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The map label for this gene is czcS [H]

Identifier: 66046604

GI number: 66046604

Start: 4033610

End: 4034998

Strand: Direct

Name: czcS [H]

Synonym: Psyr_3375

Alternate gene names: 66046604

Gene position: 4033610-4034998 (Clockwise)

Preceding gene: 66046603

Following gene: 66046606

Centisome position: 66.19

GC content: 62.56

Gene sequence:

>1389_bases
ATGCGACGCCAGCCTTCCCTGACCCTGCGCTCGACCCTGGCCTTTGCCCTGGTGGCGATGCTCACCGTCAGCGGCGCAGG
CCTGTACCTGTATCAGTCAATCGAAGAAACGGTCATGCAGCGCAGCGACCATGCCGTGCTCGCGCGGCTGGACCACTTTC
GCAAGCTGTTGCGCTATGACCTGACCATGGGCAACCTCAAGGGCAGCCCGCAGCTGTTCGAGAACATGCTCGACAGCGAA
GAAGACATCTTCATCATCGGCGAGCCGGGCAAGTCACCGGTCATCTCGGTCAATCCGCAGCACGCGCCCCTGCCGGAGCT
GCCGACCGTGGCGCAGGACCAACCGCTGCGGGTCGATGACCTGCGCAGCGGCATGAGCCTGCAAGGCGTGCCGTTGCGCG
CTGCCGCCGTCCAGGTGATGTCCAACGGTGTCGAAGTGCGCTTGCAGGCTGCGCACCTGATGGTCAAGGAAATGGCCATG
CTCGCCAGTTTCCGTCAGCGTATCTATATAGCTGTGGCCCTGGCGTTTCTGATCACCGCAGCCCTGGGTTATGTGCTGCT
GCGCCGCGGCTTGCGTCCACTGCGCAGAATGGCCGCCCACGCTGCCGCCATCACCCCGGCCAGCCTGCACAAACGCCTCG
ACAGCCGCGATACACCCGTCGAGCTGCAACAACTGAGCGATGCCTTCAACGCCATGCTTGACCGTCTGGACGATGGCTAC
CGGCGCCTGATGCAGTTTTCTGCCGATCTGGCCCATGAAATCCGCACACCGGTCGGCTCACTGATGGGCCATTGTCAGGT
CGCCTTGCGCCAGAACCGCAGCGCCGATGAATATCAGGCGCTGCTGGCCTCCAATCTGGAAGAGCTGGAACGCATCTCGC
GGCTGGTGGAAAGCATTCTGTTTCTGGCACGGGCGGACGAAGCCCAGGCCGCGCTGGAACGTCAGGCGCTGGATATGCAT
GACGAACTGCAACGGGTCGCCGGCTATTTCGAGGGGCTGGCCGAAGAACGCAACCTGACCCTGAGCACCCACGGACAAGG
CACGCTGCTGGCCGATCCGATTTTGCTGCGGCGTGCATTGAGCAATCTGGTCGCCAATGCGATTCGCTACGCTGATGAAG
ACAGCGAGATTCTGATGCGAGTGACGGCTGTGGACAGGCACTGGAAGATCGATGTGGAGAATCAGGGACCGGTGCTGCCG
GAGGCCACCCTCGCACGCTTGTTCGATCGTTTCTATCGCGGTGACGCCTCACGCCATGAGCGCTCGGATTCCAACGGCCT
GGGGCTGGCGATCGTCACGGCAATCATGCAACTGCACGGCGGTCGGGTCGAAGTCGCTCAACCCGCCGTCGGCAGAATCT
GCTTCAGTCTGATATTCCCAGCGGCCTGA

Upstream 100 bases:

>100_bases
ACGTCGCCATCAAGCGCCTGCGCAGCAAGGTCGACCTGCCCTACCCGGTCAAGCTCATCCACACCGTGCGTGGCATCGGT
TATGTGTGCGAGGTGCGGCC

Downstream 100 bases:

>100_bases
AGCCTGCAGTGCGCAAGGATCAATTCTTTTTCTCGTGGGCAATGGCCAGCTTGTAGAACGTGGCCGAGCCGCCTTCCGTG
GTGTAGCCGGTATTGTCCTG

Product: heavy metal sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MRRQPSLTLRSTLAFALVAMLTVSGAGLYLYQSIEETVMQRSDHAVLARLDHFRKLLRYDLTMGNLKGSPQLFENMLDSE
EDIFIIGEPGKSPVISVNPQHAPLPELPTVAQDQPLRVDDLRSGMSLQGVPLRAAAVQVMSNGVEVRLQAAHLMVKEMAM
LASFRQRIYIAVALAFLITAALGYVLLRRGLRPLRRMAAHAAAITPASLHKRLDSRDTPVELQQLSDAFNAMLDRLDDGY
RRLMQFSADLAHEIRTPVGSLMGHCQVALRQNRSADEYQALLASNLEELERISRLVESILFLARADEAQAALERQALDMH
DELQRVAGYFEGLAEERNLTLSTHGQGTLLADPILLRRALSNLVANAIRYADEDSEILMRVTAVDRHWKIDVENQGPVLP
EATLARLFDRFYRGDASRHERSDSNGLGLAIVTAIMQLHGGRVEVAQPAVGRICFSLIFPAA

Sequences:

>Translated_462_residues
MRRQPSLTLRSTLAFALVAMLTVSGAGLYLYQSIEETVMQRSDHAVLARLDHFRKLLRYDLTMGNLKGSPQLFENMLDSE
EDIFIIGEPGKSPVISVNPQHAPLPELPTVAQDQPLRVDDLRSGMSLQGVPLRAAAVQVMSNGVEVRLQAAHLMVKEMAM
LASFRQRIYIAVALAFLITAALGYVLLRRGLRPLRRMAAHAAAITPASLHKRLDSRDTPVELQQLSDAFNAMLDRLDDGY
RRLMQFSADLAHEIRTPVGSLMGHCQVALRQNRSADEYQALLASNLEELERISRLVESILFLARADEAQAALERQALDMH
DELQRVAGYFEGLAEERNLTLSTHGQGTLLADPILLRRALSNLVANAIRYADEDSEILMRVTAVDRHWKIDVENQGPVLP
EATLARLFDRFYRGDASRHERSDSNGLGLAIVTAIMQLHGGRVEVAQPAVGRICFSLIFPAA
>Mature_462_residues
MRRQPSLTLRSTLAFALVAMLTVSGAGLYLYQSIEETVMQRSDHAVLARLDHFRKLLRYDLTMGNLKGSPQLFENMLDSE
EDIFIIGEPGKSPVISVNPQHAPLPELPTVAQDQPLRVDDLRSGMSLQGVPLRAAAVQVMSNGVEVRLQAAHLMVKEMAM
LASFRQRIYIAVALAFLITAALGYVLLRRGLRPLRRMAAHAAAITPASLHKRLDSRDTPVELQQLSDAFNAMLDRLDDGY
RRLMQFSADLAHEIRTPVGSLMGHCQVALRQNRSADEYQALLASNLEELERISRLVESILFLARADEAQAALERQALDMH
DELQRVAGYFEGLAEERNLTLSTHGQGTLLADPILLRRALSNLVANAIRYADEDSEILMRVTAVDRHWKIDVENQGPVLP
EATLARLFDRFYRGDASRHERSDSNGLGLAIVTAIMQLHGGRVEVAQPAVGRICFSLIFPAA

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=347, Percent_Identity=38.328530259366, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1788279, Length=424, Percent_Identity=33.4905660377358, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=26.9090909090909, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1787894, Length=293, Percent_Identity=27.9863481228669, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790861, Length=299, Percent_Identity=27.0903010033445, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786912, Length=216, Percent_Identity=30.5555555555556, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=27.8985507246377, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790551, Length=281, Percent_Identity=29.1814946619217, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789403, Length=304, Percent_Identity=30.9210526315789, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=221, Percent_Identity=25.3393665158371, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082128, Length=250, Percent_Identity=24.8, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=229, Percent_Identity=27.9475982532751, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=211, Percent_Identity=23.696682464455, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788549, Length=234, Percent_Identity=26.4957264957265, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=26.6968325791855, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=225, Percent_Identity=24.4444444444444, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=297, Percent_Identity=26.9360269360269, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787374, Length=333, Percent_Identity=24.9249249249249, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51323; Mature: 51323

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRQPSLTLRSTLAFALVAMLTVSGAGLYLYQSIEETVMQRSDHAVLARLDHFRKLLRYD
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LTMGNLKGSPQLFENMLDSEEDIFIIGEPGKSPVISVNPQHAPLPELPTVAQDQPLRVDD
CHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHH
LRSGMSLQGVPLRAAAVQVMSNGVEVRLQAAHLMVKEMAMLASFRQRIYIAVALAFLITA
HHCCCCCCCCCHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGYVLLRRGLRPLRRMAAHAAAITPASLHKRLDSRDTPVELQQLSDAFNAMLDRLDDGY
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
RRLMQFSADLAHEIRTPVGSLMGHCQVALRQNRSADEYQALLASNLEELERISRLVESIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHH
FLARADEAQAALERQALDMHDELQRVAGYFEGLAEERNLTLSTHGQGTLLADPILLRRAL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHH
SNLVANAIRYADEDSEILMRVTAVDRHWKIDVENQGPVLPEATLARLFDRFYRGDASRHE
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHC
RSDSNGLGLAIVTAIMQLHGGRVEVAQPAVGRICFSLIFPAA
CCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MRRQPSLTLRSTLAFALVAMLTVSGAGLYLYQSIEETVMQRSDHAVLARLDHFRKLLRYD
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LTMGNLKGSPQLFENMLDSEEDIFIIGEPGKSPVISVNPQHAPLPELPTVAQDQPLRVDD
CHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHH
LRSGMSLQGVPLRAAAVQVMSNGVEVRLQAAHLMVKEMAMLASFRQRIYIAVALAFLITA
HHCCCCCCCCCHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGYVLLRRGLRPLRRMAAHAAAITPASLHKRLDSRDTPVELQQLSDAFNAMLDRLDDGY
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
RRLMQFSADLAHEIRTPVGSLMGHCQVALRQNRSADEYQALLASNLEELERISRLVESIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHH
FLARADEAQAALERQALDMHDELQRVAGYFEGLAEERNLTLSTHGQGTLLADPILLRRAL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHH
SNLVANAIRYADEDSEILMRVTAVDRHWKIDVENQGPVLPEATLARLFDRFYRGDASRHE
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHC
RSDSNGLGLAIVTAIMQLHGGRVEVAQPAVGRICFSLIFPAA
CCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]