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The map label for this gene is phoQ [H]

Identifier: 66046937

GI number: 66046937

Start: 4395052

End: 4396398

Strand: Reverse

Name: phoQ [H]

Synonym: Psyr_3708

Alternate gene names: 66046937

Gene position: 4396398-4395052 (Counterclockwise)

Preceding gene: 66046938

Following gene: 66046936

Centisome position: 72.15

GC content: 62.95

Gene sequence:

>1347_bases
GTGATTCGTTCGCTTCGCCTGCGCCTGATGCTGGGCGCCGCCACGCTGGCGGTGATCTTCATGCTGCTGATGCTGCCTGC
TTTGCAGGGGGCGTTCAGCCTGGCGCTGCGCGGAGCGATCGAGCAACGCCTGGCTTCCGATGTCACCACCATGATTTCGG
CCGCGCGCGTCGAAGATGGTCATCTGTTGATGCCGTCTGTACTGCCGGGCGAACAATTCAATCTGCCCGGTAGCCGTCTG
CTGGGTTACATCTATAACCGCCAGGGGCAGATGGTCTGGCGCTCGTTGTCGACCGAAGGCGAGAACATCGACTACCGCCC
GCAATACGACGGGCAGGGCAGCGAGTTCACCAAGATCAAGGAAATCAATGGCGATGAGTATTTCGTCTATGACGTCGAGA
TCCGGCTGCTCGGCGGGCGCAATGCCGCATTCAGTATCGTTGCCGTGCAGCCGTTGCGCGGCTATCAGGAAACCATCGAC
GGCCTGCGCCGCAAGCTTTATCTGGGCTTTGGCGCAGCACTGGCGGTGCTGCTCGGGTTGCTGTGGATGGGCCTGACCTG
GGGGCTGCGGGCCTTGCGCGGCTTGAGCCAGGAACTGGATCAGGTGGAAGCCGGCGTGCGCGACAGCCTCAGCGAAGAAC
ACCCCAGCGAACTGCTGCGCCTGACCGACTCGCTCAACCGCCTGTTGCGCAGCGAGCGCGAGCAGCGGATTCGTTACCGC
GACTCTCTGGACGACCTGGCGCATAGCCTGAAAACCCCGCTGGCGGTCTTGCAGGGCGTAAGCGAGAACATCGCCAAGCG
CCCCGAGGATGTCGAGCAGGCGTGGGTGCTGCAATCGCAGATCGAACGCATGAGCCAGCAAATCGGCTATCAACTGCAGC
GGGCCAGCCTGCGCAAGAGCGGTCTGGTGCGCCACCATGTGATGTTGCGGCCCGTGGTCGAAAGCCTGTGCAACACGCTG
GACAAGGTGTATCGCGACAAACAGGTGAAGGCCACGCTGGACCTGCCCGAGCACTGCCAGGTGCATATGGAAGAGGGCGC
GTTGCTGGAAATGCTCGGCAACCTGCTGGAAAACGCTTATCGGCTGTGTCTGAGCGAAGTGCGCGTCAGCTTCACGCGTT
CAACGACCGGCGATGAACTGTGCGTCGAAGACGACGGCCCCGGCGTCCCGCAGAGCCAGCGTGCCCGCATTCTCGAACGC
GGCGAACGGCTGGACCGCCAGAACCCCGGGCAAGGCATAGGCCTGGCGGTGGTCAAGGACATCATCGAAAGCTACGGCGC
GCAACTGACGCTGGGCGATTCCCCGCTGGGCGGCGCGGCGTTCAGGATTCATTTTCTGGCGCAGTGA

Upstream 100 bases:

>100_bases
TGCTGGTCGGTCGTCTGCGCCGCAAACTGGACAGCAGCGTGGCCTTCAAACCTATCGAAACCGTGCGCGGCATGGGCTAT
CTGTTCAATGAGCGCTGTAC

Downstream 100 bases:

>100_bases
CGATCGTGTTCACCCGGACACCTATCCTTCCTCACGCTCCGGCGTGGGAATGCCGTTCGTGACGCTCTGCGTCACACCTC
TGCGCGTCACCGAGCGCTCC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MIRSLRLRLMLGAATLAVIFMLLMLPALQGAFSLALRGAIEQRLASDVTTMISAARVEDGHLLMPSVLPGEQFNLPGSRL
LGYIYNRQGQMVWRSLSTEGENIDYRPQYDGQGSEFTKIKEINGDEYFVYDVEIRLLGGRNAAFSIVAVQPLRGYQETID
GLRRKLYLGFGAALAVLLGLLWMGLTWGLRALRGLSQELDQVEAGVRDSLSEEHPSELLRLTDSLNRLLRSEREQRIRYR
DSLDDLAHSLKTPLAVLQGVSENIAKRPEDVEQAWVLQSQIERMSQQIGYQLQRASLRKSGLVRHHVMLRPVVESLCNTL
DKVYRDKQVKATLDLPEHCQVHMEEGALLEMLGNLLENAYRLCLSEVRVSFTRSTTGDELCVEDDGPGVPQSQRARILER
GERLDRQNPGQGIGLAVVKDIIESYGAQLTLGDSPLGGAAFRIHFLAQ

Sequences:

>Translated_448_residues
MIRSLRLRLMLGAATLAVIFMLLMLPALQGAFSLALRGAIEQRLASDVTTMISAARVEDGHLLMPSVLPGEQFNLPGSRL
LGYIYNRQGQMVWRSLSTEGENIDYRPQYDGQGSEFTKIKEINGDEYFVYDVEIRLLGGRNAAFSIVAVQPLRGYQETID
GLRRKLYLGFGAALAVLLGLLWMGLTWGLRALRGLSQELDQVEAGVRDSLSEEHPSELLRLTDSLNRLLRSEREQRIRYR
DSLDDLAHSLKTPLAVLQGVSENIAKRPEDVEQAWVLQSQIERMSQQIGYQLQRASLRKSGLVRHHVMLRPVVESLCNTL
DKVYRDKQVKATLDLPEHCQVHMEEGALLEMLGNLLENAYRLCLSEVRVSFTRSTTGDELCVEDDGPGVPQSQRARILER
GERLDRQNPGQGIGLAVVKDIIESYGAQLTLGDSPLGGAAFRIHFLAQ
>Mature_448_residues
MIRSLRLRLMLGAATLAVIFMLLMLPALQGAFSLALRGAIEQRLASDVTTMISAARVEDGHLLMPSVLPGEQFNLPGSRL
LGYIYNRQGQMVWRSLSTEGENIDYRPQYDGQGSEFTKIKEINGDEYFVYDVEIRLLGGRNAAFSIVAVQPLRGYQETID
GLRRKLYLGFGAALAVLLGLLWMGLTWGLRALRGLSQELDQVEAGVRDSLSEEHPSELLRLTDSLNRLLRSEREQRIRYR
DSLDDLAHSLKTPLAVLQGVSENIAKRPEDVEQAWVLQSQIERMSQQIGYQLQRASLRKSGLVRHHVMLRPVVESLCNTL
DKVYRDKQVKATLDLPEHCQVHMEEGALLEMLGNLLENAYRLCLSEVRVSFTRSTTGDELCVEDDGPGVPQSQRARILER
GERLDRQNPGQGIGLAVVKDIIESYGAQLTLGDSPLGGAAFRIHFLAQ

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=472, Percent_Identity=30.9322033898305, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=28.0334728033473, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=29.8245614035088, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790346, Length=235, Percent_Identity=25.531914893617, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=29.3577981651376, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787894, Length=233, Percent_Identity=29.6137339055794, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790861, Length=288, Percent_Identity=27.0833333333333, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50134; Mature: 50134

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRSLRLRLMLGAATLAVIFMLLMLPALQGAFSLALRGAIEQRLASDVTTMISAARVEDG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HLLMPSVLPGEQFNLPGSRLLGYIYNRQGQMVWRSLSTEGENIDYRPQYDGQGSEFTKIK
CEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHE
EINGDEYFVYDVEIRLLGGRNAAFSIVAVQPLRGYQETIDGLRRKLYLGFGAALAVLLGL
ECCCCEEEEEEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LWMGLTWGLRALRGLSQELDQVEAGVRDSLSEEHPSELLRLTDSLNRLLRSEREQRIRYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DSLDDLAHSLKTPLAVLQGVSENIAKRPEDVEQAWVLQSQIERMSQQIGYQLQRASLRKS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVRHHVMLRPVVESLCNTLDKVYRDKQVKATLDLPEHCQVHMEEGALLEMLGNLLENAY
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHH
RLCLSEVRVSFTRSTTGDELCVEDDGPGVPQSQRARILERGERLDRQNPGQGIGLAVVKD
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
IIESYGAQLTLGDSPLGGAAFRIHFLAQ
HHHHCCCEEEECCCCCCCCEEEEEEECC
>Mature Secondary Structure
MIRSLRLRLMLGAATLAVIFMLLMLPALQGAFSLALRGAIEQRLASDVTTMISAARVEDG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HLLMPSVLPGEQFNLPGSRLLGYIYNRQGQMVWRSLSTEGENIDYRPQYDGQGSEFTKIK
CEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHE
EINGDEYFVYDVEIRLLGGRNAAFSIVAVQPLRGYQETIDGLRRKLYLGFGAALAVLLGL
ECCCCEEEEEEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LWMGLTWGLRALRGLSQELDQVEAGVRDSLSEEHPSELLRLTDSLNRLLRSEREQRIRYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DSLDDLAHSLKTPLAVLQGVSENIAKRPEDVEQAWVLQSQIERMSQQIGYQLQRASLRKS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVRHHVMLRPVVESLCNTLDKVYRDKQVKATLDLPEHCQVHMEEGALLEMLGNLLENAY
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHH
RLCLSEVRVSFTRSTTGDELCVEDDGPGVPQSQRARILERGERLDRQNPGQGIGLAVVKD
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
IIESYGAQLTLGDSPLGGAAFRIHFLAQ
HHHHCCCEEEECCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA