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The map label for this gene is hutI

Identifier: 59713636

GI number: 59713636

Start: 521737

End: 522963

Strand: Reverse

Name: hutI

Synonym: VF_A0453

Alternate gene names: 59713636

Gene position: 522963-521737 (Counterclockwise)

Preceding gene: 59713637

Following gene: 59713635

Centisome position: 39.31

GC content: 40.51

Gene sequence:

>1227_bases
ATGGACAGAGTTTTTATTAATTTACATCTTGTTTCTATGGTAGATAAACAGCAGACGGGTTCTGATGGCTATCAAGTGCT
AAAAGATACCATGATTGGAGTAAGAAACGGGAAAGTTGAATATGTTGGTGAACCCTGTCCCTCTATTTTACATGGCCACC
CTGATATTATTGATTGTGCACACGCATTAGTTACTCCCGGTTTCATTGACTGCCATACACATCTTATTTTTGCAGGAAAT
CGTGCAAATGAATTCGAACAACGTTTGCTAGGCATACCTTATGAAGAGATAGCAAAACAAGGTGGCGGAATTTTATCTAC
CGTTCATGCAACACGTGAAGCAAGTGAAGATGAGCTTTATCACCTAGCGGTACAGCGCCTAGAAGGACTCAAACGTGACG
GTGTCACTACGATTGAGATCAAATCAGGTTATGGTCTAACTCTTGATGATGAAATAAAAATGCTCAAGGTAGCTAAACGT
ATATCAGAATTACCTGATATGAAGGTATCAACCACTCTTCTTGCTGCTCATGCTGTCCCTCCTGAATACAAAAACCGCTC
CGATGAATATATTGATTTAATTTGCGAAAGCATCATTCCTCAAGTGGTTAAATTGAATCTTGCCAATCATGTTGATGTTT
TTTGCGAAGGCATTGGATTTTCACCCAAACAATGTGAACGAGTTTTCCGTGCAGCACTAAATCATGGATTACGAATTAAA
GGACATACAGAGCAACTATCTAACCTTGAAGGGAGTGCGTTAGCGGCCTCTATGGGAGCTGACTCTGTTGATCACATCGA
ATACCTTGATGAAAATGGTGTTAAAGCATTAGCAACGAATAATACCGTAGCAACTCTACTTCCCGGAGCCTTCTATTATC
TAAAAGAAAGCAAACTCCCCCCAATTCCTTTATTAAGGCAATATAAGATACCAATGGCCATTGCGACGGATTTTAACCCC
GGAACCTCTCCTATTGCATCATTGAGAACAATAATGAACATGGCCTGTACCTTATTTAAATTAACGCCAGAAGAATCATT
ACGAGGCGTCACTTGTCATGCAGCTCAAGCACTTGGGTTACAACATTTCAGAGGAAAAATAGCGGTTGGTATGGAGGCAG
ATTTTGCTATTTGGCAGTTGGAGTCACCCGCTGAACTTTCTTATCGATTAGGAGTACCTGACCTAATAGCTAGGGTTGTC
GATGGAGAGATCTTTCATGAAAAATAA

Upstream 100 bases:

>100_bases
TCATTACATCCCATCTTGTCTTTTCATCAAAAACAGACTATTTATTTGTATATACATATAGTTTTTTATCACGATAATCA
GATAAAAATGGACATGACGT

Downstream 100 bases:

>100_bases
TTCATCGGTCAATATGACAAGCTGGATGGGAAGAGTGGATCATGAAGATGGTGAACTTGGTTTGCGATGGCATCAAAAAG
TAAAAGTGACAAATAGTACA

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MDRVFINLHLVSMVDKQQTGSDGYQVLKDTMIGVRNGKVEYVGEPCPSILHGHPDIIDCAHALVTPGFIDCHTHLIFAGN
RANEFEQRLLGIPYEEIAKQGGGILSTVHATREASEDELYHLAVQRLEGLKRDGVTTIEIKSGYGLTLDDEIKMLKVAKR
ISELPDMKVSTTLLAAHAVPPEYKNRSDEYIDLICESIIPQVVKLNLANHVDVFCEGIGFSPKQCERVFRAALNHGLRIK
GHTEQLSNLEGSALAASMGADSVDHIEYLDENGVKALATNNTVATLLPGAFYYLKESKLPPIPLLRQYKIPMAIATDFNP
GTSPIASLRTIMNMACTLFKLTPEESLRGVTCHAAQALGLQHFRGKIAVGMEADFAIWQLESPAELSYRLGVPDLIARVV
DGEIFHEK

Sequences:

>Translated_408_residues
MDRVFINLHLVSMVDKQQTGSDGYQVLKDTMIGVRNGKVEYVGEPCPSILHGHPDIIDCAHALVTPGFIDCHTHLIFAGN
RANEFEQRLLGIPYEEIAKQGGGILSTVHATREASEDELYHLAVQRLEGLKRDGVTTIEIKSGYGLTLDDEIKMLKVAKR
ISELPDMKVSTTLLAAHAVPPEYKNRSDEYIDLICESIIPQVVKLNLANHVDVFCEGIGFSPKQCERVFRAALNHGLRIK
GHTEQLSNLEGSALAASMGADSVDHIEYLDENGVKALATNNTVATLLPGAFYYLKESKLPPIPLLRQYKIPMAIATDFNP
GTSPIASLRTIMNMACTLFKLTPEESLRGVTCHAAQALGLQHFRGKIAVGMEADFAIWQLESPAELSYRLGVPDLIARVV
DGEIFHEK
>Mature_408_residues
MDRVFINLHLVSMVDKQQTGSDGYQVLKDTMIGVRNGKVEYVGEPCPSILHGHPDIIDCAHALVTPGFIDCHTHLIFAGN
RANEFEQRLLGIPYEEIAKQGGGILSTVHATREASEDELYHLAVQRLEGLKRDGVTTIEIKSGYGLTLDDEIKMLKVAKR
ISELPDMKVSTTLLAAHAVPPEYKNRSDEYIDLICESIIPQVVKLNLANHVDVFCEGIGFSPKQCERVFRAALNHGLRIK
GHTEQLSNLEGSALAASMGADSVDHIEYLDENGVKALATNNTVATLLPGAFYYLKESKLPPIPLLRQYKIPMAIATDFNP
GTSPIASLRTIMNMACTLFKLTPEESLRGVTCHAAQALGLQHFRGKIAVGMEADFAIWQLESPAELSYRLGVPDLIARVV
DGEIFHEK

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=342, Percent_Identity=35.0877192982456, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17555004, Length=413, Percent_Identity=32.9297820823245, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_VIBF1 (Q5E0C3)

Other databases:

- EMBL:   CP000021
- RefSeq:   YP_206411.1
- HSSP:   Q8U8Z6
- ProteinModelPortal:   Q5E0C3
- SMR:   Q5E0C3
- STRING:   Q5E0C3
- GeneID:   3280586
- GenomeReviews:   CP000021_GR
- KEGG:   vfi:VF_A0453
- NMPDR:   fig|312309.3.peg.2772
- eggNOG:   COG1228
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- ProtClustDB:   PRK09356
- BioCyc:   VFIS312309:VFA0453-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR006680
- InterPro:   IPR005920
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.7

Molecular weight: Translated: 44893; Mature: 44893

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: BINDING 81-81 BINDING 94-94 BINDING 144-144 BINDING 177-177 BINDING 245-245

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRVFINLHLVSMVDKQQTGSDGYQVLKDTMIGVRNGKVEYVGEPCPSILHGHPDIIDCA
CCEEEEEEEEEHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCHHHHH
HALVTPGFIDCHTHLIFAGNRANEFEQRLLGIPYEEIAKQGGGILSTVHATREASEDELY
HHHHCCCEEECEEEEEEECCCCCHHHHHHHCCCHHHHHHCCCCEEEEHHHHHCCCHHHHH
HLAVQRLEGLKRDGVTTIEIKSGYGLTLDDEIKMLKVAKRISELPDMKVSTTLLAAHAVP
HHHHHHHHCHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
PEYKNRSDEYIDLICESIIPQVVKLNLANHVDVFCEGIGFSPKQCERVFRAALNHGLRIK
CHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEE
GHTEQLSNLEGSALAASMGADSVDHIEYLDENGVKALATNNTVATLLPGAFYYLKESKLP
ECHHHHHCCCCCHHHHHCCCCCHHHHHHHCCCCCEEEEECCEEEEHHCCHHEEECCCCCC
PIPLLRQYKIPMAIATDFNPGTSPIASLRTIMNMACTLFKLTPEESLRGVTCHAAQALGL
CCCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHEEECHHHHHCCEEHHHHHHHHH
QHFRGKIAVGMEADFAIWQLESPAELSYRLGVPDLIARVVDGEIFHEK
HHHCCEEEECCCCCEEEEEECCCCCCEEECCCHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MDRVFINLHLVSMVDKQQTGSDGYQVLKDTMIGVRNGKVEYVGEPCPSILHGHPDIIDCA
CCEEEEEEEEEHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCHHHHH
HALVTPGFIDCHTHLIFAGNRANEFEQRLLGIPYEEIAKQGGGILSTVHATREASEDELY
HHHHCCCEEECEEEEEEECCCCCHHHHHHHCCCHHHHHHCCCCEEEEHHHHHCCCHHHHH
HLAVQRLEGLKRDGVTTIEIKSGYGLTLDDEIKMLKVAKRISELPDMKVSTTLLAAHAVP
HHHHHHHHCHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
PEYKNRSDEYIDLICESIIPQVVKLNLANHVDVFCEGIGFSPKQCERVFRAALNHGLRIK
CHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEE
GHTEQLSNLEGSALAASMGADSVDHIEYLDENGVKALATNNTVATLLPGAFYYLKESKLP
ECHHHHHCCCCCHHHHHCCCCCHHHHHHHCCCCCEEEEECCEEEEHHCCHHEEECCCCCC
PIPLLRQYKIPMAIATDFNPGTSPIASLRTIMNMACTLFKLTPEESLRGVTCHAAQALGL
CCCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHEEECHHHHHCCEEHHHHHHHHH
QHFRGKIAVGMEADFAIWQLESPAELSYRLGVPDLIARVVDGEIFHEK
HHHCCEEEECCCCCEEEEEECCCCCCEEECCCHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA