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The map label for this gene is nuoL [H]

Identifier: 66767924

GI number: 66767924

Start: 1918141

End: 1920324

Strand: Direct

Name: nuoL [H]

Synonym: XC_1600

Alternate gene names: 66767924

Gene position: 1918141-1920324 (Clockwise)

Preceding gene: 66767923

Following gene: 66767925

Centisome position: 37.25

GC content: 61.68

Gene sequence:

>2184_bases
ATGGAAATCACTCTCTCCAAGAGTCTGCTGATCGCAGTGGTGCTTGCACCGCTGGTCGGCAGCATCGTCGCCGGCCTCTT
CGGTCGCCAGGTAGGGCGCAAGGGCGCGCAATACGTCACCATCCTCGGTGTGGCGGTCAGCTGCGTGTTGTCCTGCCTGA
CGCTGTACCAACTGGTGGAGCTGGGCGCCAGCCCGTTCAACCAGAACCTGTACACCTTCTTCGACGTCGGTAACTACTCG
GCGCATGTCGGCTTCATGGTCGACCGCCTGACCGCGATGATGATGGTGGTGGTGACCTTCGTGTCACTGCTGGTGCACAT
CTACACCATCGGCTACATGGAAGAAGACCCGGGTTACCAGCGCTTCTTCAGCTACATCTCGTTGTTCACCTTCTCCATGC
TGACGCTGGTGATGAGCAACAACTTCCTGCAGCTGTTCTTCGGCTGGGAAGCGGTGGGCCTGGTGTCCTACCTGTTGATC
GGCTTCTGGTTCAAGCGCCCGACCGCTGTGTTCGCCAACATGAAGGCGTTCCTGGTCAACCGCGTGGGCGACTTCGGTTT
CATCCTGGGCATTGCCGGGGTGCTGCTGTGGTTCGGCTCGCTCGACTACTCCACCGTGTTTGCCAACGCGACCACCATGG
CTGGTGCCAAGGTGCAGCTGTTCGCCGGCCACGAGTGGAGCGTGATGACGCTGATCTGCATCTGCCTGTTCATTGGTGCG
ATGGGCAAGTCGGCGCAGGTGCCGCTGCATGTGTGGCTGCCGGACTCGATGGAAGGCCCGACCCCGATTTCGGCACTGAT
CCATGCCGCGACGATGGTGACCGCGGGCATCTTCATGGTGGCGCGCATGTCGCCGCTGTTCGAGCTGTCCGAAACCGCGC
TGAACTTCATCCTGTTCATCGGTGCGACCACGGCCTTCTTCACCGGCCTGATCGGCATCGTGCAGAACGACATCAAGCGC
GTGGTGGCGTATTCCACGCTGTCGCAGCTGGGCTACATGACCGTCGCGCTGGGCGTCTCTGCCTATTCGGCCGCCGTGTT
CCACCTGATGACGCATGCCTTCTTCAAGGCGCTGCTGTTCCTTGCGGCCGGCTCGGTCATCATCGGCATGCACCACGAGC
AGGACATGCGCAAGATGGGCGGGCTGCGCAAGTACATGAAGGTGACCTACTGGACCAGCGTGATCGGTACCCTGGCGCTG
GTCGGTACGCCGTTCTTCTCGGGTTTCTACTCGAAGGACACCATCATCGAAGCGGCCGCGCACCACGCGCATGAGTCGCA
CAGCTGGATCGCCACCTACGGCTACTGGGCAGTGCTCGGCGGCGTGCTGGTCACCAGCTTCTACAGCTTCCGCCTGCTGT
TCCTGACCTTCCACGGCAAGGAACGCTTCCGCGATGCGCATGCACATGACGTGCACGCCCATCACGACAGCGCCCATACC
GATGCCGAGGCGCAGGTGCATACGCACGACAGCCACGGTCATGATGCACACGATGCGCATGGGCACGACGATCATGGTCA
TGGTCATGGTCACCACGGTGCCCACGAGCCGCACGAGCCGCACGAGTCCAAGTGGGTGGTCACGCTGCCGCTCATCTTGC
TGGCGATTCCGTCGGTGGCGATCGGCTTCTTCACCATCGGCCCGATGCTGTTCGGTACCGACTGGCAAGGCCACCACGCG
GCGCATGCGATGAAGGGGCAGGCCGTGTCGTTCTTCACCGGCATCGTCGACTTCTACGACCCGGCGCGCGACACCGTCGG
CGCATTGGCCGAAGAATTCCATGGTCCGGTGGCGTTCGCGCTGCACGGCATGATGGCGGCACCGTTCTTCCTGACGGTCG
CCGGCCTGCTGCTGGCCGCGCTGTTCTATCTCTGGAAGCCAGAGCTGGCCACCAAGTCACGCAAGGCGTTTGCGCCGATC
GTGTGGCTGCTGGAAAACAAGTACGGCTTTGACAAGCTGTGGATCAATGGCTTCGCCGGTGGTGGCGTGGTCCTTGGAAA
GGCTTCCCGCGCAATCGACACCCACGTGGTGGATGGCGTGGCGGTCAATGGTTCTGCCCGACTGATCGACCTGGCTGCAC
ATCTGCTGCGTCGCACGCAATCCGGTTTCCTCTATCACTACGCCTTCGCAATGATCATCGGTTTGATCGCCTTGTTGGCG
GTACTGATGCATTTCTGGCGTTGA

Upstream 100 bases:

>100_bases
GCGGAGGCCGCCATCGGCCTTGCGATCCTGGTGACACTGTTCCGTACGCGCCGCACGATCAATGTGGCCGAAGTCGATAC
GTTGAAGGGCTGACCTGTAG

Downstream 100 bases:

>100_bases
CCTGTACGGAATAAGAAAACGTGTCGAACTGGCCTTTACTGTCTCTTCTGATCTGGCTGCCGATTATCGGTGGCGCCCTG
ATCCTCGCATTGCGCAACGC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 727; Mature: 727

Protein sequence:

>727_residues
MEITLSKSLLIAVVLAPLVGSIVAGLFGRQVGRKGAQYVTILGVAVSCVLSCLTLYQLVELGASPFNQNLYTFFDVGNYS
AHVGFMVDRLTAMMMVVVTFVSLLVHIYTIGYMEEDPGYQRFFSYISLFTFSMLTLVMSNNFLQLFFGWEAVGLVSYLLI
GFWFKRPTAVFANMKAFLVNRVGDFGFILGIAGVLLWFGSLDYSTVFANATTMAGAKVQLFAGHEWSVMTLICICLFIGA
MGKSAQVPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSETALNFILFIGATTAFFTGLIGIVQNDIKR
VVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLAAGSVIIGMHHEQDMRKMGGLRKYMKVTYWTSVIGTLAL
VGTPFFSGFYSKDTIIEAAAHHAHESHSWIATYGYWAVLGGVLVTSFYSFRLLFLTFHGKERFRDAHAHDVHAHHDSAHT
DAEAQVHTHDSHGHDAHDAHGHDDHGHGHGHHGAHEPHEPHESKWVVTLPLILLAIPSVAIGFFTIGPMLFGTDWQGHHA
AHAMKGQAVSFFTGIVDFYDPARDTVGALAEEFHGPVAFALHGMMAAPFFLTVAGLLLAALFYLWKPELATKSRKAFAPI
VWLLENKYGFDKLWINGFAGGGVVLGKASRAIDTHVVDGVAVNGSARLIDLAAHLLRRTQSGFLYHYAFAMIIGLIALLA
VLMHFWR

Sequences:

>Translated_727_residues
MEITLSKSLLIAVVLAPLVGSIVAGLFGRQVGRKGAQYVTILGVAVSCVLSCLTLYQLVELGASPFNQNLYTFFDVGNYS
AHVGFMVDRLTAMMMVVVTFVSLLVHIYTIGYMEEDPGYQRFFSYISLFTFSMLTLVMSNNFLQLFFGWEAVGLVSYLLI
GFWFKRPTAVFANMKAFLVNRVGDFGFILGIAGVLLWFGSLDYSTVFANATTMAGAKVQLFAGHEWSVMTLICICLFIGA
MGKSAQVPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSETALNFILFIGATTAFFTGLIGIVQNDIKR
VVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLAAGSVIIGMHHEQDMRKMGGLRKYMKVTYWTSVIGTLAL
VGTPFFSGFYSKDTIIEAAAHHAHESHSWIATYGYWAVLGGVLVTSFYSFRLLFLTFHGKERFRDAHAHDVHAHHDSAHT
DAEAQVHTHDSHGHDAHDAHGHDDHGHGHGHHGAHEPHEPHESKWVVTLPLILLAIPSVAIGFFTIGPMLFGTDWQGHHA
AHAMKGQAVSFFTGIVDFYDPARDTVGALAEEFHGPVAFALHGMMAAPFFLTVAGLLLAALFYLWKPELATKSRKAFAPI
VWLLENKYGFDKLWINGFAGGGVVLGKASRAIDTHVVDGVAVNGSARLIDLAAHLLRRTQSGFLYHYAFAMIIGLIALLA
VLMHFWR
>Mature_727_residues
MEITLSKSLLIAVVLAPLVGSIVAGLFGRQVGRKGAQYVTILGVAVSCVLSCLTLYQLVELGASPFNQNLYTFFDVGNYS
AHVGFMVDRLTAMMMVVVTFVSLLVHIYTIGYMEEDPGYQRFFSYISLFTFSMLTLVMSNNFLQLFFGWEAVGLVSYLLI
GFWFKRPTAVFANMKAFLVNRVGDFGFILGIAGVLLWFGSLDYSTVFANATTMAGAKVQLFAGHEWSVMTLICICLFIGA
MGKSAQVPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSETALNFILFIGATTAFFTGLIGIVQNDIKR
VVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLAAGSVIIGMHHEQDMRKMGGLRKYMKVTYWTSVIGTLAL
VGTPFFSGFYSKDTIIEAAAHHAHESHSWIATYGYWAVLGGVLVTSFYSFRLLFLTFHGKERFRDAHAHDVHAHHDSAHT
DAEAQVHTHDSHGHDAHDAHGHDDHGHGHGHHGAHEPHEPHESKWVVTLPLILLAIPSVAIGFFTIGPMLFGTDWQGHHA
AHAMKGQAVSFFTGIVDFYDPARDTVGALAEEFHGPVAFALHGMMAAPFFLTVAGLLLAALFYLWKPELATKSRKAFAPI
VWLLENKYGFDKLWINGFAGGGVVLGKASRAIDTHVVDGVAVNGSARLIDLAAHLLRRTQSGFLYHYAFAMIIGLIALLA
VLMHFWR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=381, Percent_Identity=42.7821522309711, Blast_Score=290, Evalue=4e-78,
Organism=Escherichia coli, GI1788614, Length=478, Percent_Identity=42.4686192468619, Blast_Score=338, Evalue=8e-94,
Organism=Escherichia coli, GI1788829, Length=445, Percent_Identity=30.3370786516854, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI1788831, Length=374, Percent_Identity=27.807486631016, Blast_Score=120, Evalue=4e-28,
Organism=Escherichia coli, GI1788827, Length=354, Percent_Identity=29.0960451977401, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1788613, Length=475, Percent_Identity=24.6315789473684, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI2367154, Length=136, Percent_Identity=32.3529411764706, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI145693160, Length=232, Percent_Identity=25.8620689655172, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 79730; Mature: 79730

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCC
>Mature Secondary Structure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HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]