Click here to switch to the map view.

The map label for this gene is nodT [H]

Identifier: 66046610

GI number: 66046610

Start: 4039846

End: 4041279

Strand: Direct

Name: nodT [H]

Synonym: Psyr_3381

Alternate gene names: 66046610

Gene position: 4039846-4041279 (Clockwise)

Preceding gene: 66046609

Following gene: 66046611

Centisome position: 66.3

GC content: 64.23

Gene sequence:

>1434_bases
ATGAAACCTGCTTTACGCGTGGCCGCTCTCGGCTTTACCGCCGTGCTGTCAGCCTGCCAGATGGTCGGCCCGGATTACCA
GGTGCCCAAGGACGGCGCGATCAACCGTCCGGACCTGCAGGGTGAACTGGCTGGCCGCTCTGTCAACACGGTTTCGGCCC
CGGTGCCTGCGCACTGGTGGCGCCTGTATCAGGATGCGCGTCTGGATGAGCTGGTGCGCCAGGCTATCGCGTCCAATACC
GACCTGCGCATTGCCGCGGCCAACCTGCAGCGTGCCCGCTATCAGACCTCGGAAGCCGAGGCGGCTGGCGGCTTTACCAA
CGGCGCGAAGATCGGCGCGCAGCGCGTGCAGGAGTCAGGCGAGGCGTTTCTGCTGACCGACAAGGTGCCGGTGGCCAATG
TGGGCGACGTGGGTCTGACCACTTCGTACCAGTTCGATCTGTTCGGCACCTTGCAGCGTGGCATCGAAGCGGCGCAGGCC
AATGTCGATGCCAATCAGGCAGCGGTGGATACGGCACGCATCACGGTGGTCGCCGATGTGGTGCGCGCCTACACGCAGAT
TTGTGCGGCCAACGAAGAACTCGACATCGCCCGCGCATCGCTAGACTTGCAAAAACAGAGTGTGTCCCTCAACCAGCGCC
TGCGTGATGCCGGGCGTGGCGATGAAACGCAGGTCACTCGTTCACAGACACAGTTCAAGTCGTTACGCGCCGAAATGCCC
CGTTACGAGGCGCGCCGTCAGGCTGCAATCTTCCGCCTGTCGATGCTGCTGGCCAAACCTGTCGAGCAACTGCCCGCCGG
GGTAAGCACCTGCAACCAGCTGCCGCAGATTGCGCAGGTCATGCCTGTTGGTGACGGCGCAGCGCTGCTCAAACGCCGCC
CGGATGTGCGTCAGGCTGAACGCCATCTGGCGATGTCGACTGCCGAGATCGGTGTTGCCACCGGCGAGCTGTATCCGGAC
ATCAGCATCGGCGCGAGCATTGGCACCACCGGCCTGATCGAGAACCTTGGCAAGCCGGCGGCCAATCGCTGGGGCTTCGG
GCCGCTGCTGAACTGGACCATCCCGTCCAATGGCTCACGCGCCCGCATCCATCAGGCCGAAGCCTCGGCGCAGGCGGCAC
TGGCGCGCTTTGACGGTGTGGTGCTCAATGCCATCCGTGAAACTCAGACCGGTCTGGCGCAATACACCGCCCTGCTCGAC
CGCCGCGACGCCCTCAAAGAAGCCGAGCAATCCGCCAGGGAAGCGGCTGACCAGACGCACCGCTTCTATCAGGCCGGACG
CGCTTCGTTCCTCGCCGATCTGCAGGCCACACGCACTTACACTGACGTGCGCGCGCAAATGGCGGAGGCCAACACGCAGG
TGGCGATGGGGCAGATCAATCTGTTTCTGGCACTCGGCGGCGGCTGGGAGAAGGATGACGTGGCGCAGAAATAG

Upstream 100 bases:

>100_bases
CGGTGCGGATCGCCTTCGATGATGTGCCTGCCGACTTCCGCATGATTGCCGGGCGTACCGCGACGGTGTCGATCATCGAC
GACACCCAGGAGCGCAGCCG

Downstream 100 bases:

>100_bases
GATGGGCGTTCGCCCCGCCATCAAGCCTCGTTCGGATGGATTACGTCGCAATTTGCTTTGTCAGTGCCACTGTGATCGAA
AAGCGCTTTAGAGTAGTCGG

Product: RND efflux system, outer membrane lipoprotein, NodT

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MKPALRVAALGFTAVLSACQMVGPDYQVPKDGAINRPDLQGELAGRSVNTVSAPVPAHWWRLYQDARLDELVRQAIASNT
DLRIAAANLQRARYQTSEAEAAGGFTNGAKIGAQRVQESGEAFLLTDKVPVANVGDVGLTTSYQFDLFGTLQRGIEAAQA
NVDANQAAVDTARITVVADVVRAYTQICAANEELDIARASLDLQKQSVSLNQRLRDAGRGDETQVTRSQTQFKSLRAEMP
RYEARRQAAIFRLSMLLAKPVEQLPAGVSTCNQLPQIAQVMPVGDGAALLKRRPDVRQAERHLAMSTAEIGVATGELYPD
ISIGASIGTTGLIENLGKPAANRWGFGPLLNWTIPSNGSRARIHQAEASAQAALARFDGVVLNAIRETQTGLAQYTALLD
RRDALKEAEQSAREAADQTHRFYQAGRASFLADLQATRTYTDVRAQMAEANTQVAMGQINLFLALGGGWEKDDVAQK

Sequences:

>Translated_477_residues
MKPALRVAALGFTAVLSACQMVGPDYQVPKDGAINRPDLQGELAGRSVNTVSAPVPAHWWRLYQDARLDELVRQAIASNT
DLRIAAANLQRARYQTSEAEAAGGFTNGAKIGAQRVQESGEAFLLTDKVPVANVGDVGLTTSYQFDLFGTLQRGIEAAQA
NVDANQAAVDTARITVVADVVRAYTQICAANEELDIARASLDLQKQSVSLNQRLRDAGRGDETQVTRSQTQFKSLRAEMP
RYEARRQAAIFRLSMLLAKPVEQLPAGVSTCNQLPQIAQVMPVGDGAALLKRRPDVRQAERHLAMSTAEIGVATGELYPD
ISIGASIGTTGLIENLGKPAANRWGFGPLLNWTIPSNGSRARIHQAEASAQAALARFDGVVLNAIRETQTGLAQYTALLD
RRDALKEAEQSAREAADQTHRFYQAGRASFLADLQATRTYTDVRAQMAEANTQVAMGQINLFLALGGGWEKDDVAQK
>Mature_477_residues
MKPALRVAALGFTAVLSACQMVGPDYQVPKDGAINRPDLQGELAGRSVNTVSAPVPAHWWRLYQDARLDELVRQAIASNT
DLRIAAANLQRARYQTSEAEAAGGFTNGAKIGAQRVQESGEAFLLTDKVPVANVGDVGLTTSYQFDLFGTLQRGIEAAQA
NVDANQAAVDTARITVVADVVRAYTQICAANEELDIARASLDLQKQSVSLNQRLRDAGRGDETQVTRSQTQFKSLRAEMP
RYEARRQAAIFRLSMLLAKPVEQLPAGVSTCNQLPQIAQVMPVGDGAALLKRRPDVRQAERHLAMSTAEIGVATGELYPD
ISIGASIGTTGLIENLGKPAANRWGFGPLLNWTIPSNGSRARIHQAEASAQAALARFDGVVLNAIRETQTGLAQYTALLD
RRDALKEAEQSAREAADQTHRFYQAGRASFLADLQATRTYTDVRAQMAEANTQVAMGQINLFLALGGGWEKDDVAQK

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=462, Percent_Identity=25.974025974026, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI2367348, Length=496, Percent_Identity=23.5887096774194, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51468; Mature: 51468

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPALRVAALGFTAVLSACQMVGPDYQVPKDGAINRPDLQGELAGRSVNTVSAPVPAHWW
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHH
RLYQDARLDELVRQAIASNTDLRIAAANLQRARYQTSEAEAAGGFTNGAKIGAQRVQESG
HHHHHCCHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHCC
EAFLLTDKVPVANVGDVGLTTSYQFDLFGTLQRGIEAAQANVDANQAAVDTARITVVADV
CEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VRAYTQICAANEELDIARASLDLQKQSVSLNQRLRDAGRGDETQVTRSQTQFKSLRAEMP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
RYEARRQAAIFRLSMLLAKPVEQLPAGVSTCNQLPQIAQVMPVGDGAALLKRRPDVRQAE
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHH
RHLAMSTAEIGVATGELYPDISIGASIGTTGLIENLGKPAANRWGFGPLLNWTIPSNGSR
HHHHHHHHHHCEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCC
ARIHQAEASAQAALARFDGVVLNAIRETQTGLAQYTALLDRRDALKEAEQSAREAADQTH
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFYQAGRASFLADLQATRTYTDVRAQMAEANTQVAMGQINLFLALGGGWEKDDVAQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCHHCCCC
>Mature Secondary Structure
MKPALRVAALGFTAVLSACQMVGPDYQVPKDGAINRPDLQGELAGRSVNTVSAPVPAHWW
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHH
RLYQDARLDELVRQAIASNTDLRIAAANLQRARYQTSEAEAAGGFTNGAKIGAQRVQESG
HHHHHCCHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHCC
EAFLLTDKVPVANVGDVGLTTSYQFDLFGTLQRGIEAAQANVDANQAAVDTARITVVADV
CEEEEECCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VRAYTQICAANEELDIARASLDLQKQSVSLNQRLRDAGRGDETQVTRSQTQFKSLRAEMP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
RYEARRQAAIFRLSMLLAKPVEQLPAGVSTCNQLPQIAQVMPVGDGAALLKRRPDVRQAE
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHH
RHLAMSTAEIGVATGELYPDISIGASIGTTGLIENLGKPAANRWGFGPLLNWTIPSNGSR
HHHHHHHHHHCEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCC
ARIHQAEASAQAALARFDGVVLNAIRETQTGLAQYTALLDRRDALKEAEQSAREAADQTH
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFYQAGRASFLADLQATRTYTDVRAQMAEANTQVAMGQINLFLALGGGWEKDDVAQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]