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The map label for this gene is hexR [H]

Identifier: 66044370

GI number: 66044370

Start: 1268157

End: 1269023

Strand: Reverse

Name: hexR [H]

Synonym: Psyr_1119

Alternate gene names: 66044370

Gene position: 1269023-1268157 (Counterclockwise)

Preceding gene: 66044374

Following gene: 66044359

Centisome position: 20.83

GC content: 60.21

Gene sequence:

>867_bases
ATGGACCGCGTAAGAAACCTCCTGGAGCAAATCCAGGGCCGACTCGACGAGCTGAACAAGGCCGAACGCAAAGTGGCCGA
AGTCATCCTGCTCAACCCGCAGATGGCCACGCGGCTGAGCATTGCAGCGCTTGCCCAGGCCGCCAAGGTCAGCGAGCCGA
CGGTCAATCGCTTCTGCCGTTCGTTCAGTGTCAGTGGCTATCCGGAATTGAAGCTGCAACTGGCCCAGAGCCTGGCCAGT
GGCGCGGCCTATGTCAGCCGTGCGGTGGAAGCCGATGATAATCCGGAGGCCTATACCCAGAAGATTTTCGGCAGCGCCAT
CGCGTCACTGGACAGCGCGTGCCAGCAATTGGACCCGGCTTTGATCAGCAAGTCTGTGGACATGCTCATCCAGGCGCGGC
AGATCCATTTTTTCGGGCTGGGTGCCTCCGCGCCGGTAGCCCTGGACGCGCAGCATAAATTCTTTCGCTTCAATCTGGCG
GTGACGGCGCATGCCGATGTGCTGATGCAGCGGATGATTGCGTCGGTGGCTCATACCGGCGAGTTGTTCGTGATCATTTC
GTATACGGGCCGTACCCGTGAGTTGGTGGAGGTGGCGCGTATCGCGCGGGCCAACGGCGCGTCGGTGCTGGGGCTGACGG
CAGCCGGCTCGCCGCTGGCCCAGGCCAGTACGGTGAGTCTGAACATTCCTCTGCCGGAAGATACGGATATTTATATGCCG
ATGACGTCGCGGATCATTCAGTTGACTGTGCTCGATGTGCTGGCCACGGGTATGACGCTGCGCCGCGGCGTCGATTTTCA
GCCGCATTTGCGCAAGATCAAGGAAAGTCTGAATGACAGCCGTTATCCGATCGAGGATCAGGGCTGA

Upstream 100 bases:

>100_bases
ACAGGCCCTCAGTACGATAGGCCACCTTTGCTACAGGCTAAAGGGCTAATAAAAGCCCGAAGCAAAACCGTTGGTAAATC
AGCCCCGACAAGGACTTTGA

Downstream 100 bases:

>100_bases
CTGGGTGTCGTTGACTATCGTGCCGACGCTACGCGTCGGCATGCAGTTCGTGACGCTCTGCGTCATCTGCAACTCACCCC
GCCAGGCTGGCTTGCAGTTT

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MDRVRNLLEQIQGRLDELNKAERKVAEVILLNPQMATRLSIAALAQAAKVSEPTVNRFCRSFSVSGYPELKLQLAQSLAS
GAAYVSRAVEADDNPEAYTQKIFGSAIASLDSACQQLDPALISKSVDMLIQARQIHFFGLGASAPVALDAQHKFFRFNLA
VTAHADVLMQRMIASVAHTGELFVIISYTGRTRELVEVARIARANGASVLGLTAAGSPLAQASTVSLNIPLPEDTDIYMP
MTSRIIQLTVLDVLATGMTLRRGVDFQPHLRKIKESLNDSRYPIEDQG

Sequences:

>Translated_288_residues
MDRVRNLLEQIQGRLDELNKAERKVAEVILLNPQMATRLSIAALAQAAKVSEPTVNRFCRSFSVSGYPELKLQLAQSLAS
GAAYVSRAVEADDNPEAYTQKIFGSAIASLDSACQQLDPALISKSVDMLIQARQIHFFGLGASAPVALDAQHKFFRFNLA
VTAHADVLMQRMIASVAHTGELFVIISYTGRTRELVEVARIARANGASVLGLTAAGSPLAQASTVSLNIPLPEDTDIYMP
MTSRIIQLTVLDVLATGMTLRRGVDFQPHLRKIKESLNDSRYPIEDQG
>Mature_288_residues
MDRVRNLLEQIQGRLDELNKAERKVAEVILLNPQMATRLSIAALAQAAKVSEPTVNRFCRSFSVSGYPELKLQLAQSLAS
GAAYVSRAVEADDNPEAYTQKIFGSAIASLDSACQQLDPALISKSVDMLIQARQIHFFGLGASAPVALDAQHKFFRFNLA
VTAHADVLMQRMIASVAHTGELFVIISYTGRTRELVEVARIARANGASVLGLTAAGSPLAQASTVSLNIPLPEDTDIYMP
MTSRIIQLTVLDVLATGMTLRRGVDFQPHLRKIKESLNDSRYPIEDQG

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=277, Percent_Identity=55.956678700361, Blast_Score=323, Evalue=8e-90,
Organism=Escherichia coli, GI87082369, Length=238, Percent_Identity=24.3697478991597, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788767, Length=259, Percent_Identity=25.4826254826255, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082130, Length=215, Percent_Identity=30.2325581395349, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31363; Mature: 31363

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRVRNLLEQIQGRLDELNKAERKVAEVILLNPQMATRLSIAALAQAAKVSEPTVNRFCR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCCHHHHHHHH
SFSVSGYPELKLQLAQSLASGAAYVSRAVEADDNPEAYTQKIFGSAIASLDSACQQLDPA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHH
LISKSVDMLIQARQIHFFGLGASAPVALDAQHKFFRFNLAVTAHADVLMQRMIASVAHTG
HHHHHHHHHHHHHHEEEEECCCCCCEEECCCCEEEEEEEEEEHHHHHHHHHHHHHHHCCC
ELFVIISYTGRTRELVEVARIARANGASVLGLTAAGSPLAQASTVSLNIPLPEDTDIYMP
CEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEECC
MTSRIIQLTVLDVLATGMTLRRGVDFQPHLRKIKESLNDSRYPIEDQG
HHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDRVRNLLEQIQGRLDELNKAERKVAEVILLNPQMATRLSIAALAQAAKVSEPTVNRFCR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCCCHHHHHHHH
SFSVSGYPELKLQLAQSLASGAAYVSRAVEADDNPEAYTQKIFGSAIASLDSACQQLDPA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHH
LISKSVDMLIQARQIHFFGLGASAPVALDAQHKFFRFNLAVTAHADVLMQRMIASVAHTG
HHHHHHHHHHHHHHEEEEECCCCCCEEECCCCEEEEEEEEEEHHHHHHHHHHHHHHHCCC
ELFVIISYTGRTRELVEVARIARANGASVLGLTAAGSPLAQASTVSLNIPLPEDTDIYMP
CEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEECC
MTSRIIQLTVLDVLATGMTLRRGVDFQPHLRKIKESLNDSRYPIEDQG
HHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]