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The map label for this gene is hflK [H]

Identifier: 71891870

GI number: 71891870

Start: 99260

End: 100555

Strand: Direct

Name: hflK [H]

Synonym: BPEN_084

Alternate gene names: 71891870

Gene position: 99260-100555 (Clockwise)

Preceding gene: 71891869

Following gene: 71891871

Centisome position: 12.54

GC content: 33.02

Gene sequence:

>1296_bases
ATGATTTGTAATTATCTTAATAACTATAAATATATTCATGATCCATGGGGGCATCATGATAAGAATGATGTAGATCGTCC
TTCTATTGAAGATAAGAATAAATCTGAATTTAATATATTAGATTCAGATAAATATTTGAATAAAATAACTGATAAATTAA
ATATATTTAGTAAGCAAAATAAGGATTCAGAAAAATTTCCTAAAAATAAAAATTTTTTTATAATGTTAATGTTAATTATT
GTTGTTTTTGTGTGGATTATTAGTGGTTTGTACACGATTAAAGAAGCAGAACGCGGGGTAGTTTTAAGATTTGGAAAATA
TCATCATTTAGTGCAACCAGGTTTAAATTGGAAGCCTACTTTTTTTGATGTTGTAATTCCAGTAAATGTAGAATCAGTAC
GTGAATTAGCAGCTTCTGGTATGATGTTGACTTCAGATGAAAATGTAGTCCGAGTAGAGATGAATGTACAGTACCGCGTA
ACTGATCCAAAAAACTATTTATTTAACGTTATTGATGCTGACGATAGCTTGCGTCAAGCTACTGATAGTGCTTTGCGTGG
AGTTATTGGGAAATATAATATGGATCGTATTTTAACAGAAGGGCGCACGGTGGTACGTAGTGATACTCGAAGAGTGTTAG
AGAAAACGATACACCCTTATAATATGGGTATTACTTTATTAGATGTAAACTTTCAAACAGCTCGCCCCCCAGAAGAGGTA
AAAGCAGCATTTGATGATGCTATTGCCGCCCGAGAAAATGAACAACAATATATTCGTGAGGCTGAAGCTTATGCTAATGA
AGTACAACCACGAGCCAATGGACACGCGCAACGTATTTTAGAGGAAGGGCGAGCGTATAAAGCACGTACTGTCTTAGAAG
CACAAGGTGAAGTACAAAGATTTACTAAAATTTTGCCAGAATATAAAGCAGCTCCTGAAATTACTCGTGAGCGATTATAT
ATTAATTCCATGGAGCGTGTGTTAAGTAATACTAGAAAAATATTTGTAAATTCAAAAGATACGCAGAATGTACTATTGTT
ACCTTCAGGTCAATTAAAACAAATTAAAGATAACAATGATATTGTATATTCTGATAGTATTGATAATACTGATGATGCTT
TAAACTTAAATCAAATATGTGCTACTACTGATGCTAACATGAATAATGCACAGTTAATATCAAAAAATAGCCATCTGTCT
CGTCATACAAATTCTATACCTAAAGAAAAAGTATTAGACCAAAGACAGGCTAATGTACAACGTGTTGATATTGCGCGCAA
AGGGAGAGAGTCGTAG

Upstream 100 bases:

>100_bases
CGTTTATTAAAAAATAATAAATTATTGATAGATTATATTGTTTAATATTTTTAAAATAAAGAAAATATATAGATCACTCA
TATAATGTGTGAGGAAAAAT

Downstream 100 bases:

>100_bases
ATGATACGAAATTTTTTTTCATTTGTTATATGTGTAATAGTAATATTATTTTTTTCTTTATTTACAATAGAAGAGGGGCA
TAAGGGTATTATATTGCGTT

Product: HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MICNYLNNYKYIHDPWGHHDKNDVDRPSIEDKNKSEFNILDSDKYLNKITDKLNIFSKQNKDSEKFPKNKNFFIMLMLII
VVFVWIISGLYTIKEAERGVVLRFGKYHHLVQPGLNWKPTFFDVVIPVNVESVRELAASGMMLTSDENVVRVEMNVQYRV
TDPKNYLFNVIDADDSLRQATDSALRGVIGKYNMDRILTEGRTVVRSDTRRVLEKTIHPYNMGITLLDVNFQTARPPEEV
KAAFDDAIAARENEQQYIREAEAYANEVQPRANGHAQRILEEGRAYKARTVLEAQGEVQRFTKILPEYKAAPEITRERLY
INSMERVLSNTRKIFVNSKDTQNVLLLPSGQLKQIKDNNDIVYSDSIDNTDDALNLNQICATTDANMNNAQLISKNSHLS
RHTNSIPKEKVLDQRQANVQRVDIARKGRES

Sequences:

>Translated_431_residues
MICNYLNNYKYIHDPWGHHDKNDVDRPSIEDKNKSEFNILDSDKYLNKITDKLNIFSKQNKDSEKFPKNKNFFIMLMLII
VVFVWIISGLYTIKEAERGVVLRFGKYHHLVQPGLNWKPTFFDVVIPVNVESVRELAASGMMLTSDENVVRVEMNVQYRV
TDPKNYLFNVIDADDSLRQATDSALRGVIGKYNMDRILTEGRTVVRSDTRRVLEKTIHPYNMGITLLDVNFQTARPPEEV
KAAFDDAIAARENEQQYIREAEAYANEVQPRANGHAQRILEEGRAYKARTVLEAQGEVQRFTKILPEYKAAPEITRERLY
INSMERVLSNTRKIFVNSKDTQNVLLLPSGQLKQIKDNNDIVYSDSIDNTDDALNLNQICATTDANMNNAQLISKNSHLS
RHTNSIPKEKVLDQRQANVQRVDIARKGRES
>Mature_431_residues
MICNYLNNYKYIHDPWGHHDKNDVDRPSIEDKNKSEFNILDSDKYLNKITDKLNIFSKQNKDSEKFPKNKNFFIMLMLII
VVFVWIISGLYTIKEAERGVVLRFGKYHHLVQPGLNWKPTFFDVVIPVNVESVRELAASGMMLTSDENVVRVEMNVQYRV
TDPKNYLFNVIDADDSLRQATDSALRGVIGKYNMDRILTEGRTVVRSDTRRVLEKTIHPYNMGITLLDVNFQTARPPEEV
KAAFDDAIAARENEQQYIREAEAYANEVQPRANGHAQRILEEGRAYKARTVLEAQGEVQRFTKILPEYKAAPEITRERLY
INSMERVLSNTRKIFVNSKDTQNVLLLPSGQLKQIKDNNDIVYSDSIDNTDDALNLNQICATTDANMNNAQLISKNSHLS
RHTNSIPKEKVLDQRQANVQRVDIARKGRES

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=341, Percent_Identity=68.0351906158358, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1786697, Length=246, Percent_Identity=23.5772357723577, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 49640; Mature: 49640

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICNYLNNYKYIHDPWGHHDKNDVDRPSIEDKNKSEFNILDSDKYLNKITDKLNIFSKQN
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCC
KDSEKFPKNKNFFIMLMLIIVVFVWIISGLYTIKEAERGVVLRFGKYHHLVQPGLNWKPT
CCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCCC
FFDVVIPVNVESVRELAASGMMLTSDENVVRVEMNVQYRVTDPKNYLFNVIDADDSLRQA
EEEEEEECCHHHHHHHHHCCEEEECCCCEEEEEEEEEEEEECCCCCEEEEECCCHHHHHH
TDSALRGVIGKYNMDRILTEGRTVVRSDTRRVLEKTIHPYNMGITLLDVNFQTARPPEEV
HHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHH
KAAFDDAIAARENEQQYIREAEAYANEVQPRANGHAQRILEEGRAYKARTVLEAQGEVQR
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
FTKILPEYKAAPEITRERLYINSMERVLSNTRKIFVNSKDTQNVLLLPSGQLKQIKDNND
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHEECCCCC
IVYSDSIDNTDDALNLNQICATTDANMNNAQLISKNSHLSRHTNSIPKEKVLDQRQANVQ
EEEECCCCCCCCCCCHHHHHEECCCCCCCCEEEECCCHHHHHHCCCCHHHHHHHHHCCHH
RVDIARKGRES
HHHHHHCCCCC
>Mature Secondary Structure
MICNYLNNYKYIHDPWGHHDKNDVDRPSIEDKNKSEFNILDSDKYLNKITDKLNIFSKQN
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCC
KDSEKFPKNKNFFIMLMLIIVVFVWIISGLYTIKEAERGVVLRFGKYHHLVQPGLNWKPT
CCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCCC
FFDVVIPVNVESVRELAASGMMLTSDENVVRVEMNVQYRVTDPKNYLFNVIDADDSLRQA
EEEEEEECCHHHHHHHHHCCEEEECCCCEEEEEEEEEEEEECCCCCEEEEECCCHHHHHH
TDSALRGVIGKYNMDRILTEGRTVVRSDTRRVLEKTIHPYNMGITLLDVNFQTARPPEEV
HHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHH
KAAFDDAIAARENEQQYIREAEAYANEVQPRANGHAQRILEEGRAYKARTVLEAQGEVQR
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
FTKILPEYKAAPEITRERLYINSMERVLSNTRKIFVNSKDTQNVLLLPSGQLKQIKDNND
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHEECCCCC
IVYSDSIDNTDDALNLNQICATTDANMNNAQLISKNSHLSRHTNSIPKEKVLDQRQANVQ
EEEECCCCCCCCCCCHHHHHEECCCCCCCCEEEECCCHHHHHHCCCCHHHHHHHHHCCHH
RVDIARKGRES
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]