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The map label for this gene is tmk

Identifier: 62185123

GI number: 62185123

Start: 573766

End: 574401

Strand: Direct

Name: tmk

Synonym: CAB495

Alternate gene names: 62185123

Gene position: 573766-574401 (Clockwise)

Preceding gene: 62185122

Following gene: 62185124

Centisome position: 50.14

GC content: 40.57

Gene sequence:

>636_bases
ATGTTTATAGTGATTGAGGGATGTGAAGGGTCAGGAAAAAGCTCTTTAACACAACTTCTAAAAGATAAGCTTATGGCTGA
AGGGAAAGCAGTTGTAGCGACGAGAGAACCAGGGGGCTCTTCCCTAGGTGAACGCGTGCGTGATTGGATTTTAGACCCCT
CTACAACAGAGCTGTCTCCCTATACAGAGCTGTTTCTATTTCTTGCAGCACGTGCGCAACACATAACTGAAAAAATACTA
CCAGCTTTAGAATTGGGGAAAATTGTGGTATGTGACAGGTTCCATGATTCTACAATTGTCTATCAAGGGATCGTTGGAGG
GCTGGGTAAGGAATATGTGACCAATCTCTGTCATTCTGTGGTAGGACAAAAAAAAATTCTTCCCAATCTTACCTGCCTTT
TAGATATTCCTGCTGATGAAGGACTAAAAAGGAAACAACAACAAAAGTCTTTTGATAAGTTTGAAAATCAGTCTTTGGCG
TACCATACAAAAATCCGCGAAGGTTTTTTATCTCTTGCCGAATCACGTCTTGACAGCTATCTTGTTTTAGATGCTCGACA
ACCTATAGAGGAATCACTTAACAAAGTTATGACCGCTTATACAGAATTAGCCTTATGCAAGTCGAAGGAAAGATAA

Upstream 100 bases:

>100_bases
TACCCTTGTTGCCATGGAAAAACTCTCGTTAAATGAAGATGAGACGCTAACAAATATTGAAGAAGAGAGTGCCTCACCAC
AAGTATAAAGGAATAAAGCC

Downstream 100 bases:

>100_bases
CGAATAAACCTTGGGAAGCTTTACTTGATAACATTAATCAAGGTAAGGTAAGCCATGCTATTTTATTGCACGGAAGCTCG
TTATCGATTCTTTCTCAATA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MFIVIEGCEGSGKSSLTQLLKDKLMAEGKAVVATREPGGSSLGERVRDWILDPSTTELSPYTELFLFLAARAQHITEKIL
PALELGKIVVCDRFHDSTIVYQGIVGGLGKEYVTNLCHSVVGQKKILPNLTCLLDIPADEGLKRKQQQKSFDKFENQSLA
YHTKIREGFLSLAESRLDSYLVLDARQPIEESLNKVMTAYTELALCKSKER

Sequences:

>Translated_211_residues
MFIVIEGCEGSGKSSLTQLLKDKLMAEGKAVVATREPGGSSLGERVRDWILDPSTTELSPYTELFLFLAARAQHITEKIL
PALELGKIVVCDRFHDSTIVYQGIVGGLGKEYVTNLCHSVVGQKKILPNLTCLLDIPADEGLKRKQQQKSFDKFENQSLA
YHTKIREGFLSLAESRLDSYLVLDARQPIEESLNKVMTAYTELALCKSKER
>Mature_211_residues
MFIVIEGCEGSGKSSLTQLLKDKLMAEGKAVVATREPGGSSLGERVRDWILDPSTTELSPYTELFLFLAARAQHITEKIL
PALELGKIVVCDRFHDSTIVYQGIVGGLGKEYVTNLCHSVVGQKKILPNLTCLLDIPADEGLKRKQQQKSFDKFENQSLA
YHTKIREGFLSLAESRLDSYLVLDARQPIEESLNKVMTAYTELALCKSKER

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=204, Percent_Identity=34.3137254901961, Blast_Score=113, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_CHLAB (Q5L5Y4)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_219908.1
- ProteinModelPortal:   Q5L5Y4
- GeneID:   3337585
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB495
- HOGENOM:   HBG626009
- OMA:   MLITLEG
- PhylomeDB:   Q5L5Y4
- ProtClustDB:   PRK00698
- BioCyc:   CABO218497:CAB495-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23491; Mature: 23491

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIVIEGCEGSGKSSLTQLLKDKLMAEGKAVVATREPGGSSLGERVRDWILDPSTTELSP
CEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCH
YTELFLFLAARAQHITEKILPALELGKIVVCDRFHDSTIVYQGIVGGLGKEYVTNLCHSV
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHH
VGQKKILPNLTCLLDIPADEGLKRKQQQKSFDKFENQSLAYHTKIREGFLSLAESRLDSY
HCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHE
LVLDARQPIEESLNKVMTAYTELALCKSKER
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFIVIEGCEGSGKSSLTQLLKDKLMAEGKAVVATREPGGSSLGERVRDWILDPSTTELSP
CEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCH
YTELFLFLAARAQHITEKILPALELGKIVVCDRFHDSTIVYQGIVGGLGKEYVTNLCHSV
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHH
VGQKKILPNLTCLLDIPADEGLKRKQQQKSFDKFENQSLAYHTKIREGFLSLAESRLDSY
HCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHE
LVLDARQPIEESLNKVMTAYTELALCKSKER
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA