| Definition | Chlamydophila abortus S26/3, complete genome. |
|---|---|
| Accession | NC_004552 |
| Length | 1,144,377 |
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The map label for this gene is gyrB [H]
Identifier: 62185121
GI number: 62185121
Start: 568825
End: 571245
Strand: Direct
Name: gyrB [H]
Synonym: CAB493
Alternate gene names: 62185121
Gene position: 568825-571245 (Clockwise)
Preceding gene: 62185120
Following gene: 62185122
Centisome position: 49.71
GC content: 39.57
Gene sequence:
>2421_bases ATGGACGCAAAAGAAAAAAATTATGACGCCTCAGCTATCACTGTTTTAGAAGGGCTTCAAGCCGTTCGTGAGCGTCCTGG AATGTATATAGGCGATACTGGGATCACAGGGCTTCATCACTTAGTGTATGAGGTAGTGGATAACAGTATCGACGAAGCCA TGGCGGGGTATTGTTCCGAAATCCATGTAAGAATTTTAGAGGACGGTGGGATTACTATCTCTGACAATGGTCGAGGTATC CCAATTCAGACGCATGAAAAGGAATCTAAAAAACAAGGTAGAGATGTTTCCGCATTAGAGGTTGTTCTCACGGTACTGCA TGCTGGAGGAAAATTTGATAAGGATAGCTATAAAGTATCCGGAGGCTTACACGGTGTTGGAGTTTCTTGCGTTAACGCTT TGGCAGAAAAGTTAGTAGCTACAGTATACAAAGATAAGCAAGCGTATCAGATGGAGTTCTCCAGAGGGGTTCCTGTAACG AGTTTGCAATGTTTAGGAGCTACCAATAAGCAGGGGACAGAAATTACTTTCTACCCCGATAATAAGATCTTTTCTTCATG TGTTTTTGATCGCTCTATCTTAATTAAAAGATTACGAGAACTGGCATTTTTGAATCGTGGTGTAACGATCATTTTTGAAG ATGATCGCGACGTCAGTTTTGATAAAGTTGTCTTTTTCTATGAAGGGGGCATCCAATCCTTCGTTAGTTATTTAAATCAG AATAAAGAAAGTCTTTTTCCAGAACCCATTTATATTTCAGGTAGTCGCACGGGAGATGATGGTGAGATTGAATTCGAAGC GGCCCTGCAATGGAATTCTGGATACTCTGAATTAATTTATTCATACGCAAATAATATTCCTACACGTCAAGGAGGAACGC ACCTTACAGGATTTTCTACAGCATTAACTCGTGTTCTCAATGCCTATATTAAAGCACATAATTTAGCCAAGAATGATAAG CTCTCGTTAACGGGAGAAGACATTCGGGAAGGACTCACGGCTGTAGTTTCTGTAAAAGTTCCTAATCCTCAGTTTGAAGG GCAAACTAAGCAGAAACTAGGCAATAGTGATGTAGGCTCCGTATCACAACAGATCACTGGAGAAGCGCTAACAATATTCT TTGATGAGAACCCGCAAATTGCGAAGATGATCGTTGACAAGGTTTTCATTGCAGCTCAGGCTAGAGAAGCAGCAAAGAAA GCCAGGGAACTGACGTTAAGGAAAAGCGCTTTAGACAGCGCACGACTTCCTGGAAAGCTTATTGACTGTTTGGAAAAGGA TCCTGCAAAATGTGAAATGTACATTGTGGAGGGGGATTCCGCTGGAGGATCTGCTAAGCAAGGTAGAGACCGTCGTTTCC AGGCTATTTTACCTATCCGAGGTAAGATCTTGAATGTTGAGAAAGCTCGTTTACAAAAGATCTTCCAAAACCAAGAAATA GGAACAATTATAGCGGCTTTAGGTTGCGGGATCGGATCGGATAATTTTAATTTAAGTAAGCTACGTTATCGACGTATAAT TATCATGACAGATGCAGATGTTGATGGCTCCCATATTCGTACTCTGTTATTAACCTTCTTCTATCGCCATATGACAGCAT TAATTGAAAATGAATGTGTCTATATAGCTCAGCCTCCTTTATACAAAGTAAGCAAGAAAAAAGATTTCCGTTATATTCTT TCAGAAAAGGAAATGGATGATTATCTATTAACCTTAGGAATTTGCGACAGTAAACTGGTGTTTAAAAACGGAGATCGTGA AATAAGTGGAGAAGCTTTGGACAGCTTTGTCAAGCTGATCTTAAACATAGAAAACTTCATTGTTGCTTTAGAGAAAAAAG CTGTTCCTTTTTCTGAATTTTTAGAAATGCGCAAGGAAACTGTAGGCTATCCTTTGTACTATCGTCCTCCGCAAAGTGGG AAGCAGGGGGGACGCTATTTCTATTCTTCTGAGGAAAAAGAAGAAGAGATGGTGTCTGGAGAAGATTCGGATTCGACTAA GGTTATTGAATTATATAAAACGTCGATCTTTGCAGAAATTCAAGAGGAATTGCGAAATTATGGTTTAGATATTCGCCATT ATCTCAATCCCAAAGATTCTGAAATGGTGATAACCAATGAAGATGCAAAAACGCTGCCTTATACTTGTTATACTTTAAAA GAGGTGATCGAGCATCTCAAAGCTCTGGGAAGAAAAGGTATAGAAATTCAGCGTTATAAAGGTCTTGGAGAAATGAATGC TGATCAGCTTTGGGATATAACTATGAATCCTGAACAGAGAACTTTAGTTCGTGTGTCATTGAAAGATGCTGTTGAGGCAG ATCATATCTTCACCATGCTAATGGGAGAAGAGGTGCCTCCAAGAAGAGAATTTATTGAAAATCACGCTCTATCAGTTAAG ATGAATAATTTGGATATTTAG
Upstream 100 bases:
>100_bases TTCGCTAAAGCAAATGCACCAAAGTAGTTTACTAGCTCGTTTGCATCAAGTAGTTCCTCACGCTAAGATCAAGGAAATAC AGTTTTTGTTAGGATAATGT
Downstream 100 bases:
>100_bases GAGACGGTCATCACTATGTTGAACAAAGAAGAAATCATTGTCCCTAAAAATCTAGAAGAAGAGATGAAGGAAAGTTACCT TCGTTACTCTATGTCGGTAA
Product: DNA gyrase subunit B
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 806; Mature: 806
Protein sequence:
>806_residues MDAKEKNYDASAITVLEGLQAVRERPGMYIGDTGITGLHHLVYEVVDNSIDEAMAGYCSEIHVRILEDGGITISDNGRGI PIQTHEKESKKQGRDVSALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALAEKLVATVYKDKQAYQMEFSRGVPVT SLQCLGATNKQGTEITFYPDNKIFSSCVFDRSILIKRLRELAFLNRGVTIIFEDDRDVSFDKVVFFYEGGIQSFVSYLNQ NKESLFPEPIYISGSRTGDDGEIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFSTALTRVLNAYIKAHNLAKNDK LSLTGEDIREGLTAVVSVKVPNPQFEGQTKQKLGNSDVGSVSQQITGEALTIFFDENPQIAKMIVDKVFIAAQAREAAKK ARELTLRKSALDSARLPGKLIDCLEKDPAKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEI GTIIAALGCGIGSDNFNLSKLRYRRIIIMTDADVDGSHIRTLLLTFFYRHMTALIENECVYIAQPPLYKVSKKKDFRYIL SEKEMDDYLLTLGICDSKLVFKNGDREISGEALDSFVKLILNIENFIVALEKKAVPFSEFLEMRKETVGYPLYYRPPQSG KQGGRYFYSSEEKEEEMVSGEDSDSTKVIELYKTSIFAEIQEELRNYGLDIRHYLNPKDSEMVITNEDAKTLPYTCYTLK EVIEHLKALGRKGIEIQRYKGLGEMNADQLWDITMNPEQRTLVRVSLKDAVEADHIFTMLMGEEVPPRREFIENHALSVK MNNLDI
Sequences:
>Translated_806_residues MDAKEKNYDASAITVLEGLQAVRERPGMYIGDTGITGLHHLVYEVVDNSIDEAMAGYCSEIHVRILEDGGITISDNGRGI PIQTHEKESKKQGRDVSALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALAEKLVATVYKDKQAYQMEFSRGVPVT SLQCLGATNKQGTEITFYPDNKIFSSCVFDRSILIKRLRELAFLNRGVTIIFEDDRDVSFDKVVFFYEGGIQSFVSYLNQ NKESLFPEPIYISGSRTGDDGEIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFSTALTRVLNAYIKAHNLAKNDK LSLTGEDIREGLTAVVSVKVPNPQFEGQTKQKLGNSDVGSVSQQITGEALTIFFDENPQIAKMIVDKVFIAAQAREAAKK ARELTLRKSALDSARLPGKLIDCLEKDPAKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEI GTIIAALGCGIGSDNFNLSKLRYRRIIIMTDADVDGSHIRTLLLTFFYRHMTALIENECVYIAQPPLYKVSKKKDFRYIL SEKEMDDYLLTLGICDSKLVFKNGDREISGEALDSFVKLILNIENFIVALEKKAVPFSEFLEMRKETVGYPLYYRPPQSG KQGGRYFYSSEEKEEEMVSGEDSDSTKVIELYKTSIFAEIQEELRNYGLDIRHYLNPKDSEMVITNEDAKTLPYTCYTLK EVIEHLKALGRKGIEIQRYKGLGEMNADQLWDITMNPEQRTLVRVSLKDAVEADHIFTMLMGEEVPPRREFIENHALSVK MNNLDI >Mature_806_residues MDAKEKNYDASAITVLEGLQAVRERPGMYIGDTGITGLHHLVYEVVDNSIDEAMAGYCSEIHVRILEDGGITISDNGRGI PIQTHEKESKKQGRDVSALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALAEKLVATVYKDKQAYQMEFSRGVPVT SLQCLGATNKQGTEITFYPDNKIFSSCVFDRSILIKRLRELAFLNRGVTIIFEDDRDVSFDKVVFFYEGGIQSFVSYLNQ NKESLFPEPIYISGSRTGDDGEIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFSTALTRVLNAYIKAHNLAKNDK LSLTGEDIREGLTAVVSVKVPNPQFEGQTKQKLGNSDVGSVSQQITGEALTIFFDENPQIAKMIVDKVFIAAQAREAAKK ARELTLRKSALDSARLPGKLIDCLEKDPAKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEI GTIIAALGCGIGSDNFNLSKLRYRRIIIMTDADVDGSHIRTLLLTFFYRHMTALIENECVYIAQPPLYKVSKKKDFRYIL SEKEMDDYLLTLGICDSKLVFKNGDREISGEALDSFVKLILNIENFIVALEKKAVPFSEFLEMRKETVGYPLYYRPPQSG KQGGRYFYSSEEKEEEMVSGEDSDSTKVIELYKTSIFAEIQEELRNYGLDIRHYLNPKDSEMVITNEDAKTLPYTCYTLK EVIEHLKALGRKGIEIQRYKGLGEMNADQLWDITMNPEQRTLVRVSLKDAVEADHIFTMLMGEEVPPRREFIENHALSVK MNNLDI
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0187
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=572, Percent_Identity=26.7482517482518, Blast_Score=135, Evalue=2e-31, Organism=Homo sapiens, GI19913406, Length=592, Percent_Identity=25.5067567567568, Blast_Score=134, Evalue=5e-31, Organism=Escherichia coli, GI48994957, Length=832, Percent_Identity=48.3173076923077, Blast_Score=706, Evalue=0.0, Organism=Escherichia coli, GI1789408, Length=571, Percent_Identity=39.2294220665499, Blast_Score=388, Evalue=1e-109, Organism=Caenorhabditis elegans, GI17535065, Length=549, Percent_Identity=25.1366120218579, Blast_Score=130, Evalue=2e-30, Organism=Caenorhabditis elegans, GI212645845, Length=524, Percent_Identity=24.618320610687, Blast_Score=118, Evalue=1e-26, Organism=Caenorhabditis elegans, GI212645657, Length=144, Percent_Identity=32.6388888888889, Blast_Score=69, Evalue=9e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=620, Percent_Identity=25.4838709677419, Blast_Score=116, Evalue=1e-26, Organism=Drosophila melanogaster, GI17136538, Length=556, Percent_Identity=24.4604316546763, Blast_Score=129, Evalue=6e-30,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003594 - InterPro: IPR011557 - InterPro: IPR020568 - InterPro: IPR014721 - InterPro: IPR001241 - InterPro: IPR013759 - InterPro: IPR002288 - InterPro: IPR013506 - InterPro: IPR013760 - InterPro: IPR018522 - InterPro: IPR006171 [H]
Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 90446; Mature: 90446
Theoretical pI: Translated: 5.55; Mature: 5.55
Prosite motif: PS00177 TOPOISOMERASE_II
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDAKEKNYDASAITVLEGLQAVRERPGMYIGDTGITGLHHLVYEVVDNSIDEAMAGYCSE CCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHH IHVRILEDGGITISDNGRGIPIQTHEKESKKQGRDVSALEVVLTVLHAGGKFDKDSYKVS EEEEEEECCCEEECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEC GGLHGVGVSCVNALAEKLVATVYKDKQAYQMEFSRGVPVTSLQCLGATNKQGTEITFYPD CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCC NKIFSSCVFDRSILIKRLRELAFLNRGVTIIFEDDRDVSFDKVVFFYEGGIQSFVSYLNQ CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHCC NKESLFPEPIYISGSRTGDDGEIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFST CHHHCCCCCEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCCCCCCCEECHHHH ALTRVLNAYIKAHNLAKNDKLSLTGEDIREGLTAVVSVKVPNPQFEGQTKQKLGNSDVGS HHHHHHHHHHHHHCCCCCCCEEECHHHHHCCCEEEEEEECCCCCCCCCHHHHCCCCCHHH VSQQITGEALTIFFDENPQIAKMIVDKVFIAAQAREAAKKARELTLRKSALDSARLPGKL HHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH IDCLEKDPAKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEI HHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECCHHHHHHHHHCCCCH GTIIAALGCGIGSDNFNLSKLRYRRIIIMTDADVDGSHIRTLLLTFFYRHMTALIENECV HHHHHHHHCCCCCCCCCHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEE YIAQPPLYKVSKKKDFRYILSEKEMDDYLLTLGICDSKLVFKNGDREISGEALDSFVKLI EEECCCCEECCCCCCHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHH LNIENFIVALEKKAVPFSEFLEMRKETVGYPLYYRPPQSGKQGGRYFYSSEEKEEEMVSG HHHHHHHEEHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCEECCCCHHHHHHHCC EDSDSTKVIELYKTSIFAEIQEELRNYGLDIRHYLNPKDSEMVITNEDAKTLPYTCYTLK CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEECCCCCCCCCHHHHHH EVIEHLKALGRKGIEIQRYKGLGEMNADQLWDITMNPEQRTLVRVSLKDAVEADHIFTML HHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHH MGEEVPPRREFIENHALSVKMNNLDI HCCCCCCHHHHHHCCCEEEEECCCCC >Mature Secondary Structure MDAKEKNYDASAITVLEGLQAVRERPGMYIGDTGITGLHHLVYEVVDNSIDEAMAGYCSE CCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHH IHVRILEDGGITISDNGRGIPIQTHEKESKKQGRDVSALEVVLTVLHAGGKFDKDSYKVS EEEEEEECCCEEECCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEC GGLHGVGVSCVNALAEKLVATVYKDKQAYQMEFSRGVPVTSLQCLGATNKQGTEITFYPD CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCC NKIFSSCVFDRSILIKRLRELAFLNRGVTIIFEDDRDVSFDKVVFFYEGGIQSFVSYLNQ CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHCC NKESLFPEPIYISGSRTGDDGEIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFST CHHHCCCCCEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCCCCCCCEECHHHH ALTRVLNAYIKAHNLAKNDKLSLTGEDIREGLTAVVSVKVPNPQFEGQTKQKLGNSDVGS HHHHHHHHHHHHHCCCCCCCEEECHHHHHCCCEEEEEEECCCCCCCCCHHHHCCCCCHHH VSQQITGEALTIFFDENPQIAKMIVDKVFIAAQAREAAKKARELTLRKSALDSARLPGKL HHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH IDCLEKDPAKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEI HHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECCHHHHHHHHHCCCCH GTIIAALGCGIGSDNFNLSKLRYRRIIIMTDADVDGSHIRTLLLTFFYRHMTALIENECV HHHHHHHHCCCCCCCCCHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEE YIAQPPLYKVSKKKDFRYILSEKEMDDYLLTLGICDSKLVFKNGDREISGEALDSFVKLI EEECCCCEECCCCCCHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHH LNIENFIVALEKKAVPFSEFLEMRKETVGYPLYYRPPQSGKQGGRYFYSSEEKEEEMVSG HHHHHHHEEHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCEECCCCHHHHHHHCC EDSDSTKVIELYKTSIFAEIQEELRNYGLDIRHYLNPKDSEMVITNEDAKTLPYTCYTLK CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEECCCCCCCCCHHHHHH EVIEHLKALGRKGIEIQRYKGLGEMNADQLWDITMNPEQRTLVRVSLKDAVEADHIFTML HHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHH MGEEVPPRREFIENHALSVKMNNLDI HCCCCCCHHHHHHCCCEEEEECCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10192388; 10684935; 10871362 [H]