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The map label for this gene is phoP [H]

Identifier: 66046938

GI number: 66046938

Start: 4396395

End: 4397072

Strand: Reverse

Name: phoP [H]

Synonym: Psyr_3709

Alternate gene names: 66046938

Gene position: 4397072-4396395 (Counterclockwise)

Preceding gene: 66046939

Following gene: 66046937

Centisome position: 72.16

GC content: 60.91

Gene sequence:

>678_bases
ATGAAGTTGTTGGTAGTTGAGGATGAAGCGCTGCTGCGCCACCACCTGCGAACCCGTCTGACCGAAGCCGGGCATGTGGT
GGAAGCGGTGGCCAACGCTGAAGAAGCGTTGTATCAGGTCGCGCAATTCAATCACGACCTGGCGGTGATCGACCTGGGCC
TGCCGGGCATTGGCGGCCTGGACCTGATTCGCCAGCTGCGCGCACTAGGCAAGGCGTTTCCGATCCTGATCCTGACCGCG
CGCGGCAATTGGCAGGACAAGGTCGAAGGCCTGGCGGCCGGGGCTGACGACTACGTAGTCAAGCCCTTCCAGTTCGAAGA
GCTGGAGGCACGGCTGAACGCTTTGTTACGGCGTTCCAGCGGCTTCATCCAGTCAACCATCACCGCTGGCCCGCTGTTGC
TGGACCTCAATCGCAAGCACGCCGCCCTGGCCGAGCAACCCTTGGCGCTGACGGCCTATGAATACCGCATTCTTGAGTAC
CTGATGCTCCATCATCAGCAAGTGGTGCCCAAGGAGCGCCTGATGGAGCAGCTGTACCCTGATGACGACGAGCGCGACCC
GAACGTGATCGAAGTGCTGGTCGGTCGTCTGCGCCGCAAACTGGACAGCAGCGTGGCCTTCAAACCTATCGAAACCGTGC
GCGGCATGGGCTATCTGTTCAATGAGCGCTGTACGTGA

Upstream 100 bases:

>100_bases
GACACAACACGTGCCCGTCAGCGCCCGCCTGTTGAGTACTGATGCGACGATGTCGTTTCATTCTTTGTCTTGAGGCTGCG
ATTGTGCCTGGGAGAGCTGC

Downstream 100 bases:

>100_bases
TTCGTTCGCTTCGCCTGCGCCTGATGCTGGGCGCCGCCACGCTGGCGGTGATCTTCATGCTGCTGATGCTGCCTGCTTTG
CAGGGGGCGTTCAGCCTGGC

Product: response regulator receiver:transcriptional regulatory protein, C-terminal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKLLVVEDEALLRHHLRTRLTEAGHVVEAVANAEEALYQVAQFNHDLAVIDLGLPGIGGLDLIRQLRALGKAFPILILTA
RGNWQDKVEGLAAGADDYVVKPFQFEELEARLNALLRRSSGFIQSTITAGPLLLDLNRKHAALAEQPLALTAYEYRILEY
LMLHHQQVVPKERLMEQLYPDDDERDPNVIEVLVGRLRRKLDSSVAFKPIETVRGMGYLFNERCT

Sequences:

>Translated_225_residues
MKLLVVEDEALLRHHLRTRLTEAGHVVEAVANAEEALYQVAQFNHDLAVIDLGLPGIGGLDLIRQLRALGKAFPILILTA
RGNWQDKVEGLAAGADDYVVKPFQFEELEARLNALLRRSSGFIQSTITAGPLLLDLNRKHAALAEQPLALTAYEYRILEY
LMLHHQQVVPKERLMEQLYPDDDERDPNVIEVLVGRLRRKLDSSVAFKPIETVRGMGYLFNERCT
>Mature_225_residues
MKLLVVEDEALLRHHLRTRLTEAGHVVEAVANAEEALYQVAQFNHDLAVIDLGLPGIGGLDLIRQLRALGKAFPILILTA
RGNWQDKVEGLAAGADDYVVKPFQFEELEARLNALLRRSSGFIQSTITAGPLLLDLNRKHAALAEQPLALTAYEYRILEY
LMLHHQQVVPKERLMEQLYPDDDERDPNVIEVLVGRLRRKLDSSVAFKPIETVRGMGYLFNERCT

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=49.3273542600897, Blast_Score=220, Evalue=5e-59,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=39.8190045248869, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=39.3805309734513, Blast_Score=150, Evalue=4e-38,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=39.5454545454545, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=34.0909090909091, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32.8888888888889, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=35.6828193832599, Blast_Score=128, Evalue=2e-31,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=35.8744394618834, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=34.8017621145374, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=34.0807174887892, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=34.3347639484979, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=30.7017543859649, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=29.3103448275862, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=33.0578512396694, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=25.974025974026, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790437, Length=116, Percent_Identity=32.7586206896552, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=30.0970873786408, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25387; Mature: 25387

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVVEDEALLRHHLRTRLTEAGHVVEAVANAEEALYQVAQFNHDLAVIDLGLPGIGGL
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHH
DLIRQLRALGKAFPILILTARGNWQDKVEGLAAGADDYVVKPFQFEELEARLNALLRRSS
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHCC
GFIQSTITAGPLLLDLNRKHAALAEQPLALTAYEYRILEYLMLHHQQVVPKERLMEQLYP
CHHHHHHCCCCEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
DDDERDPNVIEVLVGRLRRKLDSSVAFKPIETVRGMGYLFNERCT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLLVVEDEALLRHHLRTRLTEAGHVVEAVANAEEALYQVAQFNHDLAVIDLGLPGIGGL
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHH
DLIRQLRALGKAFPILILTARGNWQDKVEGLAAGADDYVVKPFQFEELEARLNALLRRSS
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHCC
GFIQSTITAGPLLLDLNRKHAALAEQPLALTAYEYRILEYLMLHHQQVVPKERLMEQLYP
CHHHHHHCCCCEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
DDDERDPNVIEVLVGRLRRKLDSSVAFKPIETVRGMGYLFNERCT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA