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The map label for this gene is yleA [C]

Identifier: 62184901

GI number: 62184901

Start: 284918

End: 286183

Strand: Direct

Name: yleA [C]

Synonym: CAB260

Alternate gene names: 62184901

Gene position: 284918-286183 (Clockwise)

Preceding gene: 62184900

Following gene: 62184902

Centisome position: 24.9

GC content: 43.6

Gene sequence:

>1266_bases
ATGACAGTAATAGAAGTAAAGGGAACATTTAAACTTGTTTGTTTAGGGTGTCGTGTAAATCAATATGAAATTCAGAGTTA
CCGGGATCAGTTAAACTTCTTAGGGTACCGCGAAATCACAGATCCTGAGATTCCCTGTGATCTGTGTATTGTGAATACCT
GTGCAGTTACCGGATCGGCGGAAAGCTCTGGACGTCACGCCGTACGTCAAGTTTGTCGACAAAATCCCGATGCTTTGTTA
GTGGTGACGGGGTGTTTGGGAGAGGCTGATAAGGAATTTTTCTATTCTTTAGACAGACAATGTCTTCTTGTTTCTAACAA
AGACAAGCATCAGTTGATGGAAAAGATCTTTCCCTCGATTCAAGATCTTCCAGAATTTCGCATTCGTAGTTTTTCAGGGA
AATCGCGAGCGTTTATCAAAGTTCAGGATGGGTGCAACTCGTTTTGTTCCTATTGTATTATCCCGTATTTACGTGGTCGG
TCGCGTTCACGTCCTGTTCAGGAAATTCTTGAGGAGATATCGGGTCTTGTTTCGCAGGGGTATCGTGAAGTTGTGATTGC
GGGGATTAATGTTGGCGATTATCAAGATCAGGGAAAATCCTTAGCTTATCTGATCAGTCAGGTAGACGAGATCCCAGGTA
TAGAAAGAATACGGATTTCTTCTATAGATCCCGAGGATGTGCAGGACGACCTGCGAGATGTCTTATTATCAGGCAAGCAT
ACGTGTCACTCTTCGCATCTGGTTTTGCAATCGGGTTCTAATGCGATTTTAAAAAGGATGAACCGGAAGTACTCCCGGGG
AGATTTTTTAGATTGTGTAGAGGCTTTACGTTCTGCGGATCCGCAATATACTTTCACGACAGATGTCATCGTGGGCTTCC
CCGGGGAAACAGATCAGGATTTTGAAGAGACTTTGCGCATTGTAGAAGACGTGGGTTTTATTAAAGTCCATATTTTTCCT
TTTAGCCCTAGAGAACGAACAAAAGCCTACACCTTTTCTTCTCAACTGCCCGTATCTGTAATTAACGAACGGAAGAAGCA
TCTTGCTCATGTAGCACGAGAGGTGGCTTATAGAGAGCAGAGGCGACGTATAGGCGATACACTTTCGGTACTTGTGGAAA
GGGTGGATGAAGGCATCGCCTATGGCCATTCTTCCTACTTTGATATGGTAGGTTTCCCTGCCGATCCTGATGTTTCTGTG
AATACATTAATCGATGTCCGTATCGAGAGTGTCGAAGAAGATATTCTCAAAGGAAAACGTGTATGA

Upstream 100 bases:

>100_bases
TTACAAGCGAATAAGAAAAAAGAGAATCTTTATTAGTGAGGAAAAGTAGGGATACTTTAGAATACTGTCTTTGTGTTTTT
TCAGATTTCATTAGCAACCT

Downstream 100 bases:

>100_bases
TTAAAATAACACAGAGTTTTAGACCGTATACGTTAATTCCTGGCATGTGCCTCCCCATTCCGGGATCGGCATGGTATGCT
CAGGTATTTCCTACAGTATG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTVIEVKGTFKLVCLGCRVNQYEIQSYRDQLNFLGYREITDPEIPCDLCIVNTCAVTGSAESSGRHAVRQVCRQNPDALL
VVTGCLGEADKEFFYSLDRQCLLVSNKDKHQLMEKIFPSIQDLPEFRIRSFSGKSRAFIKVQDGCNSFCSYCIIPYLRGR
SRSRPVQEILEEISGLVSQGYREVVIAGINVGDYQDQGKSLAYLISQVDEIPGIERIRISSIDPEDVQDDLRDVLLSGKH
TCHSSHLVLQSGSNAILKRMNRKYSRGDFLDCVEALRSADPQYTFTTDVIVGFPGETDQDFEETLRIVEDVGFIKVHIFP
FSPRERTKAYTFSSQLPVSVINERKKHLAHVAREVAYREQRRRIGDTLSVLVERVDEGIAYGHSSYFDMVGFPADPDVSV
NTLIDVRIESVEEDILKGKRV

Sequences:

>Translated_421_residues
MTVIEVKGTFKLVCLGCRVNQYEIQSYRDQLNFLGYREITDPEIPCDLCIVNTCAVTGSAESSGRHAVRQVCRQNPDALL
VVTGCLGEADKEFFYSLDRQCLLVSNKDKHQLMEKIFPSIQDLPEFRIRSFSGKSRAFIKVQDGCNSFCSYCIIPYLRGR
SRSRPVQEILEEISGLVSQGYREVVIAGINVGDYQDQGKSLAYLISQVDEIPGIERIRISSIDPEDVQDDLRDVLLSGKH
TCHSSHLVLQSGSNAILKRMNRKYSRGDFLDCVEALRSADPQYTFTTDVIVGFPGETDQDFEETLRIVEDVGFIKVHIFP
FSPRERTKAYTFSSQLPVSVINERKKHLAHVAREVAYREQRRRIGDTLSVLVERVDEGIAYGHSSYFDMVGFPADPDVSV
NTLIDVRIESVEEDILKGKRV
>Mature_420_residues
TVIEVKGTFKLVCLGCRVNQYEIQSYRDQLNFLGYREITDPEIPCDLCIVNTCAVTGSAESSGRHAVRQVCRQNPDALLV
VTGCLGEADKEFFYSLDRQCLLVSNKDKHQLMEKIFPSIQDLPEFRIRSFSGKSRAFIKVQDGCNSFCSYCIIPYLRGRS
RSRPVQEILEEISGLVSQGYREVVIAGINVGDYQDQGKSLAYLISQVDEIPGIERIRISSIDPEDVQDDLRDVLLSGKHT
CHSSHLVLQSGSNAILKRMNRKYSRGDFLDCVEALRSADPQYTFTTDVIVGFPGETDQDFEETLRIVEDVGFIKVHIFPF
SPRERTKAYTFSSQLPVSVINERKKHLAHVAREVAYREQRRRIGDTLSVLVERVDEGIAYGHSSYFDMVGFPADPDVSVN
TLIDVRIESVEEDILKGKRV

Specific function: Unknown

COG id: COG0621

COG function: function code J; 2-methylthioadenine synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MTTase N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI28872784, Length=407, Percent_Identity=26.044226044226, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI28872782, Length=407, Percent_Identity=26.044226044226, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI93277076, Length=436, Percent_Identity=27.7522935779816, Blast_Score=152, Evalue=6e-37,
Organism=Escherichia coli, GI1786882, Length=437, Percent_Identity=30.6636155606407, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1787057, Length=448, Percent_Identity=25.8928571428571, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17553146, Length=424, Percent_Identity=28.5377358490566, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71996771, Length=281, Percent_Identity=27.0462633451957, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356207, Length=470, Percent_Identity=27.0212765957447, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI19922432, Length=439, Percent_Identity=28.0182232346241, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR005839
- InterPro:   IPR020612
- InterPro:   IPR013848
- InterPro:   IPR006467
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM; PF00919 UPF0004 [H]

EC number: NA

Molecular weight: Translated: 47615; Mature: 47483

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50926 TRAM ; PS01278 UPF0004

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIEVKGTFKLVCLGCRVNQYEIQSYRDQLNFLGYREITDPEIPCDLCIVNTCAVTGSA
CEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHEEECCCC
ESSGRHAVRQVCRQNPDALLVVTGCLGEADKEFFYSLDRQCLLVSNKDKHQLMEKIFPSI
CCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
QDLPEFRIRSFSGKSRAFIKVQDGCNSFCSYCIIPYLRGRSRSRPVQEILEEISGLVSQG
HCCHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
YREVVIAGINVGDYQDQGKSLAYLISQVDEIPGIERIRISSIDPEDVQDDLRDVLLSGKH
CEEEEEEECCCCCCHHHCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCC
TCHSSHLVLQSGSNAILKRMNRKYSRGDFLDCVEALRSADPQYTFTTDVIVGFPGETDQD
CCCCCEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCC
FEETLRIVEDVGFIKVHIFPFSPRERTKAYTFSSQLPVSVINERKKHLAHVAREVAYREQ
HHHHHHHHHHCCEEEEEEEECCCCHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
RRRIGDTLSVLVERVDEGIAYGHSSYFDMVGFPADPDVSVNTLIDVRIESVEEDILKGKR
HHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCCC
V
C
>Mature Secondary Structure 
TVIEVKGTFKLVCLGCRVNQYEIQSYRDQLNFLGYREITDPEIPCDLCIVNTCAVTGSA
EEEEECCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHEEECCCC
ESSGRHAVRQVCRQNPDALLVVTGCLGEADKEFFYSLDRQCLLVSNKDKHQLMEKIFPSI
CCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
QDLPEFRIRSFSGKSRAFIKVQDGCNSFCSYCIIPYLRGRSRSRPVQEILEEISGLVSQG
HCCHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
YREVVIAGINVGDYQDQGKSLAYLISQVDEIPGIERIRISSIDPEDVQDDLRDVLLSGKH
CEEEEEEECCCCCCHHHCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCC
TCHSSHLVLQSGSNAILKRMNRKYSRGDFLDCVEALRSADPQYTFTTDVIVGFPGETDQD
CCCCCEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCC
FEETLRIVEDVGFIKVHIFPFSPRERTKAYTFSSQLPVSVINERKKHLAHVAREVAYREQ
HHHHHHHHHHCCEEEEEEEECCCCHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
RRRIGDTLSVLVERVDEGIAYGHSSYFDMVGFPADPDVSVNTLIDVRIESVEEDILKGKR
HHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]