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The map label for this gene is mutT [H]

Identifier: 66047318

GI number: 66047318

Start: 4877481

End: 4878431

Strand: Reverse

Name: mutT [H]

Synonym: Psyr_4091

Alternate gene names: 66047318

Gene position: 4878431-4877481 (Counterclockwise)

Preceding gene: 66047319

Following gene: 66047314

Centisome position: 80.06

GC content: 65.51

Gene sequence:

>951_bases
GTGAAACGAGTGCATGTGGCCGCCGCCGTCATTCGTGGTGCTGACGGCAGCGTATTGATTGCCCGACGTGCCGATACCCA
GCATCAAGGTGGCCTCTGGGAGTTTCCCGGCGGTAAGGTCGAGGAGGGCGAGACCGTCCAGGCGGCGCTCGCACGTGAAC
TGCAGGAAGAGCTGGGTATCCTGGTGACGGCTGCGCGTCCGCTGATCAAGGTCTGCCACGACTATCCGGACAAGCAGGTG
CTCCTGGACGTCTGGGAAGTCTCGGCCTTCACTGGCCAGGCGCATGGCGCCGAAGGGCAGCCGCTGGTCTGGGCCACCCC
GCGCGAGCTGGCCAATTATGACTTTCCAGCCGCCAATCAGCCGATCGTCGCGGCGGCACGTTTGCCTGGCGAGTATCTGA
TCACGCCTGACGGGCTGGACACTATCGAGCTGTTGCGCGGTATGCAGAAAGCCATCGCCGGTGGCATCAAGCTGGTCCAG
TTGCGTGCGCCGGGTGGTTACGACCCGAAGTACCGCGACCTGGCCGTGGATGCGGCGGGCCTGTGTGCCGGCAAGGCGCA
ACTCATGCTCAAAGGGCCTCTGGAGTGGCTGGGCGACTTTCCGTCCGCCGGCTGGCACCTGACGGCGGAGCAACTGCGCA
AGTACGCCAGTCGCGGCCGTCCGTTCCCGGAGAACCGCTGGCTGGCGGCGTCATGCCATAACGCCGAAGAGCTGGCTCTG
GCCGAGCAGATGGGCGTGGATTTCGTCACCCTGTCGCCCGTTCAGCCAACCTTGACCCACCCTGATGCACAGCCGCTGGG
CTGGCAGCAGGCAATGCAGCTGATCGCAGGCTTCAACAAGCCGGTCTTTCTGTTGGGCGGCGTGGGCCCTGCCGAGCGTC
AACAGGCCTGGGAGAGCGGCGCACAGGGCGTGGCCGGGATTCGCGCGTTCTGGCCTGACGAGATCGTCTGA

Upstream 100 bases:

>100_bases
GTGTCGAGTTGCCCGCAGAAGCGCTGGCTTACATCGAAACCATCTACCAATGGCCTGCCTTCAAACGCTGGCAGCAGGCC
GGTCTGGAGGAGTCCTGATC

Downstream 100 bases:

>100_bases
CGCTCAGCAGAGGACGCAGAGCGTCCAGAACGGCATGCCCACGCAGAGTAACTAGCGTTATACACAAGTCTGCTCTTGAT
TCTGGCCGCAGGCCGTGGGA

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKRVHVAAAVIRGADGSVLIARRADTQHQGGLWEFPGGKVEEGETVQAALARELQEELGILVTAARPLIKVCHDYPDKQV
LLDVWEVSAFTGQAHGAEGQPLVWATPRELANYDFPAANQPIVAAARLPGEYLITPDGLDTIELLRGMQKAIAGGIKLVQ
LRAPGGYDPKYRDLAVDAAGLCAGKAQLMLKGPLEWLGDFPSAGWHLTAEQLRKYASRGRPFPENRWLAASCHNAEELAL
AEQMGVDFVTLSPVQPTLTHPDAQPLGWQQAMQLIAGFNKPVFLLGGVGPAERQQAWESGAQGVAGIRAFWPDEIV

Sequences:

>Translated_316_residues
MKRVHVAAAVIRGADGSVLIARRADTQHQGGLWEFPGGKVEEGETVQAALARELQEELGILVTAARPLIKVCHDYPDKQV
LLDVWEVSAFTGQAHGAEGQPLVWATPRELANYDFPAANQPIVAAARLPGEYLITPDGLDTIELLRGMQKAIAGGIKLVQ
LRAPGGYDPKYRDLAVDAAGLCAGKAQLMLKGPLEWLGDFPSAGWHLTAEQLRKYASRGRPFPENRWLAASCHNAEELAL
AEQMGVDFVTLSPVQPTLTHPDAQPLGWQQAMQLIAGFNKPVFLLGGVGPAERQQAWESGAQGVAGIRAFWPDEIV
>Mature_316_residues
MKRVHVAAAVIRGADGSVLIARRADTQHQGGLWEFPGGKVEEGETVQAALARELQEELGILVTAARPLIKVCHDYPDKQV
LLDVWEVSAFTGQAHGAEGQPLVWATPRELANYDFPAANQPIVAAARLPGEYLITPDGLDTIELLRGMQKAIAGGIKLVQ
LRAPGGYDPKYRDLAVDAAGLCAGKAQLMLKGPLEWLGDFPSAGWHLTAEQLRKYASRGRPFPENRWLAASCHNAEELAL
AEQMGVDFVTLSPVQPTLTHPDAQPLGWQQAMQLIAGFNKPVFLLGGVGPAERQQAWESGAQGVAGIRAFWPDEIV

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=127, Percent_Identity=39.3700787401575, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1788056, Length=125, Percent_Identity=40, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-; 2.5.1.3

Molecular weight: Translated: 34126; Mature: 34126

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVHVAAAVIRGADGSVLIARRADTQHQGGLWEFPGGKVEEGETVQAALARELQEELGI
CCCCEEEHHHHCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCE
LVTAARPLIKVCHDYPDKQVLLDVWEVSAFTGQAHGAEGQPLVWATPRELANYDFPAANQ
EEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHHCCCCCCCCC
PIVAAARLPGEYLITPDGLDTIELLRGMQKAIAGGIKLVQLRAPGGYDPKYRDLAVDAAG
CEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHCHHH
LCAGKAQLMLKGPLEWLGDFPSAGWHLTAEQLRKYASRGRPFPENRWLAASCHNAEELAL
HCCCCCEEEEECCHHHHCCCCCCCCEECHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHH
AEQMGVDFVTLSPVQPTLTHPDAQPLGWQQAMQLIAGFNKPVFLLGGVGPAERQQAWESG
HHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHC
AQGVAGIRAFWPDEIV
CCCCHHHHHCCCCCCC
>Mature Secondary Structure
MKRVHVAAAVIRGADGSVLIARRADTQHQGGLWEFPGGKVEEGETVQAALARELQEELGI
CCCCEEEHHHHCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCE
LVTAARPLIKVCHDYPDKQVLLDVWEVSAFTGQAHGAEGQPLVWATPRELANYDFPAANQ
EEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHHCCCCCCCCC
PIVAAARLPGEYLITPDGLDTIELLRGMQKAIAGGIKLVQLRAPGGYDPKYRDLAVDAAG
CEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHCHHH
LCAGKAQLMLKGPLEWLGDFPSAGWHLTAEQLRKYASRGRPFPENRWLAASCHNAEELAL
HCCCCCEEEEECCHHHHCCCCCCCCEECHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHH
AEQMGVDFVTLSPVQPTLTHPDAQPLGWQQAMQLIAGFNKPVFLLGGVGPAERQQAWESG
HHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHC
AQGVAGIRAFWPDEIV
CCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3033442; 1630901; 9278503; 2841285; 8202364; 3288626; 1851162; 1309939; 7578113; 9063868 [H]