRYYQPLPLVLRGYGAGN DVTAAGVFADLLRTLS
Sequences:
>Translated_816_residues MRVLKFGGTALSNANQFIHVANILEKNAQEEQIAAVLSAPAMITNYLVSVIDCTLSGSSVCEHIHNIETIFNTLLEDIAQ IQPGFNHITLRLILEQEFIHLKNLLHGISLLKFCPDNINANIICLGEKLSIILMERLLNARNLQITVINPVDNIIAQGRE EYLTSMVNIEESARRIKNIPISHLDIILMAGFTAGNEQGELVALGRNGSDYSAAILAACLGASRCEIWTDVDGIYTCDPR QVPNAKLLNSLSYQEAMELSYFGAKILHPRTIVPIAQFHIPCLIKNVFKPDAPGTLIGSINNDATNIVKGITYLNDMVML NISGPGMKGMIGMAARVFSAMSQAICSVVLITQSSSEYSISFCVPYQELSKACTALNEEFNLELKNGLLEPIDVIRDLAI ISVVGDGMRTQLGLSSKLFESLARANINIIAIAQGSSERSISVVVKNNVTAIGIRVAHQMLFSTDQLIEVFIIGSGGVGT ALIEQIRRQRHWLKNKHVDLRVCGIINSRMMCIDINGIDLNNWESSLKKTHEPCNLKKLMEIIQENHLLNPVIADCTSSI DVVNYYVDFLSNGCHVITPNKKANTGSMEQYRRLRDIVIKSRRKFLYDTNVGAGLPVIENLQNLLNAGDELISFSGILSG SLSFIFGKLDEGLSLSAATLLAQQKGYTEPDPRDDLSGIDVARKLLILAREVGYELELNDIQVDPVIPHNFINKNDTDSF FKKLSLLDDIIYDKAQRAYKLGHVLRYVGNIQEGQCRVKIESINNNHPLFKVKDGENALAFFTRYYQPLPLVLRGYGAGN DVTAAGVFADLLRTLS >Mature_816_residues MRVLKFGGTALSNANQFIHVANILEKNAQEEQIAAVLSAPAMITNYLVSVIDCTLSGSSVCEHIHNIETIFNTLLEDIAQ IQPGFNHITLRLILEQEFIHLKNLLHGISLLKFCPDNINANIICLGEKLSIILMERLLNARNLQITVINPVDNIIAQGRE EYLTSMVNIEESARRIKNIPISHLDIILMAGFTAGNEQGELVALGRNGSDYSAAILAACLGASRCEIWTDVDGIYTCDPR QVPNAKLLNSLSYQEAMELSYFGAKILHPRTIVPIAQFHIPCLIKNVFKPDAPGTLIGSINNDATNIVKGITYLNDMVML NISGPGMKGMIGMAARVFSAMSQAICSVVLITQSSSEYSISFCVPYQELSKACTALNEEFNLELKNGLLEPIDVIRDLAI ISVVGDGMRTQLGLSSKLFESLARANINIIAIAQGSSERSISVVVKNNVTAIGIRVAHQMLFSTDQLIEVFIIGSGGVGT ALIEQIRRQRHWLKNKHVDLRVCGIINSRMMCIDINGIDLNNWESSLKKTHEPCNLKKLMEIIQENHLLNPVIADCTSSI DVVNYYVDFLSNGCHVITPNKKANTGSMEQYRRLRDIVIKSRRKFLYDTNVGAGLPVIENLQNLLNAGDELISFSGILSG SLSFIFGKLDEGLSLSAATLLAQQKGYTEPDPRDDLSGIDVARKLLILAREVGYELELNDIQVDPVIPHNFINKNDTDSF FKKLSLLDDIIYDKAQRAYKLGHVLRYVGNIQEGQCRVKIESINNNHPLFKVKDGENALAFFTRYYQPLPLVLRGYGAGN DVTAAGVFADLLRTLS
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=819, Percent_Identity=65.6898656898657, Blast_Score=1082, Evalue=0.0, Organism=Escherichia coli, GI1790376, Length=813, Percent_Identity=28.6592865928659, Blast_Score=344, Evalue=2e-95, Organism=Escherichia coli, GI1790455, Length=461, Percent_Identity=26.6811279826464, Blast_Score=132, Evalue=8e-32, Organism=Saccharomyces cerevisiae, GI6322599, Length=336, Percent_Identity=30.952380952381, Blast_Score=154, Evalue=5e-38, Organism=Saccharomyces cerevisiae, GI6320893, Length=379, Percent_Identity=28.4960422163588, Blast_Score=149, Evalue=1e-36,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 90069; Mature: 90069
Theoretical pI: Translated: 6.33; Mature: 6.33
Prosite motif: PS01042 HOMOSER_DHGENASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.1 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 2.1 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRVLKFGGTALSNANQFIHVANILEKNAQEEQIAAVLSAPAMITNYLVSVIDCTLSGSSV CEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH CEHIHNIETIFNTLLEDIAQIQPGFNHITLRLILEQEFIHLKNLLHGISLLKFCPDNINA HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCC NIICLGEKLSIILMERLLNARNLQITVINPVDNIIAQGREEYLTSMVNIEESARRIKNIP CEEEECCHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC ISHLDIILMAGFTAGNEQGELVALGRNGSDYSAAILAACLGASRCEIWTDVDGIYTCDPR HHHHEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCEEECCCC QVPNAKLLNSLSYQEAMELSYFGAKILHPRTIVPIAQFHIPCLIKNVFKPDAPGTLIGSI CCCCHHHHHHHHHHHHHHHHHHCHHHCCCCEECHHHHHHHHHHHHHHHCCCCCCEEEECC NNDATNIVKGITYLNDMVMLNISGPGMKGMIGMAARVFSAMSQAICSVVLITQSSSEYSI CCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEE SFCVPYQELSKACTALNEEFNLELKNGLLEPIDVIRDLAIISVVGDGMRTQLGLSSKLFE EEEECHHHHHHHHHHHCHHCCEEHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHH SLARANINIIAIAQGSSERSISVVVKNNVTAIGIRVAHQMLFSTDQLIEVFIIGSGGVGT HHHHCCCEEEEEECCCCCCEEEEEEECCCEEEHHHHHHHHHHCHHCEEEEEEECCCCHHH ALIEQIRRQRHWLKNKHVDLRVCGIINSRMMCIDINGIDLNNWESSLKKTHEPCNLKKLM HHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCCCHHHHHHHHCCCCCCHHHHH EIIQENHLLNPVIADCTSSIDVVNYYVDFLSNGCHVITPNKKANTGSMEQYRRLRDIVIK HHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHH SRRKFLYDTNVGAGLPVIENLQNLLNAGDELISFSGILSGSLSFIFGKLDEGLSLSAATL HHHHEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHH LAQQKGYTEPDPRDDLSGIDVARKLLILAREVGYELELNDIQVDPVIPHNFINKNDTDSF HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCEEECCCCCCCCCCCCCHHHH FKKLSLLDDIIYDKAQRAYKLGHVLRYVGNIQEGQCRVKIESINNNHPLFKVKDGENALA HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEEECCCCHHH FFTRYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLS HHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHCC >Mature Secondary Structure MRVLKFGGTALSNANQFIHVANILEKNAQEEQIAAVLSAPAMITNYLVSVIDCTLSGSSV CEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH CEHIHNIETIFNTLLEDIAQIQPGFNHITLRLILEQEFIHLKNLLHGISLLKFCPDNINA HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCC NIICLGEKLSIILMERLLNARNLQITVINPVDNIIAQGREEYLTSMVNIEESARRIKNIP CEEEECCHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC ISHLDIILMAGFTAGNEQGELVALGRNGSDYSAAILAACLGASRCEIWTDVDGIYTCDPR HHHHEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCEEECCCC QVPNAKLLNSLSYQEAMELSYFGAKILHPRTIVPIAQFHIPCLIKNVFKPDAPGTLIGSI CCCCHHHHHHHHHHHHHHHHHHCHHHCCCCEECHHHHHHHHHHHHHHHCCCCCCEEEECC NNDATNIVKGITYLNDMVMLNISGPGMKGMIGMAARVFSAMSQAICSVVLITQSSSEYSI CCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEE SFCVPYQELSKACTALNEEFNLELKNGLLEPIDVIRDLAIISVVGDGMRTQLGLSSKLFE EEEECHHHHHHHHHHHCHHCCEEHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHH SLARANINIIAIAQGSSERSISVVVKNNVTAIGIRVAHQMLFSTDQLIEVFIIGSGGVGT HHHHCCCEEEEEECCCCCCEEEEEEECCCEEEHHHHHHHHHHCHHCEEEEEEECCCCHHH ALIEQIRRQRHWLKNKHVDLRVCGIINSRMMCIDINGIDLNNWESSLKKTHEPCNLKKLM HHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCCCHHHHHHHHCCCCCCHHHHH EIIQENHLLNPVIADCTSSIDVVNYYVDFLSNGCHVITPNKKANTGSMEQYRRLRDIVIK HHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHH SRRKFLYDTNVGAGLPVIENLQNLLNAGDELISFSGILSGSLSFIFGKLDEGLSLSAATL HHHHEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHH LAQQKGYTEPDPRDDLSGIDVARKLLILAREVGYELELNDIQVDPVIPHNFINKNDTDSF HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCEEECCCCCCCCCCCCCHHHH FKKLSLLDDIIYDKAQRAYKLGHVLRYVGNIQEGQCRVKIESINNNHPLFKVKDGENALA HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEEECCCCHHH FFTRYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLS HHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8423151 [H]