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The map label for this gene is liaR [H]

Identifier: 62390849

GI number: 62390849

Start: 2093266

End: 2093898

Strand: Reverse

Name: liaR [H]

Synonym: cg2200

Alternate gene names: 62390849

Gene position: 2093898-2093266 (Counterclockwise)

Preceding gene: 62390850

Following gene: 62390848

Centisome position: 63.79

GC content: 56.24

Gene sequence:

>633_bases
GTGATCCGTATTCTGTTGGCTGATGATCATCCCGTTGTTCGCGCAGGCCTTGCCTCCTTGCTGGTGAGTGAAGATGATTT
TGAGATAGTGGACATGGTGGGCACCCCAGATGATGCCGTTGCGCGCGCCGCGGAAGGCGGGGTGGATGTGGTGTTGATGG
ATCTGCGTTTTGGTGATCAACCAGGCATCGAGGTCGCCGGCGGGGTAGAGGCAACGCGTCGCATCCGTGCGCTGGACAAC
CCGCCACAGGTACTGGTGGTGACCAACTACTCCACAGACGGCGATGTGGTGGGCGCAGTATCTGCTGGTGCCGTGGGGTA
TTTGCTCAAAGATAGCTCCCCAGAAGATCTCATTGCCGGTGTTCGCGATGCCGCGCGGGGAGAATCAGTGCTTTCAAAGC
AGGTCGCCAGCAAGATCATGGGGCGGATGAACAACCCCATGACTGCTCTCAGTGCCAGAGAAATTGAAGTGCTGTCCTTG
GTGGCGCAAGGGCAAAGCAATAGAGAAATCGGCAAGAAACTTTTCCTCACTGAGGCCACGGTGAAAAGTCACATGGGGCA
TGTGTTCAACAAGCTGGATGTCACCTCTAGAACAGCTGCGGTAGCTGAAGCCAGACAGCGCGGAATTATCTAG

Upstream 100 bases:

>100_bases
GGGCTGAAGGGCTGGGCGGAACAATAATTATTGAATCTACAATCGGATCGGGAACTGGAATTTCCGCCCGTTTTCCCTAT
CCACAAAAGGACCAAGATAA

Downstream 100 bases:

>100_bases
ACGCACACGTGTTGGTAACCGATCACACCAGCGCACGCTGCTAATCTTCACTCCATGAACAAGGTGCAGCGCAGGTCACT
GATGGCGTTGTGCATGACGG

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MIRILLADDHPVVRAGLASLLVSEDDFEIVDMVGTPDDAVARAAEGGVDVVLMDLRFGDQPGIEVAGGVEATRRIRALDN
PPQVLVVTNYSTDGDVVGAVSAGAVGYLLKDSSPEDLIAGVRDAARGESVLSKQVASKIMGRMNNPMTALSAREIEVLSL
VAQGQSNREIGKKLFLTEATVKSHMGHVFNKLDVTSRTAAVAEARQRGII

Sequences:

>Translated_210_residues
MIRILLADDHPVVRAGLASLLVSEDDFEIVDMVGTPDDAVARAAEGGVDVVLMDLRFGDQPGIEVAGGVEATRRIRALDN
PPQVLVVTNYSTDGDVVGAVSAGAVGYLLKDSSPEDLIAGVRDAARGESVLSKQVASKIMGRMNNPMTALSAREIEVLSL
VAQGQSNREIGKKLFLTEATVKSHMGHVFNKLDVTSRTAAVAEARQRGII
>Mature_210_residues
MIRILLADDHPVVRAGLASLLVSEDDFEIVDMVGTPDDAVARAAEGGVDVVLMDLRFGDQPGIEVAGGVEATRRIRALDN
PPQVLVVTNYSTDGDVVGAVSAGAVGYLLKDSSPEDLIAGVRDAARGESVLSKQVASKIMGRMNNPMTALSAREIEVLSL
VAQGQSNREIGKKLFLTEATVKSHMGHVFNKLDVTSRTAAVAEARQRGII

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=213, Percent_Identity=34.7417840375587, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1788222, Length=200, Percent_Identity=31, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=32.1428571428571, Blast_Score=90, Evalue=9e-20,
Organism=Escherichia coli, GI1787473, Length=219, Percent_Identity=32.8767123287671, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1786747, Length=215, Percent_Identity=26.5116279069767, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788712, Length=195, Percent_Identity=24.1025641025641, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22204; Mature: 22204

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRILLADDHPVVRAGLASLLVSEDDFEIVDMVGTPDDAVARAAEGGVDVVLMDLRFGDQ
CEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCC
PGIEVAGGVEATRRIRALDNPPQVLVVTNYSTDGDVVGAVSAGAVGYLLKDSSPEDLIAG
CCCEEECCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCEEEEECCCCHHHHHHH
VRDAARGESVLSKQVASKIMGRMNNPMTALSAREIEVLSLVAQGQSNREIGKKLFLTEAT
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VKSHMGHVFNKLDVTSRTAAVAEARQRGII
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIRILLADDHPVVRAGLASLLVSEDDFEIVDMVGTPDDAVARAAEGGVDVVLMDLRFGDQ
CEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCC
PGIEVAGGVEATRRIRALDNPPQVLVVTNYSTDGDVVGAVSAGAVGYLLKDSSPEDLIAG
CCCEEECCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCEEEEECCCCHHHHHHH
VRDAARGESVLSKQVASKIMGRMNNPMTALSAREIEVLSLVAQGQSNREIGKKLFLTEAT
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VKSHMGHVFNKLDVTSRTAAVAEARQRGII
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]