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The map label for this gene is mdh2 [H]

Identifier: 62389550

GI number: 62389550

Start: 676552

End: 677595

Strand: Reverse

Name: mdh2 [H]

Synonym: cg0763

Alternate gene names: 62389550

Gene position: 677595-676552 (Counterclockwise)

Preceding gene: 62389551

Following gene: 62389543

Centisome position: 20.64

GC content: 53.26

Gene sequence:

>1044_bases
ATGCCAGAAGTCACTGTCAACGCCCAACAACTCACTGTTCTCTGCACAGACATCCTCACCAAAACTGGAGTACCTGCAGC
AGACGCCCATCTTGTCGGTGATAGTTTGGTGCAGGCTGATCTTTGGGGTCACCCCTCCCACGGTGTGCTTCGACTGCCTT
GGTATGTGCGCAGACTCCACAGTGGCGCGATGACTACACATGCACACGTGGAGGTTCTCAATGATTTGGGTGCCGTGTTG
GCGTTGGATGGACACAATGGAATCGGCCAAGTTTTAGCTGATCATGCTCGTAAAGAAGCAGTGACTAGGGCAATGATGTT
CGGCATCGGTGCGGTGTCGGTGCGCAACTCCAATCATTTTGGAACTGCCATGTACTACACCCGGAAAGCGGCAGCGCAAG
GATGTGTTTCCATTCTCACCACCAATGCATCTCCGGCGATGGCGCCCTGGGGTGGCAGAGAAAAACGGATCGGTACCAAC
CCATGGTCTATTGCGGCACCTTTTGGAGAAACGGCTACGGTAGTCGATATAGCCAATACTGCGGTTGCGCGCGGAAAGAT
CTACCACGCACGACAGACAAACATGCCCATTCCTGAGACTTGGGCGATCACGAGTGAGGGCGCACCCACCACGGATCCTG
CTGAGGCAATCAACGGTGTCGTCCTTCCCATGGCTGGTCACAAAGGTTATGCGATTAGCTTCATGATGGATGTGCTTTCT
GGAGTTCTCACTGGTTCCCAGCACAGCACCAAGGTACATGGTCCGTATGATCCCACTCCCCCAGGTGGAGCTGGCCACTT
GTTCATCGCGTTGGATGTTGCAGCGTTTCGCGATCCACAAGATTTCGATGACGCACTCAGCGATCTGGTTGGGGAAGTTA
AATCCACTCCGAAAGCACAAAACACCGAGGAGATTTTCTACCCCGGTGAATCGGAAGACCGTGCGCATCGGAAAAACTCT
GCGCACGGTATTTCATTGCCTGAAAAAACGTGGATGGAACTGCAAGAACTGGCAATCGAGAACCATGTTGTAACTCACCG
TTGA

Upstream 100 bases:

>100_bases
GGTCTTAGAACCAGCGTGCACTGATGGCGATTAAAGGGGGTTGCGCCTATACCTATTGCTGGTATACATTTCGGTATACC
TAAACCGAATTGAGGGATTC

Downstream 100 bases:

>100_bases
TCTGCGCGTTAAACCTGGCCATCTAGAGGAATTCCTCAACGCCATTTCGGAGAATGCGCAGCGCAGCTTTCAGGATGAAG
AAGGTTGCGTGTATTTCGAC

Product: malate/L-lactate dehydrogenase

Products: NA

Alternate protein names: (R)-2-hydroxyacid dehydrogenase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MPEVTVNAQQLTVLCTDILTKTGVPAADAHLVGDSLVQADLWGHPSHGVLRLPWYVRRLHSGAMTTHAHVEVLNDLGAVL
ALDGHNGIGQVLADHARKEAVTRAMMFGIGAVSVRNSNHFGTAMYYTRKAAAQGCVSILTTNASPAMAPWGGREKRIGTN
PWSIAAPFGETATVVDIANTAVARGKIYHARQTNMPIPETWAITSEGAPTTDPAEAINGVVLPMAGHKGYAISFMMDVLS
GVLTGSQHSTKVHGPYDPTPPGGAGHLFIALDVAAFRDPQDFDDALSDLVGEVKSTPKAQNTEEIFYPGESEDRAHRKNS
AHGISLPEKTWMELQELAIENHVVTHR

Sequences:

>Translated_347_residues
MPEVTVNAQQLTVLCTDILTKTGVPAADAHLVGDSLVQADLWGHPSHGVLRLPWYVRRLHSGAMTTHAHVEVLNDLGAVL
ALDGHNGIGQVLADHARKEAVTRAMMFGIGAVSVRNSNHFGTAMYYTRKAAAQGCVSILTTNASPAMAPWGGREKRIGTN
PWSIAAPFGETATVVDIANTAVARGKIYHARQTNMPIPETWAITSEGAPTTDPAEAINGVVLPMAGHKGYAISFMMDVLS
GVLTGSQHSTKVHGPYDPTPPGGAGHLFIALDVAAFRDPQDFDDALSDLVGEVKSTPKAQNTEEIFYPGESEDRAHRKNS
AHGISLPEKTWMELQELAIENHVVTHR
>Mature_346_residues
PEVTVNAQQLTVLCTDILTKTGVPAADAHLVGDSLVQADLWGHPSHGVLRLPWYVRRLHSGAMTTHAHVEVLNDLGAVLA
LDGHNGIGQVLADHARKEAVTRAMMFGIGAVSVRNSNHFGTAMYYTRKAAAQGCVSILTTNASPAMAPWGGREKRIGTNP
WSIAAPFGETATVVDIANTAVARGKIYHARQTNMPIPETWAITSEGAPTTDPAEAINGVVLPMAGHKGYAISFMMDVLSG
VLTGSQHSTKVHGPYDPTPPGGAGHLFIALDVAAFRDPQDFDDALSDLVGEVKSTPKAQNTEEIFYPGESEDRAHRKNSA
HGISLPEKTWMELQELAIENHVVTHR

Specific function: Acts on oxaloacetate, sulfopyruvate but not on pyruvate. Has a higher selectivity for the coenzyme NADH than for NADPH [H]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=341, Percent_Identity=33.1378299120235, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1787020, Length=340, Percent_Identity=32.3529411764706, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1790000, Length=335, Percent_Identity=28.3582089552239, Blast_Score=138, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17507179, Length=347, Percent_Identity=31.700288184438, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17536633, Length=322, Percent_Identity=30.1242236024845, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24667908, Length=341, Percent_Identity=32.8445747800587, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI45553211, Length=341, Percent_Identity=32.8445747800587, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24667912, Length=341, Percent_Identity=32.8445747800587, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24667904, Length=341, Percent_Identity=32.8445747800587, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24658010, Length=325, Percent_Identity=28.9230769230769, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24648360, Length=334, Percent_Identity=28.1437125748503, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.272; =1.1.1.37; =1.1.1.82 [H]

Molecular weight: Translated: 37134; Mature: 37003

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEVTVNAQQLTVLCTDILTKTGVPAADAHLVGDSLVQADLWGHPSHGVLRLPWYVRRLH
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHH
SGAMTTHAHVEVLNDLGAVLALDGHNGIGQVLADHARKEAVTRAMMFGIGAVSVRNSNHF
CCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GTAMYYTRKAAAQGCVSILTTNASPAMAPWGGREKRIGTNPWSIAAPFGETATVVDIANT
CHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEHHHH
AVARGKIYHARQTNMPIPETWAITSEGAPTTDPAEAINGVVLPMAGHKGYAISFMMDVLS
HHHCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHCCEEEEECCCCCHHHHHHHHHHH
GVLTGSQHSTKVHGPYDPTPPGGAGHLFIALDVAAFRDPQDFDDALSDLVGEVKSTPKAQ
HHHCCCCCCCEECCCCCCCCCCCCCEEEEEEEHHHCCCCHHHHHHHHHHHHHHHCCCCCC
NTEEIFYPGESEDRAHRKNSAHGISLPEKTWMELQELAIENHVVTHR
CCCEEEECCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PEVTVNAQQLTVLCTDILTKTGVPAADAHLVGDSLVQADLWGHPSHGVLRLPWYVRRLH
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHH
SGAMTTHAHVEVLNDLGAVLALDGHNGIGQVLADHARKEAVTRAMMFGIGAVSVRNSNHF
CCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GTAMYYTRKAAAQGCVSILTTNASPAMAPWGGREKRIGTNPWSIAAPFGETATVVDIANT
CHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEHHHH
AVARGKIYHARQTNMPIPETWAITSEGAPTTDPAEAINGVVLPMAGHKGYAISFMMDVLS
HHHCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHCCEEEEECCCCCHHHHHHHHHHH
GVLTGSQHSTKVHGPYDPTPPGGAGHLFIALDVAAFRDPQDFDDALSDLVGEVKSTPKAQ
HHHCCCCCCCEECCCCCCCCCCCCCEEEEEEEHHHCCCCHHHHHHHHHHHHHHHCCCCCC
NTEEIFYPGESEDRAHRKNSAHGISLPEKTWMELQELAIENHVVTHR
CCCEEEECCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2110059; 10850983 [H]