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The map label for this gene is liaS [H]

Identifier: 62390850

GI number: 62390850

Start: 2093895

End: 2094974

Strand: Reverse

Name: liaS [H]

Synonym: cg2201

Alternate gene names: 62390850

Gene position: 2094974-2093895 (Counterclockwise)

Preceding gene: 62390853

Following gene: 62390849

Centisome position: 63.82

GC content: 53.61

Gene sequence:

>1080_bases
TTGCATTTACTCATTGCCGTTTTGTTGGTGTTGGTGTGTTGGCGTGCCAGCCATTGGGGTGTGTGGGTGCTCGCTTTTGG
CTATGGCGTGGTTTATGTGGCGGGTGTGGTCCCGAATTCGCCGTTTAAGAATCACCCTATGGCGTGGTTTCTTGTGCTGA
GTTTGTTGTGGGCGAGCCTGATTTGGGATGGACCGGAGCCTGCGTATTTGGTGTTTCCGATGTTTTTCCTCGCAGTGTTG
ATCACGACACCGCTGAAATCCGCGATCATCATTGCAATACTGACGGCGATCGCGGTGGTTACGTTGGCTATGCACCTGGG
GTTTTCTGTTGGCGTTGTCACCGGTCCGATCCTTGGCGCGTTGGTGGCGTGGGTAATGGGTACGTGTTTTCAGTTATTGG
CACAAGCCTTAAAGGAGCTTGTCGACGCACGTGCGTCGGCGATCCGGGCGTCGAAAAGCGCTGGCGAGCAGGCAGAACGA
GCCCGCATAGCGGGCGAAATACATGACACTGTGGCGCAGGGGTTGTCCTCGATTCAGATGTTGTTGCATGCGGCGGAAAA
ACGGGTGGATGATCCGCAGGCGTTAAGCCATATACGGTTGGCCAGGCAAACGACAGCTGATAATTTGGCGGAGACCAGGC
AGATCATTGCTGCGCTGCAACCGACTCCACTCATTGGGGCGGATCTGCCGGTGGCGTTGGCCAGACTGTCGTCGACCACC
CCGATGGGACAGAACATCACGTTTGAAGTCGACGGATCCCCACGGGTATTACCTGATGCGATGGAGGCAGAGATCGTACG
AATTGCCCAAACGCTGCTGGGAAATGTGGTGCGGCATGCACAGGCAGATTCTGCAAAAATGACCCTGACATATCAAGATG
ATCAAATACTTCTAGATGTCATCGATAATGGGCAGGGATTTGATGTGGCAGAAGTGATCCGTAAAAAATCCATTGGACTG
CCCACAGCGCAACGCCGGGCTGAAGGGCTGGGCGGAACAATAATTATTGAATCTACAATCGGATCGGGAACTGGAATTTC
CGCCCGTTTTCCCTATCCACAAAAGGACCAAGATAAGTGA

Upstream 100 bases:

>100_bases
CCAAAGTCGGATTCGCGTTCATACTTAGTTGATCTATCGTGGTGGCGTGAAAACTAGCCAAGCGACCATCGCCCGAATTG
AGAGAGTTCTCATTTGGGGA

Downstream 100 bases:

>100_bases
TCCGTATTCTGTTGGCTGATGATCATCCCGTTGTTCGCGCAGGCCTTGCCTCCTTGCTGGTGAGTGAAGATGATTTTGAG
ATAGTGGACATGGTGGGCAC

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MHLLIAVLLVLVCWRASHWGVWVLAFGYGVVYVAGVVPNSPFKNHPMAWFLVLSLLWASLIWDGPEPAYLVFPMFFLAVL
ITTPLKSAIIIAILTAIAVVTLAMHLGFSVGVVTGPILGALVAWVMGTCFQLLAQALKELVDARASAIRASKSAGEQAER
ARIAGEIHDTVAQGLSSIQMLLHAAEKRVDDPQALSHIRLARQTTADNLAETRQIIAALQPTPLIGADLPVALARLSSTT
PMGQNITFEVDGSPRVLPDAMEAEIVRIAQTLLGNVVRHAQADSAKMTLTYQDDQILLDVIDNGQGFDVAEVIRKKSIGL
PTAQRRAEGLGGTIIIESTIGSGTGISARFPYPQKDQDK

Sequences:

>Translated_359_residues
MHLLIAVLLVLVCWRASHWGVWVLAFGYGVVYVAGVVPNSPFKNHPMAWFLVLSLLWASLIWDGPEPAYLVFPMFFLAVL
ITTPLKSAIIIAILTAIAVVTLAMHLGFSVGVVTGPILGALVAWVMGTCFQLLAQALKELVDARASAIRASKSAGEQAER
ARIAGEIHDTVAQGLSSIQMLLHAAEKRVDDPQALSHIRLARQTTADNLAETRQIIAALQPTPLIGADLPVALARLSSTT
PMGQNITFEVDGSPRVLPDAMEAEIVRIAQTLLGNVVRHAQADSAKMTLTYQDDQILLDVIDNGQGFDVAEVIRKKSIGL
PTAQRRAEGLGGTIIIESTIGSGTGISARFPYPQKDQDK
>Mature_359_residues
MHLLIAVLLVLVCWRASHWGVWVLAFGYGVVYVAGVVPNSPFKNHPMAWFLVLSLLWASLIWDGPEPAYLVFPMFFLAVL
ITTPLKSAIIIAILTAIAVVTLAMHLGFSVGVVTGPILGALVAWVMGTCFQLLAQALKELVDARASAIRASKSAGEQAER
ARIAGEIHDTVAQGLSSIQMLLHAAEKRVDDPQALSHIRLARQTTADNLAETRQIIAALQPTPLIGADLPVALARLSSTT
PMGQNITFEVDGSPRVLPDAMEAEIVRIAQTLLGNVVRHAQADSAKMTLTYQDDQILLDVIDNGQGFDVAEVIRKKSIGL
PTAQRRAEGLGGTIIIESTIGSGTGISARFPYPQKDQDK

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=205, Percent_Identity=26.8292682926829, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR017202 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38561; Mature: 38561

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLLIAVLLVLVCWRASHWGVWVLAFGYGVVYVAGVVPNSPFKNHPMAWFLVLSLLWASL
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
IWDGPEPAYLVFPMFFLAVLITTPLKSAIIIAILTAIAVVTLAMHLGFSVGVVTGPILGA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LVAWVMGTCFQLLAQALKELVDARASAIRASKSAGEQAERARIAGEIHDTVAQGLSSIQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLHAAEKRVDDPQALSHIRLARQTTADNLAETRQIIAALQPTPLIGADLPVALARLSSTT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
PMGQNITFEVDGSPRVLPDAMEAEIVRIAQTLLGNVVRHAQADSAKMTLTYQDDQILLDV
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEE
IDNGQGFDVAEVIRKKSIGLPTAQRRAEGLGGTIIIESTIGSGTGISARFPYPQKDQDK
ECCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHLLIAVLLVLVCWRASHWGVWVLAFGYGVVYVAGVVPNSPFKNHPMAWFLVLSLLWASL
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
IWDGPEPAYLVFPMFFLAVLITTPLKSAIIIAILTAIAVVTLAMHLGFSVGVVTGPILGA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LVAWVMGTCFQLLAQALKELVDARASAIRASKSAGEQAERARIAGEIHDTVAQGLSSIQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLHAAEKRVDDPQALSHIRLARQTTADNLAETRQIIAALQPTPLIGADLPVALARLSSTT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
PMGQNITFEVDGSPRVLPDAMEAEIVRIAQTLLGNVVRHAQADSAKMTLTYQDDQILLDV
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEE
IDNGQGFDVAEVIRKKSIGLPTAQRRAEGLGGTIIIESTIGSGTGISARFPYPQKDQDK
ECCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]