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The map label for this gene is irlR [H]

Identifier: 66046603

GI number: 66046603

Start: 4032942

End: 4033631

Strand: Direct

Name: irlR [H]

Synonym: Psyr_3374

Alternate gene names: 66046603

Gene position: 4032942-4033631 (Clockwise)

Preceding gene: 66046599

Following gene: 66046604

Centisome position: 66.18

GC content: 61.74

Gene sequence:

>690_bases
ATGCATATCCTGCTAATTGAAGATGACACCAAAACCGGCGAATACCTGAAGAAGGGACTGGGCGAATCCGGCTACGTGGT
CGACTGGACGCAGCACGGTGCCGACGGCCTGCATCTGGCGCTGGAAAACCGCTATGACCTCATCGTGCTGGACGTGATGC
TGCCAGGCATCGACGGCTGGCAGATCATCGAAGTCCTGCGCGCCAGGCAGGACGTGCCAGTGCTGTTTCTGACCGCGCGC
GACCAGTTGCAGGACCGGATTCGCGGCCTGGAACTGGGTGCCGACGATTATCTGGTCAAGCCGTTTTCCTTCACCGAACT
GCTGCTGCGCATCCGCACCATCCTGCGCCGCGGCGTGGTACGCGAGGCGGACCACTTTCATCTGGCCGACCTGGAACTGG
ACCTGCTGCGCCGCCGCGTAACGCGCCAGCAGCAGGTCATCGTGCTGACCAACAAGGAGTTCGCTCTGCTGCACCTGTTA
TTGCGCCGCGAAGGCGACGTACTGTCCAGGGCACAGATCGCCTCGGAAGTCTGGGACATGAATTTCGACAGCGACACCAA
TGTGGTGGACGTCGCCATCAAGCGCCTGCGCAGCAAGGTCGACCTGCCCTACCCGGTCAAGCTCATCCACACCGTGCGTG
GCATCGGTTATGTGTGCGAGGTGCGGCCATGCGACGCCAGCCTTCCCTGA

Upstream 100 bases:

>100_bases
CAATGACATTTTTGTCATTCGCCGGACACCCTGTCGGCAACTGGTTAGACTCCGGCATCGGCGCAACAAGGGCGCCAGGA
AAAGCGTAGCGGACAAAACG

Downstream 100 bases:

>100_bases
CCCTGCGCTCGACCCTGGCCTTTGCCCTGGTGGCGATGCTCACCGTCAGCGGCGCAGGCCTGTACCTGTATCAGTCAATC
GAAGAAACGGTCATGCAGCG

Product: heavy metal response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MHILLIEDDTKTGEYLKKGLGESGYVVDWTQHGADGLHLALENRYDLIVLDVMLPGIDGWQIIEVLRARQDVPVLFLTAR
DQLQDRIRGLELGADDYLVKPFSFTELLLRIRTILRRGVVREADHFHLADLELDLLRRRVTRQQQVIVLTNKEFALLHLL
LRREGDVLSRAQIASEVWDMNFDSDTNVVDVAIKRLRSKVDLPYPVKLIHTVRGIGYVCEVRPCDASLP

Sequences:

>Translated_229_residues
MHILLIEDDTKTGEYLKKGLGESGYVVDWTQHGADGLHLALENRYDLIVLDVMLPGIDGWQIIEVLRARQDVPVLFLTAR
DQLQDRIRGLELGADDYLVKPFSFTELLLRIRTILRRGVVREADHFHLADLELDLLRRRVTRQQQVIVLTNKEFALLHLL
LRREGDVLSRAQIASEVWDMNFDSDTNVVDVAIKRLRSKVDLPYPVKLIHTVRGIGYVCEVRPCDASLP
>Mature_229_residues
MHILLIEDDTKTGEYLKKGLGESGYVVDWTQHGADGLHLALENRYDLIVLDVMLPGIDGWQIIEVLRARQDVPVLFLTAR
DQLQDRIRGLELGADDYLVKPFSFTELLLRIRTILRRGVVREADHFHLADLELDLLRRRVTRQQQVIVLTNKEFALLHLL
LRREGDVLSRAQIASEVWDMNFDSDTNVVDVAIKRLRSKVDLPYPVKLIHTVRGIGYVCEVRPCDASLP

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=57.5892857142857, Blast_Score=261, Evalue=3e-71,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=54.8387096774194, Blast_Score=242, Evalue=2e-65,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=40.6392694063927, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=37.4429223744292, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=35.7142857142857, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.8385650224215, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=36.5296803652968, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=34.9557522123894, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=34.8017621145374, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=35.1598173515982, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=33.4801762114537, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=33.1896551724138, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=37.6106194690265, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=31.0344827586207, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788550, Length=129, Percent_Identity=27.1317829457364, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=104, Percent_Identity=30.7692307692308, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26284; Mature: 26284

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHILLIEDDTKTGEYLKKGLGESGYVVDWTQHGADGLHLALENRYDLIVLDVMLPGIDGW
CEEEEEECCCCHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCEEEEEEECCCCCHH
QIIEVLRARQDVPVLFLTARDQLQDRIRGLELGADDYLVKPFSFTELLLRIRTILRRGVV
HHHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHH
READHFHLADLELDLLRRRVTRQQQVIVLTNKEFALLHLLLRREGDVLSRAQIASEVWDM
CCCCCEEEEHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHCC
NFDSDTNVVDVAIKRLRSKVDLPYPVKLIHTVRGIGYVCEVRPCDASLP
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCC
>Mature Secondary Structure
MHILLIEDDTKTGEYLKKGLGESGYVVDWTQHGADGLHLALENRYDLIVLDVMLPGIDGW
CEEEEEECCCCHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCCEEEEEEECCCCCHH
QIIEVLRARQDVPVLFLTARDQLQDRIRGLELGADDYLVKPFSFTELLLRIRTILRRGVV
HHHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHH
READHFHLADLELDLLRRRVTRQQQVIVLTNKEFALLHLLLRREGDVLSRAQIASEVWDM
CCCCCEEEEHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHCC
NFDSDTNVVDVAIKRLRSKVDLPYPVKLIHTVRGIGYVCEVRPCDASLP
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]