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The map label for this gene is hexR [H]

Identifier: 66043683

GI number: 66043683

Start: 454569

End: 455429

Strand: Reverse

Name: hexR [H]

Synonym: Psyr_0416

Alternate gene names: 66043683

Gene position: 455429-454569 (Counterclockwise)

Preceding gene: 66043684

Following gene: 66043682

Centisome position: 7.47

GC content: 63.88

Gene sequence:

>861_bases
GTGGACATTCTGTACCAGATACGTGCCCGTCAGGATTCCTTCAGTGCGGGAGAAGGCCGAATCGCCAGGCTGTTGCTCAG
CGATATCGCCTTCGCGGCCAGTGCCAGTCTGGATGAGCTGGCCAGCCGCGCCGAGGTCAGCAGTGCGACGCTGTCACGTT
TTGCGCGCAGCATCGGTTGCCGGGATCTGCGCGACTTGCGCCTGCAACTGGCTCAGGCCAGCGGCGTCGGCAGCCGCTTT
TTGCATCCGGAACCGGCGCCGGAGCAGTCGGCCTTTTTCGCCCGGATTGTCGACGACATCGAAGCCACCCTGCGCCAGCA
CCTGGCAGGCTTCGATGCAACACGCTTTGCCGCCGCCATCGCCTGCGTCACCGATGCACGCATGATTCACACATTCGGCA
TGGGCGGTTGCTCCAGCCTGTGCAGCGAGGAACTGCAAACCCGGCTGGTGCGCCTGGGTTATCCGGTGGCCGCCTGCCGC
GACCCGGTGATGATGCGCATGGTCGCCGCTACGCTTGGCCCGCAACACAGTCTGATTGTCTGCTCGCTCAGCGGACGCAC
GCCGGAACTGCTCGACGCCGTGACCCTGGCGCGCAGCTACGGTGCCCGCGTGCTGGCCATCACCCTGCCTGATTCACCGC
TGGCACAACTGGCCGAGGTCGTGCTGCCGTTACAGATTGCTGAAACCAATTTCATCTATAAACCCACCGCAGCGCGTTAC
GGCATGCTGCTGACCATCGATGTGCTGGCCACTGAACTGGCGCTGTCGAGCCCTGAAGACAACCAGGAGCGGCTGCGCCG
GATCAAGCTTGCGCTGGATGAATACCGTGGCGGCGAAGATGGCCTGCCGCTGGGAGACTGA

Upstream 100 bases:

>100_bases
CATGACCGTTGCGCAAACGTTCAAGACCTGGACGGTCTTGGAGACGCTGATTTCCGTCGTCGCTTTCGCCCTGACGCTGG
GCCTGGCGCAGGTGCTTTGA

Downstream 100 bases:

>100_bases
ACCATGTTTTATGACCTGATCATCCGCGACGCACTGGTCATTGATGGCAGTGACACACCGGGGGTACGCGCCGATGTGGC
GATCAGCGACGGGCGCATTC

Product: helix-turn-helix protein RpiR:sugar isomerase (SIS)

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MDILYQIRARQDSFSAGEGRIARLLLSDIAFAASASLDELASRAEVSSATLSRFARSIGCRDLRDLRLQLAQASGVGSRF
LHPEPAPEQSAFFARIVDDIEATLRQHLAGFDATRFAAAIACVTDARMIHTFGMGGCSSLCSEELQTRLVRLGYPVAACR
DPVMMRMVAATLGPQHSLIVCSLSGRTPELLDAVTLARSYGARVLAITLPDSPLAQLAEVVLPLQIAETNFIYKPTAARY
GMLLTIDVLATELALSSPEDNQERLRRIKLALDEYRGGEDGLPLGD

Sequences:

>Translated_286_residues
MDILYQIRARQDSFSAGEGRIARLLLSDIAFAASASLDELASRAEVSSATLSRFARSIGCRDLRDLRLQLAQASGVGSRF
LHPEPAPEQSAFFARIVDDIEATLRQHLAGFDATRFAAAIACVTDARMIHTFGMGGCSSLCSEELQTRLVRLGYPVAACR
DPVMMRMVAATLGPQHSLIVCSLSGRTPELLDAVTLARSYGARVLAITLPDSPLAQLAEVVLPLQIAETNFIYKPTAARY
GMLLTIDVLATELALSSPEDNQERLRRIKLALDEYRGGEDGLPLGD
>Mature_286_residues
MDILYQIRARQDSFSAGEGRIARLLLSDIAFAASASLDELASRAEVSSATLSRFARSIGCRDLRDLRLQLAQASGVGSRF
LHPEPAPEQSAFFARIVDDIEATLRQHLAGFDATRFAAAIACVTDARMIHTFGMGGCSSLCSEELQTRLVRLGYPVAACR
DPVMMRMVAATLGPQHSLIVCSLSGRTPELLDAVTLARSYGARVLAITLPDSPLAQLAEVVLPLQIAETNFIYKPTAARY
GMLLTIDVLATELALSSPEDNQERLRRIKLALDEYRGGEDGLPLGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=288, Percent_Identity=29.5138888888889, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1788767, Length=259, Percent_Identity=27.7992277992278, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082369, Length=279, Percent_Identity=25.089605734767, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 30966; Mature: 30966

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILYQIRARQDSFSAGEGRIARLLLSDIAFAASASLDELASRAEVSSATLSRFARSIGC
CCCEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
RDLRDLRLQLAQASGVGSRFLHPEPAPEQSAFFARIVDDIEATLRQHLAGFDATRFAAAI
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ACVTDARMIHTFGMGGCSSLCSEELQTRLVRLGYPVAACRDPVMMRMVAATLGPQHSLIV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCCCEEE
CSLSGRTPELLDAVTLARSYGARVLAITLPDSPLAQLAEVVLPLQIAETNFIYKPTAARY
EEECCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCHHHC
GMLLTIDVLATELALSSPEDNQERLRRIKLALDEYRGGEDGLPLGD
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MDILYQIRARQDSFSAGEGRIARLLLSDIAFAASASLDELASRAEVSSATLSRFARSIGC
CCCEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
RDLRDLRLQLAQASGVGSRFLHPEPAPEQSAFFARIVDDIEATLRQHLAGFDATRFAAAI
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ACVTDARMIHTFGMGGCSSLCSEELQTRLVRLGYPVAACRDPVMMRMVAATLGPQHSLIV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCCCEEE
CSLSGRTPELLDAVTLARSYGARVLAITLPDSPLAQLAEVVLPLQIAETNFIYKPTAARY
EEECCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCHHHC
GMLLTIDVLATELALSSPEDNQERLRRIKLALDEYRGGEDGLPLGD
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]