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The map label for this gene is hutC [H]

Identifier: 59713637

GI number: 59713637

Start: 523147

End: 523848

Strand: Reverse

Name: hutC [H]

Synonym: VF_A0454

Alternate gene names: 59713637

Gene position: 523848-523147 (Counterclockwise)

Preceding gene: 59713639

Following gene: 59713636

Centisome position: 39.38

GC content: 34.9

Gene sequence:

>702_bases
ATGAGCCAACCTCGTTACTTACTGATAAAGCAATATCTGAACGAAAAAATTCAAACAAGAACTTGGCCTATTGGCTATAA
AATACCAACAGAGATAGATCTTGCTAATGAATTTTCAGTCAGTCGTATGACAGCAAACAAAGCCATTAAAGAGCTTGTAA
ATGAAGGCTTATTAGAGCGAACACCGCGCTTAGGCACCTTTGTTTGTCATAAAAAAGCTGAATCTCCTCTGATGGAAATT
CGTAATATAGCAACAGAAGTACACCAACGTGGTCACCATTACAGTAGTAAAGTAATTAAAAAAGAAGAAGTAATAGCTAA
AGATGATATTGCTTTAAAAATTGGGGTTCGTAATGATACTTCGATTTATTTCACTCAAATTGTTCATTACGAAAATGATG
TTCCCATTCAATTAGAAGACCGATGGGTTAATCCGCTATTTGTAAAAGATTATCTAAAACAAGATTTTACATTGCAAACA
CCGAATGAATATTTGGTTCAGATTTGCCCTTTAAGTGATATAGAACATTCTGTGGAGGCAATCATTCCAAATGAACACGT
TTCCGAACTTTTGCATATGGATAATAAAACGCCCTGCTTATTACTGAACCGTCGAACTTGGAGTGAAGACAAATTAGTTA
GCATTGCACTTTTATATCATCCAGGTGACAGATATAAACTGACATCTCGCAGTAAAGTATAA

Upstream 100 bases:

>100_bases
ATTTCATCTAACTTACTCTGATCTAATAAATAACAATTTAACTTGAAAGTTATTCAAAAAATTGCTTTTATTTGTATAGT
CAATTTAAAAGTAGAACACT

Downstream 100 bases:

>100_bases
TGTTCTAAGCTCACATTTCATCGAGTTCCCTCCTCACAATTATAAAAGTGCAATGGTTAATAATTGTACTTTTGATCACA
ACTTCATTACATCCCATCTT

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MSQPRYLLIKQYLNEKIQTRTWPIGYKIPTEIDLANEFSVSRMTANKAIKELVNEGLLERTPRLGTFVCHKKAESPLMEI
RNIATEVHQRGHHYSSKVIKKEEVIAKDDIALKIGVRNDTSIYFTQIVHYENDVPIQLEDRWVNPLFVKDYLKQDFTLQT
PNEYLVQICPLSDIEHSVEAIIPNEHVSELLHMDNKTPCLLLNRRTWSEDKLVSIALLYHPGDRYKLTSRSKV

Sequences:

>Translated_233_residues
MSQPRYLLIKQYLNEKIQTRTWPIGYKIPTEIDLANEFSVSRMTANKAIKELVNEGLLERTPRLGTFVCHKKAESPLMEI
RNIATEVHQRGHHYSSKVIKKEEVIAKDDIALKIGVRNDTSIYFTQIVHYENDVPIQLEDRWVNPLFVKDYLKQDFTLQT
PNEYLVQICPLSDIEHSVEAIIPNEHVSELLHMDNKTPCLLLNRRTWSEDKLVSIALLYHPGDRYKLTSRSKV
>Mature_232_residues
SQPRYLLIKQYLNEKIQTRTWPIGYKIPTEIDLANEFSVSRMTANKAIKELVNEGLLERTPRLGTFVCHKKAESPLMEIR
NIATEVHQRGHHYSSKVIKKEEVIAKDDIALKIGVRNDTSIYFTQIVHYENDVPIQLEDRWVNPLFVKDYLKQDFTLQTP
NEYLVQICPLSDIEHSVEAIIPNEHVSELLHMDNKTPCLLLNRRTWSEDKLVSIALLYHPGDRYKLTSRSKV

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=138, Percent_Identity=29.7101449275362, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790118, Length=225, Percent_Identity=23.5555555555556, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786950, Length=201, Percent_Identity=24.3781094527363, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27168; Mature: 27036

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPRYLLIKQYLNEKIQTRTWPIGYKIPTEIDLANEFSVSRMTANKAIKELVNEGLLER
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHC
TPRLGTFVCHKKAESPLMEIRNIATEVHQRGHHYSSKVIKKEEVIAKDDIALKIGVRNDT
CCCCCHHEEHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCEEEEEECCCCC
SIYFTQIVHYENDVPIQLEDRWVNPLFVKDYLKQDFTLQTPNEYLVQICPLSDIEHSVEA
EEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHCCCEEECCHHHEEEECCCHHHHHHHHH
IIPNEHVSELLHMDNKTPCLLLNRRTWSEDKLVSIALLYHPGDRYKLTSRSKV
CCCCHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCEEECCCCCC
>Mature Secondary Structure 
SQPRYLLIKQYLNEKIQTRTWPIGYKIPTEIDLANEFSVSRMTANKAIKELVNEGLLER
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHC
TPRLGTFVCHKKAESPLMEIRNIATEVHQRGHHYSSKVIKKEEVIAKDDIALKIGVRNDT
CCCCCHHEEHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCEEEEEECCCCC
SIYFTQIVHYENDVPIQLEDRWVNPLFVKDYLKQDFTLQTPNEYLVQICPLSDIEHSVEA
EEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHCCCEEECCHHHEEEECCCHHHHHHHHH
IIPNEHVSELLHMDNKTPCLLLNRRTWSEDKLVSIALLYHPGDRYKLTSRSKV
CCCCHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]