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The map label for this gene is cutS [H]

Identifier: 66047296

GI number: 66047296

Start: 4852564

End: 4853853

Strand: Reverse

Name: cutS [H]

Synonym: Psyr_4069

Alternate gene names: 66047296

Gene position: 4853853-4852564 (Counterclockwise)

Preceding gene: 66047297

Following gene: 66047295

Centisome position: 79.65

GC content: 60.85

Gene sequence:

>1290_bases
ATGGAGTTTAAACAGAGTCTTGCGCAACGGATCATCATTGCCTTCGCATTGATGAGTGCACTGGTCGCCGGGTCGTTCGC
CATCGGGATCATCTCCACCGTCCACCTGGTCGAAGAAAAGCTGATTTCCGCCGGCCTCGGTGGTGACCTCAACCGTCTGA
TGCTGATGGACAGCGTCAGCGACTGGAGCCACCGGCCCAAGCCCGACCAGTTGTTCTATTTCAGCAATGGTCCTGGCGAC
TTCGACCTGCCCAAGGATATTCGTCACCTTGAGCCAGGCTTCCATGAGGTGTTCCGTGGGCCGTTGTCATACCACGCCAT
GATCGAGGTGGTGGATGGCCGGCATTACGCCCTGTTGCAGGATCAGAGCGATTTTGAAGAGCGTGAGCGGGTGCTGTTCG
CCGTCGTGCTGGTCGGTTTCGTTCTGGCCCTGGCGCTGGCGGTGTTTCTGGGTTGGGTGCTGGCGCGCCGGGTCATGGCA
CCTGTGGTGCGTCTGGCCCGGCAGGTTCGCCACCGTGACCAGTTGCTCGGACTGGCACCGCCACTGGCGCCCGACTACGC
CGCTGACGAAGTCGGCGAGTTGGCGGTGGCCTTCGATGCGACATTGGGCCGTTTGCGGCAGGCGCTGATTCGCGAGCGTA
TGTTTACCAGTGACGTGAGCCATGAACTGCGTACGCCGTTGATGGTGCTGGCCAGCTCTTGTGAGCTGCTGCTGGAAAAC
CCTGCGCTCGATTTGCGCGGCCGTCGACAGGTCGAGCGTATCGGCCGTGCCTGCGAAGAAATGCGCGATCTGGTGCAAAC
CTTTCTGATGCTCGCTCGCACCCAGCGCGAGGACCCGGCCATGACGCCCAAGGCCACGCTGGTCGGGGTGGCCGAACAAT
TGATCTCCCAGTGGCGTGACCCGATAGAGAGCAAGGGGCTGCAGTTGACCTACACGCCACCGGCCGATGACCAGCTGTCC
GATATTCGTTACAACGCGACCTTCCTGCATGCCGTGATGGGCAACTTGCTGCGCAATGCCCTGCACTACACCGATCACGG
ATTCATAGCGCTGACCCTGCACGCCGAAAGCTTCACCGTGGAAGACAGTGGCGTGGGTATTCCCGAGGAGAAGCGCGAGG
CGATGTTCGAGCCTTTCGTACGCGGCAACGAGCAGCGCGGAGAAGGCCTGGGCCTCGGGCTGTCACTGGTGCAGCGCATT
TGTACCAACCAGGGATGGAGCGTCGATCTCACCCCTATGGAACCTCATGGTTGCCGGTTCAAGGTAACGCTCAACGTGAT
CAAACCCTGA

Upstream 100 bases:

>100_bases
AGCCATGTGCACCAGTTGCGTCAGGTGATCGACAAACCGTTTGGCAAACCGCTGTTGCAGACCGTGCATGGCGTGGGCTA
TCGCTTGGCCGAGGGCCGGG

Downstream 100 bases:

>100_bases
CCTTTCTCCCGAGTAGACCGGCCTCATTGTGTAGCGGCCAATTGACTGCACTTCGTCGATTGGCCACACACGGCCTCTAA
CTCTCTGTAAAATCTCGAAA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MEFKQSLAQRIIIAFALMSALVAGSFAIGIISTVHLVEEKLISAGLGGDLNRLMLMDSVSDWSHRPKPDQLFYFSNGPGD
FDLPKDIRHLEPGFHEVFRGPLSYHAMIEVVDGRHYALLQDQSDFEERERVLFAVVLVGFVLALALAVFLGWVLARRVMA
PVVRLARQVRHRDQLLGLAPPLAPDYAADEVGELAVAFDATLGRLRQALIRERMFTSDVSHELRTPLMVLASSCELLLEN
PALDLRGRRQVERIGRACEEMRDLVQTFLMLARTQREDPAMTPKATLVGVAEQLISQWRDPIESKGLQLTYTPPADDQLS
DIRYNATFLHAVMGNLLRNALHYTDHGFIALTLHAESFTVEDSGVGIPEEKREAMFEPFVRGNEQRGEGLGLGLSLVQRI
CTNQGWSVDLTPMEPHGCRFKVTLNVIKP

Sequences:

>Translated_429_residues
MEFKQSLAQRIIIAFALMSALVAGSFAIGIISTVHLVEEKLISAGLGGDLNRLMLMDSVSDWSHRPKPDQLFYFSNGPGD
FDLPKDIRHLEPGFHEVFRGPLSYHAMIEVVDGRHYALLQDQSDFEERERVLFAVVLVGFVLALALAVFLGWVLARRVMA
PVVRLARQVRHRDQLLGLAPPLAPDYAADEVGELAVAFDATLGRLRQALIRERMFTSDVSHELRTPLMVLASSCELLLEN
PALDLRGRRQVERIGRACEEMRDLVQTFLMLARTQREDPAMTPKATLVGVAEQLISQWRDPIESKGLQLTYTPPADDQLS
DIRYNATFLHAVMGNLLRNALHYTDHGFIALTLHAESFTVEDSGVGIPEEKREAMFEPFVRGNEQRGEGLGLGLSLVQRI
CTNQGWSVDLTPMEPHGCRFKVTLNVIKP
>Mature_429_residues
MEFKQSLAQRIIIAFALMSALVAGSFAIGIISTVHLVEEKLISAGLGGDLNRLMLMDSVSDWSHRPKPDQLFYFSNGPGD
FDLPKDIRHLEPGFHEVFRGPLSYHAMIEVVDGRHYALLQDQSDFEERERVLFAVVLVGFVLALALAVFLGWVLARRVMA
PVVRLARQVRHRDQLLGLAPPLAPDYAADEVGELAVAFDATLGRLRQALIRERMFTSDVSHELRTPLMVLASSCELLLEN
PALDLRGRRQVERIGRACEEMRDLVQTFLMLARTQREDPAMTPKATLVGVAEQLISQWRDPIESKGLQLTYTPPADDQLS
DIRYNATFLHAVMGNLLRNALHYTDHGFIALTLHAESFTVEDSGVGIPEEKREAMFEPFVRGNEQRGEGLGLGLSLVQRI
CTNQGWSVDLTPMEPHGCRFKVTLNVIKP

Specific function: Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=310, Percent_Identity=27.4193548387097, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1789403, Length=328, Percent_Identity=28.6585365853659, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790551, Length=284, Percent_Identity=30.9859154929577, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=24.3506493506494, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1790346, Length=221, Percent_Identity=28.0542986425339, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081816, Length=266, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790861, Length=276, Percent_Identity=27.8985507246377, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=25.6637168141593, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=25.5102040816327, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=26.5486725663717, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787894, Length=237, Percent_Identity=26.5822784810127, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786600, Length=240, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=23.4513274336283, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788393, Length=261, Percent_Identity=27.9693486590038, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789149, Length=356, Percent_Identity=22.752808988764, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48000; Mature: 48000

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFKQSLAQRIIIAFALMSALVAGSFAIGIISTVHLVEEKLISAGLGGDLNRLMLMDSVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHH
DWSHRPKPDQLFYFSNGPGDFDLPKDIRHLEPGFHEVFRGPLSYHAMIEVVDGRHYALLQ
HCCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCHHHHHCCCCHHHHHHEEECCCEEEEEC
DQSDFEERERVLFAVVLVGFVLALALAVFLGWVLARRVMAPVVRLARQVRHRDQLLGLAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLAPDYAADEVGELAVAFDATLGRLRQALIRERMFTSDVSHELRTPLMVLASSCELLLEN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PALDLRGRRQVERIGRACEEMRDLVQTFLMLARTQREDPAMTPKATLVGVAEQLISQWRD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
PIESKGLQLTYTPPADDQLSDIRYNATFLHAVMGNLLRNALHYTDHGFIALTLHAESFTV
HHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEE
EDSGVGIPEEKREAMFEPFVRGNEQRGEGLGLGLSLVQRICTNQGWSVDLTPMEPHGCRF
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCEE
KVTLNVIKP
EEEEEEECC
>Mature Secondary Structure
MEFKQSLAQRIIIAFALMSALVAGSFAIGIISTVHLVEEKLISAGLGGDLNRLMLMDSVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHH
DWSHRPKPDQLFYFSNGPGDFDLPKDIRHLEPGFHEVFRGPLSYHAMIEVVDGRHYALLQ
HCCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCHHHHHCCCCHHHHHHEEECCCEEEEEC
DQSDFEERERVLFAVVLVGFVLALALAVFLGWVLARRVMAPVVRLARQVRHRDQLLGLAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLAPDYAADEVGELAVAFDATLGRLRQALIRERMFTSDVSHELRTPLMVLASSCELLLEN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PALDLRGRRQVERIGRACEEMRDLVQTFLMLARTQREDPAMTPKATLVGVAEQLISQWRD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
PIESKGLQLTYTPPADDQLSDIRYNATFLHAVMGNLLRNALHYTDHGFIALTLHAESFTV
HHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEE
EDSGVGIPEEKREAMFEPFVRGNEQRGEGLGLGLSLVQRICTNQGWSVDLTPMEPHGCRF
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCEE
KVTLNVIKP
EEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]