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The map label for this gene is sthA [H]

Identifier: 66045142

GI number: 66045142

Start: 2176378

End: 2177811

Strand: Direct

Name: sthA [H]

Synonym: Psyr_1901

Alternate gene names: 66045142

Gene position: 2176378-2177811 (Clockwise)

Preceding gene: 66045141

Following gene: 66045145

Centisome position: 35.72

GC content: 59.0

Gene sequence:

>1434_bases
ATGCCAGAGTGGCGCCTCGGTCTGTTTAAAGGAGTACGCATGGCTGTCTACAACTACGACGTAGTGGTACTGGGTTCCGG
CCCTGCCGGAGAAGGCGCGGCAATGAACGCCGCCAAGGCGGGGCGCAAGGTCGCCATGGTCGACAGCCGTCGGCAAGTGG
GCGGTAACTGCACCCATTTGGGCACCATTCCGTCCAAGGCCCTGCGTCACTCGGTCAAGCAGATCATTCAGTTCAACACC
AACCCGATGTTTCGTGCCATCGGCGAGCCGCGCTGGTTTTCGTTTCCGGATGTGTTGAAAAACGCCGAAATGGTCATCTC
CAAGCAAGTGGCCTCGCGCACCAGTTACTACGCCCGCAACCGCGTCGACGTGTTCTTCGGCACCGGCAGTTTTGCCGACG
AGACCAGCATCAACGTGGTCTGCACCAACGGTGTGGTGGAAAAGCTGGTGGCCAACCAGATCATCATCGCCACCGGTTCG
CGCCCCTATCGGCCGGCCGACATCGATTTCAGTCACAAGCGCATCTACGACAGCGACACCATCCTCAGCCTGGGCCATAC
CCCGCGCAAGCTGATCATTTATGGCGCCGGTGTGATCGGCTGTGAATACGCCTCGATCTTCAGCGGCCTTGGCGTGCTGG
TCGAACTGGTGGATAACCGTGACCAGTTGCTGAGCTTCCTGGATTCGGAAATCTCCCAGGCGCTGAGCTATCACTTCAGC
AACAACAACGTCATGGTTCGCCACAACGAAGAGTACGAGAAGGTCGAAGGCCTGGATAACGGCGTTATCCTGCACCTGAA
GTCCGGCAAGAAGATCAAGGCCGATGCCTTGCTGTGGTGCAACGGCCGTACCGGCAACACCGACAAGCTGGGTCTTGAGA
ACATTGGTCTGAAAGCCAACGGTCGTGGTCAGATCGAAGTGGACGAGACCTACCGCACCAGCGTTTCCAACGTCTACGGC
GCAGGCGATGTGATTGGCTGGCCAAGCCTGGCCAGTGCTGCTTACGACCAGGGTCGTTCGGCCGCGGGCAGCATGGTCGA
CAATGGCAGCTGGCGTTATGTCAACGATGTGCCGACCGGGATCTACACGATTCCCGAGATCAGCTCGATCGGCAAGAACG
AACACGAACTGACGCAGGCCAAGGTGCCTTACGAGGTGGGCAAGGCGTTCTTCAAGGGCATGGCGCGCGCGCAGATTTCC
GGTGAGCGGGTCGGGATGCTGAAGATCCTGTTCCACCGCGAGACGCTCGAGGTGCTGGGCGTGCATTGCTTCGGCGACCA
GGCGTCCGAGATCGTGCACATCGGTCAGGCAATCATGAGTCAGCCGGGTGAAGCGAACACCATGAAGTACTTCGTCAACA
CCACGTTCAACTACCCGACCATGGCCGAAGCCTATCGGGTAGCCGCATACGACGGCCTCAACCGGCTTTTTTAA

Upstream 100 bases:

>100_bases
TTGCGCCATGTGCAGACAAAAATTGGCCTTCGACGCGACCAAGGGTTAATGTTCGCCGCCTCGGTGCAGCGCTAGACTGC
GCCGCGTGATTTAGCCAGAG

Downstream 100 bases:

>100_bases
GCGACTCCGGCCGGTGGCCTGAGCCGGCCGGGGAGACCGATTTCAGTGATTCCCGAGCGTGGCGGTGGCCAAACCGGGAA
AGTCTGTAATCAGGCTGTCG

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MPEWRLGLFKGVRMAVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDSRRQVGGNCTHLGTIPSKALRHSVKQIIQFNT
NPMFRAIGEPRWFSFPDVLKNAEMVISKQVASRTSYYARNRVDVFFGTGSFADETSINVVCTNGVVEKLVANQIIIATGS
RPYRPADIDFSHKRIYDSDTILSLGHTPRKLIIYGAGVIGCEYASIFSGLGVLVELVDNRDQLLSFLDSEISQALSYHFS
NNNVMVRHNEEYEKVEGLDNGVILHLKSGKKIKADALLWCNGRTGNTDKLGLENIGLKANGRGQIEVDETYRTSVSNVYG
AGDVIGWPSLASAAYDQGRSAAGSMVDNGSWRYVNDVPTGIYTIPEISSIGKNEHELTQAKVPYEVGKAFFKGMARAQIS
GERVGMLKILFHRETLEVLGVHCFGDQASEIVHIGQAIMSQPGEANTMKYFVNTTFNYPTMAEAYRVAAYDGLNRLF

Sequences:

>Translated_477_residues
MPEWRLGLFKGVRMAVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDSRRQVGGNCTHLGTIPSKALRHSVKQIIQFNT
NPMFRAIGEPRWFSFPDVLKNAEMVISKQVASRTSYYARNRVDVFFGTGSFADETSINVVCTNGVVEKLVANQIIIATGS
RPYRPADIDFSHKRIYDSDTILSLGHTPRKLIIYGAGVIGCEYASIFSGLGVLVELVDNRDQLLSFLDSEISQALSYHFS
NNNVMVRHNEEYEKVEGLDNGVILHLKSGKKIKADALLWCNGRTGNTDKLGLENIGLKANGRGQIEVDETYRTSVSNVYG
AGDVIGWPSLASAAYDQGRSAAGSMVDNGSWRYVNDVPTGIYTIPEISSIGKNEHELTQAKVPYEVGKAFFKGMARAQIS
GERVGMLKILFHRETLEVLGVHCFGDQASEIVHIGQAIMSQPGEANTMKYFVNTTFNYPTMAEAYRVAAYDGLNRLF
>Mature_476_residues
PEWRLGLFKGVRMAVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDSRRQVGGNCTHLGTIPSKALRHSVKQIIQFNTN
PMFRAIGEPRWFSFPDVLKNAEMVISKQVASRTSYYARNRVDVFFGTGSFADETSINVVCTNGVVEKLVANQIIIATGSR
PYRPADIDFSHKRIYDSDTILSLGHTPRKLIIYGAGVIGCEYASIFSGLGVLVELVDNRDQLLSFLDSEISQALSYHFSN
NNVMVRHNEEYEKVEGLDNGVILHLKSGKKIKADALLWCNGRTGNTDKLGLENIGLKANGRGQIEVDETYRTSVSNVYGA
GDVIGWPSLASAAYDQGRSAAGSMVDNGSWRYVNDVPTGIYTIPEISSIGKNEHELTQAKVPYEVGKAFFKGMARAQISG
ERVGMLKILFHRETLEVLGVHCFGDQASEIVHIGQAIMSQPGEANTMKYFVNTTFNYPTMAEAYRVAAYDGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=468, Percent_Identity=30.5555555555556, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI50301238, Length=472, Percent_Identity=26.271186440678, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI22035672, Length=487, Percent_Identity=28.1314168377823, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI291045266, Length=500, Percent_Identity=24.6, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI33519430, Length=479, Percent_Identity=24.2171189979123, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI33519428, Length=479, Percent_Identity=24.2171189979123, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI33519426, Length=479, Percent_Identity=24.2171189979123, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI148277065, Length=479, Percent_Identity=24.2171189979123, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI148277071, Length=479, Percent_Identity=24.2171189979123, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI291045268, Length=370, Percent_Identity=25.6756756756757, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=61.038961038961, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1786307, Length=460, Percent_Identity=30.6521739130435, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789915, Length=440, Percent_Identity=28.1818181818182, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87081717, Length=464, Percent_Identity=27.1551724137931, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=467, Percent_Identity=30.1927194860814, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17557007, Length=476, Percent_Identity=25.2100840336134, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71983419, Length=391, Percent_Identity=25.5754475703325, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71983429, Length=381, Percent_Identity=25.9842519685039, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17559934, Length=222, Percent_Identity=28.3783783783784, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=477, Percent_Identity=29.979035639413, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=28.6637931034483, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=27.2340425531915, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21358499, Length=469, Percent_Identity=30.9168443496802, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=26.890756302521, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=26.890756302521, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24640551, Length=479, Percent_Identity=26.7223382045929, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17737741, Length=490, Percent_Identity=25.9183673469388, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 52354; Mature: 52223

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEWRLGLFKGVRMAVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDSRRQVGGNCTHL
CCCCHHHHHHCCEEEEEEEEEEEECCCCCCCCCCCCHHHCCCEEEEECCHHHCCCCEEEE
GTIPSKALRHSVKQIIQFNTNPMFRAIGEPRWFSFPDVLKNAEMVISKQVASRTSYYARN
CCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCC
RVDVFFGTGSFADETSINVVCTNGVVEKLVANQIIIATGSRPYRPADIDFSHKRIYDSDT
CEEEEEECCCCCCCCCEEEEECCHHHHHHHCCEEEEEECCCCCCCCCCCCCHHEECCCCC
ILSLGHTPRKLIIYGAGVIGCEYASIFSGLGVLVELVDNRDQLLSFLDSEISQALSYHFS
EEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEC
NNNVMVRHNEEYEKVEGLDNGVILHLKSGKKIKADALLWCNGRTGNTDKLGLENIGLKAN
CCCEEEEECCHHHHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHCCEEEC
GRGQIEVDETYRTSVSNVYGAGDVIGWPSLASAAYDQGRSAAGSMVDNGSWRYVNDVPTG
CCCEEEECHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
IYTIPEISSIGKNEHELTQAKVPYEVGKAFFKGMARAQISGERVGMLKILFHRETLEVLG
EEECCCHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHEE
VHCFGDQASEIVHIGQAIMSQPGEANTMKYFVNTTFNYPTMAEAYRVAAYDGLNRLF
EEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PEWRLGLFKGVRMAVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDSRRQVGGNCTHL
CCCHHHHHHCCEEEEEEEEEEEECCCCCCCCCCCCHHHCCCEEEEECCHHHCCCCEEEE
GTIPSKALRHSVKQIIQFNTNPMFRAIGEPRWFSFPDVLKNAEMVISKQVASRTSYYARN
CCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCC
RVDVFFGTGSFADETSINVVCTNGVVEKLVANQIIIATGSRPYRPADIDFSHKRIYDSDT
CEEEEEECCCCCCCCCEEEEECCHHHHHHHCCEEEEEECCCCCCCCCCCCCHHEECCCCC
ILSLGHTPRKLIIYGAGVIGCEYASIFSGLGVLVELVDNRDQLLSFLDSEISQALSYHFS
EEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEC
NNNVMVRHNEEYEKVEGLDNGVILHLKSGKKIKADALLWCNGRTGNTDKLGLENIGLKAN
CCCEEEEECCHHHHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHCCEEEC
GRGQIEVDETYRTSVSNVYGAGDVIGWPSLASAAYDQGRSAAGSMVDNGSWRYVNDVPTG
CCCEEEECHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
IYTIPEISSIGKNEHELTQAKVPYEVGKAFFKGMARAQISGERVGMLKILFHRETLEVLG
EEECCCHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHEE
VHCFGDQASEIVHIGQAIMSQPGEANTMKYFVNTTFNYPTMAEAYRVAAYDGLNRLF
EEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA