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The map label for this gene is aroP [H]

Identifier: 68536477

GI number: 68536477

Start: 1651264

End: 1652727

Strand: Direct

Name: aroP [H]

Synonym: jk1391

Alternate gene names: 68536477

Gene position: 1651264-1652727 (Clockwise)

Preceding gene: 68536471

Following gene: 68536478

Centisome position: 67.06

GC content: 59.63

Gene sequence:

>1464_bases
ATGAAGACTCGAGAATCCAATTCAGGTGCCACGGAAGGCACCTCTAACCAGCTGGGTCACAGCCTAGAAACCCGGCACCT
AACAATGATGGGCTTGGGCTCAGCCATCGGCGCTGGTCTTTTCCTCGGTACCGGCGTGGGCATCCAAGCTGCAGGTCCGG
CCGTGCTGCTTTCCTACGTCGTCGCCGGCATTGTGGTGATCGCTGTGATGCAGATGCTGGGAGAGCTCGCCGCCGCCCGC
CCTGCATCCGGCACCTTCGCCACCTACGGCCAGATGGCTTTCGGCCGCTGGAACGGCTTCGCCTTGGGTTGGCTGTACTG
GTTCATGCTGATCATGGTGATGGGCGCTGAGATCACCGGCGCCGGAGCGATCATGGGTGCATGGTTCGGCGTGGAAGGTT
GGATCCCAGGCCTTGTATGCGTGGTGCTGTTCACTATCGTGAACTTGGCTGGTGTCCGCGGCTTTGGCGAGTTCGAATAC
TGGTTTGCCTTCATTAAGGTGGCCGTCATCATCGTTTTCTTGGTCATCGGCACGGGACTGCTGCTGGGGCTGTTCCCCAA
CTATGATTCCCCTGGCCTGAGCCATTTCTCCGACTTCGCCCCCAACGGCATTTCTGGCATGGCAGTAGGCCTGCTAGCCG
TGGCCTTCGCCTTCGGCGGCATCGAGATCGTAACGATCGCCGCCGCGGAATCGAAGGATCCGGCGAACTCCATTGCCGCC
GCGGTGCGCGCCGTCATTTGGCGCATTTCCGTGTTCTATTTGGGTAGCGTCTTCCTGATCTCCGCCTTGCTGCCCTTCGA
AACCCTGGGTGAGGCCGAGTCCGCTGAGGAGTCTCCGTTCACCCGCATCCTGGCTCTCGCGCAGATTCCGGGCATCGTGG
AGATCATGGAAGCCGTAATCGTCTTGGCGCTGCTGTCGGCCTTTAACGCACAGATCTATGCGACCAGCCGCCTGATGTAC
AGCTTCTCCCAAGAGCGCAACGTGCCGCGATGGTTCGGTAAGACAAATTCCCAGAAGGTGCCCTACCGCGCCGTGTGGTG
TTCCCTGTTCTTCGCCTTCGTCTCCGTGGCGCTGCAAGTGTGGGGTCCAGAGAACCTGATCAACATCCTGTTCAACGCCG
TCGGCGGCACCCTGCTGGTCATTTGGATGGTCATCGTGTTGGCTCAGATCAAGCTACGCCCCACCTTCGAACGTGACGGC
AGCCTGACTGTGCGCATGGTGGGCTACCCCGTACTGTCGTGGCTAACCTTCCTGGCGCTTATCGCCCTGACTGTCCTAAT
GCTCTTCGACAACAGCGCCCGTTTGCAGGTTCTCACCGTCACCATAGCTTTTGTCGTCTTGAGCCTGATCGGCCTAGTGC
TACAGAAGACGCAGGGGCCGCAGCAATCCAACGAAAATGCTGATGCTGCTAGTACTGCTGGCGTTGCCGGAACCACTGCG
ACAAACAGCGACCCCAACGCATAG

Upstream 100 bases:

>100_bases
AACAGGCGGGTGGTCCGCGGGATGAAAAAGTATACCCGCCGCAGGGGCTAAAAGTACCCATGCTGGCCTTTACCAGGAGC
AGTTGTGTTCTAATTTCGGT

Downstream 100 bases:

>100_bases
ACACCAACACAAATGTAGGATCGACAACCATGACTTCTGCTTATGGAAATGGATTTGCCACCCTGACCGATTCTGGCGAT
GTGCTGGACACCTGGTTCTT

Product: aromatic amino acid transport protein

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MKTRESNSGATEGTSNQLGHSLETRHLTMMGLGSAIGAGLFLGTGVGIQAAGPAVLLSYVVAGIVVIAVMQMLGELAAAR
PASGTFATYGQMAFGRWNGFALGWLYWFMLIMVMGAEITGAGAIMGAWFGVEGWIPGLVCVVLFTIVNLAGVRGFGEFEY
WFAFIKVAVIIVFLVIGTGLLLGLFPNYDSPGLSHFSDFAPNGISGMAVGLLAVAFAFGGIEIVTIAAAESKDPANSIAA
AVRAVIWRISVFYLGSVFLISALLPFETLGEAESAEESPFTRILALAQIPGIVEIMEAVIVLALLSAFNAQIYATSRLMY
SFSQERNVPRWFGKTNSQKVPYRAVWCSLFFAFVSVALQVWGPENLINILFNAVGGTLLVIWMVIVLAQIKLRPTFERDG
SLTVRMVGYPVLSWLTFLALIALTVLMLFDNSARLQVLTVTIAFVVLSLIGLVLQKTQGPQQSNENADAASTAGVAGTTA
TNSDPNA

Sequences:

>Translated_487_residues
MKTRESNSGATEGTSNQLGHSLETRHLTMMGLGSAIGAGLFLGTGVGIQAAGPAVLLSYVVAGIVVIAVMQMLGELAAAR
PASGTFATYGQMAFGRWNGFALGWLYWFMLIMVMGAEITGAGAIMGAWFGVEGWIPGLVCVVLFTIVNLAGVRGFGEFEY
WFAFIKVAVIIVFLVIGTGLLLGLFPNYDSPGLSHFSDFAPNGISGMAVGLLAVAFAFGGIEIVTIAAAESKDPANSIAA
AVRAVIWRISVFYLGSVFLISALLPFETLGEAESAEESPFTRILALAQIPGIVEIMEAVIVLALLSAFNAQIYATSRLMY
SFSQERNVPRWFGKTNSQKVPYRAVWCSLFFAFVSVALQVWGPENLINILFNAVGGTLLVIWMVIVLAQIKLRPTFERDG
SLTVRMVGYPVLSWLTFLALIALTVLMLFDNSARLQVLTVTIAFVVLSLIGLVLQKTQGPQQSNENADAASTAGVAGTTA
TNSDPNA
>Mature_487_residues
MKTRESNSGATEGTSNQLGHSLETRHLTMMGLGSAIGAGLFLGTGVGIQAAGPAVLLSYVVAGIVVIAVMQMLGELAAAR
PASGTFATYGQMAFGRWNGFALGWLYWFMLIMVMGAEITGAGAIMGAWFGVEGWIPGLVCVVLFTIVNLAGVRGFGEFEY
WFAFIKVAVIIVFLVIGTGLLLGLFPNYDSPGLSHFSDFAPNGISGMAVGLLAVAFAFGGIEIVTIAAAESKDPANSIAA
AVRAVIWRISVFYLGSVFLISALLPFETLGEAESAEESPFTRILALAQIPGIVEIMEAVIVLALLSAFNAQIYATSRLMY
SFSQERNVPRWFGKTNSQKVPYRAVWCSLFFAFVSVALQVWGPENLINILFNAVGGTLLVIWMVIVLAQIKLRPTFERDG
SLTVRMVGYPVLSWLTFLALIALTVLMLFDNSARLQVLTVTIAFVVLSLIGLVLQKTQGPQQSNENADAASTAGVAGTTA
TNSDPNA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=429, Percent_Identity=38.4615384615385, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1786302, Length=452, Percent_Identity=31.6371681415929, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1786789, Length=457, Percent_Identity=35.0109409190372, Blast_Score=242, Evalue=5e-65,
Organism=Escherichia coli, GI87081708, Length=478, Percent_Identity=32.4267782426778, Blast_Score=238, Evalue=9e-64,
Organism=Escherichia coli, GI1788480, Length=405, Percent_Identity=35.8024691358025, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87081915, Length=462, Percent_Identity=34.8484848484849, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1786602, Length=460, Percent_Identity=33.9130434782609, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI48994972, Length=430, Percent_Identity=32.5581395348837, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1790653, Length=461, Percent_Identity=27.114967462039, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87082250, Length=338, Percent_Identity=24.5562130177515, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17533459, Length=449, Percent_Identity=23.6080178173719, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=295, Percent_Identity=24.406779661017, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324990, Length=405, Percent_Identity=29.6296296296296, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324553, Length=397, Percent_Identity=30.2267002518892, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6320772, Length=407, Percent_Identity=29.4840294840295, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=340, Percent_Identity=32.6470588235294, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324924, Length=460, Percent_Identity=28.695652173913, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6324061, Length=406, Percent_Identity=28.0788177339901, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6319543, Length=428, Percent_Identity=27.1028037383178, Blast_Score=150, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6321629, Length=408, Percent_Identity=26.7156862745098, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319824, Length=410, Percent_Identity=27.0731707317073, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6321053, Length=430, Percent_Identity=27.6744186046512, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320717, Length=414, Percent_Identity=27.0531400966184, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=433, Percent_Identity=27.0207852193995, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319542, Length=431, Percent_Identity=26.9141531322506, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324059, Length=447, Percent_Identity=27.9642058165548, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=398, Percent_Identity=26.8844221105528, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319608, Length=436, Percent_Identity=23.6238532110092, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=28.030303030303, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320364, Length=514, Percent_Identity=24.7081712062257, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24667468, Length=370, Percent_Identity=22.972972972973, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24666159, Length=430, Percent_Identity=23.4883720930233, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221512776, Length=430, Percent_Identity=23.4883720930233, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51826; Mature: 51826

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCC
>Mature Secondary Structure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CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7592354; 12948626 [H]