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The map label for this gene is hemD [H]

Identifier: 66043332

GI number: 66043332

Start: 60701

End: 61474

Strand: Reverse

Name: hemD [H]

Synonym: Psyr_0061

Alternate gene names: 66043332

Gene position: 61474-60701 (Counterclockwise)

Preceding gene: 66043333

Following gene: 66043331

Centisome position: 1.01

GC content: 63.82

Gene sequence:

>774_bases
ATGAGTGGCTGGCGTCTGCTGCTGACCCGCCCGGCCGAAGAGTCGGCAGCGCTGGCCAGGGTGCTGGCCGAGGCCGGTAT
CTTCAGCAGCAGCCTGCCCCTGCTTGAAACCGAGCCGTTGCCCTTGACGCCTGCACAGCGTTCGATCATTTTCGAGCTGC
TCAATTATTGTGCAGTGATCGTGGTCAGCAAGCCGGCCGCGCGACTGGCCATCGAACTGATCGACGAAGTATGGCCGCAA
CCGCCCCTGCAACCCTGGTTCAGTGTGGGTTCAGCAACCGGGCAGATACTGGTCGATTACGGGCTCGATGCGAGCTGGCC
GGAGCAGGGCGACGACAGCGAAGCCTTGCTTGAACTGCCGCGCCTCAAACAGGCGATTGCCGTACCGGGAAGCCGTGTGT
TGATCATGCGCGGTGACGAGGGACGCGAGCTGTTGGCCGAGCAACTGCGCGCGCTGGGGGTGGGCGTTGATTACCTGCCG
CTGTATCGTCGCTATCTGCCGCAGCATGCGCCCGGCGCCCTGGCGCAACGTGTCGCGGTGGAACGCTTGAACGGGCTGGT
GGTCAGCAGTGGGCAGGGTTTTGAACATTTGCTTCAGTTGGCGGGGGATTCATGGCCGGACCTGGCCGATCTGCCGCTGT
TTGTACCGAGCCCCCGGGTTGCCAGCATTGCGCGGGCAGCCGGAGCAAGGACCGTTATTGATTGTCGTGGCGCCAGCGCC
ACGGCATTGCTGGCAGCGTTGCGGGAACAACCTCAGCCTGCCGTCAAGGCGTAA

Upstream 100 bases:

>100_bases
AGACCTCCGCCCAGGCGTTGGGTGTGCAGGTGGCCGAAGCGCTGCTGGAGCAGGGCGCCGCCGACATCCTGAAAGCGGTC
TACGGCGAGGCCAATAACGA

Downstream 100 bases:

>100_bases
TGATCGACACCTGTCGTTTACGCTATTACGCCAAAATGCAAAGGATGGGATACGTGAGCGAAACAGCCTTGCCTAAAGAC
GAAGAATCGGTGTTGAAAAC

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MSGWRLLLTRPAEESAALARVLAEAGIFSSSLPLLETEPLPLTPAQRSIIFELLNYCAVIVVSKPAARLAIELIDEVWPQ
PPLQPWFSVGSATGQILVDYGLDASWPEQGDDSEALLELPRLKQAIAVPGSRVLIMRGDEGRELLAEQLRALGVGVDYLP
LYRRYLPQHAPGALAQRVAVERLNGLVVSSGQGFEHLLQLAGDSWPDLADLPLFVPSPRVASIARAAGARTVIDCRGASA
TALLAALREQPQPAVKA

Sequences:

>Translated_257_residues
MSGWRLLLTRPAEESAALARVLAEAGIFSSSLPLLETEPLPLTPAQRSIIFELLNYCAVIVVSKPAARLAIELIDEVWPQ
PPLQPWFSVGSATGQILVDYGLDASWPEQGDDSEALLELPRLKQAIAVPGSRVLIMRGDEGRELLAEQLRALGVGVDYLP
LYRRYLPQHAPGALAQRVAVERLNGLVVSSGQGFEHLLQLAGDSWPDLADLPLFVPSPRVASIARAAGARTVIDCRGASA
TALLAALREQPQPAVKA
>Mature_256_residues
SGWRLLLTRPAEESAALARVLAEAGIFSSSLPLLETEPLPLTPAQRSIIFELLNYCAVIVVSKPAARLAIELIDEVWPQP
PLQPWFSVGSATGQILVDYGLDASWPEQGDDSEALLELPRLKQAIAVPGSRVLIMRGDEGRELLAEQLRALGVGVDYLPL
YRRYLPQHAPGALAQRVAVERLNGLVVSSGQGFEHLLQLAGDSWPDLADLPLFVPSPRVASIARAAGARTVIDCRGASAT
ALLAALREQPQPAVKA

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=251, Percent_Identity=29.0836653386454, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27615; Mature: 27484

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGWRLLLTRPAEESAALARVLAEAGIFSSSLPLLETEPLPLTPAQRSIIFELLNYCAVI
CCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHEEE
VVSKPAARLAIELIDEVWPQPPLQPWFSVGSATGQILVDYGLDASWPEQGDDSEALLELP
HCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHH
RLKQAIAVPGSRVLIMRGDEGRELLAEQLRALGVGVDYLPLYRRYLPQHAPGALAQRVAV
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHH
ERLNGLVVSSGQGFEHLLQLAGDSWPDLADLPLFVPSPRVASIARAAGARTVIDCRGASA
HHHCCEEEECCCCHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHCCCCEEEEECCCHH
TALLAALREQPQPAVKA
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SGWRLLLTRPAEESAALARVLAEAGIFSSSLPLLETEPLPLTPAQRSIIFELLNYCAVI
CCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHEEE
VVSKPAARLAIELIDEVWPQPPLQPWFSVGSATGQILVDYGLDASWPEQGDDSEALLELP
HCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHH
RLKQAIAVPGSRVLIMRGDEGRELLAEQLRALGVGVDYLPLYRRYLPQHAPGALAQRVAV
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHH
ERLNGLVVSSGQGFEHLLQLAGDSWPDLADLPLFVPSPRVASIARAAGARTVIDCRGASA
HHHCCEEEECCCCHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHCCCCEEEEECCCHH
TALLAALREQPQPAVKA
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8159168; 10984043 [H]