Click here to switch to the map view.

The map label for this gene is ubiE [H]

Identifier: 62389369

GI number: 62389369

Start: 491965

End: 492657

Strand: Direct

Name: ubiE [H]

Synonym: cg0556

Alternate gene names: 62389369

Gene position: 491965-492657 (Clockwise)

Preceding gene: 62389368

Following gene: 62389371

Centisome position: 14.99

GC content: 56.85

Gene sequence:

>693_bases
GTGGCTAAAGCAGATTTAGACAAGGACCCCTTCGACGTAGCGTCAATGTTCGATGACGTCGGAAAGAACTACGATCTCAC
CAATACCGTGCTTTCTTTTGGTCAGGACCGTGTGTGGCGAAAGCGCACTAGGCAGCGCCTGGACCTCAAGCCAGGGGAGA
AGGTGCTTGATCTAGCTGCAGGAACAGCCGTTTCCACCGTGGAGTTGGCAAAATCCGGCGCGTTTTGTGTGGCGTGTGAT
TTCTCCCAGGGCATGCTCGCCGCAGGTAAAGACCGCGATGTGTCCAAGGTTGTGGGCGATGGCATGCAGTTGCCGTTTGC
AGACAACAGCTTTGATGCTGTGACCATTTCTTATGGTCTGCGCAATATTCACGATTTCCGCGCTGGCCTGAAAGAAATGG
CCCGCGTGACTAAACCTGGTGGACGCCTCACCGTGGCGGAGTTCTCCACCCCCGTGATCCCTGTGTTCGGCACCGTGTAC
AAGGAGTACCTCATGCGCCTGCTGCCCCAGGCGGCGCGCGCAGTATCGTCCAACCCGGAGGCCTACATTTACCTGGCTGA
TTCCATCCGCGCATGGCCTAGCCAGGCGGAACTAGCACGGGAGATCAACCAGAATGGTTGGTCAGATTGCGGTTGGCAGA
ACCTGACCTTCGGCATCGTCGCGCTGCACTCGGCGATTAAACCAGAGAACTAG

Upstream 100 bases:

>100_bases
CATTTTGGGTATCGGTTGGTTGTCCATCGGTGGAGCTAAGGGCGCTAAGCATCGCAGCCAAATAACCTCCCACTAAAGCT
CCTGGGTTAGACTCGAACGC

Downstream 100 bases:

>100_bases
TCGAGTCCCACAGAGGGGAGCCCTTCCGCGCCCAACTAATCGCGGATCCGGCGGCCTGCCAACCCCTGGCGAGCAGGTCT
TTATCCTCCTCTGTGATCAG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MAKADLDKDPFDVASMFDDVGKNYDLTNTVLSFGQDRVWRKRTRQRLDLKPGEKVLDLAAGTAVSTVELAKSGAFCVACD
FSQGMLAAGKDRDVSKVVGDGMQLPFADNSFDAVTISYGLRNIHDFRAGLKEMARVTKPGGRLTVAEFSTPVIPVFGTVY
KEYLMRLLPQAARAVSSNPEAYIYLADSIRAWPSQAELAREINQNGWSDCGWQNLTFGIVALHSAIKPEN

Sequences:

>Translated_230_residues
MAKADLDKDPFDVASMFDDVGKNYDLTNTVLSFGQDRVWRKRTRQRLDLKPGEKVLDLAAGTAVSTVELAKSGAFCVACD
FSQGMLAAGKDRDVSKVVGDGMQLPFADNSFDAVTISYGLRNIHDFRAGLKEMARVTKPGGRLTVAEFSTPVIPVFGTVY
KEYLMRLLPQAARAVSSNPEAYIYLADSIRAWPSQAELAREINQNGWSDCGWQNLTFGIVALHSAIKPEN
>Mature_229_residues
AKADLDKDPFDVASMFDDVGKNYDLTNTVLSFGQDRVWRKRTRQRLDLKPGEKVLDLAAGTAVSTVELAKSGAFCVACDF
SQGMLAAGKDRDVSKVVGDGMQLPFADNSFDAVTISYGLRNIHDFRAGLKEMARVTKPGGRLTVAEFSTPVIPVFGTVYK
EYLMRLLPQAARAVSSNPEAYIYLADSIRAWPSQAELAREINQNGWSDCGWQNLTFGIVALHSAIKPEN

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=259, Percent_Identity=31.6602316602317, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI48994983, Length=226, Percent_Identity=37.6106194690265, Blast_Score=156, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17557039, Length=228, Percent_Identity=33.7719298245614, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6323526, Length=241, Percent_Identity=30.7053941908714, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24641702, Length=239, Percent_Identity=31.3807531380753, Blast_Score=130, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 25245; Mature: 25114

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKADLDKDPFDVASMFDDVGKNYDLTNTVLSFGQDRVWRKRTRQRLDLKPGEKVLDLAA
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHC
GTAVSTVELAKSGAFCVACDFSQGMLAAGKDRDVSKVVGDGMQLPFADNSFDAVTISYGL
CCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEHHH
RNIHDFRAGLKEMARVTKPGGRLTVAEFSTPVIPVFGTVYKEYLMRLLPQAARAVSSNPE
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AYIYLADSIRAWPSQAELAREINQNGWSDCGWQNLTFGIVALHSAIKPEN
EEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AKADLDKDPFDVASMFDDVGKNYDLTNTVLSFGQDRVWRKRTRQRLDLKPGEKVLDLAA
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHC
GTAVSTVELAKSGAFCVACDFSQGMLAAGKDRDVSKVVGDGMQLPFADNSFDAVTISYGL
CCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEHHH
RNIHDFRAGLKEMARVTKPGGRLTVAEFSTPVIPVFGTVYKEYLMRLLPQAARAVSSNPE
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AYIYLADSIRAWPSQAELAREINQNGWSDCGWQNLTFGIVALHSAIKPEN
EEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]