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The map label for this gene is fabF [H]

Identifier: 66043689

GI number: 66043689

Start: 461547

End: 462773

Strand: Reverse

Name: fabF [H]

Synonym: Psyr_0422

Alternate gene names: 66043689

Gene position: 462773-461547 (Counterclockwise)

Preceding gene: 66043690

Following gene: 66043687

Centisome position: 7.59

GC content: 63.41

Gene sequence:

>1227_bases
ATGAAGCGTGTGGTAGTGACCGGCATGTCCGGCATCACCTCGGTAGGCAGCGACTGGCCGACTATCGATGCACGCTTTAC
GGCCAATCGCAGCGGCATTCGCCGGATGGACGAGTGGAACCGCTTTGCCGAGCTCAATACTCGCCTGGCTGGTCCCATCG
ACGATTTCGCCGTGCCGGGGCACTGGACGCGCAAGCAACTGCGCAGCATGGGCCGCGTGTCACGCCTGGCCGTGGCGGCT
GCCGAGCAGGCCCTGATCGACGCCGGGCTGCTGAATGACCCGATCATTCGCGATGGGCGCATGGGCACGGCCTGCGGTTC
GTCCACCGGCAGCACCGACGAGATCAAGGCCTTCGGCAACATGCTGATCAACTCGGTGGCCGTGGGCCTGAACGCCAATT
CCTATGTGCGGATGATGCCGCACACCACCGCCGCCAACATCAGTATCTTCTTCGGCCTGACCGGACGCCTGATTCCGACC
TCCAGCGCCTGTACCAGCGGCAGTCAGGGCATCGGCTATGCCTATGAGGCAATCAAGTTCGGCCGTCTGCCGCTGATGCT
GGCGGGCGGGGCCGAAGAGCTGTGCCCGACCGAGGCCATGGTCTTCGACGCGCTGTACGCCACCAGCCTCAAGAATGACG
CGCCACACACCACACCACGCCCCTACGACAGCGGACGCGACGGCCTGGTGATCGGTGAAGGCGGCGGCATGCTGGTGCTT
GAAGAGCTTGAGCATGCCCAGGCACGGGGGGCGCACATCTACGCCGAAATAGTCGGCTTCGGCAGCAACGCCGACGGCGC
GCACAGCACTCGCCCCGAGCAGACCACCATGCGCCGCGCGATGGAGCTGGCCCTCGAAGACGCCAACCTGTCGCCCGACG
CCATCGGTTACGTCAACGGTCACGGCACCGCCACCGAACAAGGCGACATCGCCGAGACCCTGGCCACCAGCAGCCTGTTC
GGCCCGCGCATGCCACTTAGCTCGCAAAAAAGCTTTCTCGGTCACACGCTGGGAGCGTGCGGCGCGCTGGAATCATGGTT
CAGCATCGAAATGCTCAACAGCGATCGCTATATCCATACCCTGAACCTGGTCGACATCGACCCACAGTGCGGCGAACTGG
ACTACATCGTCGGCGAACCAAGGCACATGAGCAACGAATACGTGATGAACAACAACTTCGCATTTGGCGGCGTGAACACC
TCGCTGATCTTCAGGCGTTGGGGCTAA

Upstream 100 bases:

>100_bases
GCACGCCCGAGGAAGTGGCGGGTGCGGTGAATTTTCTGATGTCGACCGAAGCGAGCTACATCACTCGTCAGGTTCTGGCC
GTCAACGGGGGACTGTGCTG

Downstream 100 bases:

>100_bases
GGGTATTCTCTGAGCCGCCTGTCGTTCCTCACGCGCCAGCCCACACACCTATCGTTCCCTACGCTCCAGCGTGGGAATAC
AGTTCTGCACCGCATGCACC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MKRVVVTGMSGITSVGSDWPTIDARFTANRSGIRRMDEWNRFAELNTRLAGPIDDFAVPGHWTRKQLRSMGRVSRLAVAA
AEQALIDAGLLNDPIIRDGRMGTACGSSTGSTDEIKAFGNMLINSVAVGLNANSYVRMMPHTTAANISIFFGLTGRLIPT
SSACTSGSQGIGYAYEAIKFGRLPLMLAGGAEELCPTEAMVFDALYATSLKNDAPHTTPRPYDSGRDGLVIGEGGGMLVL
EELEHAQARGAHIYAEIVGFGSNADGAHSTRPEQTTMRRAMELALEDANLSPDAIGYVNGHGTATEQGDIAETLATSSLF
GPRMPLSSQKSFLGHTLGACGALESWFSIEMLNSDRYIHTLNLVDIDPQCGELDYIVGEPRHMSNEYVMNNNFAFGGVNT
SLIFRRWG

Sequences:

>Translated_408_residues
MKRVVVTGMSGITSVGSDWPTIDARFTANRSGIRRMDEWNRFAELNTRLAGPIDDFAVPGHWTRKQLRSMGRVSRLAVAA
AEQALIDAGLLNDPIIRDGRMGTACGSSTGSTDEIKAFGNMLINSVAVGLNANSYVRMMPHTTAANISIFFGLTGRLIPT
SSACTSGSQGIGYAYEAIKFGRLPLMLAGGAEELCPTEAMVFDALYATSLKNDAPHTTPRPYDSGRDGLVIGEGGGMLVL
EELEHAQARGAHIYAEIVGFGSNADGAHSTRPEQTTMRRAMELALEDANLSPDAIGYVNGHGTATEQGDIAETLATSSLF
GPRMPLSSQKSFLGHTLGACGALESWFSIEMLNSDRYIHTLNLVDIDPQCGELDYIVGEPRHMSNEYVMNNNFAFGGVNT
SLIFRRWG
>Mature_408_residues
MKRVVVTGMSGITSVGSDWPTIDARFTANRSGIRRMDEWNRFAELNTRLAGPIDDFAVPGHWTRKQLRSMGRVSRLAVAA
AEQALIDAGLLNDPIIRDGRMGTACGSSTGSTDEIKAFGNMLINSVAVGLNANSYVRMMPHTTAANISIFFGLTGRLIPT
SSACTSGSQGIGYAYEAIKFGRLPLMLAGGAEELCPTEAMVFDALYATSLKNDAPHTTPRPYDSGRDGLVIGEGGGMLVL
EELEHAQARGAHIYAEIVGFGSNADGAHSTRPEQTTMRRAMELALEDANLSPDAIGYVNGHGTATEQGDIAETLATSSLF
GPRMPLSSQKSFLGHTLGACGALESWFSIEMLNSDRYIHTLNLVDIDPQCGELDYIVGEPRHMSNEYVMNNNFAFGGVNT
SLIFRRWG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=31.0262529832936, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI223972627, Length=161, Percent_Identity=34.7826086956522, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI41872631, Length=354, Percent_Identity=26.271186440678, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=38.6473429951691, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1788663, Length=411, Percent_Identity=37.712895377129, Blast_Score=230, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=29.8329355608592, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=34.8314606741573, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI212642053, Length=358, Percent_Identity=27.3743016759777, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=265, Percent_Identity=27.1698113207547, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=33.4085778781038, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24644341, Length=424, Percent_Identity=33.9622641509434, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI19920632, Length=364, Percent_Identity=25.5494505494505, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221330659, Length=287, Percent_Identity=26.4808362369338, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581345, Length=381, Percent_Identity=24.6719160104987, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43880; Mature: 43880

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVVTGMSGITSVGSDWPTIDARFTANRSGIRRMDEWNRFAELNTRLAGPIDDFAVPG
CCEEEEECCCCHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCC
HWTRKQLRSMGRVSRLAVAAAEQALIDAGLLNDPIIRDGRMGTACGSSTGSTDEIKAFGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
MLINSVAVGLNANSYVRMMPHTTAANISIFFGLTGRLIPTSSACTSGSQGIGYAYEAIKF
HHHHHHEECCCCCCEEEECCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCHHHHHHHH
GRLPLMLAGGAEELCPTEAMVFDALYATSLKNDAPHTTPRPYDSGRDGLVIGEGGGMLVL
CCCCEEEECCCHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEE
EELEHAQARGAHIYAEIVGFGSNADGAHSTRPEQTTMRRAMELALEDANLSPDAIGYVNG
HHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECC
HGTATEQGDIAETLATSSLFGPRMPLSSQKSFLGHTLGACGALESWFSIEMLNSDRYIHT
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCEEEE
LNLVDIDPQCGELDYIVGEPRHMSNEYVMNNNFAFGGVNTSLIFRRWG
EEEEEECCCCCCCCEEECCCCCCCCCEEEECCEEECCCCEEEEEEECC
>Mature Secondary Structure
MKRVVVTGMSGITSVGSDWPTIDARFTANRSGIRRMDEWNRFAELNTRLAGPIDDFAVPG
CCEEEEECCCCHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCC
HWTRKQLRSMGRVSRLAVAAAEQALIDAGLLNDPIIRDGRMGTACGSSTGSTDEIKAFGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
MLINSVAVGLNANSYVRMMPHTTAANISIFFGLTGRLIPTSSACTSGSQGIGYAYEAIKF
HHHHHHEECCCCCCEEEECCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCHHHHHHHH
GRLPLMLAGGAEELCPTEAMVFDALYATSLKNDAPHTTPRPYDSGRDGLVIGEGGGMLVL
CCCCEEEECCCHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEE
EELEHAQARGAHIYAEIVGFGSNADGAHSTRPEQTTMRRAMELALEDANLSPDAIGYVNG
HHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECC
HGTATEQGDIAETLATSSLFGPRMPLSSQKSFLGHTLGACGALESWFSIEMLNSDRYIHT
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCEEEE
LNLVDIDPQCGELDYIVGEPRHMSNEYVMNNNFAFGGVNTSLIFRRWG
EEEEEECCCCCCCCEEECCCCCCCCCEEEECCEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]