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The map label for this gene is envZ [H]

Identifier: 66043529

GI number: 66043529

Start: 275025

End: 276347

Strand: Direct

Name: envZ [H]

Synonym: Psyr_0259

Alternate gene names: 66043529

Gene position: 275025-276347 (Clockwise)

Preceding gene: 66043528

Following gene: 66043533

Centisome position: 4.51

GC content: 62.06

Gene sequence:

>1323_bases
ATGGCTGCAGTTATGAAGACTCCGCTCTGGTTCCCGCAAAGCTTTTTCTCCCGCACGCTCTGGCTGGTGCTCATCGTCGT
GCTGTTTTCCAAGGCCCTGACGCTGGTTTATCTGCTGATGAACGAAGACGTGCTGGTCGACAGGCAATACAGCCACGGTG
TTGCTCTGACCTTGCGCGCGTACTGGGCCGCCGGTGAAAACGATCGCGAGGCGATTGCCGAGGCGGCGGGCCTGATTCGG
GTAGTGGGCGGTGGCGTGCCGGAAGGCGAGCAGCACTGGCCCTACAGTGAGATCTATCAGCGACAGATGCAGGCCGAGCT
GGGTGCCGATACGGAAGTGCGTCTGCGCGTACACGCGCCGCCCGCGCTGTGGGTGCGAGCGCCGAGCCTGGGTGACGGCT
GGCTGAAAGTGCCGCTGTATCCGCACCCGTTGCGCGGTCAGAAAATCTGGAACGTGCTGGGCTGGTTCCTGGCCATCGGA
TTGCTCTCCACGGCATCAGCCTGGATTTTCGTACGCCAGTTGAATCAGCCGCTCAAGCGTTTGGTGTTTGCGGCGCGCCA
GTTGGGGCAGGGGCGCAGCGTACGGCTGCCGGTGAGTGACACGCCGAGCGAGATGACCGAAGTCTACCGGGCCTTCAATC
AGATGGCCGAAGACGTCGAGCAGGCCGGGCAGGAACGCGAGTTGATGCTGGCCGGTGTTTCCCACGACTTGCGCACGCCG
CTGACGCGCCTGCGCCTGTCTCTGGAGCTGATGAACGACAATGAGTTCTCCGAAGGCATGGTGCGCGATATCGAGGACAT
GGACGCCATTCTCGATCAGTTCCTGGCCTTCATCCGCGATGGGCGCGACGAAGAGATCGAAGAGGTCGATCTGGGGCATC
TGGTACGCGATGTGGTTGCACCTTTCAATGACGATGAAGACAGCATCCGTCTGTGCCTGGAGCCCATTCCGCCCTTCCCG
TTACGCCGCGTGTCGATGAAGCGCCTGCTGACCAACCTGATTGGCAATGCCAAGCACCATGCCGGTAACGGTATCGAAGT
CGCCGCCTACGTATCCGGCGACCGAAACGCGCCCTACGTGGTGTTGAGCGTGCTGGACCGGGGGGCGGGCATCGATCCGT
CCGAGCTGGACACCATCTTCAACCCGTTCATTCGCGGTGATCGCGCACGCAGTGGCAAGGGCACCGGCCTCGGCCTGGCC
ATCGTCAAGCGTATCGCTGCCATGCACGGCGGCAACGTCGAGTTGAGAAATCGTTCGGGAGGCGGACTGGAAGCACGCGT
AAGGCTGCCGCTGGGGCTGATGCTGCCGAGAGATGCAATTTAA

Upstream 100 bases:

>100_bases
ATCTTTTACAGGTTTATCGACGTACTGGTTTTTTGCGTTCGTCCATCGGGTCCGGCCCGCGTTCGGCAAACCTGCGAGCC
TCGCTCGCCCTGCAAAGTGT

Downstream 100 bases:

>100_bases
GGCGAGGGCGAAGCGAGAGGGGAAATATAAAGCGCCGTACAGGGTCACGGGAGGCGTGCGAAAGGTTGACGCATTCTCGT
GAACCTGCACGGCGGCTTGC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MAAVMKTPLWFPQSFFSRTLWLVLIVVLFSKALTLVYLLMNEDVLVDRQYSHGVALTLRAYWAAGENDREAIAEAAGLIR
VVGGGVPEGEQHWPYSEIYQRQMQAELGADTEVRLRVHAPPALWVRAPSLGDGWLKVPLYPHPLRGQKIWNVLGWFLAIG
LLSTASAWIFVRQLNQPLKRLVFAARQLGQGRSVRLPVSDTPSEMTEVYRAFNQMAEDVEQAGQERELMLAGVSHDLRTP
LTRLRLSLELMNDNEFSEGMVRDIEDMDAILDQFLAFIRDGRDEEIEEVDLGHLVRDVVAPFNDDEDSIRLCLEPIPPFP
LRRVSMKRLLTNLIGNAKHHAGNGIEVAAYVSGDRNAPYVVLSVLDRGAGIDPSELDTIFNPFIRGDRARSGKGTGLGLA
IVKRIAAMHGGNVELRNRSGGGLEARVRLPLGLMLPRDAI

Sequences:

>Translated_440_residues
MAAVMKTPLWFPQSFFSRTLWLVLIVVLFSKALTLVYLLMNEDVLVDRQYSHGVALTLRAYWAAGENDREAIAEAAGLIR
VVGGGVPEGEQHWPYSEIYQRQMQAELGADTEVRLRVHAPPALWVRAPSLGDGWLKVPLYPHPLRGQKIWNVLGWFLAIG
LLSTASAWIFVRQLNQPLKRLVFAARQLGQGRSVRLPVSDTPSEMTEVYRAFNQMAEDVEQAGQERELMLAGVSHDLRTP
LTRLRLSLELMNDNEFSEGMVRDIEDMDAILDQFLAFIRDGRDEEIEEVDLGHLVRDVVAPFNDDEDSIRLCLEPIPPFP
LRRVSMKRLLTNLIGNAKHHAGNGIEVAAYVSGDRNAPYVVLSVLDRGAGIDPSELDTIFNPFIRGDRARSGKGTGLGLA
IVKRIAAMHGGNVELRNRSGGGLEARVRLPLGLMLPRDAI
>Mature_439_residues
AAVMKTPLWFPQSFFSRTLWLVLIVVLFSKALTLVYLLMNEDVLVDRQYSHGVALTLRAYWAAGENDREAIAEAAGLIRV
VGGGVPEGEQHWPYSEIYQRQMQAELGADTEVRLRVHAPPALWVRAPSLGDGWLKVPLYPHPLRGQKIWNVLGWFLAIGL
LSTASAWIFVRQLNQPLKRLVFAARQLGQGRSVRLPVSDTPSEMTEVYRAFNQMAEDVEQAGQERELMLAGVSHDLRTPL
TRLRLSLELMNDNEFSEGMVRDIEDMDAILDQFLAFIRDGRDEEIEEVDLGHLVRDVVAPFNDDEDSIRLCLEPIPPFPL
RRVSMKRLLTNLIGNAKHHAGNGIEVAAYVSGDRNAPYVVLSVLDRGAGIDPSELDTIFNPFIRGDRARSGKGTGLGLAI
VKRIAAMHGGNVELRNRSGGGLEARVRLPLGLMLPRDAI

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=442, Percent_Identity=34.1628959276018, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1787894, Length=312, Percent_Identity=33.0128205128205, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790346, Length=285, Percent_Identity=29.8245614035088, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=27.1255060728745, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082128, Length=316, Percent_Identity=28.7974683544304, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=32.618025751073, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788393, Length=282, Percent_Identity=28.3687943262411, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=271, Percent_Identity=29.1512915129151, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790861, Length=271, Percent_Identity=27.3062730627306, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788549, Length=272, Percent_Identity=27.2058823529412, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786600, Length=305, Percent_Identity=26.2295081967213, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=23.8532110091743, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788279, Length=321, Percent_Identity=25.8566978193146, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI48994928, Length=230, Percent_Identity=26.9565217391304, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=249, Percent_Identity=26.5060240963855, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=296, Percent_Identity=26.6891891891892, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081816, Length=251, Percent_Identity=27.4900398406374, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788713, Length=268, Percent_Identity=23.8805970149254, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49064; Mature: 48933

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVMKTPLWFPQSFFSRTLWLVLIVVLFSKALTLVYLLMNEDVLVDRQYSHGVALTLRA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEE
YWAAGENDREAIAEAAGLIRVVGGGVPEGEQHWPYSEIYQRQMQAELGADTEVRLRVHAP
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECC
PALWVRAPSLGDGWLKVPLYPHPLRGQKIWNVLGWFLAIGLLSTASAWIFVRQLNQPLKR
CEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVFAARQLGQGRSVRLPVSDTPSEMTEVYRAFNQMAEDVEQAGQERELMLAGVSHDLRTP
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
LTRLRLSLELMNDNEFSEGMVRDIEDMDAILDQFLAFIRDGRDEEIEEVDLGHLVRDVVA
HHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
PFNDDEDSIRLCLEPIPPFPLRRVSMKRLLTNLIGNAKHHAGNGIEVAAYVSGDRNAPYV
CCCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEE
VLSVLDRGAGIDPSELDTIFNPFIRGDRARSGKGTGLGLAIVKRIAAMHGGNVELRNRSG
EEEEHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCC
GGLEARVRLPLGLMLPRDAI
CCCEEEEECCEEECCCCCCC
>Mature Secondary Structure 
AAVMKTPLWFPQSFFSRTLWLVLIVVLFSKALTLVYLLMNEDVLVDRQYSHGVALTLRA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEE
YWAAGENDREAIAEAAGLIRVVGGGVPEGEQHWPYSEIYQRQMQAELGADTEVRLRVHAP
EECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECC
PALWVRAPSLGDGWLKVPLYPHPLRGQKIWNVLGWFLAIGLLSTASAWIFVRQLNQPLKR
CEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVFAARQLGQGRSVRLPVSDTPSEMTEVYRAFNQMAEDVEQAGQERELMLAGVSHDLRTP
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
LTRLRLSLELMNDNEFSEGMVRDIEDMDAILDQFLAFIRDGRDEEIEEVDLGHLVRDVVA
HHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
PFNDDEDSIRLCLEPIPPFPLRRVSMKRLLTNLIGNAKHHAGNGIEVAAYVSGDRNAPYV
CCCCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEE
VLSVLDRGAGIDPSELDTIFNPFIRGDRARSGKGTGLGLAIVKRIAAMHGGNVELRNRSG
EEEEHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCC
GGLEARVRLPLGLMLPRDAI
CCCEEEEECCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]