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The map label for this gene is cysK [H]

Identifier: 66767314

GI number: 66767314

Start: 1178328

End: 1179287

Strand: Reverse

Name: cysK [H]

Synonym: XC_0982

Alternate gene names: 66767314

Gene position: 1179287-1178328 (Counterclockwise)

Preceding gene: 66767315

Following gene: 66767313

Centisome position: 22.9

GC content: 68.54

Gene sequence:

>960_bases
ATGGCCCTGTACGACAACATCCTCGACACCATCGGCCGCACCCCGGTGGTCAAACTCAACCGCCTCGCCCCGGACCACGT
GTCCCTGTACGTCAAGGTCGAGTCGTTCAACCCGGGCGGATCGGTCAAGGACCGGCTGGCGCTGGCCATCATCCTGGACG
CCGAACAACGCGGCCTGCTCAAGCCCGGCGACACCATCGTGGAAGCCACCTCCGGCAACACCGGCGTGGCGCTGGCCATG
GTCGCTGCCGCGCGTGGCTACAAGTTCGTCGCCACCATGGTGGAAACCTTCTCGATCGAGCGCCGCAAGCTCATGCGCGC
CTACGGCGCCAAGGTGATCCTGACCCCGGCCGCCGAGCGCGGCAGCGGCATGGTGCGCAAGGCCAAGGAACTGGCCGAAC
AACACGGCTGGTTCCTGGCCAGCCAGTTCGCCAACCCCGCCAATCCGGCCTACCACCGCAACACCACCGCCGCCGAGATC
CTGCGCGACTTCGCCGGCCACCGGCTGGACCATTTCGTCACCGGCTGGGGCACCGGCGGCACCCTCACCGGCGTGGGCGA
AGTACTGCGCGTGGCCCGCCCGGAAGTGCGCATCACCGCCACCGAGCCGGCCGGCGCTGCGCTGCTGCAAGGCCAGGACT
GGAAGCCGCACAAGATCCAGGGCTGGACGCCGGACTTCGTGCCGGAGGTGCTCAACCGCGAGGTCGCCCACGAAATCCTC
AGCGTGGAAGACACCGACGCGATCAGCGTGGCTCGGCGGCTTGCCGCGGAAGAAGGCATCTTCACCGGCATCTCCGGCGG
CGGCACCGTCTCCACTGCCCTGCGGGTGGCCGAAACCGCGGTGCCGGGCGCGGTGATCCTTGCGATGCTGCCGGATACCG
GCGAGCGCTACTTCTCCACGCCATTGTTCGCCGACATCAACGAAGGCTCGGACGACGATTGGCTGGCCGGCCTGCCCTGA

Upstream 100 bases:

>100_bases
TTCGGCGCCGCGCCGCTCACCGGCCAGCCCGCGCACTCACCCATCGCAACGCCCCACGCGCCCACACTCGCCCACGCAGC
CTGATTCCGACGGAGACCCC

Downstream 100 bases:

>100_bases
TCGCAGGCAGCGTGACGTCAGCGTTTCTTCCCAAAGGCCGCGCCCGCCAGCGCGGCCTTTGGCATGAAGTGTCCTGCGAT
TTGCGGCGCGCTGCGGCGCT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MALYDNILDTIGRTPVVKLNRLAPDHVSLYVKVESFNPGGSVKDRLALAIILDAEQRGLLKPGDTIVEATSGNTGVALAM
VAAARGYKFVATMVETFSIERRKLMRAYGAKVILTPAAERGSGMVRKAKELAEQHGWFLASQFANPANPAYHRNTTAAEI
LRDFAGHRLDHFVTGWGTGGTLTGVGEVLRVARPEVRITATEPAGAALLQGQDWKPHKIQGWTPDFVPEVLNREVAHEIL
SVEDTDAISVARRLAAEEGIFTGISGGGTVSTALRVAETAVPGAVILAMLPDTGERYFSTPLFADINEGSDDDWLAGLP

Sequences:

>Translated_319_residues
MALYDNILDTIGRTPVVKLNRLAPDHVSLYVKVESFNPGGSVKDRLALAIILDAEQRGLLKPGDTIVEATSGNTGVALAM
VAAARGYKFVATMVETFSIERRKLMRAYGAKVILTPAAERGSGMVRKAKELAEQHGWFLASQFANPANPAYHRNTTAAEI
LRDFAGHRLDHFVTGWGTGGTLTGVGEVLRVARPEVRITATEPAGAALLQGQDWKPHKIQGWTPDFVPEVLNREVAHEIL
SVEDTDAISVARRLAAEEGIFTGISGGGTVSTALRVAETAVPGAVILAMLPDTGERYFSTPLFADINEGSDDDWLAGLP
>Mature_318_residues
ALYDNILDTIGRTPVVKLNRLAPDHVSLYVKVESFNPGGSVKDRLALAIILDAEQRGLLKPGDTIVEATSGNTGVALAMV
AAARGYKFVATMVETFSIERRKLMRAYGAKVILTPAAERGSGMVRKAKELAEQHGWFLASQFANPANPAYHRNTTAAEIL
RDFAGHRLDHFVTGWGTGGTLTGVGEVLRVARPEVRITATEPAGAALLQGQDWKPHKIQGWTPDFVPEVLNREVAHEILS
VEDTDAISVARRLAAEEGIFTGISGGGTVSTALRVAETAVPGAVILAMLPDTGERYFSTPLFADINEGSDDDWLAGLP

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=309, Percent_Identity=38.8349514563107, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI295821200, Length=309, Percent_Identity=38.8349514563107, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4557415, Length=309, Percent_Identity=38.8349514563107, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI11345492, Length=231, Percent_Identity=29.4372294372294, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=44.2953020134228, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1788754, Length=313, Percent_Identity=46.9648562300319, Blast_Score=226, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=42.8104575163399, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17562970, Length=318, Percent_Identity=42.1383647798742, Blast_Score=223, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI115535073, Length=312, Percent_Identity=43.9102564102564, Blast_Score=217, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=42.5170068027211, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=40.7284768211921, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI32566672, Length=232, Percent_Identity=40.5172413793103, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17534315, Length=330, Percent_Identity=35.4545454545455, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25147552, Length=327, Percent_Identity=33.3333333333333, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17539800, Length=340, Percent_Identity=25.2941176470588, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=34.453781512605, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71996324, Length=326, Percent_Identity=24.8466257668712, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=333, Percent_Identity=32.4324324324324, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=31.2312312312312, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=39.1025641025641, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=39.1025641025641, Blast_Score=188, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34196; Mature: 34065

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYDNILDTIGRTPVVKLNRLAPDHVSLYVKVESFNPGGSVKDRLALAIILDAEQRGLL
CCHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEEECCCCCCHHHHEEEEEEEECCCCCCC
KPGDTIVEATSGNTGVALAMVAAARGYKFVATMVETFSIERRKLMRAYGAKVILTPAAER
CCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
GSGMVRKAKELAEQHGWFLASQFANPANPAYHRNTTAAEILRDFAGHRLDHFVTGWGTGG
CCHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEECCCCCC
TLTGVGEVLRVARPEVRITATEPAGAALLQGQDWKPHKIQGWTPDFVPEVLNREVAHEIL
CHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SVEDTDAISVARRLAAEEGIFTGISGGGTVSTALRVAETAVPGAVILAMLPDTGERYFST
CCCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCC
PLFADINEGSDDDWLAGLP
CCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
ALYDNILDTIGRTPVVKLNRLAPDHVSLYVKVESFNPGGSVKDRLALAIILDAEQRGLL
CHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEEECCCCCCHHHHEEEEEEEECCCCCCC
KPGDTIVEATSGNTGVALAMVAAARGYKFVATMVETFSIERRKLMRAYGAKVILTPAAER
CCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
GSGMVRKAKELAEQHGWFLASQFANPANPAYHRNTTAAEILRDFAGHRLDHFVTGWGTGG
CCHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEECCCCCC
TLTGVGEVLRVARPEVRITATEPAGAALLQGQDWKPHKIQGWTPDFVPEVLNREVAHEIL
CHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SVEDTDAISVARRLAAEEGIFTGISGGGTVSTALRVAETAVPGAVILAMLPDTGERYFST
CCCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHCC
PLFADINEGSDDDWLAGLP
CCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA