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The map label for this gene is fkpA [H]

Identifier: 59713639

GI number: 59713639

Start: 524697

End: 525170

Strand: Reverse

Name: fkpA [H]

Synonym: VF_A0456

Alternate gene names: 59713639

Gene position: 525170-524697 (Counterclockwise)

Preceding gene: 59713640

Following gene: 59713637

Centisome position: 39.48

GC content: 39.45

Gene sequence:

>474_bases
GTGTCTAAAATCATTATCACACTAGCTATAATCGTTTTAGGTTATATGCTGCTTCAACATTTTGTGAATAACCCAAAAGC
GGCTAAAGCAAATATTGAACTTGGCAACGCATTTCTTGCTGAAAATGCGACGAAAGAAGGTGTTCAAACTACAGCTTCTG
GTCTTCAATATCTTGTACTTGAAGAAGGTACAGGCACTGAGCACCCTACAGCGAAAAGCAAAGTGAAAGTTCACTACCAT
GGAACAACTATTGACGGTAAAGTGTTTGATAGCTCTGTTGAGCGTGGCGAGCCGATTGAATTCGGTTTAAATCAAGTGAT
CAAAGGTTGGACAGAAGGTGTTCAATTAATGGTTGTTGGCCAAAAGATGCGTTTCTTTATCCCTAGCGATTTAGCTTACG
GTAATCGCTCAGCTGGCTCTATCCAACCAGGTTCAGTACTTATTTTCGATGTTGAGTTACTTGATTTTAAATAA

Upstream 100 bases:

>100_bases
ATACAACGTATTAATCGGTGGTCATGACGATCCTAAGCAAATCGCTGATACAATCCGTTACCTATTAGAAAAATAATTGA
TTTAAATATAAGGAAATAAT

Downstream 100 bases:

>100_bases
TCCAAACTCATCTCAATAAGATAAAAATAAAATGGCTAATCACTTCGATTAGCCATTTTTGTATTGGTTATTTACTACTA
TTGCTATGACGCATTACGAT

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MSKIIITLAIIVLGYMLLQHFVNNPKAAKANIELGNAFLAENATKEGVQTTASGLQYLVLEEGTGTEHPTAKSKVKVHYH
GTTIDGKVFDSSVERGEPIEFGLNQVIKGWTEGVQLMVVGQKMRFFIPSDLAYGNRSAGSIQPGSVLIFDVELLDFK

Sequences:

>Translated_157_residues
MSKIIITLAIIVLGYMLLQHFVNNPKAAKANIELGNAFLAENATKEGVQTTASGLQYLVLEEGTGTEHPTAKSKVKVHYH
GTTIDGKVFDSSVERGEPIEFGLNQVIKGWTEGVQLMVVGQKMRFFIPSDLAYGNRSAGSIQPGSVLIFDVELLDFK
>Mature_156_residues
SKIIITLAIIVLGYMLLQHFVNNPKAAKANIELGNAFLAENATKEGVQTTASGLQYLVLEEGTGTEHPTAKSKVKVHYHG
TTIDGKVFDSSVERGEPIEFGLNQVIKGWTEGVQLMVVGQKMRFFIPSDLAYGNRSAGSIQPGSVLIFDVELLDFK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=104, Percent_Identity=44.2307692307692, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4503725, Length=104, Percent_Identity=44.2307692307692, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI224809331, Length=137, Percent_Identity=40.1459854014599, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI4503729, Length=109, Percent_Identity=41.2844036697248, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI224809329, Length=135, Percent_Identity=40.7407407407407, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI224809327, Length=135, Percent_Identity=40.7407407407407, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI4758384, Length=135, Percent_Identity=40.7407407407407, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=39.2523364485981, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI206725530, Length=112, Percent_Identity=40.1785714285714, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI17149844, Length=112, Percent_Identity=40.1785714285714, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI17149842, Length=112, Percent_Identity=40.1785714285714, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI33469985, Length=84, Percent_Identity=38.0952380952381, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI8923659, Length=86, Percent_Identity=40.6976744186046, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI192448443, Length=85, Percent_Identity=40, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI87082390, Length=123, Percent_Identity=55.2845528455285, Blast_Score=129, Evalue=8e-32,
Organism=Escherichia coli, GI1789745, Length=132, Percent_Identity=46.969696969697, Blast_Score=109, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17561782, Length=106, Percent_Identity=44.3396226415094, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=104, Percent_Identity=41.3461538461538, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17540882, Length=85, Percent_Identity=48.2352941176471, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=55.6818181818182, Blast_Score=91, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324194, Length=98, Percent_Identity=46.9387755102041, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323566, Length=104, Percent_Identity=40.3846153846154, Blast_Score=65, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323482, Length=104, Percent_Identity=39.4230769230769, Blast_Score=64, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24655568, Length=104, Percent_Identity=46.1538461538462, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=43.2692307692308, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI281363946, Length=83, Percent_Identity=49.3975903614458, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17352457, Length=83, Percent_Identity=49.3975903614458, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21356629, Length=96, Percent_Identity=42.7083333333333, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17096; Mature: 16965

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIIITLAIIVLGYMLLQHFVNNPKAAKANIELGNAFLAENATKEGVQTTASGLQYLVL
CCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEECCCCCHHHHHHHHCCEEEEEE
EEGTGTEHPTAKSKVKVHYHGTTIDGKVFDSSVERGEPIEFGLNQVIKGWTEGVQLMVVG
ECCCCCCCCCCCCEEEEEECCCEECCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEE
QKMRFFIPSDLAYGNRSAGSIQPGSVLIFDVELLDFK
CCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCC
>Mature Secondary Structure 
SKIIITLAIIVLGYMLLQHFVNNPKAAKANIELGNAFLAENATKEGVQTTASGLQYLVL
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEECCCCCHHHHHHHHCCEEEEEE
EEGTGTEHPTAKSKVKVHYHGTTIDGKVFDSSVERGEPIEFGLNQVIKGWTEGVQLMVVG
ECCCCCCCCCCCCEEEEEECCCEECCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEE
QKMRFFIPSDLAYGNRSAGSIQPGSVLIFDVELLDFK
CCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]