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The map label for this gene is tdh [H]

Identifier: 59713600

GI number: 59713600

Start: 471213

End: 472244

Strand: Reverse

Name: tdh [H]

Synonym: VF_A0417

Alternate gene names: 59713600

Gene position: 472244-471213 (Counterclockwise)

Preceding gene: 59713601

Following gene: 59713599

Centisome position: 35.5

GC content: 42.05

Gene sequence:

>1032_bases
ATGAAAATTAAAGCGCTTTCAAAATTAAAACCTGAAGAAGGTATCTGGCTAACTGAGGTTGAAAAACCTGAGATGGGTCA
TAACGATCTTCTTATCCGCATTAAGAAAACTGCCATCTGTGGTACCGATGTACATATCTACAACTGGGACGAATGGTCAC
AAAAAACAATTCCAGTACCTATGGTTGTTGGTCACGAGTATGTAGGTGAAGTTGTTGGTATTGGTCAAGAAGTGCGTGGT
TTTGAAATTGGAGACCGCGTTTCAGGTGAAGGTCACATAACTTGTGGTCATTGTCGTAACTGTCGTGGCGGCCGTACTCA
CCTTTGTCGTAATACAACAGGCGTAGGTGTAAACCGTACTGGTGCTTTTTCTGAATACCTAGTGATTCCTGCTTTCAATG
CATTTAAGATCCCTGCTGGCATTTCAGATGACTTAGCATCAATCTTTGACCCATTTGGAAACGCAGTTCACACTGCTCTA
TCATTTGATTTAGTTGGTGAAGACGTTCTAATCACGGGTGCTGGTCCTATTGGCATCATGGCGGCGGCTGTTGCAAAACA
TGTTGGTGCACGTCACGTCGTGATTACTGATGTGAATGAATACCGCTTAGATCTTGCTAAGAAAATGGGCGTAACTCGTG
CCGTAAACGTAATGAACGAGAAGCTTGAAGATGTGATGTCTGAGCTTGGCATGACAGAAGGCTTTGATGTCGGTTTGGAA
ATGTCTGGTAATCCATCAGCATTTAATAGCATGCTAACTAACATGAACCATGGCGGTAAAATATCTCTTCTAGGTATTCC
ACCATCAGACATGACTGTTGATTGGAACCAAGTTATCTTTAAAGGCTTAGTCATCAAAGGCATTTACGGACGCGAGATGT
TTGAAACTTGGTATAAGATGGCAAGCTTAATTCAATCAGGCTTAGATCTAACACCAATTATCACGCACCACTATAAGATT
GATGACTTCCAAGCAGGCTTCGATATGATGCGCTCTGGTATGTCTGGTAAAGTTATTCTAGATTGGGAATAA

Upstream 100 bases:

>100_bases
GTATTCGTACACAAATGTCCGCTGCTCACACTCGTGAACAGCTAGATCGTGCAATTGATGCCTTTATCGAAGTAGGTAAA
GACATGGAGATCATTAAATA

Downstream 100 bases:

>100_bases
TCATTCTCATTTAAAATGAACTATAATAAGGCTAAACTTCGGTTTGGCCTTTTTTATTTTCATTTTTAGAGAACTATTTC
ACATGCCGCAATTAGATATC

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKIKALSKLKPEEGIWLTEVEKPEMGHNDLLIRIKKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVRG
FEIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRTGAFSEYLVIPAFNAFKIPAGISDDLASIFDPFGNAVHTAL
SFDLVGEDVLITGAGPIGIMAAAVAKHVGARHVVITDVNEYRLDLAKKMGVTRAVNVMNEKLEDVMSELGMTEGFDVGLE
MSGNPSAFNSMLTNMNHGGKISLLGIPPSDMTVDWNQVIFKGLVIKGIYGREMFETWYKMASLIQSGLDLTPIITHHYKI
DDFQAGFDMMRSGMSGKVILDWE

Sequences:

>Translated_343_residues
MKIKALSKLKPEEGIWLTEVEKPEMGHNDLLIRIKKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVRG
FEIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRTGAFSEYLVIPAFNAFKIPAGISDDLASIFDPFGNAVHTAL
SFDLVGEDVLITGAGPIGIMAAAVAKHVGARHVVITDVNEYRLDLAKKMGVTRAVNVMNEKLEDVMSELGMTEGFDVGLE
MSGNPSAFNSMLTNMNHGGKISLLGIPPSDMTVDWNQVIFKGLVIKGIYGREMFETWYKMASLIQSGLDLTPIITHHYKI
DDFQAGFDMMRSGMSGKVILDWE
>Mature_343_residues
MKIKALSKLKPEEGIWLTEVEKPEMGHNDLLIRIKKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVRG
FEIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRTGAFSEYLVIPAFNAFKIPAGISDDLASIFDPFGNAVHTAL
SFDLVGEDVLITGAGPIGIMAAAVAKHVGARHVVITDVNEYRLDLAKKMGVTRAVNVMNEKLEDVMSELGMTEGFDVGLE
MSGNPSAFNSMLTNMNHGGKISLLGIPPSDMTVDWNQVIFKGLVIKGIYGREMFETWYKMASLIQSGLDLTPIITHHYKI
DDFQAGFDMMRSGMSGKVILDWE

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=326, Percent_Identity=26.0736196319018, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI4501929, Length=375, Percent_Identity=25.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI34577061, Length=349, Percent_Identity=26.0744985673352, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4501933, Length=377, Percent_Identity=24.4031830238727, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI156523966, Length=376, Percent_Identity=23.936170212766, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4501939, Length=369, Percent_Identity=23.8482384823848, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71743840, Length=377, Percent_Identity=24.6684350132626, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI262073058, Length=377, Percent_Identity=24.6684350132626, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71565154, Length=375, Percent_Identity=24.5333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=84.4574780058651, Blast_Score=613, Evalue=1e-177,
Organism=Escherichia coli, GI1788073, Length=318, Percent_Identity=28.6163522012579, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788075, Length=368, Percent_Identity=27.7173913043478, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787863, Length=288, Percent_Identity=30.5555555555556, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI226510992, Length=262, Percent_Identity=31.6793893129771, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87082125, Length=369, Percent_Identity=29.810298102981, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790718, Length=304, Percent_Identity=27.3026315789474, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=26.2390670553936, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87081918, Length=330, Percent_Identity=27.5757575757576, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786825, Length=400, Percent_Identity=27.5, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1786552, Length=378, Percent_Identity=25.3968253968254, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786518, Length=283, Percent_Identity=27.5618374558304, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=31.3432835820896, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17562878, Length=329, Percent_Identity=31.306990881459, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71988145, Length=187, Percent_Identity=31.5508021390374, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=360, Percent_Identity=25.5555555555556, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=364, Percent_Identity=25.2747252747253, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=335, Percent_Identity=25.6716417910448, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=330, Percent_Identity=23.9393939393939, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=342, Percent_Identity=25.4385964912281, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=306, Percent_Identity=28.1045751633987, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=322, Percent_Identity=29.1925465838509, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=306, Percent_Identity=27.7777777777778, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319258, Length=363, Percent_Identity=24.5179063360882, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=263, Percent_Identity=26.615969581749, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=280, Percent_Identity=30.3571428571429, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=363, Percent_Identity=25.3443526170799, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=280, Percent_Identity=30.3571428571429, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=27.5449101796407, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=271, Percent_Identity=27.6752767527675, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=308, Percent_Identity=25.974025974026, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=257, Percent_Identity=29.1828793774319, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737897, Length=334, Percent_Identity=26.0479041916168, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=25.3012048192771, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17737895, Length=362, Percent_Identity=24.8618784530387, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221457811, Length=188, Percent_Identity=27.6595744680851, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550770, Length=188, Percent_Identity=27.6595744680851, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551930, Length=188, Percent_Identity=27.6595744680851, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37615; Mature: 37615

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKALSKLKPEEGIWLTEVEKPEMGHNDLLIRIKKTAICGTDVHIYNWDEWSQKTIPVP
CCCCCHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCCCCCE
MVVGHEYVGEVVGIGQEVRGFEIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRT
EEECHHHHHHHHCCCCHHCCEECCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCC
GAFSEYLVIPAFNAFKIPAGISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIM
CCCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHH
AAAVAKHVGARHVVITDVNEYRLDLAKKMGVTRAVNVMNEKLEDVMSELGMTEGFDVGLE
HHHHHHHCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
MSGNPSAFNSMLTNMNHGGKISLLGIPPSDMTVDWNQVIFKGLVIKGIYGREMFETWYKM
ECCCHHHHHHHHHCCCCCCEEEEEECCCCCCEECHHHHHHHHHHEECCCCHHHHHHHHHH
ASLIQSGLDLTPIITHHYKIDDFQAGFDMMRSGMSGKVILDWE
HHHHHCCCCCCEEEEEEEECCHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure
MKIKALSKLKPEEGIWLTEVEKPEMGHNDLLIRIKKTAICGTDVHIYNWDEWSQKTIPVP
CCCCCHHHCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCCCCCE
MVVGHEYVGEVVGIGQEVRGFEIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRT
EEECHHHHHHHHCCCCHHCCEECCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCC
GAFSEYLVIPAFNAFKIPAGISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIM
CCCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHH
AAAVAKHVGARHVVITDVNEYRLDLAKKMGVTRAVNVMNEKLEDVMSELGMTEGFDVGLE
HHHHHHHCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
MSGNPSAFNSMLTNMNHGGKISLLGIPPSDMTVDWNQVIFKGLVIKGIYGREMFETWYKM
ECCCHHHHHHHHHCCCCCCEEEEEECCCCCCEECHHHHHHHHHHEECCCCHHHHHHHHHH
ASLIQSGLDLTPIITHHYKIDDFQAGFDMMRSGMSGKVILDWE
HHHHHCCCCCCEEEEEEEECCHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA