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The map label for this gene is cysG [H]

Identifier: 66767315

GI number: 66767315

Start: 1179304

End: 1180509

Strand: Reverse

Name: cysG [H]

Synonym: XC_0983

Alternate gene names: 66767315

Gene position: 1180509-1179304 (Counterclockwise)

Preceding gene: 66767318

Following gene: 66767314

Centisome position: 22.93

GC content: 71.97

Gene sequence:

>1206_bases
GTGACTGCCCTGTTCCCGCTCCTTGCCGATCTGCGTGGCCGTGCCGTCCTGGTGGTCGGCGGCGGCCGCGCTGCCGAAAG
CGCCACCGCCAGCCTGCTGCAGGCCGGCGCGGTGCCGCTGGTGGGCGCGCCGGAACTGACACCGGCGTTGCGCGGCTGGG
CGCAGTCCGGTCAGGTGCGCTGGCTGGTGGGCAGCTTTGACCCGCAGTGGCTGGCGCTGCCGGACCAGCCGGTCTGGCTG
ACCATTGCGGCCAGCGATGTGCCGGCCGTGAACGCTGCCTTGCGCAGCGTCGCCGGCGCACAACGGCTGCTGACCCATGA
GGCCGCTCCCGCAGCGGCAGCATTGCCGCCCATCGCCAGCGAACCACCGCCACCAGCAAGCCGCCTCACCCTCACGCCCG
GCAGCGTGGCGCTGGTCGGTGCCGGCCCGGGCGACCCCGGCCTGCTCACCCGCAATGCGGTGCGCGCGCTGCGGCAGGCC
GAGGTGATCCTGTACGACCGCCTGGTCAGCCCGCAGATCCTGCGTCTGGCCCAGCGCGCAGCGCGCTGCATCGAAGTGGG
CAAATCCGCCCAAGGCCACAGCACGCGCCAGGAGCAGATCCATGCGCTGATGCTCGAACATGCGCGCGCCGGGCGGCGCG
TGGTGCGCCTGAAAGGTGGCGACCCGTTCGTGTTTGGCCGCGGCGGCGAAGAGCTCGAATTCCTGCACGCGCACGGCATC
GGTTTCCAGGTGGTGCCCGGCATCACTGCCGCAGTGGCCTGTGCCGCCTACGCCGGTATCCCGCTCACCCACCGCGACCA
TGCGCAATCGCTGCGCCTGATCACCGCGCACTGCAAGGATTCGCTGGACACGCTGGACTGGCACGCATTGGGCCAGGAGC
GGCAGACGCTGGCCTTCTACATGGGCGTGGCCGGCCTGGATAGCATCCAGCAGCGCCTGCTGCAGGCCGGCCGCGCCGCG
GACACGCCATTTGCGCTGGTCGAAAATGGCTCGCGCCCGGAACAGCGCGTGGTCACCGGCACCTTGTCGCAGCTGGCCGC
CACCGCGCGCTTGCATGCGGTGCGCTCGCCCGCACTGTTGATCCTGGGCGACGTCGCCGCGCTGTCGCAGTCGCTGCACT
GGTTCGGCGCCGCGCCGCTCACCGGCCAGCCCGCGCACTCACCCATCGCAACGCCCCACGCGCCCACACTCGCCCACGCA
GCCTGA

Upstream 100 bases:

>100_bases
CCAGCTTATAACCGAACGCTATTTTTAGGACGCATGAAGTCATTTCCGACGGCTATAAGCCCGGCGTTACGGTCTGGCCC
TCCCCTCGAAGCCCCGGTCC

Downstream 100 bases:

>100_bases
TTCCGACGGAGACCCCATGGCCCTGTACGACAACATCCTCGACACCATCGGCCGCACCCCGGTGGTCAAACTCAACCGCC
TCGCCCCGGACCACGTGTCC

Product: siroheme synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTALFPLLADLRGRAVLVVGGGRAAESATASLLQAGAVPLVGAPELTPALRGWAQSGQVRWLVGSFDPQWLALPDQPVWL
TIAASDVPAVNAALRSVAGAQRLLTHEAAPAAAALPPIASEPPPPASRLTLTPGSVALVGAGPGDPGLLTRNAVRALRQA
EVILYDRLVSPQILRLAQRAARCIEVGKSAQGHSTRQEQIHALMLEHARAGRRVVRLKGGDPFVFGRGGEELEFLHAHGI
GFQVVPGITAAVACAAYAGIPLTHRDHAQSLRLITAHCKDSLDTLDWHALGQERQTLAFYMGVAGLDSIQQRLLQAGRAA
DTPFALVENGSRPEQRVVTGTLSQLAATARLHAVRSPALLILGDVAALSQSLHWFGAAPLTGQPAHSPIATPHAPTLAHA
A

Sequences:

>Translated_401_residues
MTALFPLLADLRGRAVLVVGGGRAAESATASLLQAGAVPLVGAPELTPALRGWAQSGQVRWLVGSFDPQWLALPDQPVWL
TIAASDVPAVNAALRSVAGAQRLLTHEAAPAAAALPPIASEPPPPASRLTLTPGSVALVGAGPGDPGLLTRNAVRALRQA
EVILYDRLVSPQILRLAQRAARCIEVGKSAQGHSTRQEQIHALMLEHARAGRRVVRLKGGDPFVFGRGGEELEFLHAHGI
GFQVVPGITAAVACAAYAGIPLTHRDHAQSLRLITAHCKDSLDTLDWHALGQERQTLAFYMGVAGLDSIQQRLLQAGRAA
DTPFALVENGSRPEQRVVTGTLSQLAATARLHAVRSPALLILGDVAALSQSLHWFGAAPLTGQPAHSPIATPHAPTLAHA
A
>Mature_400_residues
TALFPLLADLRGRAVLVVGGGRAAESATASLLQAGAVPLVGAPELTPALRGWAQSGQVRWLVGSFDPQWLALPDQPVWLT
IAASDVPAVNAALRSVAGAQRLLTHEAAPAAAALPPIASEPPPPASRLTLTPGSVALVGAGPGDPGLLTRNAVRALRQAE
VILYDRLVSPQILRLAQRAARCIEVGKSAQGHSTRQEQIHALMLEHARAGRRVVRLKGGDPFVFGRGGEELEFLHAHGIG
FQVVPGITAAVACAAYAGIPLTHRDHAQSLRLITAHCKDSLDTLDWHALGQERQTLAFYMGVAGLDSIQQRLLQAGRAAD
TPFALVENGSRPEQRVVTGTLSQLAATARLHAVRSPALLILGDVAALSQSLHWFGAAPLTGQPAHSPIATPHAPTLAHAA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=242, Percent_Identity=54.5454545454545, Blast_Score=261, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6322922, Length=232, Percent_Identity=36.2068965517241, Blast_Score=129, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 41911; Mature: 41779

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALFPLLADLRGRAVLVVGGGRAAESATASLLQAGAVPLVGAPELTPALRGWAQSGQVR
CCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEE
WLVGSFDPQWLALPDQPVWLTIAASDVPAVNAALRSVAGAQRLLTHEAAPAAAALPPIAS
EEEECCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC
EPPPPASRLTLTPGSVALVGAGPGDPGLLTRNAVRALRQAEVILYDRLVSPQILRLAQRA
CCCCCCCEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ARCIEVGKSAQGHSTRQEQIHALMLEHARAGRRVVRLKGGDPFVFGRGGEELEFLHAHGI
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCEEEEEECCC
GFQVVPGITAAVACAAYAGIPLTHRDHAQSLRLITAHCKDSLDTLDWHALGQERQTLAFY
CEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHH
MGVAGLDSIQQRLLQAGRAADTPFALVENGSRPEQRVVTGTLSQLAATARLHAVRSPALL
HHHCCHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ILGDVAALSQSLHWFGAAPLTGQPAHSPIATPHAPTLAHAA
EEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TALFPLLADLRGRAVLVVGGGRAAESATASLLQAGAVPLVGAPELTPALRGWAQSGQVR
CHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCEE
WLVGSFDPQWLALPDQPVWLTIAASDVPAVNAALRSVAGAQRLLTHEAAPAAAALPPIAS
EEEECCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC
EPPPPASRLTLTPGSVALVGAGPGDPGLLTRNAVRALRQAEVILYDRLVSPQILRLAQRA
CCCCCCCEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ARCIEVGKSAQGHSTRQEQIHALMLEHARAGRRVVRLKGGDPFVFGRGGEELEFLHAHGI
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCEEEEEECCC
GFQVVPGITAAVACAAYAGIPLTHRDHAQSLRLITAHCKDSLDTLDWHALGQERQTLAFY
CEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHH
MGVAGLDSIQQRLLQAGRAADTPFALVENGSRPEQRVVTGTLSQLAATARLHAVRSPALL
HHHCCHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ILGDVAALSQSLHWFGAAPLTGQPAHSPIATPHAPTLAHAA
EEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA