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The map label for this gene is hlyB [H]

Identifier: 66045592

GI number: 66045592

Start: 2731882

End: 2733741

Strand: Direct

Name: hlyB [H]

Synonym: Psyr_2356

Alternate gene names: 66045592

Gene position: 2731882-2733741 (Clockwise)

Preceding gene: 66045590

Following gene: 66045594

Centisome position: 44.83

GC content: 58.49

Gene sequence:

>1860_bases
GTGCTCGGGTTTGCTCTGGTCATCGTACTGACGGTGCTGATCGCGCTGACAGGCTGGACAGGCATCACCTCACTGAGCGA
ACGAAGCGAGCGGATTTCCGACATCGGCAAGCTGAGCGCACTCACGCGAGATGTCCGCATTGCCCGATTGGCCTATTCGG
TCAACTATGACGCCGAGCGCGCCAGCAACTGGTTGAAAGCGCTCGAAGGTCTCGAAAATCATGTGAAGTACGCGCAGAAG
GTGTTCGATTCTCCGTTGAACGTACCGTTGGTGAATACTGCCGCAGACGCCTTGAAGGATTACCGTATTCACTACGACAA
CCTCATGCAGGCAACCGCTGCCCGTGAGGCGACCCGTTCGGTGTTTGGCCAGTACGCCGATGCAGGCGCTGATGATTTGC
AAAAGCTCAACGCCGTTGCCCGATCCGATGACGGGACTCCCGCGCAGCGCGATGCCATCGTGCAGGCGATGACGCTGTTC
CAGAAAATGCGCTTCGACTTGCGTGGCTACACCTATTCGCTGAAGGCGGAAAACCGTGCTCCAGCGGAAACATCGATGAA
CACGGTTATCGAGTTTGTCAGAAATCTGCAGGGTTTCGATGGCCAGTCGGCGATCATCAAGCACCTTGTGGACTCGATGA
TCAGCTACCAGAACACCTTGAATCAGTTCACCGCGGCGCAGGCCAGGATTGATCTGGCTCAGGCAGGCATCACCAAAGAC
ATCGGCATCCTGTTTGAATGTGCTGACAAGCTGTCCGAGAACCAGGTCAACCTGAGAGTGGAGGATGTGAGTCAGGCCAA
GATGCTGCTCTCTGTCTGGCTGATTGCAGCGTTGATCATGAGTGCCCTGGCGGCGTGGGTCATTACCAACCTTATCGTTG
GCCCGCTGCGTGACACACTGAAACTGGCCGAGCGTGTCGCTGATGGTGATTTGACGCACAACCAGGTGGTTACCCGCAAG
GATGAACTGGGCCAGCTGCAGGGCAGCATGATGCGCATGACCGGTAACCTGCGCGAGCTGATTGGTGGTCTGCGCGATGG
CGTGACACAAATCGCCAGTGCCGCCGAACAGTTGTCGGCCGTCACCGAGCAGACCAGTGCCGGCGTCAACAGCCAGAAGA
ACGAAACCGATCAGGTCGCCACTGCGATGCACGAAATGTCTGCGACCGTTCAGGAAGTCGCACGCAACGCAGAGCAGGCT
TCACACGCTGCGGTCAACGCCTCGAAAGAAGCTCGCGAAGGCGACGGCGTGGTTTCCAAGGCTGTTGCGCAGATCGAGAA
GCTTGCGACTGAGGTCACTCACTCCAAGTCCGCGATGGACGATCTCAAGAACGAAAGCAACAAGATTGGTGGCGTGCTCG
ATGTCATCAAGGCCGTTGCCGAGCAGACCAATCTGCTGGCCCTCAACGCTGCAATCGAAGCAGCGCGTGCGGGCGAAGCA
GGCCGAGGCTTTGCGGTGGTGGCTGACGAAGTGAGAAGCCTGGCCCAGCGCACGCAGACGTCGACCGAAGAGATCGCGGC
CTTGATCAGCGGCCTGCATACCCGCACGGCGCAGGTGGCGACGATCCTCGACAACAGCCAGGCACTGACTGCAAACAGTG
TCGAGCTGACGCGCAATGCGGGTGTTTCCATCAATAACATGACGCAGGCAATCTCGACGATCGAGACGATGAACCATCAG
ATCGCCGCTGCCGCCGAAGAGCAGAGCGCCGTTGCCGAAGAGATCAACCGCAGTGTCCTGAATGTGCGAGACATCTCCGA
ACAGACGGCTTCCGCCAGTGAAGAGACCGCTGCGTCGAGCGTCGAGCTCGCTCGTCTGGGCGTGCATCTGCAAAGCCTGG
TCAGTCGATTCCGGGTCTGA

Upstream 100 bases:

>100_bases
AGCTGGCAAGGACAGGCCTCTTGTACTCCACTGATGACCAACGAAAGAGCGACTCCCTGTGATAAACACTCTGCGCAATA
TTTCTGTCAGGTCCAAGCTC

Downstream 100 bases:

>100_bases
CGTTCATTCCCGGTAAACCCCGGCGCGCACCGCAAAGGCCGCGCGCAGGGGGCGACCCGGTGACCCTCCGGCGGTAAGTC
CTTACCGCCCCCAAAGCCCC

Product: histidine kinase, HAMP region: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MLGFALVIVLTVLIALTGWTGITSLSERSERISDIGKLSALTRDVRIARLAYSVNYDAERASNWLKALEGLENHVKYAQK
VFDSPLNVPLVNTAADALKDYRIHYDNLMQATAAREATRSVFGQYADAGADDLQKLNAVARSDDGTPAQRDAIVQAMTLF
QKMRFDLRGYTYSLKAENRAPAETSMNTVIEFVRNLQGFDGQSAIIKHLVDSMISYQNTLNQFTAAQARIDLAQAGITKD
IGILFECADKLSENQVNLRVEDVSQAKMLLSVWLIAALIMSALAAWVITNLIVGPLRDTLKLAERVADGDLTHNQVVTRK
DELGQLQGSMMRMTGNLRELIGGLRDGVTQIASAAEQLSAVTEQTSAGVNSQKNETDQVATAMHEMSATVQEVARNAEQA
SHAAVNASKEAREGDGVVSKAVAQIEKLATEVTHSKSAMDDLKNESNKIGGVLDVIKAVAEQTNLLALNAAIEAARAGEA
GRGFAVVADEVRSLAQRTQTSTEEIAALISGLHTRTAQVATILDNSQALTANSVELTRNAGVSINNMTQAISTIETMNHQ
IAAAAEEQSAVAEEINRSVLNVRDISEQTASASEETAASSVELARLGVHLQSLVSRFRV

Sequences:

>Translated_619_residues
MLGFALVIVLTVLIALTGWTGITSLSERSERISDIGKLSALTRDVRIARLAYSVNYDAERASNWLKALEGLENHVKYAQK
VFDSPLNVPLVNTAADALKDYRIHYDNLMQATAAREATRSVFGQYADAGADDLQKLNAVARSDDGTPAQRDAIVQAMTLF
QKMRFDLRGYTYSLKAENRAPAETSMNTVIEFVRNLQGFDGQSAIIKHLVDSMISYQNTLNQFTAAQARIDLAQAGITKD
IGILFECADKLSENQVNLRVEDVSQAKMLLSVWLIAALIMSALAAWVITNLIVGPLRDTLKLAERVADGDLTHNQVVTRK
DELGQLQGSMMRMTGNLRELIGGLRDGVTQIASAAEQLSAVTEQTSAGVNSQKNETDQVATAMHEMSATVQEVARNAEQA
SHAAVNASKEAREGDGVVSKAVAQIEKLATEVTHSKSAMDDLKNESNKIGGVLDVIKAVAEQTNLLALNAAIEAARAGEA
GRGFAVVADEVRSLAQRTQTSTEEIAALISGLHTRTAQVATILDNSQALTANSVELTRNAGVSINNMTQAISTIETMNHQ
IAAAAEEQSAVAEEINRSVLNVRDISEQTASASEETAASSVELARLGVHLQSLVSRFRV
>Mature_619_residues
MLGFALVIVLTVLIALTGWTGITSLSERSERISDIGKLSALTRDVRIARLAYSVNYDAERASNWLKALEGLENHVKYAQK
VFDSPLNVPLVNTAADALKDYRIHYDNLMQATAAREATRSVFGQYADAGADDLQKLNAVARSDDGTPAQRDAIVQAMTLF
QKMRFDLRGYTYSLKAENRAPAETSMNTVIEFVRNLQGFDGQSAIIKHLVDSMISYQNTLNQFTAAQARIDLAQAGITKD
IGILFECADKLSENQVNLRVEDVSQAKMLLSVWLIAALIMSALAAWVITNLIVGPLRDTLKLAERVADGDLTHNQVVTRK
DELGQLQGSMMRMTGNLRELIGGLRDGVTQIASAAEQLSAVTEQTSAGVNSQKNETDQVATAMHEMSATVQEVARNAEQA
SHAAVNASKEAREGDGVVSKAVAQIEKLATEVTHSKSAMDDLKNESNKIGGVLDVIKAVAEQTNLLALNAAIEAARAGEA
GRGFAVVADEVRSLAQRTQTSTEEIAALISGLHTRTAQVATILDNSQALTANSVELTRNAGVSINNMTQAISTIETMNHQ
IAAAAEEQSAVAEEINRSVLNVRDISEQTASASEETAASSVELARLGVHLQSLVSRFRV

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=454, Percent_Identity=29.295154185022, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI2367378, Length=387, Percent_Identity=32.2997416020672, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788194, Length=520, Percent_Identity=29.4230769230769, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788195, Length=335, Percent_Identity=32.2388059701493, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI1789453, Length=341, Percent_Identity=27.5659824046921, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 66676; Mature: 66676

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGFALVIVLTVLIALTGWTGITSLSERSERISDIGKLSALTRDVRIARLAYSVNYDAER
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ASNWLKALEGLENHVKYAQKVFDSPLNVPLVNTAADALKDYRIHYDNLMQATAAREATRS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFGQYADAGADDLQKLNAVARSDDGTPAQRDAIVQAMTLFQKMRFDLRGYTYSLKAENRA
HHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
PAETSMNTVIEFVRNLQGFDGQSAIIKHLVDSMISYQNTLNQFTAAQARIDLAQAGITKD
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IGILFECADKLSENQVNLRVEDVSQAKMLLSVWLIAALIMSALAAWVITNLIVGPLRDTL
HHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLAERVADGDLTHNQVVTRKDELGQLQGSMMRMTGNLRELIGGLRDGVTQIASAAEQLSA
HHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VTEQTSAGVNSQKNETDQVATAMHEMSATVQEVARNAEQASHAAVNASKEAREGDGVVSK
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHH
AVAQIEKLATEVTHSKSAMDDLKNESNKIGGVLDVIKAVAEQTNLLALNAAIEAARAGEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
GRGFAVVADEVRSLAQRTQTSTEEIAALISGLHTRTAQVATILDNSQALTANSVELTRNA
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC
GVSINNMTQAISTIETMNHQIAAAAEEQSAVAEEINRSVLNVRDISEQTASASEETAASS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VELARLGVHLQSLVSRFRV
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLGFALVIVLTVLIALTGWTGITSLSERSERISDIGKLSALTRDVRIARLAYSVNYDAER
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ASNWLKALEGLENHVKYAQKVFDSPLNVPLVNTAADALKDYRIHYDNLMQATAAREATRS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFGQYADAGADDLQKLNAVARSDDGTPAQRDAIVQAMTLFQKMRFDLRGYTYSLKAENRA
HHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
PAETSMNTVIEFVRNLQGFDGQSAIIKHLVDSMISYQNTLNQFTAAQARIDLAQAGITKD
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IGILFECADKLSENQVNLRVEDVSQAKMLLSVWLIAALIMSALAAWVITNLIVGPLRDTL
HHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLAERVADGDLTHNQVVTRKDELGQLQGSMMRMTGNLRELIGGLRDGVTQIASAAEQLSA
HHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VTEQTSAGVNSQKNETDQVATAMHEMSATVQEVARNAEQASHAAVNASKEAREGDGVVSK
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHH
AVAQIEKLATEVTHSKSAMDDLKNESNKIGGVLDVIKAVAEQTNLLALNAAIEAARAGEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
GRGFAVVADEVRSLAQRTQTSTEEIAALISGLHTRTAQVATILDNSQALTANSVELTRNA
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC
GVSINNMTQAISTIETMNHQIAAAAEEQSAVAEEINRSVLNVRDISEQTASASEETAASS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VELARLGVHLQSLVSRFRV
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]