Click here to switch to the map view.

The map label for this gene is nuoM [H]

Identifier: 66767925

GI number: 66767925

Start: 1920345

End: 1921847

Strand: Direct

Name: nuoM [H]

Synonym: XC_1601

Alternate gene names: 66767925

Gene position: 1920345-1921847 (Clockwise)

Preceding gene: 66767924

Following gene: 66767926

Centisome position: 37.3

GC content: 62.01

Gene sequence:

>1503_bases
GTGTCGAACTGGCCTTTACTGTCTCTTCTGATCTGGCTGCCGATTATCGGTGGCGCCCTGATCCTCGCATTGCGCAACGC
CGAGACCGCCCGCTGGGCGTCTCTTGCGGTGGCCGTGGCGACCTTCGTGCTGAGTCTGCCGCTGCTCGGGTATGACACGG
CGAACGATGCCATGCAGTTCATCGAGCAACATGCCTGGATCCCGGCCTACAACATCGGCTACAACCTGGGCGTGGACGGC
ATTGCGGTCGCGTTGATCGTGTTGACCACGCTGGTGACCGTGCTTGCGTTGATCGGCGCCTGGCGCTCGATCGACAAGCG
CGTCAACCAGTACGTTGCGGCCTTCCTGATCCTCGAAGGCGTCACGGTCGGCATCTTTGCGGCCACCGACGCGATGCTGT
TCTACGTGTTCTTCGAAGCCATGCTGATCCCGATGTTCCTGATCATCGGTGTCTGGGGCGGCCCGCGTCGCATCTACGCG
GCCATGAAGTTCTTCCTGTACACCTTCCTCGGCTCGGTGCTGATGCTGGTGGGCCTGATCTACCTGTACCTGAAGGGTGG
CAGCTTCCAGCTCGCCGACCTGTACGCGCTGCAGCTGACCGCCAAGGAACAGACCTGGATCTTCTTCGCGTTCATGATCG
CTTTCGCGGTCAAGGTGCCGATGTTCCCGGTGCACACCTGGCTGCCGGATGCGCACGTTGAGGCACCGACCGCCGGCTCG
GTGATCCTTGCGGCGATCGCGCTGAAGATCGGCGGCTACGGCTTCCTGCGCTTCAACCTGCCGATCCTGCCTGACGCCAG
CAACCAATGGGCCTGGCTGGTGATCGCGCTGTCGCTGATCGCGGTGATTTACGTCGGCCTGGTGGCGCTGGTGCAGGACG
ACATGAAGAAGCTGGTGGCGTATTCGTCCATCGCGCACATGGGCTTCGTCACCCTCGGCACCTTCATCGCGTTCACCCTG
GTGCGCGAGTACGGCAGCACCGATGCGGCCCGTCTTGGCCTGCAGGGCGCGATGGTGCAAATGATTTCGCACGGCTTCGT
ATCCGGCGCGATGTTCTCCTGCATCGGCGTGCTGTACGACCGCATGCATACCCGCCGCATTGCCGATTACGGCGGCGTGG
TGAATGTCATGCCGTGGTTTGCCACCTTTGCCATGTTGTTCTTCATGGCGAACGCCGGCCTGCCGGGCACGAGCGGTTTC
GTTGGCGAATTCATGGTCATCCTGGCCAGCTTCCAGAAGCATCCGTTGGTGGCCTTTGCTGCGGCAACCACGCTGGTGAT
CACCGCGGCCTACACGCTGTGGCTCTACAAGCGCGTGTTCTTCGGCGAAGTGGCCAATGCGCATGTGGCGGAGCTGAAGG
ACATCAACGGTCGCGAGGCCTTCGTGTTGGGCGTGTTTGCTGCCGGTGTACTGGCGCTTGGCCTGTATCCGAAGCCGCTG
ACCGACCTGATGGAACCGTCGATCGCCAAGCTGGCGACCCAGATTGCAACGACCAAGCTCTAA

Upstream 100 bases:

>100_bases
GTTTCCTCTATCACTACGCCTTCGCAATGATCATCGGTTTGATCGCCTTGTTGGCGGTACTGATGCATTTCTGGCGTTGA
CCTGTACGGAATAAGAAAAC

Downstream 100 bases:

>100_bases
CCGCTTGCCGTCCGTATTGATTTTCAGGATTTGATGATGACCACGCCAACGCTCGCGCCGTTGACCACCGCTGACCTGGC
TCCGCTCGCACCGGAGCTGG

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSNWPLLSLLIWLPIIGGALILALRNAETARWASLAVAVATFVLSLPLLGYDTANDAMQFIEQHAWIPAYNIGYNLGVDG
IAVALIVLTTLVTVLALIGAWRSIDKRVNQYVAAFLILEGVTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYA
AMKFFLYTFLGSVLMLVGLIYLYLKGGSFQLADLYALQLTAKEQTWIFFAFMIAFAVKVPMFPVHTWLPDAHVEAPTAGS
VILAAIALKIGGYGFLRFNLPILPDASNQWAWLVIALSLIAVIYVGLVALVQDDMKKLVAYSSIAHMGFVTLGTFIAFTL
VREYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYDRMHTRRIADYGGVVNVMPWFATFAMLFFMANAGLPGTSGF
VGEFMVILASFQKHPLVAFAAATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPL
TDLMEPSIAKLATQIATTKL

Sequences:

>Translated_500_residues
MSNWPLLSLLIWLPIIGGALILALRNAETARWASLAVAVATFVLSLPLLGYDTANDAMQFIEQHAWIPAYNIGYNLGVDG
IAVALIVLTTLVTVLALIGAWRSIDKRVNQYVAAFLILEGVTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYA
AMKFFLYTFLGSVLMLVGLIYLYLKGGSFQLADLYALQLTAKEQTWIFFAFMIAFAVKVPMFPVHTWLPDAHVEAPTAGS
VILAAIALKIGGYGFLRFNLPILPDASNQWAWLVIALSLIAVIYVGLVALVQDDMKKLVAYSSIAHMGFVTLGTFIAFTL
VREYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYDRMHTRRIADYGGVVNVMPWFATFAMLFFMANAGLPGTSGF
VGEFMVILASFQKHPLVAFAAATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPL
TDLMEPSIAKLATQIATTKL
>Mature_499_residues
SNWPLLSLLIWLPIIGGALILALRNAETARWASLAVAVATFVLSLPLLGYDTANDAMQFIEQHAWIPAYNIGYNLGVDGI
AVALIVLTTLVTVLALIGAWRSIDKRVNQYVAAFLILEGVTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYAA
MKFFLYTFLGSVLMLVGLIYLYLKGGSFQLADLYALQLTAKEQTWIFFAFMIAFAVKVPMFPVHTWLPDAHVEAPTAGSV
ILAAIALKIGGYGFLRFNLPILPDASNQWAWLVIALSLIAVIYVGLVALVQDDMKKLVAYSSIAHMGFVTLGTFIAFTLV
REYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYDRMHTRRIADYGGVVNVMPWFATFAMLFFMANAGLPGTSGFV
GEFMVILASFQKHPLVAFAAATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPLT
DLMEPSIAKLATQIATTKL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=383, Percent_Identity=33.420365535248, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI251831117, Length=377, Percent_Identity=23.8726790450928, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1788613, Length=520, Percent_Identity=35.7692307692308, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1788827, Length=284, Percent_Identity=27.112676056338, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1788831, Length=304, Percent_Identity=25.9868421052632, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788829, Length=430, Percent_Identity=25.1162790697674, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI145693160, Length=467, Percent_Identity=23.3404710920771, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788614, Length=480, Percent_Identity=24.375, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI2367154, Length=308, Percent_Identity=26.2987012987013, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54473; Mature: 54342

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNWPLLSLLIWLPIIGGALILALRNAETARWASLAVAVATFVLSLPLLGYDTANDAMQF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IEQHAWIPAYNIGYNLGVDGIAVALIVLTTLVTVLALIGAWRSIDKRVNQYVAAFLILEG
HHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VTVGIFAATDAMLFYVFFEAMLIPMFLIIGVWGGPRRIYAAMKFFLYTFLGSVLMLVGLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLYLKGGSFQLADLYALQLTAKEQTWIFFAFMIAFAVKVPMFPVHTWLPDAHVEAPTAGS
HHHHCCCCEEHHHHEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHH
VILAAIALKIGGYGFLRFNLPILPDASNQWAWLVIALSLIAVIYVGLVALVQDDMKKLVA
HHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSSIAHMGFVTLGTFIAFTLVREYGSTDAARLGLQGAMVQMISHGFVSGAMFSCIGVLYD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMHTRRIADYGGVVNVMPWFATFAMLFFMANAGLPGTSGFVGEFMVILASFQKHPLVAFA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
AATTLVITAAYTLWLYKRVFFGEVANAHVAELKDINGREAFVLGVFAAGVLALGLYPKPL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCH
TDLMEPSIAKLATQIATTKL
HHHHCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNWPLLSLLIWLPIIGGALILALRNAETARWASLAVAVATFVLSLPLLGYDTANDAMQF
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH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HHHHCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]