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The map label for this gene is gap [H]

Identifier: 66045138

GI number: 66045138

Start: 2170617

End: 2172080

Strand: Direct

Name: gap [H]

Synonym: Psyr_1897

Alternate gene names: 66045138

Gene position: 2170617-2172080 (Clockwise)

Preceding gene: 66045134

Following gene: 66045139

Centisome position: 35.62

GC content: 59.63

Gene sequence:

>1464_bases
ATGTGGAAGGTTCCCGTGACTCAGAAGCCCGACCAGTGTCTTGGTGAATGGATTGATCGTGAAGCTCTCGCCGAAGCGAT
GATCCCGCTCATCGGTCAGCTCTACCGCAATAATAATGTGGTGAGCTCGATCTATGGCCGTAGCCTGATCAACCGTTCAG
TCATCGCGATTCTCAAAGCTCACCGCTTTGCGCGTCATCGTCAGTCCGATGCGGTTGAGTTGTCCGTACACGAGACGTTC
CCGCTGATCAAGGCGATGAGCGAGCTCAAGCTGGGTGCCGCTTCGGTGGACCTGGGCAAGCTGGCCGTGAAGTTCAAGAC
CGAAGGCAATGGCCGCACGCCAGAGCAGTTCGTTCGTGAAGAACTGGCCAGTGTAGTGGGTCAGCAGGGCACCAGCCCTC
GCAAGGGCACTGACGTCGTGCTGTACGGTTTCGGTCGTATCGGTCGCCTGCTGGCGCGGATCCTGATCGAGAAGACCGGT
GGTGGCGACGGCCTGCGTCTGCGCGCCATCGTGGTCCGCAAGGGCGCGGAAAACGATCTGGTCAAGCGCGCGAGCCTGCT
GCGCCGTGACTCGGTTCACGGTCCGTTCGATGGCACTATCACCATCGACGAAGCCAATAGCACGCTCACCGCCAACGGCA
ACCTGATTCAGGTGATCTACGCCAAGAACCCGTCCGAGGTGGATTACACCCAGTACGGTATCAAGGACGCCCTGCTGGTG
GACAACACCGGTGTATGGCGTGATGCCGAAGGTCTGGGTCAGCATCTGGCCTGCCCGGGCATCGACCGTGTGGTCCTGAC
CGCGCCGGGCAAAGGCAAGCTGAAGAACATCGTGCACGGTATCAACCACGGTGAAATCACCGCGGACGACAAGATCGTCT
CGGCGGCCTCCTGCACCACCAACGCCATTGTGCCGGTGCTCAAGGCGGTCAACGACAAGTTCGGCATCACCAACGGTCAC
GTCGAAACGGTTCACTCGTACACCAACGACCAGAACCTGATCGACAACTTCCACAAGGGCGACCGCCGTGGTCGCAGCGC
TGCGTTGAACATGGTCATCACCGAAACCGGTGCGGCCACCGCTGCTGCCAAGGCATTGCCTGAGCTGGCCGGCAAGCTGA
CCGGCAACGCGATTCGTGTTCCGACGCCGAACGTGTCCATGGCCATTCTCAACCTCAACCTCGAGAAGCAGACCACTCGC
GAAGAAATGAACGAGTACCTGCGCTACATGGCGCTGCACTCGGACCTGCACAAGCAGATCGACTTCGTGAACTCGCAGGA
AGTGGTCTCCACTGACTTCGTCGGCTCGCGTCACGCCGGTGTCGTGGACGCCGAAGCCACCATCGTCAACGACAATCGCG
TTGTGCTGTACGTCTGGTACGACAACGAATTCGGTTACAGCCACCAGGTGGTTCGTGTGATGGAAGACATGGCAGACGTC
AATCCGCCAGCTTTCCCGCAGTAA

Upstream 100 bases:

>100_bases
TTTACGGGCGAAAATTATGTAGTGCGTGTCGATATGACAGCCGTGCATTGCTCATAAACAAAGGCGCGGTCATAATGTAG
CCCCTTTTTTCAGCCCCTAC

Downstream 100 bases:

>100_bases
ACGTTGAACGCTTGAGCTGTCCGGTCTGACCGGGGCAGCAGATAAACGGGCCGAACCCTGCGCAGGCAGGCTTCGGCCCG
TTTTGTTTTGTGGCTGACCA

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MWKVPVTQKPDQCLGEWIDREALAEAMIPLIGQLYRNNNVVSSIYGRSLINRSVIAILKAHRFARHRQSDAVELSVHETF
PLIKAMSELKLGAASVDLGKLAVKFKTEGNGRTPEQFVREELASVVGQQGTSPRKGTDVVLYGFGRIGRLLARILIEKTG
GGDGLRLRAIVVRKGAENDLVKRASLLRRDSVHGPFDGTITIDEANSTLTANGNLIQVIYAKNPSEVDYTQYGIKDALLV
DNTGVWRDAEGLGQHLACPGIDRVVLTAPGKGKLKNIVHGINHGEITADDKIVSAASCTTNAIVPVLKAVNDKFGITNGH
VETVHSYTNDQNLIDNFHKGDRRGRSAALNMVITETGAATAAAKALPELAGKLTGNAIRVPTPNVSMAILNLNLEKQTTR
EEMNEYLRYMALHSDLHKQIDFVNSQEVVSTDFVGSRHAGVVDAEATIVNDNRVVLYVWYDNEFGYSHQVVRVMEDMADV
NPPAFPQ

Sequences:

>Translated_487_residues
MWKVPVTQKPDQCLGEWIDREALAEAMIPLIGQLYRNNNVVSSIYGRSLINRSVIAILKAHRFARHRQSDAVELSVHETF
PLIKAMSELKLGAASVDLGKLAVKFKTEGNGRTPEQFVREELASVVGQQGTSPRKGTDVVLYGFGRIGRLLARILIEKTG
GGDGLRLRAIVVRKGAENDLVKRASLLRRDSVHGPFDGTITIDEANSTLTANGNLIQVIYAKNPSEVDYTQYGIKDALLV
DNTGVWRDAEGLGQHLACPGIDRVVLTAPGKGKLKNIVHGINHGEITADDKIVSAASCTTNAIVPVLKAVNDKFGITNGH
VETVHSYTNDQNLIDNFHKGDRRGRSAALNMVITETGAATAAAKALPELAGKLTGNAIRVPTPNVSMAILNLNLEKQTTR
EEMNEYLRYMALHSDLHKQIDFVNSQEVVSTDFVGSRHAGVVDAEATIVNDNRVVLYVWYDNEFGYSHQVVRVMEDMADV
NPPAFPQ
>Mature_487_residues
MWKVPVTQKPDQCLGEWIDREALAEAMIPLIGQLYRNNNVVSSIYGRSLINRSVIAILKAHRFARHRQSDAVELSVHETF
PLIKAMSELKLGAASVDLGKLAVKFKTEGNGRTPEQFVREELASVVGQQGTSPRKGTDVVLYGFGRIGRLLARILIEKTG
GGDGLRLRAIVVRKGAENDLVKRASLLRRDSVHGPFDGTITIDEANSTLTANGNLIQVIYAKNPSEVDYTQYGIKDALLV
DNTGVWRDAEGLGQHLACPGIDRVVLTAPGKGKLKNIVHGINHGEITADDKIVSAASCTTNAIVPVLKAVNDKFGITNGH
VETVHSYTNDQNLIDNFHKGDRRGRSAALNMVITETGAATAAAKALPELAGKLTGNAIRVPTPNVSMAILNLNLEKQTTR
EEMNEYLRYMALHSDLHKQIDFVNSQEVVSTDFVGSRHAGVVDAEATIVNDNRVVLYVWYDNEFGYSHQVVRVMEDMADV
NPPAFPQ

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=338, Percent_Identity=39.3491124260355, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI7657116, Length=338, Percent_Identity=37.2781065088757, Blast_Score=195, Evalue=1e-49,
Organism=Escherichia coli, GI1788079, Length=341, Percent_Identity=38.7096774193548, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1789295, Length=344, Percent_Identity=31.6860465116279, Blast_Score=165, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17534677, Length=351, Percent_Identity=37.8917378917379, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17534679, Length=351, Percent_Identity=37.3219373219373, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17568413, Length=348, Percent_Identity=38.2183908045977, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI32566163, Length=348, Percent_Identity=38.2183908045977, Blast_Score=186, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6322409, Length=343, Percent_Identity=37.9008746355685, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322468, Length=346, Percent_Identity=36.9942196531792, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6321631, Length=346, Percent_Identity=36.9942196531792, Blast_Score=196, Evalue=8e-51,
Organism=Drosophila melanogaster, GI85725000, Length=337, Percent_Identity=37.9821958456973, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI22023983, Length=337, Percent_Identity=37.9821958456973, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17933600, Length=337, Percent_Identity=37.6854599406528, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI18110149, Length=337, Percent_Identity=37.6854599406528, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI19922412, Length=332, Percent_Identity=37.9518072289157, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 53257; Mature: 53257

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWKVPVTQKPDQCLGEWIDREALAEAMIPLIGQLYRNNNVVSSIYGRSLINRSVIAILKA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
HRFARHRQSDAVELSVHETFPLIKAMSELKLGAASVDLGKLAVKFKTEGNGRTPEQFVRE
HHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHH
ELASVVGQQGTSPRKGTDVVLYGFGRIGRLLARILIEKTGGGDGLRLRAIVVRKGAENDL
HHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHH
VKRASLLRRDSVHGPFDGTITIDEANSTLTANGNLIQVIYAKNPSEVDYTQYGIKDALLV
HHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCEEEEEEECCCCCCCHHHHCCCCEEEE
DNTGVWRDAEGLGQHLACPGIDRVVLTAPGKGKLKNIVHGINHGEITADDKIVSAASCTT
CCCCCCCCHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCEECCCCEEEHHCCCH
NAIVPVLKAVNDKFGITNGHVETVHSYTNDQNLIDNFHKGDRRGRSAALNMVITETGAAT
HHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCHHEEEEEEECCCCHH
AAAKALPELAGKLTGNAIRVPTPNVSMAILNLNLEKQTTREEMNEYLRYMALHSDLHKQI
HHHHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
DFVNSQEVVSTDFVGSRHAGVVDAEATIVNDNRVVLYVWYDNEFGYSHQVVRVMEDMADV
HCCCCCHHHHHCCCCCCCCCEEECCEEEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHC
NPPAFPQ
CCCCCCC
>Mature Secondary Structure
MWKVPVTQKPDQCLGEWIDREALAEAMIPLIGQLYRNNNVVSSIYGRSLINRSVIAILKA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
HRFARHRQSDAVELSVHETFPLIKAMSELKLGAASVDLGKLAVKFKTEGNGRTPEQFVRE
HHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHH
ELASVVGQQGTSPRKGTDVVLYGFGRIGRLLARILIEKTGGGDGLRLRAIVVRKGAENDL
HHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHH
VKRASLLRRDSVHGPFDGTITIDEANSTLTANGNLIQVIYAKNPSEVDYTQYGIKDALLV
HHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCEEEEEEECCCCCCCHHHHCCCCEEEE
DNTGVWRDAEGLGQHLACPGIDRVVLTAPGKGKLKNIVHGINHGEITADDKIVSAASCTT
CCCCCCCCHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCEECCCCEEEHHCCCH
NAIVPVLKAVNDKFGITNGHVETVHSYTNDQNLIDNFHKGDRRGRSAALNMVITETGAAT
HHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCHHEEEEEEECCCCHH
AAAKALPELAGKLTGNAIRVPTPNVSMAILNLNLEKQTTREEMNEYLRYMALHSDLHKQI
HHHHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
DFVNSQEVVSTDFVGSRHAGVVDAEATIVNDNRVVLYVWYDNEFGYSHQVVRVMEDMADV
HCCCCCHHHHHCCCCCCCCCEEECCEEEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHC
NPPAFPQ
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8508805; 10360571; 2401296; 7877172 [H]