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The map label for this gene is accC [H]

Identifier: 62185165

GI number: 62185165

Start: 618561

End: 619916

Strand: Direct

Name: accC [H]

Synonym: CAB540

Alternate gene names: 62185165

Gene position: 618561-619916 (Clockwise)

Preceding gene: 161501894

Following gene: 62185173

Centisome position: 54.05

GC content: 41.81

Gene sequence:

>1356_bases
ATGAAAAAAGTCTTAATCGCTAATCGCGGAGAAATTGCAGTGCGTATTATACGTGCTTGTCATGATCTGGGATTGGCCAC
AGTTGCAGTATATTCCCTGGCAGATCAAGAAGCCCTACACGTGCTACTAGCAGATGAAGCCGTGTGTATAGGAGAGCCTC
AAGCGGCTAAATCCTACTTAAAAATATCGAATATTCTCGCTGCTTGTGAAATTACAGGAGCAGATGCTGTTCATCCCGGC
TACGGTTTTTTAAGTGAAAATGCTAATTTCGCTTCCATATGCGAAAGCTGTGGTCTGACTTTTATTGGTCCTAGCTCAGA
ATCTATAGCGACAATGGGAGATAAAATCGCAGCGAAACAACTCGCTAAGAAAGTGAAATGTCCTGTCATTCCTGGCTCTG
AAGGCATTATTAAGGATGAAGCCGAAGGATTAAAAATTGCAGAGAAGATAGGTTTCCCAATAGTCATCAAAGCTGTTGCT
GGTGGAGGTGGTCGCGGTATCCGTATCGTTAAAGAAAAAGATGAGTTTTTCAGAGCTTTTTCAGCAGCAAGAGCAGAAGC
AGAGGCGGGATTCAATAATCCCGATGTCTATATTGAGAAGTTTATTGAAAACCCTAGACATCTAGAAGTCCAAATCCTCG
GAGATAAACATGGGAACTATGTGCATCTAGGGGAGAGAGATTGCACAGTACAAAGACGTAGGCAAAAACTCATTGAAGAG
ACCCCAAGTCCCATACTTACCCCAGAACTCCGAGCAAAAGTAGGGAAAGTCGCTGTTGATTTAGCAAGAAGTGCAAACTA
CCACTCCGTAGGTACAGTAGAATTTCTGTTAGATAAGGATAAGAAATTCTATTTCATGGAAATGAATACGCGTATCCAAG
TCGAGCACACGATCACTGAAGAAGTTACGGGCATAGATCTCCTGAAAGAGCAAATTTATGTAGCTATGGGGAATAAACTG
ACTTGGAAACAAAAAAATATTGTTTTCAAAGGGCACGTCATACAATGCCGTATTAATGCTGAGGATCCTAGCAACAATTT
CGCACCCTCTCCAGGGCGTTTAGACTACTATCTTCCACCTGCAGGCCCTTCTATACGTCTAGATGGAGCTTGCTATAGCG
GCTATGCTATTCCTCCTTATTACGATTCTATGATTGCTAAAGTGATTTCTAAGGGCAAGAATCGCGAAGAAGCTATAGCA
ATTATGAAGCGTGCTCTGAAAGAATTTCATATTGGGGGTGTCCACTCCACAATTCCTTTCCATCAATTCATGCTGGATAA
CCCTAAATTCATTAACTCAGACTATGATATCAACTATGTTGATCATCTTCTTTCCCAGGGCAACTCCTTATTTTAA

Upstream 100 bases:

>100_bases
TTAAAGCTGGTATGTCCGGTCGCGTTGTTGAAGTTCTCATCGCCAACGGCGACGCAGTACAATTTGGATCTAAGTTATTT
CGTATAGTTAAAGCTGAGTA

Downstream 100 bases:

>100_bases
GAATTTTTTTACAATTCTTGTGTCTAGAGATTCCTTCTCTAGACTCATGGGTCGATAATGACAATGTTAATAAAAATTAA
GAGAAGTGATTCTAGAAATC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKKVLIANRGEIAVRIIRACHDLGLATVAVYSLADQEALHVLLADEAVCIGEPQAAKSYLKISNILAACEITGADAVHPG
YGFLSENANFASICESCGLTFIGPSSESIATMGDKIAAKQLAKKVKCPVIPGSEGIIKDEAEGLKIAEKIGFPIVIKAVA
GGGGRGIRIVKEKDEFFRAFSAARAEAEAGFNNPDVYIEKFIENPRHLEVQILGDKHGNYVHLGERDCTVQRRRQKLIEE
TPSPILTPELRAKVGKVAVDLARSANYHSVGTVEFLLDKDKKFYFMEMNTRIQVEHTITEEVTGIDLLKEQIYVAMGNKL
TWKQKNIVFKGHVIQCRINAEDPSNNFAPSPGRLDYYLPPAGPSIRLDGACYSGYAIPPYYDSMIAKVISKGKNREEAIA
IMKRALKEFHIGGVHSTIPFHQFMLDNPKFINSDYDINYVDHLLSQGNSLF

Sequences:

>Translated_451_residues
MKKVLIANRGEIAVRIIRACHDLGLATVAVYSLADQEALHVLLADEAVCIGEPQAAKSYLKISNILAACEITGADAVHPG
YGFLSENANFASICESCGLTFIGPSSESIATMGDKIAAKQLAKKVKCPVIPGSEGIIKDEAEGLKIAEKIGFPIVIKAVA
GGGGRGIRIVKEKDEFFRAFSAARAEAEAGFNNPDVYIEKFIENPRHLEVQILGDKHGNYVHLGERDCTVQRRRQKLIEE
TPSPILTPELRAKVGKVAVDLARSANYHSVGTVEFLLDKDKKFYFMEMNTRIQVEHTITEEVTGIDLLKEQIYVAMGNKL
TWKQKNIVFKGHVIQCRINAEDPSNNFAPSPGRLDYYLPPAGPSIRLDGACYSGYAIPPYYDSMIAKVISKGKNREEAIA
IMKRALKEFHIGGVHSTIPFHQFMLDNPKFINSDYDINYVDHLLSQGNSLF
>Mature_451_residues
MKKVLIANRGEIAVRIIRACHDLGLATVAVYSLADQEALHVLLADEAVCIGEPQAAKSYLKISNILAACEITGADAVHPG
YGFLSENANFASICESCGLTFIGPSSESIATMGDKIAAKQLAKKVKCPVIPGSEGIIKDEAEGLKIAEKIGFPIVIKAVA
GGGGRGIRIVKEKDEFFRAFSAARAEAEAGFNNPDVYIEKFIENPRHLEVQILGDKHGNYVHLGERDCTVQRRRQKLIEE
TPSPILTPELRAKVGKVAVDLARSANYHSVGTVEFLLDKDKKFYFMEMNTRIQVEHTITEEVTGIDLLKEQIYVAMGNKL
TWKQKNIVFKGHVIQCRINAEDPSNNFAPSPGRLDYYLPPAGPSIRLDGACYSGYAIPPYYDSMIAKVISKGKNREEAIA
IMKRALKEFHIGGVHSTIPFHQFMLDNPKFINSDYDINYVDHLLSQGNSLF

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=47.427293064877, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI65506442, Length=447, Percent_Identity=47.427293064877, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=47.427293064877, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=46.4125560538117, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=46.4125560538117, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=46.4125560538117, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI116805327, Length=449, Percent_Identity=44.097995545657, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI38679977, Length=506, Percent_Identity=32.0158102766798, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI38679967, Length=506, Percent_Identity=32.0158102766798, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI38679960, Length=506, Percent_Identity=32.0158102766798, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI38679971, Length=506, Percent_Identity=32.0158102766798, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI38679974, Length=506, Percent_Identity=32.0158102766798, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI134142062, Length=507, Percent_Identity=31.3609467455621, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=50.3370786516854, Blast_Score=443, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17567343, Length=447, Percent_Identity=46.0850111856823, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71987519, Length=452, Percent_Identity=45.353982300885, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17562816, Length=446, Percent_Identity=46.1883408071749, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI133931226, Length=486, Percent_Identity=32.0987654320988, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71997163, Length=420, Percent_Identity=29.5238095238095, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71997168, Length=420, Percent_Identity=29.5238095238095, Blast_Score=190, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=45.9641255605381, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6321376, Length=446, Percent_Identity=45.7399103139013, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319685, Length=440, Percent_Identity=41.8181818181818, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6324343, Length=514, Percent_Identity=30.9338521400778, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323863, Length=454, Percent_Identity=32.15859030837, Blast_Score=223, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=47.9820627802691, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=47.9820627802691, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=47.9820627802691, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=47.9820627802691, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=47.9820627802691, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=47.9820627802691, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=47.9820627802691, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=47.9820627802691, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=47.9820627802691, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=47.9820627802691, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651757, Length=454, Percent_Identity=43.3920704845815, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651759, Length=416, Percent_Identity=42.5480769230769, Blast_Score=349, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24586458, Length=501, Percent_Identity=30.3393213572854, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI161076407, Length=501, Percent_Identity=30.3393213572854, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24586460, Length=501, Percent_Identity=30.3393213572854, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI161076409, Length=501, Percent_Identity=30.3393213572854, Blast_Score=233, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49682; Mature: 49682

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIANRGEIAVRIIRACHDLGLATVAVYSLADQEALHVLLADEAVCIGEPQAAKSYL
CCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHEEEEEECCEEECCCCHHHHHHH
KISNILAACEITGADAVHPGYGFLSENANFASICESCGLTFIGPSSESIATMGDKIAAKQ
HHHHHHHEEEECCCCCCCCCCCEECCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
LAKKVKCPVIPGSEGIIKDEAEGLKIAEKIGFPIVIKAVAGGGGRGIRIVKEKDEFFRAF
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCEEEEEECHHHHHHHH
SAARAEAEAGFNNPDVYIEKFIENPRHLEVQILGDKHGNYVHLGERDCTVQRRRQKLIEE
HHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
TPSPILTPELRAKVGKVAVDLARSANYHSVGTVEFLLDKDKKFYFMEMNTRIQVEHTITE
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEECCEEEEEEEHHH
EVTGIDLLKEQIYVAMGNKLTWKQKNIVFKGHVIQCRINAEDPSNNFAPSPGRLDYYLPP
HHHHHHHHHHHHHHEECCEEEEECCCEEEECEEEEEEEECCCCCCCCCCCCCCEEEEECC
AGPSIRLDGACYSGYAIPPYYDSMIAKVISKGKNREEAIAIMKRALKEFHIGGVHSTIPF
CCCCEEECCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCH
HQFMLDNPKFINSDYDINYVDHLLSQGNSLF
HHHHCCCCCEECCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKVLIANRGEIAVRIIRACHDLGLATVAVYSLADQEALHVLLADEAVCIGEPQAAKSYL
CCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHEEEEEECCEEECCCCHHHHHHH
KISNILAACEITGADAVHPGYGFLSENANFASICESCGLTFIGPSSESIATMGDKIAAKQ
HHHHHHHEEEECCCCCCCCCCCEECCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
LAKKVKCPVIPGSEGIIKDEAEGLKIAEKIGFPIVIKAVAGGGGRGIRIVKEKDEFFRAF
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCEEEEEECHHHHHHHH
SAARAEAEAGFNNPDVYIEKFIENPRHLEVQILGDKHGNYVHLGERDCTVQRRRQKLIEE
HHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHH
TPSPILTPELRAKVGKVAVDLARSANYHSVGTVEFLLDKDKKFYFMEMNTRIQVEHTITE
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEECCEEEEEEEHHH
EVTGIDLLKEQIYVAMGNKLTWKQKNIVFKGHVIQCRINAEDPSNNFAPSPGRLDYYLPP
HHHHHHHHHHHHHHEECCEEEEECCCEEEECEEEEEEEECCCCCCCCCCCCCCEEEEECC
AGPSIRLDGACYSGYAIPPYYDSMIAKVISKGKNREEAIAIMKRALKEFHIGGVHSTIPF
CCCCEEECCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCH
HQFMLDNPKFINSDYDINYVDHLLSQGNSLF
HHHHCCCCCEECCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]