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The map label for this gene is pepA [H]

Identifier: 71891827

GI number: 71891827

Start: 44226

End: 45737

Strand: Reverse

Name: pepA [H]

Synonym: BPEN_035

Alternate gene names: 71891827

Gene position: 45737-44226 (Counterclockwise)

Preceding gene: 71891830

Following gene: 71891826

Centisome position: 5.78

GC content: 31.94

Gene sequence:

>1512_bases
ATGATAAAATTTAGCGTTACTAGCGGGCATCAAGAATTATATCCTGATAGTTGCATAATTACTGGTACATTTGAAGAATT
AAATTTATTTCCTTCAACAAAAAAAATTGATGACGTAAGCAAAGGATACATCAGTTCATTGTTGCGTCGTGGCGCGTTAC
ACGGAAAAGTCGCACAAACGCTCTTATTATACGATGTTCCTCATTTACATAATAGACAAATTTTATTAGTTGGGTGCGGT
AAAAAATCTGATTTTGATGAAAATTGTTATAGAAAATTAATTCGAAAAATAACAATCTTATGTAAAGAGATACCTATAAT
TAAAATATTACTTTTTTTAAGTGAATTAAATATAAAAGGATACGATAATTATTGGAAAATAAGACAAACCATGGAAATCG
TTAATGAAGAGTTGTATGTTTTTAATAAATTTAAAAATAGCAAAAAAACTACACTGAATAAATCACTAAATGAAATAATA
TTACATATACCTAATGAAAATGAATTAGGATGTTGTAAAAAATCTATTAGAGATGGATTATCTATCGTTCATGGAATAAA
AATAGCTAAAGACCTAGGAAATATGCCTCCTAATTTTTGTACTCCTGATTACTTTGTAAATCAAGTAAATGAATTATCTA
ATTGTGATAACGTCACAATAAATATAATCAATGCTTTAGAAATGAAAAAATTAGGTATGAATGCTTATTTAGCGGTAGGA
AAAGGGTCTAATTATGCTCCCACAATGCCTATAATTAAATACAGAGGGCATCCTGAAGGGGCTAATGTTCCTCCCATTGT
ACTTATAGGAAAAGGTTTGACCTTTGATTCTGGTGGAATTTCTATCAAAGAATCAAATAAAATGGACGAAATGAAATATG
ATATGTGCGGAGCTGCCGTAGTATATGCAATTATGCGTATAGCCATAGAACTAGATTTACCATTAAATATTATCGGAATA
CTTGCTATTTGTGAAAATATGATAAGTCATACTTCATTTCGTCCAGGTGATATCCTGACTACTTTATCTGGAAAAACAGT
GGAGGTATTAAACACCGATGCTGAAGGTCGTTTGGTTCTATGTGATGCATTGACATATGCAGAACGTTATAAACCAGATG
TTGTAATAGATATAGCTACATTAACTGGAGCTTGTGTTATCGCTTTAGGACATCATTTTAGCGGTTTAATGTCTAACAAC
AAAAATTTAGCCGACGAACTAATTCTGGCTGGACAACAATCTAAAGATTATGTTTGGAAATTACCATTAGACGAAGTGTT
CCAAAAACAATTAAAATCTACATGTGCGGATATGACAAATGTTGGAGGTAGACCTGGTGGCGCTATTACAGCCGGATGTT
TTCTTCATCAGTTTGCCTATAAATATCGTTGGGCCCATTTAGATATTGCTGGAACAGCATGGATATCTGATTATTGTGAT
AAAAGCGCAACAGGTCGACCCGTTGCGCTTTTATCACAATATCTGATTAATAGATCATCCCATAAAATTTAA

Upstream 100 bases:

>100_bases
ATGTATTTCAATGTTTTATATAAAATATAAAAATTGTAAATATTGTGACTGATTTATTTTTTGAGTATGTCATTTGACAT
ATTTATATACAGGAAATATT

Downstream 100 bases:

>100_bases
ATTATCTTTATTAATCAATACTAACTTTATAACAGAATCACACCAAAATAAATTTATATTTTATTTTTATAATCAATTAT
CATTGATTATAAAAATAATA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MIKFSVTSGHQELYPDSCIITGTFEELNLFPSTKKIDDVSKGYISSLLRRGALHGKVAQTLLLYDVPHLHNRQILLVGCG
KKSDFDENCYRKLIRKITILCKEIPIIKILLFLSELNIKGYDNYWKIRQTMEIVNEELYVFNKFKNSKKTTLNKSLNEII
LHIPNENELGCCKKSIRDGLSIVHGIKIAKDLGNMPPNFCTPDYFVNQVNELSNCDNVTINIINALEMKKLGMNAYLAVG
KGSNYAPTMPIIKYRGHPEGANVPPIVLIGKGLTFDSGGISIKESNKMDEMKYDMCGAAVVYAIMRIAIELDLPLNIIGI
LAICENMISHTSFRPGDILTTLSGKTVEVLNTDAEGRLVLCDALTYAERYKPDVVIDIATLTGACVIALGHHFSGLMSNN
KNLADELILAGQQSKDYVWKLPLDEVFQKQLKSTCADMTNVGGRPGGAITAGCFLHQFAYKYRWAHLDIAGTAWISDYCD
KSATGRPVALLSQYLINRSSHKI

Sequences:

>Translated_503_residues
MIKFSVTSGHQELYPDSCIITGTFEELNLFPSTKKIDDVSKGYISSLLRRGALHGKVAQTLLLYDVPHLHNRQILLVGCG
KKSDFDENCYRKLIRKITILCKEIPIIKILLFLSELNIKGYDNYWKIRQTMEIVNEELYVFNKFKNSKKTTLNKSLNEII
LHIPNENELGCCKKSIRDGLSIVHGIKIAKDLGNMPPNFCTPDYFVNQVNELSNCDNVTINIINALEMKKLGMNAYLAVG
KGSNYAPTMPIIKYRGHPEGANVPPIVLIGKGLTFDSGGISIKESNKMDEMKYDMCGAAVVYAIMRIAIELDLPLNIIGI
LAICENMISHTSFRPGDILTTLSGKTVEVLNTDAEGRLVLCDALTYAERYKPDVVIDIATLTGACVIALGHHFSGLMSNN
KNLADELILAGQQSKDYVWKLPLDEVFQKQLKSTCADMTNVGGRPGGAITAGCFLHQFAYKYRWAHLDIAGTAWISDYCD
KSATGRPVALLSQYLINRSSHKI
>Mature_503_residues
MIKFSVTSGHQELYPDSCIITGTFEELNLFPSTKKIDDVSKGYISSLLRRGALHGKVAQTLLLYDVPHLHNRQILLVGCG
KKSDFDENCYRKLIRKITILCKEIPIIKILLFLSELNIKGYDNYWKIRQTMEIVNEELYVFNKFKNSKKTTLNKSLNEII
LHIPNENELGCCKKSIRDGLSIVHGIKIAKDLGNMPPNFCTPDYFVNQVNELSNCDNVTINIINALEMKKLGMNAYLAVG
KGSNYAPTMPIIKYRGHPEGANVPPIVLIGKGLTFDSGGISIKESNKMDEMKYDMCGAAVVYAIMRIAIELDLPLNIIGI
LAICENMISHTSFRPGDILTTLSGKTVEVLNTDAEGRLVLCDALTYAERYKPDVVIDIATLTGACVIALGHHFSGLMSNN
KNLADELILAGQQSKDYVWKLPLDEVFQKQLKSTCADMTNVGGRPGGAITAGCFLHQFAYKYRWAHLDIAGTAWISDYCD
KSATGRPVALLSQYLINRSSHKI

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=457, Percent_Identity=36.1050328227571, Blast_Score=252, Evalue=7e-67,
Organism=Homo sapiens, GI47155554, Length=324, Percent_Identity=34.2592592592593, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1790710, Length=500, Percent_Identity=54.8, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI87082123, Length=296, Percent_Identity=39.8648648648649, Blast_Score=195, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17556903, Length=369, Percent_Identity=33.6043360433604, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=222, Percent_Identity=27.4774774774775, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24661038, Length=365, Percent_Identity=33.4246575342466, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI21355725, Length=331, Percent_Identity=34.1389728096677, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI20129969, Length=318, Percent_Identity=34.9056603773585, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24662227, Length=319, Percent_Identity=33.8557993730408, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI161077148, Length=508, Percent_Identity=27.755905511811, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI20130057, Length=508, Percent_Identity=27.755905511811, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI21355645, Length=500, Percent_Identity=27, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24662223, Length=500, Percent_Identity=27, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI20129963, Length=493, Percent_Identity=28.3975659229209, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI221379063, Length=333, Percent_Identity=31.8318318318318, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379062, Length=333, Percent_Identity=31.8318318318318, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21357381, Length=333, Percent_Identity=31.8318318318318, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI19922386, Length=483, Percent_Identity=27.9503105590062, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24646701, Length=302, Percent_Identity=27.1523178807947, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24646703, Length=302, Percent_Identity=27.1523178807947, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21358201, Length=302, Percent_Identity=27.1523178807947, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 55952; Mature: 55952

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKFSVTSGHQELYPDSCIITGTFEELNLFPSTKKIDDVSKGYISSLLRRGALHGKVAQT
CEEEEECCCCHHHCCCCEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
LLLYDVPHLHNRQILLVGCGKKSDFDENCYRKLIRKITILCKEIPIIKILLFLSELNIKG
HHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCC
YDNYWKIRQTMEIVNEELYVFNKFKNSKKTTLNKSLNEIILHIPNENELGCCKKSIRDGL
CCHHHHHHHHHHHHHHHHEEEHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHH
SIVHGIKIAKDLGNMPPNFCTPDYFVNQVNELSNCDNVTINIINALEMKKLGMNAYLAVG
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHCCCCEEEEEC
KGSNYAPTMPIIKYRGHPEGANVPPIVLIGKGLTFDSGGISIKESNKMDEMKYDMCGAAV
CCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCEECCCCEEEECCCCHHHHHHHHHHHHH
VYAIMRIAIELDLPLNIIGILAICENMISHTSFRPGDILTTLSGKTVEVLNTDAEGRLVL
HHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCCCCEEE
CDALTYAERYKPDVVIDIATLTGACVIALGHHFSGLMSNNKNLADELILAGQQSKDYVWK
EEHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEE
LPLDEVFQKQLKSTCADMTNVGGRPGGAITAGCFLHQFAYKYRWAHLDIAGTAWISDYCD
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEEECHHHHHHHHHC
KSATGRPVALLSQYLINRSSHKI
CCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIKFSVTSGHQELYPDSCIITGTFEELNLFPSTKKIDDVSKGYISSLLRRGALHGKVAQT
CEEEEECCCCHHHCCCCEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
LLLYDVPHLHNRQILLVGCGKKSDFDENCYRKLIRKITILCKEIPIIKILLFLSELNIKG
HHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCC
YDNYWKIRQTMEIVNEELYVFNKFKNSKKTTLNKSLNEIILHIPNENELGCCKKSIRDGL
CCHHHHHHHHHHHHHHHHEEEHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHH
SIVHGIKIAKDLGNMPPNFCTPDYFVNQVNELSNCDNVTINIINALEMKKLGMNAYLAVG
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHCCCCEEEEEC
KGSNYAPTMPIIKYRGHPEGANVPPIVLIGKGLTFDSGGISIKESNKMDEMKYDMCGAAV
CCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCEECCCCEEEECCCCHHHHHHHHHHHHH
VYAIMRIAIELDLPLNIIGILAICENMISHTSFRPGDILTTLSGKTVEVLNTDAEGRLVL
HHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCCCCEEE
CDALTYAERYKPDVVIDIATLTGACVIALGHHFSGLMSNNKNLADELILAGQQSKDYVWK
EEHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEE
LPLDEVFQKQLKSTCADMTNVGGRPGGAITAGCFLHQFAYKYRWAHLDIAGTAWISDYCD
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEEECHHHHHHHHHC
KSATGRPVALLSQYLINRSSHKI
CCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12886019 [H]