Click here to switch to the map view.

The map label for this gene is hpd [H]

Identifier: 66046559

GI number: 66046559

Start: 3984231

End: 3985307

Strand: Reverse

Name: hpd [H]

Synonym: Psyr_3330

Alternate gene names: 66046559

Gene position: 3985307-3984231 (Counterclockwise)

Preceding gene: 66046564

Following gene: 66046557

Centisome position: 65.4

GC content: 58.5

Gene sequence:

>1077_bases
ATGGCTGATCTTTACGAAAATCCAATGGGCCTGATGGGCTTTGAATTCATCGAATTCGCATCACCGACGCCCAATAGCCT
TGAGCCCGTGTTTCAGATGATGGGCTTCACCAAAGTCGCGACCCACCGCTCCAAGGACGTGTCCCTGTATCGTCAGGGCG
CGATCAACCTGATTCTCAACAACGAGCCGCATAGTCTGGCATCGTACTTTGCCGCCGAGCATGGTCCTTCGGTGTGCGGC
ATGGCGTTCCGCGTGAAAGATGCGCAGAAGGCCTATAGCCGGGCGCTTGAACTGGGCGCCCAACCGCTGGAAATCGCTAC
CGGGCCCATGGAGTTGCGCCTGCCCGCCATCAAGGGCATCGGTGGCGCGCCGCTTTACCTGATCGATCGCTTCGGCGAGG
GCACGTCGATCTACGACATCGATTTCAACTTCATCGAGGGCGTTGACCGCCACCCGGTCGGTGCCGGTCTGAAATTCATC
GACCACCTGACCCACAACGTGTACCGCGGGCGCATGGCGTATTGGGCCGGTTTCTATGAAAAGCTGTTCAATTTCCGCGA
GCTGCGTTACTTCGACATCAAGGGCGAATACACCGGCCTGACCTCCAAAGCCATGACCGCCCCGGACGGCATGATCCGCA
TTCCGCTCAACGAAGAATCGTCCAAGGGCGCGGGGCAGATCGAAGAGTTCCTGATGCAGTTCAATGGCGAAGGCATTCAG
CATGTAGCCTTCTTCACCGATGACCTGATCAAGACCTGGGACGCGCTGAAAGCCACCGGCATGCGCTTCATGACTGCGCC
GCCGGATACCTACTACGAGATGCTGCAAGGCCGCCTGCCCGACCACGGTGAGCCGGAGGCCGAGCTCAAGTCACGCGGGA
TTCTGCTCGATGGTTCTTCCGAAGGCGGCGAGCGTCGTTTGCTGTTGCAGATATTCTCCGCAACGCTGATGGGCCCGGTA
TTTTTCGAATTCATTCAGCGCAAGGGCGATGACGGGTTTGGCGAGGGCAACTTCAAGGCACTGTTCGAATCCATCGAACG
CGACCAGATCCAGCGTGGTGTACTGACGCCGGACTGA

Upstream 100 bases:

>100_bases
GATTTTCTCGCACGCAGCGTGCGAGGGATTCCGTGTGCGCCGCCCGCAGGACAGTGATTGCCAGGGTTACCCACTCTCAC
TTTCCTGCAAGGAGCCAGTC

Downstream 100 bases:

>100_bases
GTGATCACCAGAGGCGTCCATATTGCGCGATCAGACGAGCCTGCCCAGGCTCGTTCTGAGTCAGTTGTGCTTGAGCACGT
CAGCGTGCCAATTGTGAGAA

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MADLYENPMGLMGFEFIEFASPTPNSLEPVFQMMGFTKVATHRSKDVSLYRQGAINLILNNEPHSLASYFAAEHGPSVCG
MAFRVKDAQKAYSRALELGAQPLEIATGPMELRLPAIKGIGGAPLYLIDRFGEGTSIYDIDFNFIEGVDRHPVGAGLKFI
DHLTHNVYRGRMAYWAGFYEKLFNFRELRYFDIKGEYTGLTSKAMTAPDGMIRIPLNEESSKGAGQIEEFLMQFNGEGIQ
HVAFFTDDLIKTWDALKATGMRFMTAPPDTYYEMLQGRLPDHGEPEAELKSRGILLDGSSEGGERRLLLQIFSATLMGPV
FFEFIQRKGDDGFGEGNFKALFESIERDQIQRGVLTPD

Sequences:

>Translated_358_residues
MADLYENPMGLMGFEFIEFASPTPNSLEPVFQMMGFTKVATHRSKDVSLYRQGAINLILNNEPHSLASYFAAEHGPSVCG
MAFRVKDAQKAYSRALELGAQPLEIATGPMELRLPAIKGIGGAPLYLIDRFGEGTSIYDIDFNFIEGVDRHPVGAGLKFI
DHLTHNVYRGRMAYWAGFYEKLFNFRELRYFDIKGEYTGLTSKAMTAPDGMIRIPLNEESSKGAGQIEEFLMQFNGEGIQ
HVAFFTDDLIKTWDALKATGMRFMTAPPDTYYEMLQGRLPDHGEPEAELKSRGILLDGSSEGGERRLLLQIFSATLMGPV
FFEFIQRKGDDGFGEGNFKALFESIERDQIQRGVLTPD
>Mature_357_residues
ADLYENPMGLMGFEFIEFASPTPNSLEPVFQMMGFTKVATHRSKDVSLYRQGAINLILNNEPHSLASYFAAEHGPSVCGM
AFRVKDAQKAYSRALELGAQPLEIATGPMELRLPAIKGIGGAPLYLIDRFGEGTSIYDIDFNFIEGVDRHPVGAGLKFID
HLTHNVYRGRMAYWAGFYEKLFNFRELRYFDIKGEYTGLTSKAMTAPDGMIRIPLNEESSKGAGQIEEFLMQFNGEGIQH
VAFFTDDLIKTWDALKATGMRFMTAPPDTYYEMLQGRLPDHGEPEAELKSRGILLDGSSEGGERRLLLQIFSATLMGPVF
FEFIQRKGDDGFGEGNFKALFESIERDQIQRGVLTPD

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=356, Percent_Identity=27.247191011236, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4504477, Length=356, Percent_Identity=27.247191011236, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI14249394, Length=304, Percent_Identity=28.6184210526316, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555220, Length=312, Percent_Identity=32.0512820512821, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17550752, Length=365, Percent_Identity=27.9452054794521, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21356105, Length=304, Percent_Identity=32.8947368421053, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24667510, Length=304, Percent_Identity=32.8947368421053, Blast_Score=134, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40068; Mature: 39937

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLYENPMGLMGFEFIEFASPTPNSLEPVFQMMGFTKVATHRSKDVSLYRQGAINLILN
CCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCCCCHHHHHCCCEEEEEC
NEPHSLASYFAAEHGPSVCGMAFRVKDAQKAYSRALELGAQPLEIATGPMELRLPAIKGI
CCCHHHHHHHHHHCCCCHHCCEEEEHHHHHHHHHHHHHCCCCCEECCCCCEEEEHHHCCC
GGAPLYLIDRFGEGTSIYDIDFNFIEGVDRHPVGAGLKFIDHLTHNVYRGRMAYWAGFYE
CCCCEEEEEECCCCCEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KLFNFRELRYFDIKGEYTGLTSKAMTAPDGMIRIPLNEESSKGAGQIEEFLMQFNGEGIQ
HHHCHHHEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCE
HVAFFTDDLIKTWDALKATGMRFMTAPPDTYYEMLQGRLPDHGEPEAELKSRGILLDGSS
EHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCCCHHHHHHCCEEEECCC
EGGERRLLLQIFSATLMGPVFFEFIQRKGDDGFGEGNFKALFESIERDQIQRGVLTPD
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ADLYENPMGLMGFEFIEFASPTPNSLEPVFQMMGFTKVATHRSKDVSLYRQGAINLILN
CCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCCCCHHHHHCCCEEEEEC
NEPHSLASYFAAEHGPSVCGMAFRVKDAQKAYSRALELGAQPLEIATGPMELRLPAIKGI
CCCHHHHHHHHHHCCCCHHCCEEEEHHHHHHHHHHHHHCCCCCEECCCCCEEEEHHHCCC
GGAPLYLIDRFGEGTSIYDIDFNFIEGVDRHPVGAGLKFIDHLTHNVYRGRMAYWAGFYE
CCCCEEEEEECCCCCEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KLFNFRELRYFDIKGEYTGLTSKAMTAPDGMIRIPLNEESSKGAGQIEEFLMQFNGEGIQ
HHHCHHHEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCE
HVAFFTDDLIKTWDALKATGMRFMTAPPDTYYEMLQGRLPDHGEPEAELKSRGILLDGSS
EHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCCCHHHHHHCCEEEECCC
EGGERRLLLQIFSATLMGPVFFEFIQRKGDDGFGEGNFKALFESIERDQIQRGVLTPD
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]