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The map label for this gene is accB [H]

Identifier: 161501894

GI number: 161501894

Start: 618061

End: 618561

Strand: Direct

Name: accB [H]

Synonym: CAB539

Alternate gene names: 161501894

Gene position: 618061-618561 (Clockwise)

Preceding gene: 62185163

Following gene: 62185165

Centisome position: 54.01

GC content: 40.12

Gene sequence:

>501_bases
ATGGATTTAAAGCAAATAGAAAAGCTCATGATTGCTATGGGACGTAATAGCATGAAGCGTTTTGTGATAAAACGTGAAGG
GCTAGAGCTTGAATTGGAAAGAGACACAGGAGATAAACCTAATCAAGAACCCGTGTTTTACGACAGTAGGTTATTCGCAG
GTTTTGCTCAGGAGCGCCCTATTCCTACCGATCCTAATAAAACAATCGCTAAAGATGTGGCTCCTGAAAAAACAGAAACT
GAATCTCAACAAGCTCTTGGAGATTTTATTAGCTCTCCACTAGTAGGCACATTTTATAGTTCTCCTTCTCCAGACTCTCC
ATCTTTTGTTAAACCTGGTGATGTCGTTTCTGAAGATACCATTGTTTGTATCGTAGAAGCTATGAAAGTGATGAATGAAG
TTAAAGCTGGTATGTCCGGTCGCGTTGTTGAAGTTCTCATCGCCAACGGCGACGCAGTACAATTTGGATCTAAGTTATTT
CGTATAGTTAAAGCTGAGTAA

Upstream 100 bases:

>100_bases
CCTTTCATAGAAATTGGGGATATTATAAAAATTGATACGCGCACGTGTGAATATATTCAACGCGTCTAACTTCAGGCTGA
GAAGATAAGAGAAAATAAAT

Downstream 100 bases:

>100_bases
TGAAAAAAGTCTTAATCGCTAATCGCGGAGAAATTGCAGTGCGTATTATACGTGCTTGTCATGATCTGGGATTGGCCACA
GTTGCAGTATATTCCCTGGC

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MDLKQIEKLMIAMGRNSMKRFVIKREGLELELERDTGDKPNQEPVFYDSRLFAGFAQERPIPTDPNKTIAKDVAPEKTET
ESQQALGDFISSPLVGTFYSSPSPDSPSFVKPGDVVSEDTIVCIVEAMKVMNEVKAGMSGRVVEVLIANGDAVQFGSKLF
RIVKAE

Sequences:

>Translated_166_residues
MDLKQIEKLMIAMGRNSMKRFVIKREGLELELERDTGDKPNQEPVFYDSRLFAGFAQERPIPTDPNKTIAKDVAPEKTET
ESQQALGDFISSPLVGTFYSSPSPDSPSFVKPGDVVSEDTIVCIVEAMKVMNEVKAGMSGRVVEVLIANGDAVQFGSKLF
RIVKAE
>Mature_166_residues
MDLKQIEKLMIAMGRNSMKRFVIKREGLELELERDTGDKPNQEPVFYDSRLFAGFAQERPIPTDPNKTIAKDVAPEKTET
ESQQALGDFISSPLVGTFYSSPSPDSPSFVKPGDVVSEDTIVCIVEAMKVMNEVKAGMSGRVVEVLIANGDAVQFGSKLF
RIVKAE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=76, Percent_Identity=44.7368421052632, Blast_Score=74, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 18315; Mature: 18315

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKQIEKLMIAMGRNSMKRFVIKREGLELELERDTGDKPNQEPVFYDSRLFAGFAQERP
CCHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEECHHHHHHHHHCCC
IPTDPNKTIAKDVAPEKTETESQQALGDFISSPLVGTFYSSPSPDSPSFVKPGDVVSEDT
CCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCH
IVCIVEAMKVMNEVKAGMSGRVVEVLIANGDAVQFGSKLFRIVKAE
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLKQIEKLMIAMGRNSMKRFVIKREGLELELERDTGDKPNQEPVFYDSRLFAGFAQERP
CCHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEECHHHHHHHHHCCC
IPTDPNKTIAKDVAPEKTETESQQALGDFISSPLVGTFYSSPSPDSPSFVKPGDVVSEDT
CCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCH
IVCIVEAMKVMNEVKAGMSGRVVEVLIANGDAVQFGSKLFRIVKAE
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]