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The map label for this gene is dctA [H]

Identifier: 66046936

GI number: 66046936

Start: 4393305

End: 4394657

Strand: Reverse

Name: dctA [H]

Synonym: Psyr_3707

Alternate gene names: 66046936

Gene position: 4394657-4393305 (Counterclockwise)

Preceding gene: 66046937

Following gene: 66046934

Centisome position: 72.12

GC content: 58.02

Gene sequence:

>1353_bases
ATGACGACTCGTCAGCCCATCTACAAATCCCTCTATTTTCAGGTAATCGTTGCGATTGTCATCGGTATCCTGATCGGTCA
TTTCTACCCGGACACCGGCAAGGCGTTAAAACCGCTGGGTGACGGGTTCATCAAACTGATCAAGATGGTTATTGCCCCGA
TCATCTTCTGTACCGTCGTCAGTGGTATCGCTGGCATGCAGAGCATGAAGTCGGTCGGCAAGACCGGCGGTTATGCGCTG
CTGTATTTCGAGATCGTTTCGACCATCGCCCTGCTGATCGGTCTGATCGTGGTCAACGTGGTTCAGCCGGGTGCCGGCAT
GAATATCGACGTCAGCACGCTCGACGCTTCGAAGATCGCTGCCTACGTCACTGCCGGTCAGGACCAGAGTATCGTCGGCT
TCATCCTTAACGTGATTCCGAACACCATCGTCGGCGCGTTTGCCAACGGCGATATCCTGCAAGTCCTGATGTTCTCGGTG
ATCTTCGGCTTCGCGCTGCATCGCCTGGGTGCCTACGGCAAGCCGGTTCTGGACTTCATCGATCGCTTCGCCCACGTGAT
GTTCAACATCATCAACATGATCATGAAACTGGCCCCGCTGGGTGCGTTCGGTGCCATGGCCTTCACCATCGGTGCCTACG
GCGTGAGCTCGCTGGTGCAACTGGGTCAGTTGATGATCTGCTTCTACATCACCTGCGCACTGTTCGTCGTGTTTGTACTG
GGCGCGATCGCCCGCGCTCACGGCTTCAGCATCTTCAAGCTGATTCGCTACATCCGTGAAGAGCTGCTGATCGTACTGGG
TACGTCTTCTTCGGAATCGGCCCTGCCGCGCATGCTGATCAAGATGGAGCGCCTGGGTGCCAAGAAGTCTGTGGTCGGTC
TGGTTATCCCGACGGGCTACTCGTTCAACCTGGACGGTACGTCGATCTACCTGACCATGGCCGCCGTGTTCATCGCTCAG
GCGACCAACACGCACATGGATATCACGCATCAGATCACCCTGCTGCTGGTACTGCTGCTGTCGTCCAAAGGTGCTGCCGG
CGTAACCGGTAGCGGCTTTATCGTACTGGCTGCGACCCTGTCGGCTGTAGGCCACCTGCCGGTGGCTGGTCTGGCGCTGA
TTCTGGGTATCGACCGCTTCATGTCCGAAGCCCGCGCCCTGACCAACCTGGTCGGTAACGCTGTTGCCACCGTTGTGGTT
GCCAAGTGGGTCGGCGAGCTGGACACCGACAAGCTGCAGTCCGAGCTGGCTTCCGGTGGCTCTGCCATTCTGGAAACCCG
CCCTGAAGACGACCTCGGCGTTGCCGAAGGCCCGACTCCAGGCGCTGCAGTTAACACTACCAAGACCGTCTGA

Upstream 100 bases:

>100_bases
GCTCGACAAAACAAATCCCTCCAGTGCAGGAGGGTTAGCGCTTTATAGGCTCGCGTGCATCAGGTGAAGATGCCCGACGA
CGCCCTTGAGGAAAACTGCA

Downstream 100 bases:

>100_bases
TACCCTTCAGGCCATAAAAAACCCATCTTCGGATGGGTTTTTTTATGCCTGCCGTTTACCGGAGGACTATTCCGTGCGCG
TCTCGCCGCTGAACACCAGC

Product: C4-dicarboxylate transporter DctA

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTTRQPIYKSLYFQVIVAIVIGILIGHFYPDTGKALKPLGDGFIKLIKMVIAPIIFCTVVSGIAGMQSMKSVGKTGGYAL
LYFEIVSTIALLIGLIVVNVVQPGAGMNIDVSTLDASKIAAYVTAGQDQSIVGFILNVIPNTIVGAFANGDILQVLMFSV
IFGFALHRLGAYGKPVLDFIDRFAHVMFNIINMIMKLAPLGAFGAMAFTIGAYGVSSLVQLGQLMICFYITCALFVVFVL
GAIARAHGFSIFKLIRYIREELLIVLGTSSSESALPRMLIKMERLGAKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQ
ATNTHMDITHQITLLLVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNAVATVVV
AKWVGELDTDKLQSELASGGSAILETRPEDDLGVAEGPTPGAAVNTTKTV

Sequences:

>Translated_450_residues
MTTRQPIYKSLYFQVIVAIVIGILIGHFYPDTGKALKPLGDGFIKLIKMVIAPIIFCTVVSGIAGMQSMKSVGKTGGYAL
LYFEIVSTIALLIGLIVVNVVQPGAGMNIDVSTLDASKIAAYVTAGQDQSIVGFILNVIPNTIVGAFANGDILQVLMFSV
IFGFALHRLGAYGKPVLDFIDRFAHVMFNIINMIMKLAPLGAFGAMAFTIGAYGVSSLVQLGQLMICFYITCALFVVFVL
GAIARAHGFSIFKLIRYIREELLIVLGTSSSESALPRMLIKMERLGAKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQ
ATNTHMDITHQITLLLVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNAVATVVV
AKWVGELDTDKLQSELASGGSAILETRPEDDLGVAEGPTPGAAVNTTKTV
>Mature_449_residues
TTRQPIYKSLYFQVIVAIVIGILIGHFYPDTGKALKPLGDGFIKLIKMVIAPIIFCTVVSGIAGMQSMKSVGKTGGYALL
YFEIVSTIALLIGLIVVNVVQPGAGMNIDVSTLDASKIAAYVTAGQDQSIVGFILNVIPNTIVGAFANGDILQVLMFSVI
FGFALHRLGAYGKPVLDFIDRFAHVMFNIINMIMKLAPLGAFGAMAFTIGAYGVSSLVQLGQLMICFYITCALFVVFVLG
AIARAHGFSIFKLIRYIREELLIVLGTSSSESALPRMLIKMERLGAKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQA
TNTHMDITHQITLLLVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNAVATVVVA
KWVGELDTDKLQSELASGGSAILETRPEDDLGVAEGPTPGAAVNTTKTV

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=459, Percent_Identity=26.797385620915, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI5032093, Length=402, Percent_Identity=27.363184079602, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI21314632, Length=440, Percent_Identity=25.6818181818182, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI169790839, Length=470, Percent_Identity=25.1063829787234, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI223468566, Length=303, Percent_Identity=29.7029702970297, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI66773030, Length=419, Percent_Identity=26.2529832935561, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI223468564, Length=291, Percent_Identity=29.8969072164948, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI4827012, Length=439, Percent_Identity=26.1958997722096, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI194239697, Length=463, Percent_Identity=23.110151187905, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI262359914, Length=399, Percent_Identity=24.0601503759398, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI301601644, Length=199, Percent_Identity=30.1507537688442, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1789947, Length=413, Percent_Identity=77.7239709443099, Blast_Score=657, Evalue=0.0,
Organism=Escherichia coli, GI1790514, Length=414, Percent_Identity=42.0289855072464, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1788024, Length=404, Percent_Identity=24.5049504950495, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1789473, Length=331, Percent_Identity=22.6586102719033, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17537407, Length=451, Percent_Identity=25.2771618625277, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71996953, Length=481, Percent_Identity=24.7401247401247, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71983106, Length=454, Percent_Identity=25.1101321585903, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71983099, Length=452, Percent_Identity=24.7787610619469, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI193206654, Length=476, Percent_Identity=25.2100840336134, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI193206505, Length=443, Percent_Identity=23.7020316027088, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17541374, Length=451, Percent_Identity=21.7294900221729, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24583025, Length=398, Percent_Identity=25.6281407035176, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17137668, Length=398, Percent_Identity=25.6281407035176, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24583023, Length=398, Percent_Identity=25.6281407035176, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281360481, Length=421, Percent_Identity=23.9904988123515, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281360483, Length=421, Percent_Identity=23.9904988123515, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137666, Length=421, Percent_Identity=23.9904988123515, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47485; Mature: 47354

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CEEECCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTRQPIYKSLYFQVIVAIVIGILIGHFYPDTGKALKPLGDGFIKLIKMVIAPIIFCTVV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SGIAGMQSMKSVGKTGGYALLYFEIVSTIALLIGLIVVNVVQPGAGMNIDVSTLDASKIA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
AYVTAGQDQSIVGFILNVIPNTIVGAFANGDILQVLMFSVIFGFALHRLGAYGKPVLDFI
HHEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
DRFAHVMFNIINMIMKLAPLGAFGAMAFTIGAYGVSSLVQLGQLMICFYITCALFVVFVL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAIARAHGFSIFKLIRYIREELLIVLGTSSSESALPRMLIKMERLGAKKSVVGLVIPTGY
HHHHHHHCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCE
SFNLDGTSIYLTMAAVFIAQATNTHMDITHQITLLLVLLLSSKGAAGVTGSGFIVLAATL
EECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
SAVGHLPVAGLALILGIDRFMSEARALTNLVGNAVATVVVAKWVGELDTDKLQSELASGG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
SAILETRPEDDLGVAEGPTPGAAVNTTKTV
CEEECCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA