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The map label for this gene is hemC [H]

Identifier: 66043333

GI number: 66043333

Start: 61471

End: 62412

Strand: Reverse

Name: hemC [H]

Synonym: Psyr_0062

Alternate gene names: 66043333

Gene position: 62412-61471 (Counterclockwise)

Preceding gene: 66043334

Following gene: 66043332

Centisome position: 1.02

GC content: 63.8

Gene sequence:

>942_bases
ATGTCCTCTCGCGAAATCCGCATCGCCACTCGCAAAAGCGCGTTGGCACTCTGGCAGGCAGAATACGTCAAGGCCCGCCT
GGAACAGGCCCACCCCGGCCTGCTCGTGACGTTGGTGCCCATGGTCAGCCGTGGCGACAAACTGCTCGACTCCCCGCTGT
CGAAAATCGGTGGCAAAGGGCTGTTCGTCAAGGAGCTGGAAACCGCGCTTCTGGAAAACAACGCCGACATCGCCGTGCAT
TCGATGAAAGACGTGCCGATGGATTTTCCACAAGGCCTGGGCCTGTTCTGCATCTGCGAGCGTGAAGACCCGCGCGATGC
ATTCGTCTCCAACACCTTTGCCAGCCTGGACCAGTTACCGGCGGGCAGCATTGTCGGCACCTCCAGCCTGCGCCGTCAGG
CCCAATTGCTGGCGCGTCGACCCGACCTGCAGATCCGTTTCCTGCGCGGCAACGTCAATACCCGTCTGGCCAAGCTCGAT
GCCGGTGAGTACGACGCCATCATCCTCGCCGCCGCCGGCCTGATCCGCCTGGGTTTCGAAGACCGCATCACCTCGGCAAT
CAGCGTCGATGACAGCCTGCCAGCCGGTGGCCAGGGCGCGGTGGGTATCGAATGCCGCAGCGTCGACGCCGAAATTCATG
CGCTGCTTGCCCCTCTGCACCACGAAGACACCGCCGTGCGCGTGATTGCCGAACGTTCGCTGAACAAGCACCTCAACGGT
GGCTGCCAGGTGCCGATTGCCTGCTACGCCGTGCTGGAAGGCGATGACGTCTGGTTGCGCGGCCTGGTGGGTGATCCGTC
CGGCAGCGTGTTGCTGCATGCAGATGCCCGGGCGCCCCAGACCTCCGCCCAGGCGTTGGGTGTGCAGGTGGCCGAAGCGC
TGCTGGAGCAGGGCGCCGCCGACATCCTGAAAGCGGTCTACGGCGAGGCCAATAACGAATGA

Upstream 100 bases:

>100_bases
TCGGCTTAGTGTCTGAAGCAATTCCCAATCGGCGCCGAAGCCGCCCTGACCGGGATTGAGCTGTTATTATCCGTCGCATT
CACTCAGTACGGATTGTTCA

Downstream 100 bases:

>100_bases
GTGGCTGGCGTCTGCTGCTGACCCGCCCGGCCGAAGAGTCGGCAGCGCTGGCCAGGGTGCTGGCCGAGGCCGGTATCTTC
AGCAGCAGCCTGCCCCTGCT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSSREIRIATRKSALALWQAEYVKARLEQAHPGLLVTLVPMVSRGDKLLDSPLSKIGGKGLFVKELETALLENNADIAVH
SMKDVPMDFPQGLGLFCICEREDPRDAFVSNTFASLDQLPAGSIVGTSSLRRQAQLLARRPDLQIRFLRGNVNTRLAKLD
AGEYDAIILAAAGLIRLGFEDRITSAISVDDSLPAGGQGAVGIECRSVDAEIHALLAPLHHEDTAVRVIAERSLNKHLNG
GCQVPIACYAVLEGDDVWLRGLVGDPSGSVLLHADARAPQTSAQALGVQVAEALLEQGAADILKAVYGEANNE

Sequences:

>Translated_313_residues
MSSREIRIATRKSALALWQAEYVKARLEQAHPGLLVTLVPMVSRGDKLLDSPLSKIGGKGLFVKELETALLENNADIAVH
SMKDVPMDFPQGLGLFCICEREDPRDAFVSNTFASLDQLPAGSIVGTSSLRRQAQLLARRPDLQIRFLRGNVNTRLAKLD
AGEYDAIILAAAGLIRLGFEDRITSAISVDDSLPAGGQGAVGIECRSVDAEIHALLAPLHHEDTAVRVIAERSLNKHLNG
GCQVPIACYAVLEGDDVWLRGLVGDPSGSVLLHADARAPQTSAQALGVQVAEALLEQGAADILKAVYGEANNE
>Mature_312_residues
SSREIRIATRKSALALWQAEYVKARLEQAHPGLLVTLVPMVSRGDKLLDSPLSKIGGKGLFVKELETALLENNADIAVHS
MKDVPMDFPQGLGLFCICEREDPRDAFVSNTFASLDQLPAGSIVGTSSLRRQAQLLARRPDLQIRFLRGNVNTRLAKLDA
GEYDAIILAAAGLIRLGFEDRITSAISVDDSLPAGGQGAVGIECRSVDAEIHALLAPLHHEDTAVRVIAERSLNKHLNGG
CQVPIACYAVLEGDDVWLRGLVGDPSGSVLLHADARAPQTSAQALGVQVAEALLEQGAADILKAVYGEANNE

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=333, Percent_Identity=42.6426426426426, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI66933009, Length=333, Percent_Identity=42.6426426426426, Blast_Score=245, Evalue=5e-65,
Organism=Escherichia coli, GI48994974, Length=302, Percent_Identity=66.5562913907285, Blast_Score=400, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=36.4485981308411, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI20130425, Length=265, Percent_Identity=44.5283018867925, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33467; Mature: 33335

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSREIRIATRKSALALWQAEYVKARLEQAHPGLLVTLVPMVSRGDKLLDSPLSKIGGKG
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHCCCC
LFVKELETALLENNADIAVHSMKDVPMDFPQGLGLFCICEREDPRDAFVSNTFASLDQLP
EEHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
AGSIVGTSSLRRQAQLLARRPDLQIRFLRGNVNTRLAKLDAGEYDAIILAAAGLIRLGFE
CCCEECHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCHHEEHHHHHHCCCH
DRITSAISVDDSLPAGGQGAVGIECRSVDAEIHALLAPLHHEDTAVRVIAERSLNKHLNG
HHHHHEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
GCQVPIACYAVLEGDDVWLRGLVGDPSGSVLLHADARAPQTSAQALGVQVAEALLEQGAA
CCCCCEEEEEEECCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHH
DILKAVYGEANNE
HHHHHHHCCCCCC
>Mature Secondary Structure 
SSREIRIATRKSALALWQAEYVKARLEQAHPGLLVTLVPMVSRGDKLLDSPLSKIGGKG
CCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHCCCC
LFVKELETALLENNADIAVHSMKDVPMDFPQGLGLFCICEREDPRDAFVSNTFASLDQLP
EEHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
AGSIVGTSSLRRQAQLLARRPDLQIRFLRGNVNTRLAKLDAGEYDAIILAAAGLIRLGFE
CCCEECHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCHHEEHHHHHHCCCH
DRITSAISVDDSLPAGGQGAVGIECRSVDAEIHALLAPLHHEDTAVRVIAERSLNKHLNG
HHHHHEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
GCQVPIACYAVLEGDDVWLRGLVGDPSGSVLLHADARAPQTSAQALGVQVAEALLEQGAA
CCCCCEEEEEEECCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHH
DILKAVYGEANNE
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]