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The map label for this gene is iunH2 [H]

Identifier: 68537173

GI number: 68537173

Start: 2432102

End: 2433172

Strand: Direct

Name: iunH2 [H]

Synonym: jk2078

Alternate gene names: 68537173

Gene position: 2432102-2433172 (Clockwise)

Preceding gene: 68537172

Following gene: 68537177

Centisome position: 98.77

GC content: 67.04

Gene sequence:

>1071_bases
ATGACTCAGAAGATCATCCTGGACTGCGATCCGGGGCACGACGACGCAATCGCCATGCTCCTAGCCTGGGGAAACCCTAA
CCTGGACCTGGTGGCGGTCACGACGGTGGCGGGCAACCAGACGCTGGAGAAGGTGACCAAGAACGCCCTGGCGCTGGCGC
GCGTCGGCAACATCACCGGCATTCCCTTCGCCGCCGGAGCGGACCGCCCGCTGGTGGCGCCGCAGATCATTCCGGAGGAA
ATCCACGGGGACAGCGGCCTGGACGGCCCGCAGTTGCCCGCCGCCGGAGCCGAGCTGGATTCACGCCATGCGGTGAACCT
CATTGCGGACCTCATCCGCGACAACGAGCCGGGTAGTGTGACCCTCGTCCCCACGGGAGCGCTGACTAGCATCGCTCTTT
TTGCCCGCATGTATCCCGAGCTGGTGAAGCGCGTCGGTGGCGTCACCCTGATGGGTGGTGCGCACCACGCGGGCAACATG
ACCCCGAGCGCCGAGTTCAACATCCTGGCCGACCCGGAGGCCGCGAAGATCGTGTTCGGCGCGGGTTGGCCGGTGACGAT
GGTCGGGTTGGACGTCACACACAAGGTGCTGGCCACGCCGCAGCGGATGGCGCAGCTGGCAGAGGTCGACACGGACGTGG
CGAAGTTCATCGCGGAGCTTGTGGAATTCTTCGGCGGTGCGTACATGAAGGAGCGCCACTACCCCGGCCCACCGATGCAC
GACCCGCTGGCCGTCGCGGCCGTGGCAGACCCGCAGGTCGTACGCACAATCCTGGCACCCATCGACGTGGAGACCAAGGG
CGAGCTGACGCGCGGGGCGACGGTCGTGGACCTGCGGCGCACCTGGGGAAGCCAGGGTGGCGGGCAAGATCCGACGGCCC
TGGGTACGGCGGATGATTCTGATTTTGACGCCACCGCGTCCGCCACTGCAGCGGATGCAACCGGCACGGCCGGGCAGCCT
GGTGCAGCGGACACTACCCTGCGCACCCGCGTGGCCGTGGATGTCGACGCGGAGCGCTTCTGGAACCTGCTGGTTGACGC
ACTACAGCGCATCGGGAATACCGGCTTCTAA

Upstream 100 bases:

>100_bases
CACGTTGGGCGCGGCGGCCGGGGCGCTGGCCACGCAGAAGCGCGGCGCAGCGGGCAGCTACGCCACCGAGAACGAAATCC
GTCGACTAGGAGAAGCATAA

Downstream 100 bases:

>100_bases
AGAAGCTCTTCGAGAGCTCTATGCGGCTTTGGGCGGCCTTAAGCTGCCTGAAGCTGCCTAAACTGCCTACACAGCCAGCT
AGGGCAGCGCAGCCAACTGG

Product: putative inosine-uridine preferring nucleoside hydrolase

Products: D-ribose; purine

Alternate protein names: Cytidine/uridine-specific hydrolase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTQKIILDCDPGHDDAIAMLLAWGNPNLDLVAVTTVAGNQTLEKVTKNALALARVGNITGIPFAAGADRPLVAPQIIPEE
IHGDSGLDGPQLPAAGAELDSRHAVNLIADLIRDNEPGSVTLVPTGALTSIALFARMYPELVKRVGGVTLMGGAHHAGNM
TPSAEFNILADPEAAKIVFGAGWPVTMVGLDVTHKVLATPQRMAQLAEVDTDVAKFIAELVEFFGGAYMKERHYPGPPMH
DPLAVAAVADPQVVRTILAPIDVETKGELTRGATVVDLRRTWGSQGGGQDPTALGTADDSDFDATASATAADATGTAGQP
GAADTTLRTRVAVDVDAERFWNLLVDALQRIGNTGF

Sequences:

>Translated_356_residues
MTQKIILDCDPGHDDAIAMLLAWGNPNLDLVAVTTVAGNQTLEKVTKNALALARVGNITGIPFAAGADRPLVAPQIIPEE
IHGDSGLDGPQLPAAGAELDSRHAVNLIADLIRDNEPGSVTLVPTGALTSIALFARMYPELVKRVGGVTLMGGAHHAGNM
TPSAEFNILADPEAAKIVFGAGWPVTMVGLDVTHKVLATPQRMAQLAEVDTDVAKFIAELVEFFGGAYMKERHYPGPPMH
DPLAVAAVADPQVVRTILAPIDVETKGELTRGATVVDLRRTWGSQGGGQDPTALGTADDSDFDATASATAADATGTAGQP
GAADTTLRTRVAVDVDAERFWNLLVDALQRIGNTGF
>Mature_355_residues
TQKIILDCDPGHDDAIAMLLAWGNPNLDLVAVTTVAGNQTLEKVTKNALALARVGNITGIPFAAGADRPLVAPQIIPEEI
HGDSGLDGPQLPAAGAELDSRHAVNLIADLIRDNEPGSVTLVPTGALTSIALFARMYPELVKRVGGVTLMGGAHHAGNMT
PSAEFNILADPEAAKIVFGAGWPVTMVGLDVTHKVLATPQRMAQLAEVDTDVAKFIAELVEFFGGAYMKERHYPGPPMHD
PLAVAAVADPQVVRTILAPIDVETKGELTRGATVVDLRRTWGSQGGGQDPTALGTADDSDFDATASATAADATGTAGQPG
AADTTLRTRVAVDVDAERFWNLLVDALQRIGNTGF

Specific function: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786871, Length=287, Percent_Identity=43.9024390243902, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1788486, Length=300, Percent_Identity=37.6666666666667, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1786213, Length=290, Percent_Identity=39.6551724137931, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32565474, Length=294, Percent_Identity=30.952380952381, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17565698, Length=304, Percent_Identity=26.9736842105263, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320608, Length=359, Percent_Identity=31.7548746518106, Blast_Score=142, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24583915, Length=190, Percent_Identity=30.5263157894737, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24641839, Length=188, Percent_Identity=36.7021276595745, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641837, Length=196, Percent_Identity=34.1836734693878, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022975 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: 3.2.2.1

Molecular weight: Translated: 37156; Mature: 37024

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS01247 IUNH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKIILDCDPGHDDAIAMLLAWGNPNLDLVAVTTVAGNQTLEKVTKNALALARVGNITG
CCCEEEEECCCCCCCEEEEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCC
IPFAAGADRPLVAPQIIPEEIHGDSGLDGPQLPAAGAELDSRHAVNLIADLIRDNEPGSV
CCCCCCCCCCCCCHHCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEE
TLVPTGALTSIALFARMYPELVKRVGGVTLMGGAHHAGNMTPSAEFNILADPEAAKIVFG
EEEECCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCEEEEECCCCEEEEEE
AGWPVTMVGLDVTHKVLATPQRMAQLAEVDTDVAKFIAELVEFFGGAYMKERHYPGPPMH
CCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCC
DPLAVAAVADPQVVRTILAPIDVETKGELTRGATVVDLRRTWGSQGGGQDPTALGTADDS
CCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCEECCCCCC
DFDATASATAADATGTAGQPGAADTTLRTRVAVDVDAERFWNLLVDALQRIGNTGF
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TQKIILDCDPGHDDAIAMLLAWGNPNLDLVAVTTVAGNQTLEKVTKNALALARVGNITG
CCEEEEECCCCCCCEEEEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCC
IPFAAGADRPLVAPQIIPEEIHGDSGLDGPQLPAAGAELDSRHAVNLIADLIRDNEPGSV
CCCCCCCCCCCCCHHCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEE
TLVPTGALTSIALFARMYPELVKRVGGVTLMGGAHHAGNMTPSAEFNILADPEAAKIVFG
EEEECCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCEEEEECCCCEEEEEE
AGWPVTMVGLDVTHKVLATPQRMAQLAEVDTDVAKFIAELVEFFGGAYMKERHYPGPPMH
CCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCC
DPLAVAAVADPQVVRTILAPIDVETKGELTRGATVVDLRRTWGSQGGGQDPTALGTADDS
CCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCEECCCCCC
DFDATASATAADATGTAGQPGAADTTLRTRVAVDVDAERFWNLLVDALQRIGNTGF
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-D-ribosylpurine; H2O

Specific reaction: an N-D-ribosylpurine + H2O = D-ribose + a purine

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA