Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 62185122

GI number: 62185122

Start: 571261

End: 573753

Strand: Direct

Name: gyrA [H]

Synonym: CAB494

Alternate gene names: 62185122

Gene position: 571261-573753 (Clockwise)

Preceding gene: 62185121

Following gene: 62185123

Centisome position: 49.92

GC content: 41.2

Gene sequence:

>2493_bases
ATGTTGAACAAAGAAGAAATCATTGTCCCTAAAAATCTAGAAGAAGAGATGAAGGAAAGTTACCTTCGTTACTCTATGTC
GGTAATTATTTCTCGCGCACTTCCTGATGTCCGGGATGGTTTGAAACCTTCGCAAAGACGTATTCTTTATGCAATGAAGC
AGTTAAACCTCACTCCTGGAGCGAAGCATCGTAAATGTGCTAAAATTTGCGGTGATACTTCCGGAGATTACCATCCTCAT
GGAGAGAGTGTAATTTATCCTACGTTAGTGCGTATGGCTCAAAACTGGGCGATGCGTTATCCACTAGTCGATGGTCAAGG
AAACTTCGGCTCTATTGACGGGGATCCTGCCGCTGCTATGCGTTATACGGAAGCCCGCTTAACCCATAGCGCGATCTTCC
TCATGGAAGATTTAGATAAAGATACCGTAGACATGGTATCCAACTATGACGAAACGAAGCACGAGCCTGTTGTTTTTCCT
TCGAAGTTTCCTAATCTTCTTTGCAATGGTTCCTCTGGTATTGCTGTCGGTATGGCAACAAATATCCCTCCTCATAACCT
CGGGGAGTTAATAGAAGCCACGCTCTTGGTGTTGAGTAAGCCTGATGTCTCTATAGAAGAAATCTTAGAAGTCATGCCAG
GACCAGATTTCCCCACAGGGGGATTGATTTGTGGTAGTGAGGGTATCCGCTCTACCTACTATACAGGAAGAGGAAAGATA
AAAGTTCGTGCACGTCTTCATGTAGAAGAGAACGCGGACAAACATCGTGAGAATATCATTCTTACAGAGATGCCCTACAA
TGTAAACAAGTCAAGATTAATCGAACAAATTGCTGATCTTGTTAACGATAAGACTTTATCGGGTATTTCTGATGTTCGAG
ATGAATCAGATAAAGATGGTATCCGTGTTGTTCTCGAGCTTAAGAAGGGAGAGTCATCGGAAGTTGTTATCAACCGTCTC
TATAAATTTACTGATATTCAGGTGACTTTCGGAGCCAATATGCTCGCCTTGGATAAAAATCTTCCAAGGACAATGAATAT
TCATAGAATGATTTCTGTATGGGTGCGCCACCGTACAGAGGTAATCCGTAGAAGAACTCGTTATGAGTTAAATAAAGCTG
AAGCACGTGCTCATATCCTCGAAGGTTTCTTAAAAGCTCTTTCTTGTTTAGACGATGTTGTACACACAATCCGTAATAGT
GAGAGTAAAGAACACGCTAAGCATCAATTGATTGAAAAGTTTGGATTTACTGAACATCAATCTATAGCAATTCTGGAGTT
GCGTTTATACCAACTTACCGGATTGGAAGCTGAGAAAATTCAAAAAGAATACGATGAGTTAGTCAATAAAATTGCTTACT
ACAAACGTGTTCTTGCTGATGAAGGCTTAGTAAAAGATATCATTAGAAATGAACTTCAAGAGCTGCAAAAGCTTCATAAA
ACTCCTCGTAGAACGACGATAGAATTTGATGCGGATGACATTCGTGATATTGAAGATATTATCACCAACGAACCTGTGAT
TATTACAATATCAGGAGATGATTACGTAAAAAGAATGCCTATAAAGGTCTTTAGAGAACAGAAACGCGGTGGTCACGGTG
TTTCCGGATTTGACATGAAGAAAGGTTCGGACTTTTTAAAGGCAGTATATTCAGCATCAACAAAAGACTACCTGTTGATT
TTCACCAATTTTGGACAATGTTATTGGTTGAAAGTGTGGCAATTGCCAGAGGGGGAAAGACGAGCTAAGGGTAAACCGAT
CATCAATTTTCTTGAAGGTATTCGTCCTGGGGAACAGTTAGCAGCTGTTCTGAATATTAAGAATTTTGAAAATGCAGGAT
TCTTATTCTTAGCAACCAAACACGGTGTAGTCAAAAAAGTAGCTCTTGATGCGTTCAGCAATCCCAGAAAGAAAGGCATT
CGCGCTCTAGAAATCGATGACGGTGATGAGCTTATTGCTGCTGTGCACATTACTAGTGAAGAAGAAAAGGTCATGCTATT
CACAAGATTGGGGATGGCGGTACGCTTTCCTCATGATAAGGTGCGGCCTATGGGAAGAACAGCACGTGGCGTACGTGGGG
TCTCATTGAAAAATGAAAAAGATCGTGTTGTTGCTTGTCAAATTGTTAGAGATGATCAATCTGTTCTTGTTGTCTGCGAT
AATGGCTTCGGGAAACGCTCTCAAGTAGAAGATTTCCGAGAAACTAATCGAGGAGGGGTAGGAGTACGTTCTATTCTTAT
CAACGAGAGAAATGGAGATGTTCTTGGAGCAATTTCTGTGACAGATCACGACAGTATCTTACTCATGTCAGCACAAGGAC
AGGCTATTCGTATTAACATGCAGGATGTACGTGTGATGGGAAGGTCCACTCAAGGGGTGCGCTTAGTTCACGTTAAAGAA
GGTGATACCCTTGTTGCCATGGAAAAACTCTCGTTAAATGAAGATGAGACGCTAACAAATATTGAAGAAGAGAGTGCCTC
ACCACAAGTATAA

Upstream 100 bases:

>100_bases
GCTAATGGGAGAAGAGGTGCCTCCAAGAAGAGAATTTATTGAAAATCACGCTCTATCAGTTAAGATGAATAATTTGGATA
TTTAGGAGACGGTCATCACT

Downstream 100 bases:

>100_bases
AGGAATAAAGCCATGTTTATAGTGATTGAGGGATGTGAAGGGTCAGGAAAAAGCTCTTTAACACAACTTCTAAAAGATAA
GCTTATGGCTGAAGGGAAAG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 830; Mature: 830

Protein sequence:

>830_residues
MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDVRDGLKPSQRRILYAMKQLNLTPGAKHRKCAKICGDTSGDYHPH
GESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPAAAMRYTEARLTHSAIFLMEDLDKDTVDMVSNYDETKHEPVVFP
SKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLVLSKPDVSIEEILEVMPGPDFPTGGLICGSEGIRSTYYTGRGKI
KVRARLHVEENADKHRENIILTEMPYNVNKSRLIEQIADLVNDKTLSGISDVRDESDKDGIRVVLELKKGESSEVVINRL
YKFTDIQVTFGANMLALDKNLPRTMNIHRMISVWVRHRTEVIRRRTRYELNKAEARAHILEGFLKALSCLDDVVHTIRNS
ESKEHAKHQLIEKFGFTEHQSIAILELRLYQLTGLEAEKIQKEYDELVNKIAYYKRVLADEGLVKDIIRNELQELQKLHK
TPRRTTIEFDADDIRDIEDIITNEPVIITISGDDYVKRMPIKVFREQKRGGHGVSGFDMKKGSDFLKAVYSASTKDYLLI
FTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEQLAAVLNIKNFENAGFLFLATKHGVVKKVALDAFSNPRKKGI
RALEIDDGDELIAAVHITSEEEKVMLFTRLGMAVRFPHDKVRPMGRTARGVRGVSLKNEKDRVVACQIVRDDQSVLVVCD
NGFGKRSQVEDFRETNRGGVGVRSILINERNGDVLGAISVTDHDSILLMSAQGQAIRINMQDVRVMGRSTQGVRLVHVKE
GDTLVAMEKLSLNEDETLTNIEEESASPQV

Sequences:

>Translated_830_residues
MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDVRDGLKPSQRRILYAMKQLNLTPGAKHRKCAKICGDTSGDYHPH
GESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPAAAMRYTEARLTHSAIFLMEDLDKDTVDMVSNYDETKHEPVVFP
SKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLVLSKPDVSIEEILEVMPGPDFPTGGLICGSEGIRSTYYTGRGKI
KVRARLHVEENADKHRENIILTEMPYNVNKSRLIEQIADLVNDKTLSGISDVRDESDKDGIRVVLELKKGESSEVVINRL
YKFTDIQVTFGANMLALDKNLPRTMNIHRMISVWVRHRTEVIRRRTRYELNKAEARAHILEGFLKALSCLDDVVHTIRNS
ESKEHAKHQLIEKFGFTEHQSIAILELRLYQLTGLEAEKIQKEYDELVNKIAYYKRVLADEGLVKDIIRNELQELQKLHK
TPRRTTIEFDADDIRDIEDIITNEPVIITISGDDYVKRMPIKVFREQKRGGHGVSGFDMKKGSDFLKAVYSASTKDYLLI
FTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEQLAAVLNIKNFENAGFLFLATKHGVVKKVALDAFSNPRKKGI
RALEIDDGDELIAAVHITSEEEKVMLFTRLGMAVRFPHDKVRPMGRTARGVRGVSLKNEKDRVVACQIVRDDQSVLVVCD
NGFGKRSQVEDFRETNRGGVGVRSILINERNGDVLGAISVTDHDSILLMSAQGQAIRINMQDVRVMGRSTQGVRLVHVKE
GDTLVAMEKLSLNEDETLTNIEEESASPQV
>Mature_830_residues
MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDVRDGLKPSQRRILYAMKQLNLTPGAKHRKCAKICGDTSGDYHPH
GESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPAAAMRYTEARLTHSAIFLMEDLDKDTVDMVSNYDETKHEPVVFP
SKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLVLSKPDVSIEEILEVMPGPDFPTGGLICGSEGIRSTYYTGRGKI
KVRARLHVEENADKHRENIILTEMPYNVNKSRLIEQIADLVNDKTLSGISDVRDESDKDGIRVVLELKKGESSEVVINRL
YKFTDIQVTFGANMLALDKNLPRTMNIHRMISVWVRHRTEVIRRRTRYELNKAEARAHILEGFLKALSCLDDVVHTIRNS
ESKEHAKHQLIEKFGFTEHQSIAILELRLYQLTGLEAEKIQKEYDELVNKIAYYKRVLADEGLVKDIIRNELQELQKLHK
TPRRTTIEFDADDIRDIEDIITNEPVIITISGDDYVKRMPIKVFREQKRGGHGVSGFDMKKGSDFLKAVYSASTKDYLLI
FTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEQLAAVLNIKNFENAGFLFLATKHGVVKKVALDAFSNPRKKGI
RALEIDDGDELIAAVHITSEEEKVMLFTRLGMAVRFPHDKVRPMGRTARGVRGVSLKNEKDRVVACQIVRDDQSVLVVCD
NGFGKRSQVEDFRETNRGGVGVRSILINERNGDVLGAISVTDHDSILLMSAQGQAIRINMQDVRVMGRSTQGVRLVHVKE
GDTLVAMEKLSLNEDETLTNIEEESASPQV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=317, Percent_Identity=25.8675078864353, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI19913406, Length=316, Percent_Identity=24.0506329113924, Blast_Score=74, Evalue=8e-13,
Organism=Escherichia coli, GI1788562, Length=843, Percent_Identity=46.6192170818505, Blast_Score=739, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=681, Percent_Identity=34.9486049926579, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI212645845, Length=403, Percent_Identity=25.5583126550869, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324241, Length=345, Percent_Identity=28.1159420289855, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136538, Length=366, Percent_Identity=24.0437158469945, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93644; Mature: 93644

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDVRDGLKPSQRRILYAMKQLNLTPG
CCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCC
AKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPAAAM
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCEECCCCCCCCCCCCHHHHH
RYTEARLTHSAIFLMEDLDKDTVDMVSNYDETKHEPVVFPSKFPNLLCNGSSGIAVGMAT
HHHHHHHHHHHEEEHHHCCCHHHHHHHCCCCCCCCCEECCCCCCCEEECCCCCEEEEEEC
NIPPHNLGELIEATLLVLSKPDVSIEEILEVMPGPDFPTGGLICGSEGIRSTYYTGRGKI
CCCCCCHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCCCEEECCCEE
KVRARLHVEENADKHRENIILTEMPYNVNKSRLIEQIADLVNDKTLSGISDVRDESDKDG
EEEEEEEECCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCHHCCHHHHCCCCCCCC
IRVVLELKKGESSEVVINRLYKFTDIQVTFGANMLALDKNLPRTMNIHRMISVWVRHRTE
EEEEEEECCCCCHHHHHHHHHHHEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHH
VIRRRTRYELNKAEARAHILEGFLKALSCLDDVVHTIRNSESKEHAKHQLIEKFGFTEHQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
SIAILELRLYQLTGLEAEKIQKEYDELVNKIAYYKRVLADEGLVKDIIRNELQELQKLHK
CEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
TPRRTTIEFDADDIRDIEDIITNEPVIITISGDDYVKRMPIKVFREQKRGGHGVSGFDMK
CCCCEEEEECCHHHHHHHHHHCCCCEEEEECCCHHHHHCCHHHHHHHHCCCCCCCCCCCC
KGSDFLKAVYSASTKDYLLIFTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEQL
CCHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCHHHCCCCHHHHHHHCCCCHHHH
AAVLNIKNFENAGFLFLATKHGVVKKVALDAFSNPRKKGIRALEIDDGDELIAAVHITSE
HHHHEECCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCEEEEECCCCCEEEEEEEECC
EEKVMLFTRLGMAVRFPHDKVRPMGRTARGVRGVSLKNEKDRVVACQIVRDDQSVLVVCD
CCEEEEEEECCCEEECCCHHCCCCCCHHCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEC
NGFGKRSQVEDFRETNRGGVGVRSILINERNGDVLGAISVTDHDSILLMSAQGQAIRINM
CCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEECCCCEEEEEH
QDVRVMGRSTQGVRLVHVKEGDTLVAMEKLSLNEDETLTNIEEESASPQV
HHHHEECCCCCCEEEEEEECCCEEEEEEECCCCCCCHHHCCHHCCCCCCC
>Mature Secondary Structure
MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDVRDGLKPSQRRILYAMKQLNLTPG
CCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCC
AKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPAAAM
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHEECCEECCCCCCCCCCCCHHHHH
RYTEARLTHSAIFLMEDLDKDTVDMVSNYDETKHEPVVFPSKFPNLLCNGSSGIAVGMAT
HHHHHHHHHHHEEEHHHCCCHHHHHHHCCCCCCCCCEECCCCCCCEEECCCCCEEEEEEC
NIPPHNLGELIEATLLVLSKPDVSIEEILEVMPGPDFPTGGLICGSEGIRSTYYTGRGKI
CCCCCCHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCCCEEECCCEE
KVRARLHVEENADKHRENIILTEMPYNVNKSRLIEQIADLVNDKTLSGISDVRDESDKDG
EEEEEEEECCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCHHCCHHHHCCCCCCCC
IRVVLELKKGESSEVVINRLYKFTDIQVTFGANMLALDKNLPRTMNIHRMISVWVRHRTE
EEEEEEECCCCCHHHHHHHHHHHEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHH
VIRRRTRYELNKAEARAHILEGFLKALSCLDDVVHTIRNSESKEHAKHQLIEKFGFTEHQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
SIAILELRLYQLTGLEAEKIQKEYDELVNKIAYYKRVLADEGLVKDIIRNELQELQKLHK
CEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
TPRRTTIEFDADDIRDIEDIITNEPVIITISGDDYVKRMPIKVFREQKRGGHGVSGFDMK
CCCCEEEEECCHHHHHHHHHHCCCCEEEEECCCHHHHHCCHHHHHHHHCCCCCCCCCCCC
KGSDFLKAVYSASTKDYLLIFTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEQL
CCHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCHHHCCCCHHHHHHHCCCCHHHH
AAVLNIKNFENAGFLFLATKHGVVKKVALDAFSNPRKKGIRALEIDDGDELIAAVHITSE
HHHHEECCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCEEEEECCCCCEEEEEEEECC
EEKVMLFTRLGMAVRFPHDKVRPMGRTARGVRGVSLKNEKDRVVACQIVRDDQSVLVVCD
CCEEEEEEECCCEEECCCHHCCCCCCHHCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEC
NGFGKRSQVEDFRETNRGGVGVRSILINERNGDVLGAISVTDHDSILLMSAQGQAIRINM
CCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEEECCCCCEEEEECCCCEEEEEH
QDVRVMGRSTQGVRLVHVKEGDTLVAMEKLSLNEDETLTNIEEESASPQV
HHHHEECCCCCCEEEEEEECCCEEEEEEECCCCCCCHHHCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9784136 [H]