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The map label for this gene is sucD [H]

Identifier: 66045253

GI number: 66045253

Start: 2336753

End: 2337634

Strand: Direct

Name: sucD [H]

Synonym: Psyr_2013

Alternate gene names: 66045253

Gene position: 2336753-2337634 (Clockwise)

Preceding gene: 66045252

Following gene: 66045255

Centisome position: 38.35

GC content: 58.16

Gene sequence:

>882_bases
ATGAGCGTCCTGATCAATAAAGACACCAAGGTTATCTGCCAGGGTTTCACTGGTTCGCAAGGTACCTTCCACTCCGAGCA
AGCCATTGCCTACGGCACCAAGATGGTGGGCGGCGTGACACCAGGCAAGGGTGGCACCACGCACCTGAACCTGCCCGTGT
TCAACACTGTGAAAGAAGCAGTAGACACCACTGGCGCAACCGCCAGCGTGATCTACGTTCCGGCTCCTTTCTGCAAGGAT
TCCATCCTTGAAGCAGCGTTCGGCGGCATCAAGCTGATCGTTTGCATCACCGAAGGCATCCCGACCATCGACATGCTGGA
AGCCAAGGTCAAGTGCGACGAGCTGGGTGTGGTCCTGATCGGTCCTAACTGCCCAGGCGTCATCACTCCGGGCGAGTGCA
AGATCGGCATCATGCCAGGTCACATTCACTTGCCAGGCAAGGTCGGCATCGTGTCGCGTTCCGGCACCCTGACTTACGAA
GCTGTGAAGCAGACCACTGACGCCGGTTTCGGTCAGTCCACCTGTGTTGGTATCGGCGGTGACCCGATCCCTGGCTCGAA
CTTCATCGACATCCTGAAGCTGTTCCAGGAAGATCCTAAGACCGAAGCGATCGTCATGATCGGTGAGATCGGCGGTTCGG
CTGAAGAAGAAGCGGCTGCCTACATCAAGGCACACGTGACCAAGCCGGTTGTTTCCTACATCGCTGGTGTGACTGCTCCT
CCGGGCAAGCGCATGGGCCATGCCGGTGCAATCATCTCGGGTGGTAAAGGTACTGCAGACGAGAAATTCGCTGCACTGCA
GGACGCTGGCGTGAAAACCGTGCGCTCCCTGGCAGACATCGGCAAGGCCCTGGCCGAGCTGACCGGTTGGCCGACCAAGT
AA

Upstream 100 bases:

>100_bases
TGGGCGCTAAAGTACTGGCAGAAAGCGGTTTGAACATCATCGCTGCTACCAGCCTGACCGACGCTGCTCAACAAGTTGTC
AAAGCCGCGGAGGGCAAGTA

Downstream 100 bases:

>100_bases
GCCTCGCTTGCTTTTCGGGTAATCGACAAAAGCCACCTCCGGGTGGCTTTTGTTTGGGCGGGTGAAAAGACCGCGGGGCG
TTCTGGCCCTGTTTCCTTCT

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSVLINKDTKVICQGFTGSQGTFHSEQAIAYGTKMVGGVTPGKGGTTHLNLPVFNTVKEAVDTTGATASVIYVPAPFCKD
SILEAAFGGIKLIVCITEGIPTIDMLEAKVKCDELGVVLIGPNCPGVITPGECKIGIMPGHIHLPGKVGIVSRSGTLTYE
AVKQTTDAGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPKTEAIVMIGEIGGSAEEEAAAYIKAHVTKPVVSYIAGVTAP
PGKRMGHAGAIISGGKGTADEKFAALQDAGVKTVRSLADIGKALAELTGWPTK

Sequences:

>Translated_293_residues
MSVLINKDTKVICQGFTGSQGTFHSEQAIAYGTKMVGGVTPGKGGTTHLNLPVFNTVKEAVDTTGATASVIYVPAPFCKD
SILEAAFGGIKLIVCITEGIPTIDMLEAKVKCDELGVVLIGPNCPGVITPGECKIGIMPGHIHLPGKVGIVSRSGTLTYE
AVKQTTDAGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPKTEAIVMIGEIGGSAEEEAAAYIKAHVTKPVVSYIAGVTAP
PGKRMGHAGAIISGGKGTADEKFAALQDAGVKTVRSLADIGKALAELTGWPTK
>Mature_292_residues
SVLINKDTKVICQGFTGSQGTFHSEQAIAYGTKMVGGVTPGKGGTTHLNLPVFNTVKEAVDTTGATASVIYVPAPFCKDS
ILEAAFGGIKLIVCITEGIPTIDMLEAKVKCDELGVVLIGPNCPGVITPGECKIGIMPGHIHLPGKVGIVSRSGTLTYEA
VKQTTDAGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPKTEAIVMIGEIGGSAEEEAAAYIKAHVTKPVVSYIAGVTAPP
GKRMGHAGAIISGGKGTADEKFAALQDAGVKTVRSLADIGKALAELTGWPTK

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=284, Percent_Identity=66.5492957746479, Blast_Score=324, Evalue=7e-89,
Organism=Homo sapiens, GI38569423, Length=255, Percent_Identity=34.5098039215686, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI38569421, Length=255, Percent_Identity=34.5098039215686, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786949, Length=284, Percent_Identity=88.0281690140845, Blast_Score=499, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17550194, Length=289, Percent_Identity=63.3217993079585, Blast_Score=338, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17553126, Length=290, Percent_Identity=60, Blast_Score=321, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17557344, Length=256, Percent_Identity=31.25, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17551266, Length=256, Percent_Identity=31.25, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324716, Length=294, Percent_Identity=52.3809523809524, Blast_Score=276, Evalue=2e-75,
Organism=Drosophila melanogaster, GI21356559, Length=291, Percent_Identity=58.4192439862543, Blast_Score=321, Evalue=3e-88,
Organism=Drosophila melanogaster, GI28574296, Length=288, Percent_Identity=60.4166666666667, Blast_Score=317, Evalue=8e-87,
Organism=Drosophila melanogaster, GI281363477, Length=259, Percent_Identity=30.8880308880309, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281363475, Length=259, Percent_Identity=30.8880308880309, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI281363473, Length=259, Percent_Identity=30.8880308880309, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30078; Mature: 29947

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLINKDTKVICQGFTGSQGTFHSEQAIAYGTKMVGGVTPGKGGTTHLNLPVFNTVKEA
CEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHH
VDTTGATASVIYVPAPFCKDSILEAAFGGIKLIVCITEGIPTIDMLEAKVKCDELGVVLI
HHCCCCCEEEEEECCCCCHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHEEHHHCCEEEE
GPNCPGVITPGECKIGIMPGHIHLPGKVGIVSRSGTLTYEAVKQTTDAGFGQSTCVGIGG
CCCCCCEECCCCEEEEEECCEEECCCCEEEEECCCCEEHHHHHHHHCCCCCCCEEEECCC
DPIPGSNFIDILKLFQEDPKTEAIVMIGEIGGSAEEEAAAYIKAHVTKPVVSYIAGVTAP
CCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTADEKFAALQDAGVKTVRSLADIGKALAELTGWPTK
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SVLINKDTKVICQGFTGSQGTFHSEQAIAYGTKMVGGVTPGKGGTTHLNLPVFNTVKEA
EEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHH
VDTTGATASVIYVPAPFCKDSILEAAFGGIKLIVCITEGIPTIDMLEAKVKCDELGVVLI
HHCCCCCEEEEEECCCCCHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHEEHHHCCEEEE
GPNCPGVITPGECKIGIMPGHIHLPGKVGIVSRSGTLTYEAVKQTTDAGFGQSTCVGIGG
CCCCCCEECCCCEEEEEECCEEECCCCEEEEECCCCEEHHHHHHHHCCCCCCCEEEECCC
DPIPGSNFIDILKLFQEDPKTEAIVMIGEIGGSAEEEAAAYIKAHVTKPVVSYIAGVTAP
CCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTADEKFAALQDAGVKTVRSLADIGKALAELTGWPTK
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]