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The map label for this gene is cycA [H]

Identifier: 62389368

GI number: 62389368

Start: 490579

End: 491940

Strand: Direct

Name: cycA [H]

Synonym: cg0555

Alternate gene names: 62389368

Gene position: 490579-491940 (Clockwise)

Preceding gene: 62389367

Following gene: 62389369

Centisome position: 14.94

GC content: 53.52

Gene sequence:

>1362_bases
TTGAGCAATAGACACCTTCAGCTCATCGCCATCGGCGGAGCGATCGGTACGGGTCTGTTCATGGGGTCCGGCAAGACGAT
CTCCGTTGCGGGGCCATCAGTAATTTTGGTGTACGCCATTATTGGTTTCATGCTTTTCTTCGTCATGCGTGCCATGGGAG
AGCTGCTGCTCGCCAATTTGAATTACAAATCTTTGCGCGATGCGGTCTCTGATATTTTGGGTCCTGGCGCAGGTTTTGTC
ACCGGCTGGACATATTGGTTCTGCTGGATTGCCACAGGCATGGCGGACATCGTGGCGATCACTGGATACACCCAATACTG
GTGGCCTGAGATCCCATTGTGGCTTCCAGGTGTGCTCACCATTGCGTTGCTGTTTGCCCTGAACTTGGCTGCGGTACGAC
TGTTCGGTGAGATGGAGTTTTGGTTCGCCATCATCAAAATCGTGGCTATCGTGTCCTTGATCGTCGTGGGACTTTTCATG
GTGGTCACAGCCTTTGAATCACCTAATGGCACCACCGCGCAGTTCAACAACCTCATTGAGCATGGCGGATTTTTCCCCAA
CGGCATCACCGGTTTCTTGGCTGGTTTCCAGATCGCTATCTTTGCGTTCGTCGGGATTGAACTTGCCGGCACTGCAGCTG
CAGAGACTGAGAATCCCACCAAGACGCTTCCTCGGGCAATCAACTCCATTCCCATCCGCATCGTGGTGTTCTATGTTTTG
GCGTTGGCTGTCATCATGATGGTCACCCCATGGGATCAGGTCCGTGCTGACAACAGCCCATTCGTGCAGATGTTCGCGCT
GGCAGGAATCCCAGCGGCGGCAGGCATCATTAACTTTGTGGTCATCACTTCTGCAGCGTCGTCTGCCAACAGTGGTATTT
TCTCCACCTCCCGCATGTTGTATGGATTGTCTTTGGAAGGCGCAGCTCCGAAACGGTGGAGCCGGTTGTCCAAGAACTTG
GTGCCAGCCAGGGGATTGACTTTTTCTGTGATTTGCCTCATTCCAGCGGTGGGTTTGCTGTACGCTGGCGGCACTGTCAT
CGAGGCATTCACACTGATCACCACGGTTTCTTCGGTGTTGTTCATGGTGGTGTGGTCCTACATTTTGGTGGCTTATATCG
TCTACCGCCGCAACAGCCCGGAATTACACAAAAAGTCGATTTTCAAAATGCCTGGCGGCGTGGTCATGGCAGTTGTGGTG
TTGGTGTTCTTCGCAGCGATGTTGGTGGTGCTGTCCCTGGAGCCGGATACCCGTGCAGCGCTCATCGCGACGCCAGTGTG
GTTCATCATTTTGGGTATCGGTTGGTTGTCCATCGGTGGAGCTAAGGGCGCTAAGCATCGCAGCCAAATAACCTCCCACT
AA

Upstream 100 bases:

>100_bases
TTAGCGCCCATTAACGCTTCACATCCTTATATTCCCAAGGAGCACGACCATTTCTGATTCAGCAGTCCAGGAGAATCACG
AACCGCACCTCAAGCGCGGT

Downstream 100 bases:

>100_bases
AGCTCCTGGGTTAGACTCGAACGCGTGGCTAAAGCAGATTTAGACAAGGACCCCTTCGACGTAGCGTCAATGTTCGATGA
CGTCGGAAAGAACTACGATC

Product: amino acid permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSNRHLQLIAIGGAIGTGLFMGSGKTISVAGPSVILVYAIIGFMLFFVMRAMGELLLANLNYKSLRDAVSDILGPGAGFV
TGWTYWFCWIATGMADIVAITGYTQYWWPEIPLWLPGVLTIALLFALNLAAVRLFGEMEFWFAIIKIVAIVSLIVVGLFM
VVTAFESPNGTTAQFNNLIEHGGFFPNGITGFLAGFQIAIFAFVGIELAGTAAAETENPTKTLPRAINSIPIRIVVFYVL
ALAVIMMVTPWDQVRADNSPFVQMFALAGIPAAAGIINFVVITSAASSANSGIFSTSRMLYGLSLEGAAPKRWSRLSKNL
VPARGLTFSVICLIPAVGLLYAGGTVIEAFTLITTVSSVLFMVVWSYILVAYIVYRRNSPELHKKSIFKMPGGVVMAVVV
LVFFAAMLVVLSLEPDTRAALIATPVWFIILGIGWLSIGGAKGAKHRSQITSH

Sequences:

>Translated_453_residues
MSNRHLQLIAIGGAIGTGLFMGSGKTISVAGPSVILVYAIIGFMLFFVMRAMGELLLANLNYKSLRDAVSDILGPGAGFV
TGWTYWFCWIATGMADIVAITGYTQYWWPEIPLWLPGVLTIALLFALNLAAVRLFGEMEFWFAIIKIVAIVSLIVVGLFM
VVTAFESPNGTTAQFNNLIEHGGFFPNGITGFLAGFQIAIFAFVGIELAGTAAAETENPTKTLPRAINSIPIRIVVFYVL
ALAVIMMVTPWDQVRADNSPFVQMFALAGIPAAAGIINFVVITSAASSANSGIFSTSRMLYGLSLEGAAPKRWSRLSKNL
VPARGLTFSVICLIPAVGLLYAGGTVIEAFTLITTVSSVLFMVVWSYILVAYIVYRRNSPELHKKSIFKMPGGVVMAVVV
LVFFAAMLVVLSLEPDTRAALIATPVWFIILGIGWLSIGGAKGAKHRSQITSH
>Mature_452_residues
SNRHLQLIAIGGAIGTGLFMGSGKTISVAGPSVILVYAIIGFMLFFVMRAMGELLLANLNYKSLRDAVSDILGPGAGFVT
GWTYWFCWIATGMADIVAITGYTQYWWPEIPLWLPGVLTIALLFALNLAAVRLFGEMEFWFAIIKIVAIVSLIVVGLFMV
VTAFESPNGTTAQFNNLIEHGGFFPNGITGFLAGFQIAIFAFVGIELAGTAAAETENPTKTLPRAINSIPIRIVVFYVLA
LAVIMMVTPWDQVRADNSPFVQMFALAGIPAAAGIINFVVITSAASSANSGIFSTSRMLYGLSLEGAAPKRWSRLSKNLV
PARGLTFSVICLIPAVGLLYAGGTVIEAFTLITTVSSVLFMVVWSYILVAYIVYRRNSPELHKKSIFKMPGGVVMAVVVL
VFFAAMLVVLSLEPDTRAALIATPVWFIILGIGWLSIGGAKGAKHRSQITSH

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=329, Percent_Identity=24.0121580547112, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790653, Length=448, Percent_Identity=65.8482142857143, Blast_Score=609, Evalue=1e-175,
Organism=Escherichia coli, GI1786302, Length=436, Percent_Identity=39.4495412844037, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI48994972, Length=425, Percent_Identity=40.4705882352941, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI1786602, Length=454, Percent_Identity=38.3259911894273, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI1786789, Length=436, Percent_Identity=36.4678899082569, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI87081915, Length=442, Percent_Identity=36.4253393665158, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI87081708, Length=461, Percent_Identity=32.9718004338395, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1788480, Length=404, Percent_Identity=33.9108910891089, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1789017, Length=326, Percent_Identity=33.7423312883436, Blast_Score=192, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17531343, Length=143, Percent_Identity=27.972027972028, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324924, Length=407, Percent_Identity=30.958230958231, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324061, Length=400, Percent_Identity=31.75, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324990, Length=397, Percent_Identity=31.4861460957179, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6320772, Length=343, Percent_Identity=32.0699708454811, Blast_Score=153, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=383, Percent_Identity=28.9817232375979, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319608, Length=438, Percent_Identity=26.2557077625571, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322892, Length=414, Percent_Identity=27.2946859903382, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6321629, Length=419, Percent_Identity=26.9689737470167, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6319543, Length=390, Percent_Identity=26.9230769230769, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324059, Length=339, Percent_Identity=31.2684365781711, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6319824, Length=389, Percent_Identity=26.9922879177378, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320251, Length=404, Percent_Identity=26.980198019802, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6319542, Length=396, Percent_Identity=25.2525252525253, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320717, Length=396, Percent_Identity=25.2525252525253, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321053, Length=428, Percent_Identity=28.2710280373832, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322967, Length=416, Percent_Identity=25.2403846153846, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324981, Length=434, Percent_Identity=26.2672811059908, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320364, Length=462, Percent_Identity=24.8917748917749, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI161077963, Length=213, Percent_Identity=25.3521126760563, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48692; Mature: 48560

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRHLQLIAIGGAIGTGLFMGSGKTISVAGPSVILVYAIIGFMLFFVMRAMGELLLANL
CCCCEEEEEEECCHHHHHEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NYKSLRDAVSDILGPGAGFVTGWTYWFCWIATGMADIVAITGYTQYWWPEIPLWLPGVLT
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHH
IALLFALNLAAVRLFGEMEFWFAIIKIVAIVSLIVVGLFMVVTAFESPNGTTAQFNNLIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
HGGFFPNGITGFLAGFQIAIFAFVGIELAGTAAAETENPTKTLPRAINSIPIRIVVFYVL
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
ALAVIMMVTPWDQVRADNSPFVQMFALAGIPAAAGIINFVVITSAASSANSGIFSTSRML
HHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YGLSLEGAAPKRWSRLSKNLVPARGLTFSVICLIPAVGLLYAGGTVIEAFTLITTVSSVL
EEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FMVVWSYILVAYIVYRRNSPELHKKSIFKMPGGVVMAVVVLVFFAAMLVVLSLEPDTRAA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHH
LIATPVWFIILGIGWLSIGGAKGAKHRSQITSH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCC
>Mature Secondary Structure 
SNRHLQLIAIGGAIGTGLFMGSGKTISVAGPSVILVYAIIGFMLFFVMRAMGELLLANL
CCCEEEEEEECCHHHHHEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NYKSLRDAVSDILGPGAGFVTGWTYWFCWIATGMADIVAITGYTQYWWPEIPLWLPGVLT
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHH
IALLFALNLAAVRLFGEMEFWFAIIKIVAIVSLIVVGLFMVVTAFESPNGTTAQFNNLIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
HGGFFPNGITGFLAGFQIAIFAFVGIELAGTAAAETENPTKTLPRAINSIPIRIVVFYVL
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
ALAVIMMVTPWDQVRADNSPFVQMFALAGIPAAAGIINFVVITSAASSANSGIFSTSRML
HHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YGLSLEGAAPKRWSRLSKNLVPARGLTFSVICLIPAVGLLYAGGTVIEAFTLITTVSSVL
EEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FMVVWSYILVAYIVYRRNSPELHKKSIFKMPGGVVMAVVVLVFFAAMLVVLSLEPDTRAA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHH
LIATPVWFIILGIGWLSIGGAKGAKHRSQITSH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]